메뉴 건너뛰기




Volumn 311, Issue , 2006, Pages 155-178

Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA

Author keywords

[No Author keywords available]

Indexed keywords

1018 ISS; ALUMINUM POTASSIUM SULFATE; B LYMPHOCYTE RECEPTOR; CPG 7909; CPG OLIGODEOXYNUCLEOTIDE; CYTRX; EMULSIGEN; FREUND ADJUVANT; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEPATITIS B SURFACE ANTIGEN; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 12; KEYHOLE LIMPET HEMOCYANIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONTANIDE ISA 51; MONTANIDE ISA720; MYELOID DIFFERENTIATION FACTOR 88; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINYLALANYL DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; NORCROSS; PHOSPHORYL LIPID A; POLYMYXIN B; QS 21; QUILLL A; RECOMBINANT HEPATITIS B VACCINE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; RIXENSART; STRESS ACTIVATED PROTEIN KINASE; TITERMAX; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE; VAXIMMUNE; BACTERIAL DNA; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; VIRUS DNA;

EID: 33750961667     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/3-540-32636-7_6     Document Type: Review
Times cited : (78)

References (142)
  • 1
    • 14044257261 scopus 로고    scopus 로고
    • Variegation of the immune response with dendritic cells and pathogen recognition receptors
    • Pulendran B (2005) Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol 174:2457-2465
    • (2005) J Immunol , vol.174 , pp. 2457-2465
    • Pulendran, B.1
  • 4
    • 0035187324 scopus 로고    scopus 로고
    • Rankin R, Pontarollo R, Ioannou X, Krieg AM, Hecker R, Babiuk LA, van Drunen Littel-van den Hurk S (2001) CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved. Anti-sense Nucleic Acid Drug Dev 11:333-340
    • Rankin R, Pontarollo R, Ioannou X, Krieg AM, Hecker R, Babiuk LA, van Drunen Littel-van den Hurk S (2001) CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved. Anti-sense Nucleic Acid Drug Dev 11:333-340
  • 5
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H, Kaisho T, Takeda K, Akira S (2003) The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 170:3059-3064
    • (2003) J Immunol , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4
  • 8
    • 0345447639 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
    • Spies B, Hochrein H, Vabulas M, Huster K, Busch DH, Schmitz F, Heit A, Wagner H (2003) Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 171:5908-5912
    • (2003) J Immunol , vol.171 , pp. 5908-5912
    • Spies, B.1    Hochrein, H.2    Vabulas, M.3    Huster, K.4    Busch, D.H.5    Schmitz, F.6    Heit, A.7    Wagner, H.8
  • 9
    • 4444325043 scopus 로고    scopus 로고
    • Babiuk S, Mookherjee N, Pontarollo R, Griebel P, van Drunen Littel-van den Hurk S, Hecker R, Babiuk L (2004) TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. Immunology 113:114-120
    • Babiuk S, Mookherjee N, Pontarollo R, Griebel P, van Drunen Littel-van den Hurk S, Hecker R, Babiuk L (2004) TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. Immunology 113:114-120
  • 10
  • 12
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM (2002) CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20:709-760
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 13
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-995
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 14
    • 0141705297 scopus 로고    scopus 로고
    • Toll-like receptors stimulate human neutrophil function
    • Hayashi F, Means TK, Luster AD (2003) Toll-like receptors stimulate human neutrophil function. Blood 102:2660-2669
    • (2003) Blood , vol.102 , pp. 2660-2669
    • Hayashi, F.1    Means, T.K.2    Luster, A.D.3
  • 18
    • 0032526607 scopus 로고    scopus 로고
    • Yi AK, Chang M, Peckham DW, Krieg AM, Ashman RF (1998) CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry [published erratum appears in J Immunol 1999 Jul 15;163(2):1093]. J Immunol 160:5898-5906
    • Yi AK, Chang M, Peckham DW, Krieg AM, Ashman RF (1998) CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry [published erratum appears in J Immunol 1999 Jul 15;163(2):1093]. J Immunol 160:5898-5906
  • 19
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann G, Krieg AM (2000) Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J Immunol 164:944-953
    • (2000) J Immunol , vol.164 , pp. 944-953
    • Hartmann, G.1    Krieg, A.M.2
  • 20
    • 0032435640 scopus 로고    scopus 로고
    • DNA and a CpG oligonucleotide derived from Babesia bovis aremitogenic for bovine B cells
    • Brown WC, Estes DM, Chantler SE, Kegerreis KA, Suarez CE (1998) DNA and a CpG oligonucleotide derived from Babesia bovis aremitogenic for bovine B cells. Infect Immun 66:5423-5432
    • (1998) Infect Immun , vol.66 , pp. 5423-5432
    • Brown, W.C.1    Estes, D.M.2    Chantler, S.E.3    Kegerreis, K.A.4    Suarez, C.E.5
  • 21
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL, Krieg AM (1996) Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157:1840-1845
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 23
    • 0345516037 scopus 로고    scopus 로고
