Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

Biochemistry

Volumn 42, Issue 20, 2003, Pages 6057-6066

  Lewandowicz, Andrzej ^a   Shi, Wuxian ^a   Evans, Gary B ^b   Tyler, Peter C ^b   Furneaux, Richard H ^b   Basso, Luiz A ^c   Santos, Diogenes S ^c   Almo, Steven C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DISEASES; SYNTHESIS (CHEMICAL);

TRANSITION STATES;

ENZYME INHIBITION;

BACTERIAL PROTEIN; IMMUCILLIN H; N RIBOSYLTRANSFERASE; PURINE; PURINE NUCLEOSIDE PHOSPHORYLASE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; INOSINE; KINETICS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLES; SUBSTRATE SPECIFICITY;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0038522525     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0343830     Document Type: Article

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