Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor - BCX-1777

International Immunopharmacology

Volumn 3, Issue 6, 2003, Pages 879-887

  Bantia, Shanta ^a   Ananth, Sandya L ^a   Parker, Cynthia D ^a   Horn, LaShun L ^a   Upshaw, Ramanda ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

Apoptosis; dNTP levels; T ALL

Indexed keywords

DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; IMMUCILLIN H; LAMIVUDINE; NUCLEOTIDASE; PHOSPHOTRANSFERASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL TRIAL; DRUG ACCUMULATION; DRUG HALF LIFE; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0038730672     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(03)00076-6     Document Type: Article

References (20)

1. Martin D.W., Gelfand E.W. Biochemistry of diseases of immunodevelopment. Annu. Rev. Biochem. 50:1981;845-877.
2. Giblett E.R., Ammann A.J., Wara D.W., Sandman R., Diamond L.K. Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet. 1:1975;1010-1013.
3. Markert M.L. Purine nucleoside phosphorylase deficiency. Immunodefic. Rev. 3:1991;45-81.
4. Kazmers I.S., Mitchell B.S., DaDonna P.E., Wotring I.I., Townsend L.B., Kelly W.N. Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T-lymphocytes. Science. 214:1981;1137-1139.
5. Dong M.K., Gilbertsen R.B. PD 141955 and CI-972. 9-deazaguanine analog purine nucleoside phosphorylase inhibitors: II. Effects on nucleoside catabolism in human and rat blood in vitro. Agents Actions. 39:1993;C99-C101. (special conference issue).
6. Viegas T.X., Omura G.A., Stoltz R.R., Kisicki J. Pharmacokinetics and pharmacodynamics of Peldesine (BCX-34), a purine nucleoside phosphorylase inhibitor, following single and multiple oral doses in healthy volunteers. J. Clin. Pharmacol. 40:2000;410-420.
7. Bantia S., Miller P.J., Parker C.D., Ananth S.L., Horn L.L.et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H) - a novel potent and orally active immunosuppressive agent. Int. Immunopharmacol. 1:2001;1199-1210.
8. Miles R.W., Tyler P.C., Furneaux R.H., Bagdassarian C.K., Schramm V.L. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry. 37:1998;8615-8621.
9. Kicska G.A., Long L., Horig H., Fairchild C., Tyler P.C.et al. Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes. Proc. Natl. Acad. Sci. 98:2001;4593-4598.
10. Rizzardi G.P., Harari A., Capiluppi B., Tambussi G., Ellefsen K.et al. Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy. JCI. 109:2002;681-688.
11. Sherman P.A., Fyfe J.A. Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. Anal. Biochem. 180:1989;222-226.
12. Bantia S., Miller P.J., Parker C.D., Ananth S.L., Horn L.L.et al. Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777. Int. Immunopharmacol. 2:2002;913-923.
13. Cohen A., Doyle D., Martin D.W., Ammann A.J. Abnormal purine metabolism and purine overproduction in a patient deficient of purine nucleoside phosphorylase. N. Engl. J. Med. 295:1976;1449-1454.
14. Krenitsky T.A., Tuttle J.V., Koszalka G.W., Chen I.S., Beacham L.M.et al. Deoxycytidine kinase from calf thymus: substrate and inhibitor specificity. J. Biol. Chem. 251:1976;4055-4061.
15. Kazmers I.S., Mitchell B.S., DaDonna P.E., Wotring I.I., Townsend L.B., Kelly W.N. Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T-lymphocytes. Science. 214:1981;1137-1139.
16. Eriksson S., Thelander L., Kaerman M. Allosteric regulation of calf thymus ribonucleoside diphosphate reductase. Biochemistry. 18:1979;2946-2952.
17. Oliver F.J., Collins M.K., Lopez-Rivas A. dNTP pools imbalance as a signal to initiate apoptosis. Experentia. 52:1996;995-1000.
18. Hirota Y., Yoshioka A., Tanaka S., Watanabe K., Otani T.et al. Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells. Cancer Res. 49:1989;915-919.
19. Oliver F.J., Collins M.K., Lopez-Rivas A. Regulation of the salvage pathway of deoxynucleotide synthesis in apoptosis induced by growth factor deprivation. Biochem. J. 316:1996;421-425.
20. Meuth M. The molecular basis of mutation induced by dNTP pool imbalances in mammalian cells. Exp. Cell Res. 181:1989;305-316.