    • Pisetsky DS, Reich CF 3rd (1998) The influence of base sequence on the immunological properties of defined oligonucleotides. Immunopharmacology 40:199-208
    • Pisetsky DS, Reich CF 3rd (1998) The influence of base sequence on the immunological properties of defined oligonucleotides. Immunopharmacology 40:199-208
  • 24
    • 11844290125 scopus 로고    scopus 로고
    • Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
    • Roberts TL, Sweet MJ, Hume DA, Stacey KJ (2005) Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J Immunol 174:605-608
    • (2005) J Immunol , vol.174 , pp. 605-608
    • Roberts, T.L.1    Sweet, M.J.2    Hume, D.A.3    Stacey, K.J.4
  • 27
    • 0038236749 scopus 로고    scopus 로고
    • Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
    • Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, Lubenow N, Rothenfusser S, Endres S (2003) Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur J Immunol 33:1633-1641
    • (2003) Eur J Immunol , vol.33 , pp. 1633-1641
    • Hartmann, G.1    Battiany, J.2    Poeck, H.3    Wagner, M.4    Kerkmann, M.5    Lubenow, N.6    Rothenfusser, S.7    Endres, S.8
  • 28
  • 29
  • 30
    • 85053326915 scopus 로고
    • Uptake and localization of phosphodiester and chimeric oligodeoxynucleotides in normal and leukemic primary cells
    • Akhtar S ed, CRC Press, Boca Raton, pp
    • Krieg AM (1995) Uptake and localization of phosphodiester and chimeric oligodeoxynucleotides in normal and leukemic primary cells. In: Akhtar S (ed) Delivery strategies for antisense oligonucleotide therapeutics. CRC Press, Boca Raton, pp 177-190
    • (1995) Delivery strategies for antisense oligonucleotide therapeutics , pp. 177-190
    • Krieg, A.M.1
  • 32
  • 33
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi AK, Tuetken R, Redford T, Waldschmidt M, Kirsch J, Krieg AM (1998) CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 160:4755-4761
    • (1998) J Immunol , vol.160 , pp. 4755-4761
    • Yi, A.K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 34
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P, Hacker H, Rutz M, Bauer S, Vabulas RM, Wagner H (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32:1958-1968
    • (2002) Eur J Immunol , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 35
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Hacker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 17:6230-6240
    • (1998) EMBO J , vol.17 , pp. 6230-6240
    • Hacker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 36
    • 0032732168 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: Mechanistic studies
    • Manzel L, Strekowski L, Ismail FM, Smith JC, Macfarlane DE (1999) Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: mechanistic studies. J Pharmacol Exp Ther 291:1337-1347
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1337-1347
    • Manzel, L.1    Strekowski, L.2    Ismail, F.M.3    Smith, J.C.4    Macfarlane, D.E.5
  • 37
    • 0037099629 scopus 로고    scopus 로고
    • Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
    • Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM (2002) Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J Exp Med 196:269-274
    • (2002) J Exp Med , vol.196 , pp. 269-274
    • Ishii, K.J.1    Takeshita, F.2    Gursel, I.3    Gursel, M.4    Conover, J.5    Nussenzweig, A.6    Klinman, D.M.7
  • 38
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H (2000) Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med 192:595-600
    • (2000) J Exp Med , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 39
    • 0034699340 scopus 로고    scopus 로고
    • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
    • Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R (2000) Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 10:1139-1142
    • (2000) Curr Biol , vol.10 , pp. 1139-1142
    • Schnare, M.1    Holt, A.C.2    Takeda, K.3    Akira, S.4    Medzhitov, R.5
  • 40
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M, Ni J, Feng P, Dixit VM (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278:1612-1615
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 41
    • 0032526861 scopus 로고    scopus 로고
    • The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    • Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A (1998) The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187:2097-2101
    • (1998) J Exp Med , vol.187 , pp. 2097-2101
    • Muzio, M.1    Natoli, G.2    Saccani, S.3    Levrero, M.4    Mantovani, A.5
  • 42
    • 0032209664 scopus 로고    scopus 로고
    • Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
    • Yi AK, Krieg AM (1998) Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J Immunol 161:4493-4497
    • (1998) J Immunol , vol.161 , pp. 4493-4497
    • Yi, A.K.1    Krieg, A.M.2
  • 43
    • 0033923207 scopus 로고    scopus 로고
    • CpG ODN-mediated regulation of IL-12 p40 transcription
    • Takeshita F, Klinman DM (2000) CpG ODN-mediated regulation of IL-12 p40 transcription. Eur J Immunol 30:1967-1976
    • (2000) Eur J Immunol , vol.30 , pp. 1967-1976
    • Takeshita, F.1    Klinman, D.M.2
  • 44
