Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

Biochemical and Biophysical Research Communications

Volumn 308, Issue 3, 2003, Pages 553-559

  Dos Santos, Denis Marangoni ^a,b   Canduri, Fernanda ^a,b   Pereira, José Henrique ^a,b   Dias, Márcio Vinicius Bertacine ^a   Silva, Rafael Guimarães ^c   Mendes, Maria Anita ^a,b   Palma, Mário Sérgio ^a,b   Basso, Luiz Augusto ^c   De Azevedo Jr , Walter Filgueira ^a,b   Santos, Diógenes Santiago ^c,d  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Acyclovir; Drug design; PNP; Structure; Synchrotron radiation

Indexed keywords

ACICLOVIR; IMMUCILLIN H; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME INHIBITION; HERPES SIMPLEX VIRUS; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; PROTEIN TARGETING; T LYMPHOCYTE;

SIMPLEXVIRUS;

EID: 0042165032     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01433-5     Document Type: Article

References (32)

1. Parks R.E. Jr., Agarwal R.P. Boyer P.D. The Enzymes. 1972;483-514 Academic Press, New York.
2. Schramm V.L. Enzymatic transition states and transition state analog design. Annu. Rev. Biochem. 67:1998;693-720.
3. Stoeckler J.D., Cambor C., Parks R.E. Jr. Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleosides substrates. Biochemistry. 19:1980;102-107.
4. Porter D.J.T. Purine nucleoside phosphorylase. Kinetic mechanism of the enzyme from calf spleen. J. Biol. Chem. 267:1992;7342-7351.
5. Giblett E.R., Ammann A.J., Wara D.W., Sandman R.D., Diamond L.K. Nucleoside phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet. I:1975;1010-1013.
6. Datta N.S., Shewach D.S., Mitchell B.S., Fox I.H. Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase. J. Biol. Chem. 264:1989;9359-9364.
7. Thelander L., Reichard P. Reduction of ribonucleotides. Ann. Rev. Biochem. 48:1979;133-158.
8. Bzowska A., Kulikowska E., Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol. Therap. 88:2000;349-425.
9. Schramm V.L. Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents. Biochim. Biophys. Acta. 1587:2002;107-117.
10. Tuttle J.V., Krenitsky T.A. Effects of acyclovir and its metabolites on purine nucleoside phosphorylase. J. Biol. Chem. 259:1984;4065-4069.
11. Montgomery J.A. Purine nucleoside phosphorylase: a target for drug design. Med. Res. Rev. 13(3):1993;209-228.
12. Silva R.G., Carvalho L.P., Oliveira J.S., Pinto C.A., Mendes M.A., Palma M.S., Basso L.A., Santos D.S. Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase. Protein Expr. Purif. 27(1):2003;158-164.
13. de Azevedo W.F. Jr., Canduri F., Santos D.M., Silva R.G., Oliveira J.S., Carvalho L.P.S., Basso L.A., Mendes M.A., Palma M.S., Santos D.S. Crystal structure of human purine nucleoside phosphorylase at 2.3. Å resolution Biochem. Biophys. Res. Commun. 308:2003;545-552.
14. Cook W.J., Ealick S.E., Bugg C.E., Stoeckler J.D., Parks R.E. Jr. Crystallization and preliminary X-ray investigation of human erythrocytic purine nucleoside phosphorylase. J. Biol. Chem. 256:1981;4079-4080.
15. Ealick S.E., Babu Y.S., Bugg C.E., Erion M.D., Guida W.C., Montgomery J.A., Secrist III J.A. Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. Proc. Natl. Acad. Sci. USA. 91:1991;11540-11544.
16. Collaborative Computational Project, Number 4, The CCP4 suite: programs for protein, Acta Crystallogr. D50 (1994) 760-763.
17. Navaza J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A. 50:1994;157-163.
18. Brünger A.T. X-PLOR Version 3.1: A System for Crystallography and NMR. 1992;Yale University Press, New Haven.
19. R.A. Laskowski, M.W. MacArthur, D.K. Smith, D.T. Jones, E.G. Hutchinson, A.L. Morris, D. Naylor, D.S. Moss, J.M. Thorton, PROCHECK v.3.0 - Program to Check the Stereochemistry Quality of Protein Structures - Operating Instructions, 1994.
20. McRee D.E. XtalView/Xfit - A versatile program for manipulating atomic coordinates and electron density. J. Struct. Biol. 125:1999;156-165.
21. Luzzati P.V. Traitement statistique des erreurs dans la determination des structures cristallines. Acta Crystallogr. 5:1952;802-810.
22. Ropp P.A., Traut T.W. Allosteric regulation of purine nucleoside phosphorylase. Arch. Biochem. Biophys. 288(2):1991;614-620.
23. Erion M.D., Takabayashi K., Smith H.B., Kessi J., Wagner S., Hönger S., Shames S.L., Ealick S.E. Purine nucleoside phosphorylase. 1. Structure-function studies. Biochemistry. 36:1997;11725-11734.
24. Canduri F., Teodoro L.G.V.L., Lorenzi C.C.B., Hial V., Gomes R.A.S., Ruggiero Neto J., de Azevedo W.F. Jr. Crystal structure of human uropepsin at 2.45. Å resolution Acta Crystallogr. D57:2001;1560-1570.
25. de Azevedo W.F. Jr., Canduri F., Fadel V., Teodoro L.G.V.L., Hial V., Gomes R.A.S. Molecular model for the binary complex of uropepsin and pepstatin. Biochem. Biophys. Res. Commun. 287(1):2001;277-281.
26. de Azevedo W.F. Jr., Canduri F., da Silveira N.J.F. Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol. Biochem. Biophys. Res. Commun. 293:2002;566-571.
27. de Azevedo W.F. Jr., de Oliveira J.S., Basso L.A., Palma M.S., Pereira J.H., Canduri F., Santos D.S. Molecular model of shikimate kinase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 295(1):2002;142-148.
28. de Azevedo W.F. Jr., Gaspar R.T., Canduri F., Camera J.C., da Silveira N.J.F. Molecular model of cyclin-dependent kinase 5 complexed with roscovitine. Biochem. Biophys. Res. Commun. 297:2002;1154-1158.
29. Miles R.W., Tyler P.C., Furneaux R.H., Bagdassarian C.K., Schramm V.L. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry. 37:1998;8615-8621.
30. Nicholls A., Sharp K., Honig B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins Struct. Funct. Genet. 11:1991;281-296.
31. Kraulis P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of proteins. J. Appl. Cryst. 24:1991;946-950.
32. Merritt E.A., Bacon D.J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277:1997;505-524.