Toxoplasma gondii purine nucleoside phosphorylase biochemical characterization, inhibitor profiles, and comparison with the Plasmodium falciparum ortholog

Journal of Biological Chemistry

Volumn 281, Issue 35, 2006, Pages 25652-25658

  Chaudhary, Kshitiz ^a,c   Li, Min Ting ^b   Kim, Kami ^b   Roos, David S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NEW ENGLAND BIOLABS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; DISEASES; GENES; METABOLISM; SUBSTRATES;

MUTANTS; PURINE NUCLEOSIDE PHOSPHORYLASE (PNP); SALVAGE PATHWAY;

ENZYMES;

5' METHYLTHIOINOSINE; ADENOSINE KINASE; HYPOXANTHINE; IMMUCILLIN H; INOSINE; POLYAMINE; PURINE NUCLEOSIDE PHOSPHORYLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APICOMPLEXA; ARTICLE; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL REACTION; CONTROLLED STUDY; DEAMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; GENOME; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MALARIA; MICROBIAL GROWTH; MUTANT; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PHYLUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PURINE METABOLISM; SIGNAL TRANSDUCTION; SPECIES COMPARISON; TOXOPLASMA GONDII; TOXOPLASMOSIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; PLASMODIUM FALCIPARUM; PURINE-NUCLEOSIDE PHOSPHORYLASE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TOXOPLASMA;

APICOMPLEXA; PLASMODIUM (APICOMPLEXA); PLASMODIUM FALCIPARUM; TOXOPLASMA GONDII;

EID: 33748748908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602624200     Document Type: Article

References (29)

1. Greenwood, B., and Mutabingwa, T. (2002) Nature 415, 670-672
2. Hill, D., and Dubey, J. P. (2002) Clin. Microbiol. Infect. 8, 634-640
3. Berens, R. L., Krug, E. C., and Marr, J. J. (1995) in Biochemistry and Molecular Biology of Parasites (Marr, J. J., and Muller, M., eds) pp. 323-336, Academic Press, London
4. Krug, E. C., Marr, J. J., and Berens, R. L. (1989) J. Biol. Chem. 264, 10601-10607
5. Donald, R. G., Carter, D., Ullman, B., and Roos, D. S. (1996) J. Biol. Chem. 271, 14010-14019
6. Chaudhary, K., Donald, R. G., Nishi, M., Carter, D., Ullman, B., and Roos, D. S. (2005) J. Biol. Chem. 280, 22053-22059
7. Sullivan, W. J., Jr., Chiang, C. W., Wilson, C. M., Naguib, F. N., el Kouni, M. H., Donald, R. G., and Roos, D. S. (1999) Mol. Biochem. Parasitol. 103, 1-14
8. Chaudhary, K., Darling, J. A., Fohl, L. M., Sullivan, W. J., Jr., Donald, R. G., Pfefferkorn, E. R., Ullman, B., and Roos, D. S. (2004) J. Biol. Chem. 279, 31221-31227
9. Striepen, B., Pruijssers, A. J., Huang, J., Li, C., Gubbels, M. J., Umejiego, N. N., Hedstrom, L., and Kissinger, J. C. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 3154-3159
10. Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., and Schramm, V. L. (2002) J. Biol. Chem. 277, 3219-3225
11. Ting, L. M., Shi, W., Lewandowicz, A., Singh, V., Mwakingwe, A., Birck, M. R., Taylor Ringia, E. A., Bench, G., Madrid, D. C., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2005) J. Biol. Chem. 280, 9547-9554
12. Pugmire, E. J., and Ealick, S. E. (2002) Biochem. J. 361, Pt. 1, 1-25
13. Shi, W., Ting, L. M., Kicska, G. A., Lewandowicz, A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., Almo, S. C., and Schramm, V. L. (2004) J. Biol. Chem. 279, 18103-18106
14. Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2002) J. Biol. Chem. 277, 3226-3231
15. Kissinger, J. C., Gajria, B., Li, L., Paulsen, I. T., and Roos, D. S. (2003) Nucleic Acids Res. 31, 234-236
16. Roos, D. S., Donald, R. G., Morrissette, N. S., and Moulton, A. L. (1994) Methods Cell Biol. 45, 27-63
17. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
18. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
19. Saitou, N., and Nei, M. (1987) Mol. Biol. Evol. 4, 406-425
20. Hillis, D., and Bull, J. (1993) Syst. Biol. 42, 182-192
21. Schramm, V. L. (1998) Annu. Rev. Biochem. 67, 693-720
22. Miles, R. W., Tyler, P. C., Furneaux, R. H., Bagdassarian, C. K., and Schramm, V. L. (1998) Biochemistry 37, 8615-8621
23. Mao, C., Cook, W. J., Zhou, M., Koszalka, G. W., Krenitsky, T. A., and Ealick, S. E. (1997) Structure 5, 1373-1383
24. Williams, S. R., Goddard, J. M., and Martin, D. W., Jr. (1984) Nucleic Acids Res. 12, 5779-5787
25. Li, L., Stoeckert, C. J., Jr., and Roos, D. S. (2003) Genome Res. 13, 2178-2190
26. Morgunova, E., Mikhailov, A. M., Popov, A. N., Blagova, E. V., Smirnova, E. A., Vainshtein, B. K., Mao, C., Armstrong Sh, R., Ealick, S. E., Komissarov, A. A., Linkova, E. V., Burlakova, A. A., Mironov, A. S., and Debabov, V. G. (1995) FEBS Lett. 367, 183-187
27. Muller, S., Da'dara, A., Luersen, K., Wrenger, C., Das Gupta, R., Madhubala, R., and Walter, R. D. (2000) J. Biol. Chem. 275, 8097-8102
28. Keithly, J. S., Zhu, G., Upton, S. J., Woods, K. M., Martinez, M. P., and Yarlett, N. (1997) Mol. Biochem. Parasitol. 88, 35-42
29. Seabra, S. H., DaMatta, R. A., de Mello, F. G., and de Souza, W. (2004) J. Parasitol. 90, 455-460