    • 2442689141 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells
    • Tsujimura H, Tamura T, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, Ozato K (2004) Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol 172:6820-6827
    • (2004) J Immunol , vol.172 , pp. 6820-6827
    • Tsujimura, H.1    Tamura, T.2    Kong, H.J.3    Nishiyama, A.4    Ishii, K.J.5    Klinman, D.M.6    Ozato, K.7
  • 45
    • 0037111477 scopus 로고    scopus 로고
    • In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma
    • Choudhury BK, Wild JS, Alam R, Klinman DM, Boldogh I, Dharajiya N, Mileski WJ, Sur S (2002) In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma. J Immunol 169:5955-5961
    • (2002) J Immunol , vol.169 , pp. 5955-5961
    • Choudhury, B.K.1    Wild, J.S.2    Alam, R.3    Klinman, D.M.4    Boldogh, I.5    Dharajiya, N.6    Mileski, W.J.7    Sur, S.8
  • 46
    • 0037408105 scopus 로고    scopus 로고
    • Convergence of CpG DNA- and BCR-mediated signals at the c-Jun N-terminal kinase and NF-kappaB activation pathways: Regulation by mitogen-activated protein kinases
    • Yi AK, Yoon JG, Krieg AM (2003) Convergence of CpG DNA- and BCR-mediated signals at the c-Jun N-terminal kinase and NF-kappaB activation pathways: regulation by mitogen-activated protein kinases. Int Immunol 15:577-591
    • (2003) Int Immunol , vol.15 , pp. 577-591
    • Yi, A.K.1    Yoon, J.G.2    Krieg, A.M.3
  • 47
    • 0036569711 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: Central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response
    • Yi AK, Yoon JG, Yeo SJ, Hong SC, English BK, Krieg AM (2002) Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response. J Immunol 168:4711-4720
    • (2002) J Immunol , vol.168 , pp. 4711-4720
    • Yi, A.K.1    Yoon, J.G.2    Yeo, S.J.3    Hong, S.C.4    English, B.K.5    Krieg, A.M.6
  • 50
    • 0142039981 scopus 로고    scopus 로고
    • Myeloid differentiation factor 88-dependent post-transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: Tumor necrosis factor-alpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling
    • Yeo SJ, Yoon JG, Yi AK (2003) Myeloid differentiation factor 88-dependent post-transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: tumor necrosis factor-alpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling. J Biol Chem 278:40590-40600
    • (2003) J Biol Chem , vol.278 , pp. 40590-40600
    • Yeo, S.J.1    Yoon, J.G.2    Yi, A.K.3
  • 51
    • 0038265538 scopus 로고    scopus 로고
    • Myeloid differentiation factor 88-dependent transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: Role of NF-kappaB and p38
    • Yeo SJ, Gravis D, Yoon JG, Yi AK (2003) Myeloid differentiation factor 88-dependent transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: role of NF-kappaB and p38. J Biol Chem 278:22563-22573
    • (2003) J Biol Chem , vol.278 , pp. 22563-22573
    • Yeo, S.J.1    Gravis, D.2    Yoon, J.G.3    Yi, A.K.4
  • 53
    • 17444374245 scopus 로고    scopus 로고
    • Upon TLR9 signaling, CD5+B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
    • Sun CM, Deriaud E, Leclerc C, Lo-Man R (2005) Upon TLR9 signaling, CD5+B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 22:467-477
    • (2005) Immunity , vol.22 , pp. 467-477
    • Sun, C.M.1    Deriaud, E.2    Leclerc, C.3    Lo-Man, R.4
  • 54
    • 0344737658 scopus 로고    scopus 로고
    • IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences
    • Duramad O, Fearon KL, Chan JH, Kanzler H, Marshall JD, Coffman RL, Barrat FJ (2003) IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood 102:4487-4492
    • (2003) Blood , vol.102 , pp. 4487-4492
    • Duramad, O.1    Fearon, K.L.2    Chan, J.H.3    Kanzler, H.4    Marshall, J.D.5    Coffman, R.L.6    Barrat, F.J.7
  • 56
    • 0035879198 scopus 로고    scopus 로고
    • Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity
    • Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM (2001) Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity. J Immunol 167:623-627
    • (2001) J Immunol , vol.167 , pp. 623-627
    • Cole, A.M.1    Ganz, T.2    Liese, A.M.3    Burdick, M.D.4    Liu, L.5    Strieter, R.M.6
  • 57
    • 0034045085 scopus 로고    scopus 로고
    • A chemokine-to-cytokine- tochemokine cascade critical in antiviral defense
    • Salazar-Mather TP, Hamilton TA, Biron CA (2000) A chemokine-to-cytokine- tochemokine cascade critical in antiviral defense. J Clin Invest 105:985-993
    • (2000) J Clin Invest , vol.105 , pp. 985-993
    • Salazar-Mather, T.P.1    Hamilton, T.A.2    Biron, C.A.3
  • 58
    • 0034266098 scopus 로고    scopus 로고
    • The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
    • Liu MT, Chen BP, Oertel P, Buchmeier MJ, Armstrong D, Hamilton TA, Lane TE (2000) The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J Immunol 165:2327-2330
    • (2000) J Immunol , vol.165 , pp. 2327-2330
    • Liu, M.T.1    Chen, B.P.2    Oertel, P.3    Buchmeier, M.J.4    Armstrong, D.5    Hamilton, T.A.6    Lane, T.E.7
  • 59
    • 0032960970 scopus 로고    scopus 로고
    • The interferon-inducible chemokines MuMig and Crg-2 exhibit antiviral activity In vivo
