메뉴 건너뛰기




Volumn 20, Issue 27-28, 2002, Pages 3342-3354

Liposomal immunostimulatory DNA sequence (ISS-ODN): An efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines

Author keywords

Hepatitis B; Influenza; ISS ODN; Liposomes

Indexed keywords

GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G2; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; LIPOSOME; OLIGODEOXYNUCLEOTIDE; SIALIDASE; VIRUS DNA; VIRUS HEMAGGLUTININ;

EID: 0037056027     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00295-5     Document Type: Article
Times cited : (77)

References (69)
  • 1
    • 0005163505 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences (ISS)
    • Raz E., editor. Immunostimulatory DNA sequences (ISS). Springer Semin Immunopathol 2000;22:1-183.
    • (2000) Springer Semin Immunopathol , vol.22 , pp. 1-183
    • Raz, E.1
  • 2
    • 0034623661 scopus 로고    scopus 로고
    • Immune effects and mechanisms of action of CpG motifs
    • Krieg A.M. Immune effects and mechanisms of action of CpG motifs. Vaccine. 19:2000;618-622.
    • (2000) Vaccine , vol.19 , pp. 618-622
    • Krieg, A.M.1
  • 3
    • 0033374028 scopus 로고    scopus 로고
    • Use of CpG DNA for enhancing specific immune responses
    • Davis H.L. Use of CpG DNA for enhancing specific immune responses. Curr. Top Microbiol. Immunol. 247:2000;171-183.
    • (2000) Curr. Top Microbiol. Immunol. , vol.247 , pp. 171-183
    • Davis, H.L.1
  • 4
    • 0033741199 scopus 로고    scopus 로고
    • Introduction to immunostimulatory DNA sequences
    • Van Uden J., Raz E. Introduction to immunostimulatory DNA sequences. Springer Semin. Immunopathol. 22:2000;1-9.
    • (2000) Springer Semin. Immunopathol. , vol.22 , pp. 1-9
    • Van Uden, J.1    Raz, E.2
  • 5
    • 0033749217 scopus 로고    scopus 로고
    • Mechanisms of immune stimulation by bacterial DNA
    • Pisetsky D.S. Mechanisms of immune stimulation by bacterial DNA. Springer Semin. Immunopathol. 22:2000;21-33.
    • (2000) Springer Semin. Immunopathol. , vol.22 , pp. 21-33
    • Pisetsky, D.S.1
  • 6
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman D.M., Yi A.K., Beaucage S.L., Conover J., Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2879-2883.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 7
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas Z.K., Rasmussen W.L., Krieg A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1996;1840-1845.
    • (1996) J. Immunol. , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 8
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T., Koch E.S., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W.et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:1998;2045-2054.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6
  • 10
    • 0031460777 scopus 로고    scopus 로고
    • Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
    • Lipford G.B., Sparwasser T., Bauer M., Zimmermann S., Koch E.S., Heeg K.et al. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:1997;3420-3426.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3420-3426
    • Lipford, G.B.1    Sparwasser, T.2    Bauer, M.3    Zimmermann, S.4    Koch, E.S.5    Heeg, K.6
  • 12
    • 0032775793 scopus 로고    scopus 로고
    • Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences
    • Martin-Orozco E., Kobayashi H., Van Uden J., Nguyen M.D., Kornbluth R.S., Raz E. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int. Immunol. 11:1999;1111-1118.
    • (1999) Int. Immunol. , vol.11 , pp. 1111-1118
    • Martin-Orozco, E.1    Kobayashi, H.2    Van Uden, J.3    Nguyen, M.D.4    Kornbluth, R.S.5    Raz, E.6
  • 14
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu R.S., Targoni O.S., Krieg A.M., Lehmann P.V., Harding C.V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1997;1623-1631.
