Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis

Biochemistry

Volumn 36, Issue 39, 1997, Pages 11749-11756

  Stoeckler, Johanna D ^a   Poirot, Anne F ^a   Smith, Rose Marie ^a   Parks Jr , Robert E ^a   Ealick, Steven E ^b   Takabayashi, Kenji ^c   Erion, Mark D ^c,d  

^a BROWN UNIVERSITY   (United States)

^b Cornell University ^*  (United States)

^c CIBA GEIGY LTD   (Switzerland)

^d Gensia Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENETIC ENGINEERING; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

2-AMINOPURINE; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDES; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINONES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

FELIS CATUS;

EID: 0030874772     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961971n     Document Type: Article

References (29)

1. Agarwal, R. P., & Parks, R. E., Jr. (1978) Methods Enzymol. 51, 502-507.
2. Bzowska, A., Kulikowska, E., & Shugar, D. (1990) Z. Naturforsch. 45c, 59-70.
3. Clarke, A. R., Atkinson, T., & Holbrook, J. J. (1989) Trends Biochem. Sci. 14, 145-148.
4. Corbier, C., Clermont, S., Billard, P. Skarzynski, T., Branlant, C., Wonacott, A., & Branlant, G. (1990) Biochemistry 29, 7101-7106.
5. Ealick, S. E., Rule, S. A., Carter, D. C., Greenhough, T. J., Babu, Y. S., Cook, W. J., Habash, J., Helliwell, J. R., Stoeckler, J. D., Parks, R. E., Jr., Chen, S. F., & Bugg, C. E. (1990) J. Biol. Chem. 265, 1812-1820.
6. Erion, M. D., Takabayashi, K., Smith, H. B., Kessi, J., Wagner, S., Hönger, S., Shames, S. L. & Ealick, S. E. (1997a) Biochemistry 36, 11725-11734.
7. Erion, M. D., Stoeckler, J. D., Guida, W. C., Walter, R. L., & Ealick, S. E. (1997b) Biochemistry 36, 11735-11748.
8. Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., & Winter, G. (1985) Nature 314, 235-238.
9. Haschenmeyer, R. H., & Haschenmeyer, A. E. V. (1974) in Proteins: A Guide to Study by Physical and Chemical Methods; pp 266-267, Wiley, New York.
10. Huennekens, F. M., Nurk, E., & Gabrio, B. W. (1956) J. Biol. Chem. 221, 971-981.
11. Hutchinson, D. W. (1990) Trends Biotechnol. 8, 348-353.
12. Kalckar, H. M. (1947a) J. Biol. Chem. 167, 429-443.
13. Kalckar, H. M. (1947b) J. Biol. Chem. 167, 461-475.
14. Krenitsky, T. A., Koszalka, G. W., Tuttle, J. V., Rideout, J. L., & Elion, G. B. (1981) Carbohydr. Res. 97, 139-146.
15. Krenitsky, T. P., Rideout, J. L., Choa, E. Y., Koszalka, G. W., Gurney, F., Crouch, R. C., Cohn, N. K., Wolberg, G., & Vinegar, R. (1986) J. Med. Chem. 29, 138-143.
16. Meng, M., Lee, C., Bagdasarian, M., & Zeikus, J. G. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 4015-4019.
17. Murakami, K., Shirasaka, T., Yoshioka, H., Kojima, E., Aoki, S., Ford, H., Jr., Driscoll, J. S., Kelley, J. A., & Mitsuya, H. (1991) J. Med. Chem. 34, 1606-1612.
18. Olopade, O. I., Pomykala, H. M., Hagos, F., Sveen, L. W., Espinosa, R., III, Dreyling, M. H. Gursky, S., Stadler, W. M., Le Beau, M. M., & Bohlander, S. K. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 6489-6493.
19. Pantoliano, M. W., Landner, R. C., Bryan, P. N., Rollence, M. L., Wood, J. F., & Poulous, T. I. (1987) Biochemistry 26, 2077-2082.
20. Polastro, E. T., Walker, A., & Teeuwen, H. W. A. (1989) Biotechnology 7, 1238-1241.
21. Scrutton, N. S., Berry, A., & Perham, R. N. (1990) Nature 343, 38-43.
22. Sigal, I. S., Gibbs, J. B., D'Alonzo, J. S., Temeles, G. L., Wolanski, B. S., Socher, S. H., & Scolnick, E. M. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 952-956.
23. Stoeckler, J. D. (1984) in Developments in Cancer Chemotherapy (Glazer, R. I., Ed.) pp 35-60, CRC, Boca Raton, FL.
24. Stoeckler, J. D., Agarwal, R. P., Agarwal, & Parks, R. E., Jr. (1978) Methods Enzymol. 51, 530-538.
25. Stoeckler, J. D., Cambor, C., & Parks, R. E., Jr. (1980) Biochemistry 19, 102-107.
26. Valencia, A., Chardin, P., Wittinghofer, A., & Sander, C. (1991) Biochemistry 30, 4637-4648.
27. Wolley, P., & Clark, B. F. C. (1989) Bio/Technology 7, 913-920.
28. Yokozeki, K., Shirae, H., & Kubota, K. (1990) Ann. NY Acad. Sci. 613, 757-759.
29. Zimmerman, T. P., Gersten, N. B., Ross, A. F., & Miech, R. P. (1971) Can. J. Biochem. 49, 1050-1054.