    • Mahalingam S, Farber JM, Karupiah G (1999) The interferon-inducible chemokines MuMig and Crg-2 exhibit antiviral activity In vivo. J Virol 73:1479-1491
    • (1999) J Virol , vol.73 , pp. 1479-1491
    • Mahalingam, S.1    Farber, J.M.2    Karupiah, G.3
  • 60
    • 0032528446 scopus 로고    scopus 로고
    • The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
    • Tannenbaum CS, Tubbs R, Armstrong D, Finke JH, Bukowski RM, Hamilton TA (1998) The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. J Immunol 161:927-932
    • (1998) J Immunol , vol.161 , pp. 927-932
    • Tannenbaum, C.S.1    Tubbs, R.2    Armstrong, D.3    Finke, J.H.4    Bukowski, R.M.5    Hamilton, T.A.6
  • 61
    • 0034653833 scopus 로고    scopus 로고
    • Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy
    • Narvaiza I, Mazzolini G, Barajas M, Duarte M, Zaratiegui M, Qian C, Melero I, Prieto J (2000) Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy. J Immunol 164:3112-3122
    • (2000) J Immunol , vol.164 , pp. 3112-3122
    • Narvaiza, I.1    Mazzolini, G.2    Barajas, M.3    Duarte, M.4    Zaratiegui, M.5    Qian, C.6    Melero, I.7    Prieto, J.8
  • 62
    • 0035336451 scopus 로고    scopus 로고
    • IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy
    • Pertl U, Luster AD, Varki NM, Homann D, Gaedicke G, Reisfeld RA, Lode HN (2001) IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy. J Immunol 166:6944-6951
    • (2001) J Immunol , vol.166 , pp. 6944-6951
    • Pertl, U.1    Luster, A.D.2    Varki, N.M.3    Homann, D.4    Gaedicke, G.5    Reisfeld, R.A.6    Lode, H.N.7
  • 63
    • 0034668119 scopus 로고    scopus 로고
    • Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response
    • Weighardt H, Feterowski C, Veit M, Rump M, Wagner H, Holzmann B (2000) Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response. J Immunol 165:4537-4543
    • (2000) J Immunol , vol.165 , pp. 4537-4543
    • Weighardt, H.1    Feterowski, C.2    Veit, M.3    Rump, M.4    Wagner, H.5    Holzmann, B.6
  • 66
    • 0037530629 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related apoptosis-inducing ligand/Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation
    • Kemp TJ, Elzey BD, Griffith TS (2003) Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related apoptosis-inducing ligand/Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation. J Immunol 171:212-218
    • (2003) J Immunol , vol.171 , pp. 212-218
    • Kemp, T.J.1    Elzey, B.D.2    Griffith, T.S.3
  • 68
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23:275-306
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 69
    • 2942516628 scopus 로고    scopus 로고
    • Modulating vaccine responses with dendritic cells and Toll-like receptors
    • Pulendran B (2004) Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol Rev 199:227-250
    • (2004) Immunol Rev , vol.199 , pp. 227-250
    • Pulendran, B.1
  • 70
  • 73
    • 0034532681 scopus 로고    scopus 로고
    • Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins
    • Sparwasser T, Vabulas RM, Villmow B, Lipford GB, Wagner H (2000) Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J Immunol 30:3591-3597
    • (2000) Eur J Immunol , vol.30 , pp. 3591-3597
    • Sparwasser, T.1    Vabulas, R.M.2    Villmow, B.3    Lipford, G.B.4    Wagner, H.5
  • 74
    • 0031964257 scopus 로고    scopus 로고
    • Davis HL, Weeratna R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM (1998) CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen [published erratum appears in J Immunol 1999 Mar 1;162(5):3103]. J Immunol 160:870-876
    • Davis HL, Weeratna R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM (1998) CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen [published erratum appears in J Immunol 1999 Mar 1;162(5):3103]. J Immunol 160:870-876
  • 75
    • 4644241216 scopus 로고    scopus 로고
    • CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10
    • He B, Qiao X, Cerutti A (2004) CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J Immunol 173:4479-4491
    • (2004) J Immunol , vol.173 , pp. 4479-4491
    • He, B.1    Qiao, X.2    Cerutti, A.3
  • 76
    • 0034254201 scopus 로고    scopus 로고
    • CpG-DNA mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses
    • Lipford GB, Sparwasser T, Zimmermann S, Heeg K, Wagner H (2000) CpG-DNA mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J Immunol 165:1228-1235
    • (2000) J Immunol , vol.165 , pp. 1228-1235
    • Lipford, G.B.1    Sparwasser, T.2    Zimmermann, S.3    Heeg, K.4    Wagner, H.5
  • 77
    • 0033969664 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies
    • Chu RS, McCool T, Greenspan NS, Schreiber JR, Harding CV (2000) CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies. Infect Immun 68:1450-1456
    • (2000) Infect Immun , vol.68 , pp. 1450-1456
    • Chu, R.S.1    McCool, T.2    Greenspan, N.S.3    Schreiber, J.R.4    Harding, C.V.5
  • 79
    • 0034006047 scopus 로고    scopus 로고
    • Synthetic oligodeoxynucleotide containing CpG motif induces an anti-polysaccharide type 1-like immune response after immunization of mice with Haemophilus influenzae type b conjugate vaccine