    • (1997) J. Exp. Med. , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 16
    • 0032876565 scopus 로고    scopus 로고
    • CpG DNA as mucosal adjuvant
    • McCluskie M.J., Davis H.L. CpG DNA as mucosal adjuvant. Vaccine. 18:1999;231-237.
    • (1999) Vaccine , vol.18 , pp. 231-237
    • McCluskie, M.J.1    Davis, H.L.2
  • 18
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigens: A new class of vaccine adjuvants
    • Lipford G.B., Bauer M., Blank C., Reiter R., Wagner H., Heeg K. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigens: a new class of vaccine adjuvants. Eur. J. Immunol. 27:1997;2340-2344.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 20
    • 0034073872 scopus 로고    scopus 로고
    • Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
    • Cho H.J., Takabayashi K., Cheng P.M., Nguyen M.D., Corr M., Tuck S.et al. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat. Biotechnol. 18:2000;509-514.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 509-514
    • Cho, H.J.1    Takabayashi, K.2    Cheng, P.M.3    Nguyen, M.D.4    Corr, M.5    Tuck, S.6
  • 21
    • 0034668209 scopus 로고    scopus 로고
    • Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
    • McCluskie M.J., Davis H.L. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine. 19:2001;413-422.
    • (2001) Vaccine , vol.19 , pp. 413-422
    • McCluskie, M.J.1    Davis, H.L.2
  • 22
    • 0035112910 scopus 로고    scopus 로고
    • Enhancing vaccines with immune stimulatory CpG DNA
    • Krieg A.M., Davis H.L. Enhancing vaccines with immune stimulatory CpG DNA. Curr. Opin. Mol. Ther. 3:2001;15-24.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 15-24
    • Krieg, A.M.1    Davis, H.L.2
  • 23
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu Z., Love-Homan L., Huang W.Q., Krieg A.M. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine. 16:1998;1216-1224.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 24
    • 0033997899 scopus 로고    scopus 로고
    • CpG DNA induces stronger immune responses with less toxicity than other adjuvants
    • Weeratna R.D., McCluskie M.J., Xu Y., Davis H.L. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine. 18:2000;1755-1762.
    • (2000) Vaccine , vol.18 , pp. 1755-1762
    • Weeratna, R.D.1    McCluskie, M.J.2    Xu, Y.3    Davis, H.L.4
  • 25
    • 0034090116 scopus 로고    scopus 로고
    • Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
    • Shirota H., Sano K., Kikuchi T., Tamura G., Shirato K. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J. Immunol. 164:2000;5575-5582.
    • (2000) J. Immunol. , vol.164 , pp. 5575-5582
    • Shirota, H.1    Sano, K.2    Kikuchi, T.3    Tamura, G.4    Shirato, K.5
  • 26
    • 0343953087 scopus 로고    scopus 로고
    • Conjugation of immunostimulatory DNA to the short ragweed allergen amb a1 enhances its immunogenicity and reduces its allergenicity
    • Tighe H., Takabayashi K., Schwartz D., Van Nest G., Tuck S., Eiden J.J.et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol. 106:2000;124-134.
    • (2000) J. Allergy Clin. Immunol. , vol.106 , pp. 124-134
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3    Van Nest, G.4    Tuck, S.5    Eiden, J.J.6
  • 28
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg A.M., Love-Homan L., Yi A.K., Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:1998;2428-2434.
    • (1998) J. Immunol. , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.K.3    Harty, J.T.4
  • 29
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins K.L., Reinehart-Jones T.R., Stibitz S., Conover J.S., Klinman D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162:1999;2291-2298.
    • (1999) J. Immunol. , vol.162 , pp. 2291-2298
    • Elkins, K.L.1    Reinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 30
    • 0033732327 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences help to eradicate intracellular pathogens
    • Wagner H., Häcker H., Lipford G.B. Immunostimulatory DNA sequences help to eradicate intracellular pathogens. Springer Semin. Immunopathol. 22:2000;147-152.
