Purine nucleoside phosphorylase. 1. Structure - Function studies

Biochemistry

Volumn 36, Issue 39, 1997, Pages 11725-11734

  Erion, Mark D ^a,d   Takabayashi, Kenji ^a   Smith, Harry B ^a   Kessi, Janine ^a   Wagner, Sylvia ^a   Hönger, Sybille ^a   Shames, Spencer L ^b,e   Ealick, Steven E ^c  

^a CIBA GEIGY LTD   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Department of Population Medicine and Diagnostic Sciences   (United States)

^d Gensia Inc   (United States)

^e GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDES; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

FELIS CATUS;

EID: 0030817010     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961969w     Document Type: Article

References (41)

1. Agarwal, K. C., Agarwal, R. P., Stoeckler, J. D., & Parks, R. E., Jr. (1975) Biochemistry 14, 79-84.
2. Bennett, L. L., Jr., Allan, P. W., Noker, P. E., Rose, L. M., Niwas, S., Montgomery, J. A., & Erion, M. D. (1993) J. Pharm. Exp. Ther. 266, 707-714.
3. Bradford, M. M. (1976) Anal. Biochem. 72, 248.
4. Bzowska, A., Kulikowska, E., & Shugar, D. (1990) Z. Naturforsh. 45, 59-70.
5. Chang, C.-H., Bennett, L. L., Jr., & Brockman, R. W. (1989) Anal. Biochem. 183, 279-282.
6. DeGroot, H., DeGroot, H., & Noll, T. (1985) Biochem. J. 229, 255.
7. Ealick, S. E., Rule, S. A., Carter, D. C., Greenhough, T. J., Babu, Y. S., Cook, W. J., Habash, J., Helliwell, J. R., Stoeckler, J. D., Parks, R. E., Jr., Chen, S.-F., & Bugg, C. E. (1990) J. Biol. Chem. 265, 1812-1820.
8. Ealick, S. E., Babu, Y. S., Bugg, C. E., Erion, M. D., Guida, W. C., Montgomery, J. A., & Secrist, J. A., III (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11540-11544.
9. Erion, M. D. (1990) Eur. Patent Appl. 374,096.
10. Erion, M. D., Stoeckler, J. D., Guida, W. C., Walter, R. L., & Ealick, S. E. (1997) Biochemistry 36, 11735-11748.
11. Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., & Winter, G. (1985) Nature 314, 235-238.
12. Friedkin, M. (1950) J. Biol Chem. 184, 449-464.
13. Giblett, E. R., Ammann, A. J., Wara, D. W., Sandman, R., & Diamond, L. K. (1975) Lancet 1, 1010-1013.
14. Goddard, J. M., Caput, D., Williams, S. R., & Martin, D. W., Jr. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 4281-4285.
15. Jochimsen, B., Nygaard, P., & Veestergaard, T. (1975) Mol. Gen. Genet. 143, 85-91.
16. Jordan, F., & Wu, A. (1978) J. Med. Chem. 21, 877-882.
17. Kalckar, H. M. (1947) J. Biol. Chem. 167, 429-443.
18. Kim, B. K., Cha, S., & Parks, R. E., Jr. (1968) J. Biol. Chem. 243, 1771-1776.
19. Kirby, A. J. (1987) CRC Crit. Rev. Biochem. 22, 283-315.
20. Kline, P. C., & Schramm, V. L. (1992) Biochemistry 31, 5964-5973.
21. Kline, P. C., & Schramm, V. L. (1993) Biochemistry 32, 13212-13219.
22. Kline, P. C., & Schramm, V. L. (1995) Biochemistry 34, 1153-1162.
23. Krenitsky, T. (1967) Mol. Pharmacol. 3, 526-536.
24. Krenitsky, T. A., Koszalka, G. W., & Tuttle, J. V. (1981) Biochemistry 20, 3615-3621.
25. Kunkel, T. A., Roberts, J. D., & Zakour, R. A. (1987) Methods Enzymol. 154, 367-382.
26. Lanzetta, P. A., Alvarez, L., Reinach, P. S., & Candia, O. A. (1979) Anal. Biochem. 100, 95-97.
27. Parks, R. E., Jr., & Agarwal, R. P. (1972) Enzymes 7, 3rd ed., 483-514.
28. Porter, D. J. T. (1992) J. Biol. Chem. 267, 7342-7351.
29. Ropp, P. A., & Traut, T. W. (1991) J. Biol. Chem. 266, 7682-7687.
30. Saheki, S., Takeda, A., & Shimazu, T. (1985) Anal. Biochem. 148, 277-281.
31. Sanger, F., Nicklen, S., & Coulson, A. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463.
32. Sircar, J. C., & Gilbertsen, R. B. (1988) Drugs of the Future 13, 653-668.
33. Stein, R. L., & Cordes, E. H. (1981) J. Biol. Chem. 256, 767-772.
34. Stoeckler, J. D. (1984) in Developments in Cancer Chemotherapy (Glazer, R. I., Ed.) pp 35-60, CRC Press: Boca Raton, FL.
35. Stoeckler, J. D., & Parks, R. E., Jr. (1985) in Methods in Pharmacology (Paton, D. M., Ed.) vol 6, pp 147-162, Plenum Press, New York.
36. Stoeckler, J. D., Cambor, C., & Parks, R. E., Jr. (1980) Biochemistry 19, 102-107.
37. Stoeckler, J. D., Poirot, A. F., Smith, R. M., Parks, R. E., Jr., Ealick, S. E., Takabayashi, K., & Erion, M. D. (1997) Biochemistry 36, 11749-11756.
38. Williams, S. R., Goddard, J. M., & Martin, Jr., D. W. (1984) Nucleic Acids Res. 12, 5779-5787.
39. Williams, S. R., Gekeler, V., McIvor, R. S., & Martin, D. W., Jr. (1987) J. Biol. Chem. 262, 2332-2338.
40. Zimmerman, T. P., Gersten, N. B., Ross, A. F., & Miech, R. P. (1971) Can. J. Biochem. 49, 1050-1054.
41. Zoltewicz, J. A., Clark, D. F., Sharpless, T. W., & Grahe, G. (1970) J. Am. Chem. Soc. 92, 1741-1749.