    • von Hunolstein C, Teloni R, Mariotti S, Recchia S, Orefici G, Nisini R (2000) Synthetic oligodeoxynucleotide containing CpG motif induces an anti-polysaccharide type 1-like immune response after immunization of mice with Haemophilus influenzae type b conjugate vaccine. Int Immunol 12:295-303
    • (2000) Int Immunol , vol.12 , pp. 295-303
    • von Hunolstein, C.1    Teloni, R.2    Mariotti, S.3    Recchia, S.4    Orefici, G.5    Nisini, R.6
  • 82
    • 0010993390 scopus 로고    scopus 로고
    • Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines
    • Kim SK, Ragupathi G, Musselli C, Choi SJ, Park YS, Livingston PO (2000) Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines. Vaccine 18:597-603
    • (2000) Vaccine , vol.18 , pp. 597-603
    • Kim, S.K.1    Ragupathi, G.2    Musselli, C.3    Choi, S.J.4    Park, Y.S.5    Livingston, P.O.6
  • 83
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV (1997) CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 186:1623-1631
    • (1997) J Exp Med , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 84
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K (1997) CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol 27:2340-2344
    • (1997) Eur J Immunol , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 87
    • 0033374028 scopus 로고    scopus 로고
    • Use of CpG DNA for enhancing specific immune responses
    • Davis HL (2000) Use of CpG DNA for enhancing specific immune responses. Curr Top Microbiol Immunol 247:171-183
    • (2000) Curr Top Microbiol Immunol , vol.247 , pp. 171-183
    • Davis, H.L.1
  • 88
    • 0011017020 scopus 로고    scopus 로고
    • Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates
    • Kim SK, Ragupathi G, Cappello S, Kagan E, Livingston PO (2001) Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates. Vaccine 19:530-537
    • (2001) Vaccine , vol.19 , pp. 530-537
    • Kim, S.K.1    Ragupathi, G.2    Cappello, S.3    Kagan, E.4    Livingston, P.O.5
  • 89
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM (1989) Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 169:59-72
    • (1989) J Exp Med , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 90
    • 0027121651 scopus 로고
    • Schistosomiasis. Parasitizing the cytokine system
    • Sher A (1992) Schistosomiasis. Parasitizing the cytokine system. Nature 356:565-566
    • (1992) Nature , vol.356 , pp. 565-566
    • Sher, A.1
  • 91
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV, Ferrari C (1995) Hepatitis B virus immunopathogenesis. Annu Rev Immunol 13:29-60
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 92
    • 34548676586 scopus 로고    scopus 로고
    • World Health Organization (2001) Global Alliance for Vaccines and Immunization (GAVI). Fact Sheet No. 169
    • World Health Organization (2001) Global Alliance for Vaccines and Immunization (GAVI). Fact Sheet No. 169
  • 93
    • 0033624828 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis
    • Freidag BL, Melton GB, Collins F, Klinman DM, Cheever A, Stobie L, Suen W, Seder RA (2000) CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect Immun 68:2948-2953
    • (2000) Infect Immun , vol.68 , pp. 2948-2953
    • Freidag, B.L.1    Melton, G.B.2    Collins, F.3    Klinman, D.M.4    Cheever, A.5    Stobie, L.6    Suen, W.7    Seder, R.A.8
  • 95
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms
    • Walker PS, Scharton-Kersten T, Krieg AM, Love-Homan L, Rowton ED, Udey MC, Vogel JC (1999) Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms. Proc Natl Acad Sci U S A 96:6970-6975
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6970-6975
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6    Vogel, J.C.7
  • 96
    • 0035825599 scopus 로고    scopus 로고
    • Oligonucleotide containing CpG motifs enhances immune response tomucosally or systemically administered tetanus toxoid
    • Eastcott JW, Holmberg CJ, Dewhirst FE, Esch TR, Smith DJ, Taubman MA (2001) Oligonucleotide containing CpG motifs enhances immune response tomucosally or systemically administered tetanus toxoid. Vaccine 19:1636-1642
    • (2001) Vaccine , vol.19 , pp. 1636-1642
    • Eastcott, J.W.1    Holmberg, C.J.2    Dewhirst, F.E.3    Esch, T.R.4    Smith, D.J.5    Taubman, M.A.6
  • 98
    • 10444280011 scopus 로고    scopus 로고
    • Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant
    • Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V, BenMohamed L (2005) Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine 23:873-883
    • (2005) Vaccine , vol.23 , pp. 873-883
    • Nesburn, A.B.1    Ramos, T.V.2    Zhu, X.3    Asgarzadeh, H.4    Nguyen, V.5    BenMohamed, L.6
  • 99
    • 0037435891 scopus 로고    scopus 로고
    • Evaluation of adjuvants for protein vaccines against tuberculosis in guinea pigs
    • Hogarth PJ, Jahans KJ, Hecker R, Hewinson RG, Chambers MA (2003) Evaluation of adjuvants for protein vaccines against tuberculosis in guinea pigs. Vaccine 21:977-982
    • (2003) Vaccine , vol.21 , pp. 977-982
    • Hogarth, P.J.1    Jahans, K.J.2    Hecker, R.3    Hewinson, R.G.4    Chambers, M.A.5
  • 100
    • 0036728506 scopus 로고    scopus 로고