    • (2000) Springer Semin. Immunopathol. , vol.22 , pp. 147-152
    • Wagner, H.1    Häcker, H.2    Lipford, G.B.3
  • 31
    • 0035117252 scopus 로고    scopus 로고
    • Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    • Gramzinski R.A., Doolan D.L., Sedegah M., Davis H.L., Krieg A.M., Hoffman S.L. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect. Immun. 69:2001;1643-1649.
    • (2001) Infect. Immun. , vol.69 , pp. 1643-1649
    • Gramzinski, R.A.1    Doolan, D.L.2    Sedegah, M.3    Davis, H.L.4    Krieg, A.M.5    Hoffman, S.L.6
  • 32
    • 0035501012 scopus 로고    scopus 로고
    • Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs
    • Ballas Z.K., Krieg A.M., Warren T., Rasmussen W., Davis H.L.et al. Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J. Immunol. 167:2001;4878-4886.
    • (2001) J. Immunol. , vol.167 , pp. 4878-4886
    • Ballas, Z.K.1    Krieg, A.M.2    Warren, T.3    Rasmussen, W.4    Davis, H.L.5
  • 33
    • 0035500280 scopus 로고    scopus 로고
    • NK and CD8(+) T cell-mediated eradication of established tumor by peritumoral injection of CpG-containing oligodeoxynucleotides
    • Kawarada Y., Ganss R., Garbi N., Sacher T., Arnold B., Hammerling G.J. NK and CD8(+) T cell-mediated eradication of established tumor by peritumoral injection of CpG-containing oligodeoxynucleotides. J. Immunol. 167:2001;5247-5253.
    • (2001) J. Immunol. , vol.167 , pp. 5247-5253
    • Kawarada, Y.1    Ganss, R.2    Garbi, N.3    Sacher, T.4    Arnold, B.5    Hammerling, G.J.6
  • 34
    • 0033742274 scopus 로고    scopus 로고
    • Signal transduction induced by immunostimulatory CpG DNA
    • Krieg A.M. Signal transduction induced by immunostimulatory CpG DNA. Springer Semin. Immunopathol. 22:2000;97-105.
    • (2000) Springer Semin. Immunopathol. , vol.22 , pp. 97-105
    • Krieg, A.M.1
  • 36
    • 0033637315 scopus 로고    scopus 로고
    • DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
    • Chu W., Gong X., Li Z., Takabayashi K., Ouyang H., Chen Y.et al. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 103:2000;909-918.
    • (2000) Cell , vol.103 , pp. 909-918
    • Chu, W.1    Gong, X.2    Li, Z.3    Takabayashi, K.4    Ouyang, H.5    Chen, Y.6
  • 38
    • 0002044739 scopus 로고
    • Liposomes as pharmaceutical dosage forms
    • Swarbrick J, Boylan EC, editors. New York: Marcel Dekker
    • Barenholz Y., Crommelin DJA. Liposomes as pharmaceutical dosage forms. In: Swarbrick J, Boylan EC, editors. Encyclopedia of pharmaceutical technology, vol. 9. New York: Marcel Dekker, 1994. p. 1-39.
    • (1994) Encyclopedia of Pharmaceutical Technology , vol.9 , pp. 1-39
    • Barenholz, Y.1    Crommelin, D.J.A.2
  • 41
    • 0002680825 scopus 로고    scopus 로고
    • Liposomes as adjuvants for vaccines
    • Levine MM, Woodrow GC, Kaper JB, Cobon GS, editors. New York: Marcel Dekker
    • Alving CR. Liposomes as adjuvants for vaccines. In: Levine MM, Woodrow GC, Kaper JB, Cobon GS, editors. New generation vaccines. 2nd ed. New York: Marcel Dekker, 1997. p. 207-13.
