Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30320-30328

  Lewandowicz, Andrzej ^a,c   Ringia, Erika A Taylor ^a   Ting, Li Min ^a   Kim, Kami ^a   Tyler, Peter C ^b   Evans, Gary B ^b   Zubkova, Olga V ^b   Mee, Simon ^b   Painter, Gavin F ^b   Lenz, Dirk H ^b   Furneaux, Richard H ^b   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGY; MICROORGANISMS; SUBSTITUTION REACTIONS;

DECOXYGUANOSINE; HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE (HUPNP); IMMUCILLIN-H; PLASMODIUM FALCIPARUM;

ENZYMES;

5' METHYLTHIOINOSINE; 6 METHYLTHIOINOSINE; ASPARAGINE; ASPARTIC ACID; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; IMMUCILLIN H; POLYAMINE; PURINE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL DIVISION; CELL KILLING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG PROTEIN BINDING; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PLASMODIUM FALCIPARUM; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURINE METABOLISM; T LYMPHOCYTE;

ANIMALS; ASPARTIC ACID; CATTLE; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PLASMODIUM FALCIPARUM; POLYAMINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; PYRIMIDINONES; PYRROLES; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

BOVINAE; PLASMODIUM FALCIPARUM;

EID: 24044440419     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505033200     Document Type: Article

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