    • Stimulatory effect of CpG sequences on humoral response in chickens
    • Vleugels B, Ververken C, Goddeeris BM (2002) Stimulatory effect of CpG sequences on humoral response in chickens. Poult Sci 81:1317-1321
    • (2002) Poult Sci , vol.81 , pp. 1317-1321
    • Vleugels, B.1    Ververken, C.2    Goddeeris, B.M.3
  • 101
    • 0037449106 scopus 로고    scopus 로고
    • Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix)
    • Alcon VL, Foldvari M, Snider M, Willson P, Gomis S, Hecker R, Babiuk LA, Baca-Estrada ME (2003) Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix). Vaccine 21:1811-1814
    • (2003) Vaccine , vol.21 , pp. 1811-1814
    • Alcon, V.L.1    Foldvari, M.2    Snider, M.3    Willson, P.4    Gomis, S.5    Hecker, R.6    Babiuk, L.A.7    Baca-Estrada, M.E.8
  • 102
  • 103
    • 0037178315 scopus 로고    scopus 로고
    • Rankin R, Pontarollo R, Gomis S, Karvonen B, Willson P, Loehr BI, Godson DL, Babiuk LA, Hecker R, van Drunen Littel-van den Hurk S (2002) CpG-containing oligodeoxynucleotides augment and switch the immune responses of cattle to bovine herpesvirus-1 glycoprotein D. Vaccine 20:3014-3022
    • Rankin R, Pontarollo R, Gomis S, Karvonen B, Willson P, Loehr BI, Godson DL, Babiuk LA, Hecker R, van Drunen Littel-van den Hurk S (2002) CpG-containing oligodeoxynucleotides augment and switch the immune responses of cattle to bovine herpesvirus-1 glycoprotein D. Vaccine 20:3014-3022
  • 104
    • 19344372713 scopus 로고    scopus 로고
    • Wedlock DN, Denis M, Skinner MA, Koach J, de Lisle GW, Vordermeier HM, Hewinson RG, van Drunen Littel-van den Hurk S, Babiuk LA, Hecker R, Buddle BM (2005) Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis. Vet Immunol Immunopathol 106:53-63
    • Wedlock DN, Denis M, Skinner MA, Koach J, de Lisle GW, Vordermeier HM, Hewinson RG, van Drunen Littel-van den Hurk S, Babiuk LA, Hecker R, Buddle BM (2005) Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis. Vet Immunol Immunopathol 106:53-63
  • 105
    • 0037159625 scopus 로고    scopus 로고
    • Ioannou XP, Gomis SM, Karvonen B, Hecker R, Babiuk LA, van Drunen Littel-van den Hurk S (2002) CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein. Vaccine 21:127-137
    • Ioannou XP, Gomis SM, Karvonen B, Hecker R, Babiuk LA, van Drunen Littel-van den Hurk S (2002) CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein. Vaccine 21:127-137
  • 106
    • 21044441505 scopus 로고    scopus 로고
    • Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum
    • Rafati S, Nakhaee A, Taheri T, Taslimi Y, Darabi H, Eravani D, Sanos S, Kaye P, Taghikhani M, Jamshidi S, Rad MA (2005) Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Vaccine 23:3716-3725
    • (2005) Vaccine , vol.23 , pp. 3716-3725
    • Rafati, S.1    Nakhaee, A.2    Taheri, T.3    Taslimi, Y.4    Darabi, H.5    Eravani, D.6    Sanos, S.7    Kaye, P.8    Taghikhani, M.9    Jamshidi, S.10    Rad, M.A.11
  • 107
    • 17944402906 scopus 로고    scopus 로고
    • Davis HL, Suparto II, Weeratna RR, Jumintarto, Iskandriati DD, Chamzah SS, Ma'ruf AA, Nente CC, Pawitri DD, Krieg AM, Heriyanto, Smits W, Sajuthi DD (2000) CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 18:1920-1924
    • Davis HL, Suparto II, Weeratna RR, Jumintarto, Iskandriati DD, Chamzah SS, Ma'ruf AA, Nente CC, Pawitri DD, Krieg AM, Heriyanto, Smits W, Sajuthi DD (2000) CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 18:1920-1924
  • 109
    • 25844484501 scopus 로고    scopus 로고
    • CPG 7909 adjuvant improves hepatitis B virus vaccine sero-protection in antiretroviral-treated HIV-infected adults
    • Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW (2005) CPG 7909 adjuvant improves hepatitis B virus vaccine sero-protection in antiretroviral-treated HIV-infected adults. AIDS 19:1473-1479
    • (2005) AIDS , vol.19 , pp. 1473-1479
    • Cooper, C.L.1    Davis, H.L.2    Angel, J.B.3    Morris, M.L.4    Elfer, S.M.5    Seguin, I.6    Krieg, A.M.7    Cameron, D.W.8
  • 110
    • 11344257404 scopus 로고    scopus 로고
    • CpG 7909, animmunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper CL, Davis HL, Morris ML, Efler SM, Adhami MA, Krieg AM, Cameron DW, Heathcote J (2004) CpG 7909, animmunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J Clin Immunol 24:693-702
    • (2004) J Clin Immunol , vol.24 , pp. 693-702
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 111
    • 3843052308 scopus 로고    scopus 로고
    • Safety and immunogenicity of CpG 7909 injection as an adjuvant to Fluarix influenza vaccine
    • Cooper CL, Davis HL, Morris ML, et al (2004) Safety and immunogenicity of CpG 7909 injection as an adjuvant to Fluarix influenza vaccine. Vaccine 22:3136-3143
    • (2004) Vaccine , vol.22 , pp. 3136-3143
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3
  • 112
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety andimmunogenicity of recombinan the patitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin SA, Van Nest G, Smith B, Abtahi S, Whiley H, Eiden JJ (2003) A phase I study of the safety andimmunogenicity of recombinan the patitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 21:2461-2467