    • (1997) New Generation Vaccines. 2nd ed. , pp. 207-213
    • Alving, C.R.1
  • 42
    • 0033525805 scopus 로고    scopus 로고
    • A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of Th1 and Th2 responses in mice
    • Babai I., Samira S., Barenholz Y., Zakay-Rones Z., Kedar E. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of Th1 and Th2 responses in mice. Vaccine. 17:1999;1239-1250.
    • (1999) Vaccine , vol.17 , pp. 1239-1250
    • Babai, I.1    Samira, S.2    Barenholz, Y.3    Zakay-Rones, Z.4    Kedar, E.5
  • 43
    • 0002635121 scopus 로고    scopus 로고
    • Delivery of cytokines by liposomes: A means of improving their immunomodulatory and anti-tumor activity
    • Chouaib S, editor. Paris: INSERM
    • Kedar E, Barenholz Y. Delivery of cytokines by liposomes: a means of improving their immunomodulatory and anti-tumor activity. In: Chouaib S, editor. The biotherapy of cancers: from immunotherapy to gene therapy. Paris: INSERM, 1998. p. 333-62.
    • (1998) The Biotherapy of Cancers: From Immunotherapy to Gene Therapy , pp. 333-362
    • Kedar E1    Barenholz, Y.2
  • 44
    • 0028346537 scopus 로고
    • Cytokines in liposomes: Preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-γ
    • Anderson P.M., Hanson D.C., Hasz D.E., Halet M.R., Blazar B.R., Ochoa A.C. Cytokines in liposomes: preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-γ Cytokine. 6:1994;92-101.
    • (1994) Cytokine , vol.6 , pp. 92-101
    • Anderson, P.M.1    Hanson, D.C.2    Hasz, D.E.3    Halet, M.R.4    Blazar, B.R.5    Ochoa, A.C.6
  • 47
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: Immunology, application, and optimization
    • Gurunathan S., Klinman D.M., Seder R.A. DNA vaccines: immunology, application, and optimization. Ann. Rev. Immunol. 18:2000;927-974.
    • (2000) Ann. Rev. Immunol. , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 48
    • 0031464145 scopus 로고    scopus 로고
    • Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNFα show improved pharmacokinetics and biological activity and reduced toxicity in mice
    • Kedar E., Palgi O., Golod G., Babai I., Barenholz Y. Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNFα show improved pharmacokinetics and biological activity and reduced toxicity in mice. J. Immunother. 20:1997;180-193.
    • (1997) J. Immunother. , vol.20 , pp. 180-193
    • Kedar, E.1    Palgi, O.2    Golod, G.3    Babai, I.4    Barenholz, Y.5
  • 49
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E.J., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.J.1    Dyer, W.J.2
  • 50
    • 0003038975 scopus 로고
    • Quality control assays in the development and clinical use of liposome-based formulations
    • Gregoriadis G, editor. Boca Raton: CRC Press
    • Barenholz Y, Amselem S. Quality control assays in the development and clinical use of liposome-based formulations. In: Gregoriadis G, editor. Liposome technology, vol. I. 2nd ed. Boca Raton: CRC Press, 1993. p. 527-616.
    • (1993) Liposome Technology, vol. I. 2nd ed. , vol.1 , pp. 527-616
    • Barenholz, Y.1    Amselem, S.2
  • 51
    • 0020669405 scopus 로고
    • Determination of total protein
    • Peterson G.L. Determination of total protein. Methods Enzymol. 91:1983;95-119.
    • (1983) Methods Enzymol. , vol.91 , pp. 95-119
    • Peterson, G.L.1
  • 52
    • 0000064358 scopus 로고
    • Application of microtechnique to viral serologic investigation
    • Sever J. Application of microtechnique to viral serologic investigation. J. Immunol. 88:1962;321-325.
