Purine nucleoside phosphorylase: A potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases

Current Drug Targets

Volumn 8, Issue 3, 2007, Pages 413-422

  Silva, R G ^a,b   Nunes, J E S ^a   Canduri, F ^c   Borges, J C ^c   Gava, L M ^c   Moreno, F B ^c   Basso, Luiz A ^a   Santos, Diogenes S ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Autoimmune diseases; Drug design; Enzyme inhibition; Malaria; Protein structure; Purine nucleoside phosphorylase

Indexed keywords

DNA; IMMUCILLIN H; PURINE NUCLEOSIDE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; RIBOSE 1 PHOSPHATE; RNA;

APICOMPLEXA; AUTOIMMUNE DISEASE; CATALYSIS; DNA SYNTHESIS; DRUG DESIGN; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; GENETIC DISORDER; GRAFT REJECTION; HUMAN; IMMUNOMODULATION; IMMUNOPATHOLOGY; LEUKEMIA; MAMMAL; NONHUMAN; NUCLEOTIDE METABOLISM; ORGAN TRANSPLANTATION; PARASITOSIS; PLASMODIUM FALCIPARUM; PRODUCT DEVELOPMENT; PROTEIN FUNCTION; PROTEIN STRUCTURE; PURINE METABOLISM; REVIEW; RNA SYNTHESIS; T LYMPHOCYTE;

ANIMALS; APICOMPLEXA; DRUG DELIVERY SYSTEMS; HUMANS; PROTOZOAN INFECTIONS; PURINE-NUCLEOSIDE PHOSPHORYLASE; T-LYMPHOCYTES;

EID: 33847739654     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780058997     Document Type: Review

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