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 114
    • 0033997899 scopus 로고    scopus 로고
    • CpG DNA induces stronger immune responses with less toxicity than other adjuvants
    • Weeratna RD, McCluskie MJ, Xu Y, Davis HL (2000) CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 18:1755-1762
    • (2000) Vaccine , vol.18 , pp. 1755-1762
    • Weeratna, R.D.1    McCluskie, M.J.2    Xu, Y.3    Davis, H.L.4
  • 115
    • 27644544886 scopus 로고    scopus 로고
    • A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine
    • Sugai T, Mori M, Nakazawa M, Ichino M, Naruto T, Kobayashi N, Kobayashi Y, Minami M, Yokota S (2005) A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine. Vaccine 23:5450-5456
    • (2005) Vaccine , vol.23 , pp. 5450-5456
    • Sugai, T.1    Mori, M.2    Nakazawa, M.3    Ichino, M.4    Naruto, T.5    Kobayashi, N.6    Kobayashi, Y.7    Minami, M.8    Yokota, S.9
  • 116
    • 13444292924 scopus 로고    scopus 로고
    • Oumouna M, Mapletoft JW, Karvonen BC, Babiuk LA, van Drunen Littel-van den Hurk S (2005) Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine. J Virol 79:2024-2032
    • Oumouna M, Mapletoft JW, Karvonen BC, Babiuk LA, van Drunen Littel-van den Hurk S (2005) Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine. J Virol 79:2024-2032
  • 117
    • 0346817398 scopus 로고    scopus 로고
    • Adjuvants recognized by toll-like receptors inhibit the induction of polarized type 2 T cell responses by natural attachment (G) protein of respiratory syncytial virus
    • Hancock GE, Heers KM, Pryharski KS, Smith JD, Tiberio L (2003) Adjuvants recognized by toll-like receptors inhibit the induction of polarized type 2 T cell responses by natural attachment (G) protein of respiratory syncytial virus. Vaccine 21:4348-4358
    • (2003) Vaccine , vol.21 , pp. 4348-4358
    • Hancock, G.E.1    Heers, K.M.2    Pryharski, K.S.3    Smith, J.D.4    Tiberio, L.5
  • 118
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • Brazolot Millan CL, Weeratna R, Krieg AM, Siegrist CA, Davis HL (1998) CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci USA 95:15553-15558
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 119
    • 0035037517 scopus 로고    scopus 로고
    • Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies
    • Weeratna RD, Brazolot Millan CL, McCluskie MJ, Siegrist CA, Davis HL (2001) Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies. FEMS Immunol Med Microbiol 30:241-247
    • (2001) FEMS Immunol Med Microbiol , vol.30 , pp. 241-247
    • Weeratna, R.D.1    Brazolot Millan, C.L.2    McCluskie, M.J.3    Siegrist, C.A.4    Davis, H.L.5
  • 120
    • 0034890076 scopus 로고    scopus 로고
    • Modulation of gene-gun-mediated Th2 immunity to hepatitis B surface antigen by bacterial CpG motifs or IL-12
    • Schirmbeck R, Reimann J (2001) Modulation of gene-gun-mediated Th2 immunity to hepatitis B surface antigen by bacterial CpG motifs or IL-12. Intervirology 44:115-123
    • (2001) Intervirology , vol.44 , pp. 115-123
    • Schirmbeck, R.1    Reimann, J.2
  • 121
    • 0042412313 scopus 로고    scopus 로고
    • T helper 2 immunity to hepatitis B surface antigen primed by gene-gun-mediated DNA vaccination can be shifted towards T helper 1 immunity by codelivery of CpG motif-containing oligodeoxynucleotides
    • Zhou X, Zheng L, Liu L, Xiang L, Yuan Z (2003) T helper 2 immunity to hepatitis B surface antigen primed by gene-gun-mediated DNA vaccination can be shifted towards T helper 1 immunity by codelivery of CpG motif-containing oligodeoxynucleotides. Scand J Immunol 58:350-357
    • (2003) Scand J Immunol , vol.58 , pp. 350-357
    • Zhou, X.1    Zheng, L.2    Liu, L.3    Xiang, L.4    Yuan, Z.5
  • 123
    • 0035218374 scopus 로고    scopus 로고
    • CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice
    • Manning BM, Enioutina EY, Visic DM, Knudson AD, Daynes RA (2001) CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp Gerontol 37:107-126
    • (2001) Exp Gerontol , vol.37 , pp. 107-126
    • Manning, B.M.1    Enioutina, E.Y.2    Visic, D.M.3    Knudson, A.D.4    Daynes, R.A.5
  • 124
    • 0036746072 scopus 로고    scopus 로고
    • CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice
    • Maletto B, Ropolo A, Moron V, Pistoresi-Palencia MC (2002) CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice. J Leukoc Biol 72:447-454
    • (2002) J Leukoc Biol , vol.72 , pp. 447-454
    • Maletto, B.1    Ropolo, A.2    Moron, V.3    Pistoresi-Palencia, M.C.4
  • 125
    • 20044379241 scopus 로고    scopus 로고
    • Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice
    • Alignani D, Maletto B, Liscovsky M, Ropolo A, Moron G, Pistoresi-Palencia MC (2005) Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice. J Leukoc Biol 77:898-905
    • (2005) J Leukoc Biol , vol.77 , pp. 898-905
    • Alignani, D.1    Maletto, B.2    Liscovsky, M.3    Ropolo, A.4    Moron, G.5    Pistoresi-Palencia, M.C.6
  • 126
    • 0037324369 scopus 로고    scopus 로고
    • CPG ODN allows lower dose of antigen against hepatitis B surface antigen in BALB/c mice