    • (1962) J. Immunol. , vol.88 , pp. 321-325
    • Sever, J.1
  • 53
    • 0032875048 scopus 로고    scopus 로고
    • Induction of preferential cytotoxicity against allogeneic mouse lymphoma cells: In vitro and in vivo studies
    • Leshem B., Dorfman Y., Kedar E. Induction of preferential cytotoxicity against allogeneic mouse lymphoma cells: in vitro and in vivo studies. Cancer Immunol. Immunother. 48:1999;179-188.
    • (1999) Cancer Immunol. Immunother. , vol.48 , pp. 179-188
    • Leshem, B.1    Dorfman, Y.2    Kedar, E.3
  • 54
    • 0033974941 scopus 로고    scopus 로고
    • Delivery of cytokines by liposomes: Hematopoietic and immunomodulatory activity of interleukin-2 encapsulated in conventional liposomes and in long-circulating liposomes
    • Kedar E., Gur H., Babai I., Samira S., Even-Chen S., Barenholz Y. Delivery of cytokines by liposomes: hematopoietic and immunomodulatory activity of interleukin-2 encapsulated in conventional liposomes and in long-circulating liposomes. J. Immunother. 23:2000;131-145.
    • (2000) J. Immunother. , vol.23 , pp. 131-145
    • Kedar, E.1    Gur, H.2    Babai, I.3    Samira, S.4    Even-Chen, S.5    Barenholz, Y.6
  • 55
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • Gürsel I., Gürsel M., Ishii K.J., Klinman D.M. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J. Immunol. 167:2001;324-328.
    • (2001) J. Immunol. , vol.167 , pp. 324-328
    • Gürsel, I.1    Gürsel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 56
    • 0033923205 scopus 로고    scopus 로고
    • Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
    • Tighe H., Takabayashi K., Schwartz D., Marsden R., Beck L., Corbeil J.et al. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur. J. Immunol. 30:2000;1939-1947.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1939-1947
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3    Marsden, R.4    Beck, L.5    Corbeil, J.6
  • 57
    • 0035825599 scopus 로고    scopus 로고
    • Oligonucleotide containing CpG motifs enhances immune responses to mucosally or systemically administered tetanus toxoid
    • Eastcott J.W., Holmberg C.J., Dewhirst F.E., Esch T.R., Smith D.J., Taubman M.A. Oligonucleotide containing CpG motifs enhances immune responses to mucosally or systemically administered tetanus toxoid. Vaccine. 19:2001;1636-1642.
    • (2001) Vaccine , vol.19 , pp. 1636-1642
    • Eastcott, J.W.1    Holmberg, C.J.2    Dewhirst, F.E.3    Esch, T.R.4    Smith, D.J.5    Taubman, M.A.6
  • 59
    • 0034663576 scopus 로고    scopus 로고
    • In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective anti-viral and anti-tumor immunity
    • Ludewig B., Barchiesi F., Pericin M., Zinkernagel R.M., Hengartner H., Schwendener R.A. In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective anti-viral and anti-tumor immunity. Vaccine. 19:2001;23-32.
    • (2001) Vaccine , vol.19 , pp. 23-32
    • Ludewig, B.1    Barchiesi, F.2    Pericin, M.3    Zinkernagel, R.M.4    Hengartner, H.5    Schwendener, R.A.6
  • 60
    • 0035850998 scopus 로고    scopus 로고
    • Enhanced immune response to T-independent antigen by using CpG oligodeoxynucleotide encapsulated in liposomes
    • Li W.M., Bally M.B., Schutze-Redelmeier M. Enhanced immune response to T-independent antigen by using CpG oligodeoxynucleotide encapsulated in liposomes. Vaccine. 20:2001;148-157.
