Purine nucleoside phosphorylase. 2. Catalytic mechanism

Biochemistry

Volumn 36, Issue 39, 1997, Pages 11735-11748

  Erion, Mark D ^a,e   Stoeckler, Johanna D ^b   Guida, Wayne C ^c   Walter, Richard L ^d   Ealick, Steven E ^d  

^a CIBA GEIGY LTD   (Switzerland)

^b BROWN UNIVERSITY   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Department of Obstetrics Gynecology   (United States)

^e Gensia Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINONES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0030760959     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961970v     Document Type: Article

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