Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine

Archives of Biochemistry and Biophysics

Volumn 442, Issue 1, 2005, Pages 49-58

  Silva, Rafael G ^a   Pereira, José H ^b   Canduri, Fernanda ^b   De Azevedo Jr , Walter F ^b   Basso, Luiz A ^a   Santos, Diógenes S ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Crystal structure; Drug design; Kinetic mechanism; MESG; Purine nucleoside phosphorylase

Indexed keywords

7 METHYL 6 THIOGUANOSINE; GUANOSINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; CATABOLISM; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GUANOSINE; HUMANS; KINETICS; LIGANDS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; RIBOSEMONOPHOSPHATES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIONUCLEOSIDES; THIONUCLEOTIDES;

EID: 24944507288     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2005.07.021     Document Type: Article

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