Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7135-7146

  Mao, Chen ^a,d   Cook, William J ^b   Zhou, Min ^a   Federov, Alexander A ^c   Almo, Steven C ^c   Ealick, Steven E ^a  

^a Cornell University ^*  (United States)

^b University of Alabama at Birmingham   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CELLULAR IMMUNITY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEFICIENCY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ACYCLOVIR; ANIMALS; ARSENATES; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; FORMYCINS; GUANINE; HUMANS; HYPOXANTHINE; INOSINE; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PHOSPHATES; PURINE-NUCLEOSIDE PHOSPHORYLASE; RIBOSEMONOPHOSPHATES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFATES;

BOVINAE;

EID: 0032546620     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9723919     Document Type: Article

References (25)

1. Erion, M. D., Stoeckler, J. D., Guida, W. C., Walter, R. L., and Ealick, S. E. (1997) Purine nucleoside phosphorylase. 2. Catalytic mechanism. Biochemistry 36, 11735-11748.
2. Parks, R. E., Jr., and Agarwal, R. B. (1972) Purine nucleoside phosphorylase, in The Enzymes (Boyer, P. D., Ed.) Vol. 7, pp 483-514, Academic Press, New York.
3. Giblett, E. R., Ammann, A. J., Wara, D. W., Sandman, R., and Diamond, L. K. (1975) Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity, Lancet 1, 1010-1013.
4. Ealick, S. E., Rule, S. A., Carter, D. C., Greenhough, T. J., Babu, Y. S., Cook, W. J., Habash, J., Stoeckler, J. D., Parks, R. E., Jr., Chen, S., and Bugg, C. E. (1990) Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 Å resolution, J. Biol. Chem. 265, 1812-1820.
5. Bzowska, A., Luic, M., Schroder, W., Shugar, D., Saenger, W., and Koellner, G. (1995) Calf spleen purine nucleoside phosphorylase: Purification, sequence and crystal structure of its complex with an N(7)-acycloguanosine inhibitor, FEBS Lett. 367, 214-218.
6. Koellner, G., Luic, M., Shugar, D., Saenger, W., and Browska, A. (1997) Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 Å resolution, J. Mol. Biol. 265, 202-216.
7. Ealick, S. E., Babu, Y. S., Bugg, C. E., Erion, M. D., Guida, W. C., Montgomery, J. A., and Secrist, J. A., III (1991) Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors, Proc. Natl. Acad. Sci. U.S.A. 88, 11540-11544.
8. Navaza, J. (1994) AMoRe: an automated package for molecular replacement, Acta Crystallogr. A50, 157-163.
9. Brünger, A. T. (1988) XPLOR Manual, Version 3.1, Yale University Press, New Haven, CT.
10. Brünger, A. T. (1992) Free R value: a novel statistical quantity for assessing the accuracy of crystal structures, Nature 355, 472-475.
11. Engh, R. A., and Huber, R. (1991) Accurate bond and angle parameters for X-ray protein structure refinement, Acta Crystallogr. A47, 392-400.
12. Tuttle, J. V., and Kenitsky, T. A. (1984) Effects of acyclovir and its metabolites on purine nucleoside phosphorylase, J. Biol. Chem. 259, 4065-4069.
13. Kabsch, W. (1976) A solution for the best rotation to relate two sets of vectors, Acta Crystallogr. A32, 922-923.
14. Ropp, P. A., and Traut, T. W. (1991) Purine nucleoside phosphorylase. Allosteric regulation of a dissociating enzyme, J. Biol. Chem. 266, 7682-7687.
15. Erion, M. D., Takabayashi, K., Smith, H. B., Kessi, J., Wagner, S., Honger, S., Shames, S. L., and Ealick, S. E. (1997) Purine nucleoside phosphorylase. 1. Structure - function studies, Biochemistry 36, 11725-11734.
16. Noel, J. P., Hamm, H. E., and Sigler, P. B. (1993) The 2.2 Å crystal structure of transducin-α complexed with GTPγS, Nature 366, 654-663.
17. Lambright, D. G., Noel, J. P., Hamm, H. E., and Sigler, P. B. (1994) Structural determinants for activation of the α-subunit of a heterotrimeric G protein, Nature 369, 621-628.
18. Mao, C., Cook, W. J., Zhou, M., Koszalka, G. W., Krenitsky, T. A., and Ealick, S. E. (1997) The crystal structure of Escherichia coli purine nucleoside phosphorylase at 2.0 Aring; resolution, Structure 5, 1373-1383.
19. Kline, P. C., and Schramm, V. L. (1992) Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity, Biochemistry 31, 5964-5973.
20. Carlson, J. D., and Fischer, A. G. (1979) Thyroid purine nucleoside phosphorylase. II. Kinetic model by alternate substrate and inhibition studies, Biochim. Biophys. Acta 566, 259-265.
21. Stein, R. L., and Corder, E. H. (1981) Kinetic alpha-deuterium isotope effects for Escherichia coli purine nucleoside phsophorylase-catalyzed phosphorolysis of adenosine and inosine, J. Biol. Chem. 256, 767-772.
22. Lehikoinen, P. K., Sinnott, M. L., and Krenitsky, T. A. (1989) Investigation of alpha-deuterium kinetic isotope effects on the purine nucleoside phosphorylase reaction by the equilibrium-perturbation technique, Biochem. J. 257, 355-359.
23. Kline, P. C., and Schramm, V. L. (1993) Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction, Biochemistry 32, 13212-13219.
24. Carson, M. (1987) Ribbon models of macromolecules, J. Mol. Graphics 5, 103-106.
25. Sack, J. S. (1988) CHAIN - a crystallographic modeling program, J. Mol. Graphics 6, 244-245.