Structures of human purine nucleoside phosphorylase complexed with inosine and ddI

Biochemical and Biophysical Research Communications

Volumn 313, Issue 4, 2004, Pages 907-914

  Canduri, Fernanda ^a,b   Dos Santos, Denis Marangoni ^a,b   Silva, Rafael Guimarães ^c   Mendes, Maria Anita ^b,d   Basso, Luiz Augusto ^c   Palma, Mário Sérgio ^b,d   De Azevedo Jr , Walter Filgueira ^a,b   Santos, Diógenes Santiago ^c,e  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Institute of Biosciences   (Brazil)

^e PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Drug design; PNP; Structure; Synchrotron radiation

Indexed keywords

ADENINE; ADENOSINE MONOPHOSPHATE DEAMINASE; DIDANOSINE; INOSINE; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; B LYMPHOCYTE; BINDING SITE; CATALYSIS; CATALYST; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME DEFICIENCY; ENZYME STRUCTURE; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; RADIATION; SYNCHROTRON; SYNCHROTRON RADIATION; T LYMPHOCYTE;

EID: 0347989420     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.11.179     Document Type: Article

References (29)

1. Stoeckler J.D. Glazer R.I. Developments in Cancer Chemotherapy. 1984;35-60 CRC, Boca Raton, FL.
2. Bzowska A., Kulikowska E., Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol. Therapeut. 88:2000;349-425.
3. Mao C., Cook W.J., Zhou M., Federov A.A., Almo S.C., Ealick S.E. Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues. Biochemistry. 37:1998;7135-7146.
4. De Azevedo W.F., Canduri F., dos Santos D.M., Silva R.G., Oliveira J.S., Carvalho L.P.S., Basso L.A., Mendes M.A., Palma M.S., Santos D.S. Crystal structure of human purine nucleoside phosphorylase at 2.3. Å resolution Biochem. Biophys. Res. Commun. 308(3):2003;545-552.
5. De Azevedo W.F., Santos G.C., dos Santos D.M., Olivieri J.R., Canduri F., Silva R.G., Basso L.A., Mendes M.A., Palma M.S., Santos D.S. Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase. Biochem. Biophys. Res. Commun. 309:2003;928-933.
6. De Azevedo W.F., Canduri F., dos Santos D.M., Pereira J.H., Dias M.V.B., Silva R.G., Mendes M.A., Basso L.A., Palma M.S., Santos D.S. Crystal structure of human PNP complexed with guanine. Biochem. Biophys. Res. Commun. 312:2003;767-772.
7. ′ -dideoxyinosine (ddI) in human blood Br. J. Clin. Pharmacol. 33:1992;319-322.
8. Silva R.G., Carvalho L.P., Oliveira J.S., Pinto C.A., Mendes M.A., Palma M.S., Basso L.A., Santos D.S. Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase. Protein Expr. Purif. 27(1):2003;158-164.
9. dos Santos D.M., Canduri F., Pereira J.H., Dias M.V.B., Silva R.G., Mendes M.A., Palma M.S., Basso L.A., de Azevedo W.F., Santos D.S. Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir. Biochem. Biophys. Res. Commun. 308(3):2003;553-559.
10. De Azevedo W.F., Canduri F., dos Santos D.M., Pereira J.H., Dias M.V.B., Silva R.G., Mendes M.A., Basso L.A., Palma M.S., Santos D.S. Structural basis for inhibition of human PNP by immucillin-H. Biochem. Biophys. Res. Commun. 309:2003;922-927.
11. Collaborative Computational Project, Acta Crystallogr. D 50 (4) (1994) 760-763.
12. Navaza J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A. 50:1994;157-163.
13. Brünger A.T. X-PLOR Version 3.1: A System for Crystallography and NMR. 1992;Yale University Press, New Haven.
14. R.A. Laskowski, M.W. MacArthur, D.K. Smith, D.T. Jones, E.G. Hutchinson, A.L. Morris, D. Naylor, D.S. Moss, J.M. Thorton, PROCHECK v.3.0 - program to check the stereochemistry quality of protein structures - operating instructions, 1994.
15. McRee D.E. XtalView/Xfit - a versatile program for manipulating atomic coordinates and electron density. J. Struct. Biol. 125:1999;156-165.
16. Luzzati P.V. Traitement statistique des erreurs dans la determination des structures cristallines. Acta Crystallogr. 5:1952;802-810.
17. Ealick S.E., Rule S.A., Carter D.C., Greenhough T.J., Babu Y.S., Cook W.J., Habash J., Helliwell J.R., Stoeckler J.D., Parks R.E. Jr., Chen S.-F., Bugg C.E. Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2. Å resolution J. Biol. Chem. 265(3):1990;1812-1820.
18. De Azevedo W.F., MuellerDieckmann H.J., SchulzeGahmen U., Worland P.J., Sausville E., Kim S.H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA. 93(7):1996;2735-2740.
19. De Azevedo W.F., Leclerc S., Meijer L., Havlicek L., Strnad M, Kim S.H. Inhibition of cyclin-dependent kinases by purine analogues - crystal structure of human cdk2 complexed with roscovitine. Eur. J. Biochem. 243(1-2):1997;518- 526.
20. Kim S.H., Schulze-Gahmen U., Brandsen J., de Azevedo W.F. Structural basis for chemical inhibition of CDK2. Prog. Cell Cycle Res. 2:1996;137-145.
21. De Azevedo W.F., Canduri F., da Silveira N.J.F. Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol. Biochem Biophys. Res. Commun. 293:2002;566-571.
22. De Azevedo W.F., Gaspar R.T., Canduri F., Camera J.C., da Silveira N.J.F. Molecular model of cyclin-dependent kinase 5 complexed with roscovitine. Biochem Biophys. Res. Commun. 297:2002;1154-1158.
23. De Azevedo W.F., de Oliveira J.S., Basso L.A., Palma M.S., Pereira J.H., Canduri F., Santos D.S. Molecular model of shikimate kinase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 295(1):2002;142-148.
24. Canduri F., Silveira N.J.F., Camera J.C., de Azevedo W.F. Structural bioinformatics study of cyclin-dependent kinases complexed with inhibitors. Ecletica Quim. 28:2003;45-53.
25. Pereira J.H., Canduri F., Oliveira J.S., Silveira N.J.F., Basso L.A., Palma M.S., De Azevedo W.F., Santos D.S. Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 312:2003;608-614.
26. Nicholls A., Sharp K., Honig B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins Struct. Funct. Genet. 11:1991;281-296.
27. Montgomery J.A. Purine nucleoside phosphorylase: a target for drug design. Med. Res. Rev. 13(3):1993;209-228.
28. Kraulis P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of proteins. J. Appl. Cryst. 24:1991;946-950.
29. Merritt E.A., Bacon D.J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277:1997;505-524.