    • (2001) Vaccine , vol.20 , pp. 148-157
    • Li, W.M.1    Bally, M.B.2    Schutze-Redelmeier, M.3
  • 61
    • 0034893986 scopus 로고    scopus 로고
    • Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles
    • Mui B., Raney S.G., Semple S.C., Hope M.J. Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles. J. Pharmacol. Exp. Ther. 298:2001;1185-1192.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 1185-1192
    • Mui, B.1    Raney, S.G.2    Semple, S.C.3    Hope, M.J.4
  • 62
    • 0029493562 scopus 로고
    • The mucosal adjuvant activities of ADP-ribosylating bacterial enterotoxins
    • Snider D.P. The mucosal adjuvant activities of ADP-ribosylating bacterial enterotoxins. Crit. Rev. Immunol. 15:1995;317-348.
    • (1995) Crit. Rev. Immunol. , vol.15 , pp. 317-348
    • Snider, D.P.1
  • 63
    • 0035284751 scopus 로고    scopus 로고
    • Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
    • Gallichan W.S., Woolstencroft R.N., Guarasci T., McCluskie M.J., Davis H.L., Rosenthal K.L. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166:2001;3451-3457.
    • (2001) J. Immunol. , vol.166 , pp. 3451-3457
    • Gallichan, W.S.1    Woolstencroft, R.N.2    Guarasci, T.3    McCluskie, M.J.4    Davis, H.L.5    Rosenthal, K.L.6
  • 64
    • 0035888201 scopus 로고    scopus 로고
    • Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization
    • Glueck R. Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization. Vaccine. 20(Suppl 1):2001;S42-S44.
    • (2001) Vaccine , vol.20 , Issue.SUPPL. 1
    • Glueck, R.1
  • 65
    • 0034801645 scopus 로고    scopus 로고
    • Increased immunogenicity of the MF59 adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects
    • Gasparini R., Pozzi T., Montomoli E., Fragapane E., Senatore F., Minutello M.et al. Increased immunogenicity of the MF59 adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects. Eur. J. Epidemiol. 17:2001;135-140.
    • (2001) Eur. J. Epidemiol. , vol.17 , pp. 135-140
    • Gasparini, R.1    Pozzi, T.2    Montomoli, E.3    Fragapane, E.4    Senatore, F.5    Minutello, M.6
  • 66
    • 0035888254 scopus 로고    scopus 로고
    • What are the limits of adjuvanticity?
    • Del Guidice G., Padda A., Rappuoli R. What are the limits of adjuvanticity? Vaccine. 20(Suppl 1):2001;S38-S41.
    • (2001) Vaccine , vol.20 , Issue.SUPPL. 1
    • Del Guidice, G.1    Padda, A.2    Rappuoli, R.3
  • 67
    • 0035925668 scopus 로고    scopus 로고
    • Immunotherapy of chronic hepatitis B by anti-HBV vaccine: From present to future
    • Michel M.-L., Pol S., Brechot C., Tiollais P. Immunotherapy of chronic hepatitis B by anti-HBV vaccine: from present to future. Vaccine. 19:2001;2395-2399.
    • (2001) Vaccine , vol.19 , pp. 2395-2399
    • Michel, M.-L.1    Pol, S.2    Brechot, C.3    Tiollais, P.4
  • 68
    • 0035925576 scopus 로고    scopus 로고
    • The potential of oligodeoxynucleotides as mucosal and parenteral adjuvants
    • McCluskie M.J., Weeratna R.D., Davis H.L. The potential of oligodeoxynucleotides as mucosal and parenteral adjuvants. Vaccine. 19:2001;2657-2660.
    • (2001) Vaccine , vol.19 , pp. 2657-2660
    • McCluskie, M.J.1    Weeratna, R.D.2    Davis, H.L.3
  • 69
    • 0035423454 scopus 로고    scopus 로고
    • Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites
    • Horner A.A., Datta S.K., Takabayashi K., Belyakov I.M., Hayashi T., Cinman N.et al. Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J. Immunol. 167:2001;1584-1591.
    • (2001) J. Immunol. , vol.167 , pp. 1584-1591
    • Horner, A.A.1    Datta, S.K.2    Takabayashi, K.3    Belyakov, I.M.4    Hayashi, T.5    Cinman, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.