    • Weeratna R, Comanita L, Davis HL (2003) CPG ODN allows lower dose of antigen against hepatitis B surface antigen in BALB/c mice. Immunol Cell Biol 81:59-62
    • (2003) Immunol Cell Biol , vol.81 , pp. 59-62
    • Weeratna, R.1    Comanita, L.2    Davis, H.L.3
  • 129
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu Z, Love-Homan L, Huang WQ, Krieg AM (1998) CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16:1216-1224
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 130
    • 0035284751 scopus 로고    scopus 로고
    • Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
    • Gallichan WS, Woolstencroft RN, Guarasci T, McCluskie MJ, Davis HL, Rosenthal KL (2001) Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J Immunol 166:3451-3457
    • (2001) J Immunol , vol.166 , pp. 3451-3457
    • Gallichan, W.S.1    Woolstencroft, R.N.2    Guarasci, T.3    McCluskie, M.J.4    Davis, H.L.5    Rosenthal, K.L.6
  • 131
    • 0032209286 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • McCluskie MJ, Davis HL (1998) CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J Immunol 161:4463-4466
    • (1998) J Immunol , vol.161 , pp. 4463-4466
    • McCluskie, M.J.1    Davis, H.L.2
  • 132
    • 0034668209 scopus 로고    scopus 로고
    • Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
    • McCluskie MJ, Davis HL (2001) Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine 19:413-422
    • (2001) Vaccine , vol.19 , pp. 413-422
    • McCluskie, M.J.1    Davis, H.L.2
  • 133
    • 3843066750 scopus 로고    scopus 로고
    • Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2
    • Kwant A, Rosenthal KL (2004) Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 22:3098-3104
    • (2004) Vaccine , vol.22 , pp. 3098-3104
    • Kwant, A.1    Rosenthal, K.L.2
  • 134
    • 0034703827 scopus 로고    scopus 로고
    • CpG DNA is an effective oral adjuvant to protein antigens in mice
    • McCluskie MJ, Weeratna RD, Krieg AM, Davis HL (2001) CpG DNA is an effective oral adjuvant to protein antigens in mice. Vaccine 19:950-957
    • (2001) Vaccine , vol.19 , pp. 950-957
    • McCluskie, M.J.1    Weeratna, R.D.2    Krieg, A.M.3    Davis, H.L.4
  • 135
    • 23844440305 scopus 로고    scopus 로고
    • Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection
    • Dong JL, Liang BG, Jin YS, Zhang WJ, Wang T (2005) Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection. Virology 339:153-163
    • (2005) Virology , vol.339 , pp. 153-163
    • Dong, J.L.1    Liang, B.G.2    Jin, Y.S.3    Zhang, W.J.4    Wang, T.5
  • 136
    • 0037108812 scopus 로고    scopus 로고
    • Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge
    • Dumais N, Patrick A, Moss RB, Davis HL, Rosenthal KL (2002) Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J Infect Dis 186:1098-1105
    • (2002) J Infect Dis , vol.186 , pp. 1098-1105
    • Dumais, N.1    Patrick, A.2    Moss, R.B.3    Davis, H.L.4    Rosenthal, K.L.5
  • 137
    • 0842326199 scopus 로고    scopus 로고
    • Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection
    • Berry LJ, Hickey DK, Skelding KA, Bao S, Rendina AM, Hansbro PM, Gockel CM, Beagley KW (2004) Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect Immun 72:1019-1028
    • (2004) Infect Immun , vol.72 , pp. 1019-1028
    • Berry, L.J.1    Hickey, D.K.2    Skelding, K.A.3    Bao, S.4    Rendina, A.M.5    Hansbro, P.M.6    Gockel, C.M.7    Beagley, K.W.8
  • 139
    • 0034295582 scopus 로고    scopus 로고
    • Intranasal immunization of mice with CpG DNA induces strong systemic andmucosal responses that are influenced by other mucosal adjuvants and antigen distribution
    • McCluskie MJ, Weeratna RD, Davis HL (2000) Intranasal immunization of mice with CpG DNA induces strong systemic andmucosal responses that are influenced by other mucosal adjuvants and antigen distribution. Mol Med 6:867-877
    • (2000) Mol Med , vol.6 , pp. 867-877
    • McCluskie, M.J.1    Weeratna, R.D.2    Davis, H.L.3
  • 140
    • 0037220304 scopus 로고    scopus 로고
    • Mucosal immunization with helicobacter, CpG DNA, and cholera toxin is protective
    • Jiang W, Baker HJ, Smith BF (2003) Mucosal immunization with helicobacter, CpG DNA, and cholera toxin is protective. Infect Immun 71:40-46
    • (2003) Infect Immun , vol.71 , pp. 40-46
    • Jiang, W.1    Baker, H.J.2    Smith, B.F.3
  • 141
    • 0035859288 scopus 로고    scopus 로고
    • Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants
    • McCluskie MJ, Weeratna RD, Clements JD, Davis HL (2001) Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants. Vaccine 19:3759-3768
    • (2001) Vaccine , vol.19 , pp. 3759-3768
    • McCluskie, M.J.1    Weeratna, R.D.2    Clements, J.D.3    Davis, H.L.4
  • 142
    • 0033857494 scopus 로고    scopus 로고
    • Antipeptide antibody responses following intranasal immunization: Effectiveness of mucosal adjuvants
    • Olszewska W, Partidos CD, Steward MW (2000) Antipeptide antibody responses following intranasal immunization: effectiveness of mucosal adjuvants. Infect Immun 68:4923-4929
    • (2000) Infect Immun , vol.68 , pp. 4923-4929
    • Olszewska, W.1    Partidos, C.D.2    Steward, M.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.