Stimulatory effect of CpG sequences on humoral response in chickens

Poultry Science

Volumn 81, Issue 9, 2002, Pages 1317-1321

  Vleugels, B ^a   Ververken, C ^a   Goddeeris, B M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Adjuvant; Antibody; Chicken; Enzyme linked immunosorbent assay; Oligonucleotide

Indexed keywords

AVES; GALLUS GALLUS; MAMMALIA; PROKARYOTA;

BOVINE SERUM ALBUMIN; CYTIDYLYL 3' 5' GUANOSINE; CYTIDYLYL-3'-5'-GUANOSINE; DINUCLEOSIDE PHOSPHATE; FREUND ADJUVANT; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE;

ANALYSIS OF VARIANCE; ANIMAL; ANTIBODY PRODUCTION; ARTICLE; CATTLE; CHICKEN; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; NUCLEOTIDE SEQUENCE; REGRESSION ANALYSIS; TIME;

ADJUVANTS, IMMUNOLOGIC; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODY FORMATION; BASE SEQUENCE; CATTLE; CHICKENS; DINUCLEOSIDE PHOSPHATES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FREUND'S ADJUVANT; OLIGODEOXYRIBONUCLEOTIDES; REGRESSION ANALYSIS; SERUM ALBUMIN, BOVINE; TIME FACTORS;

EID: 0036728506     PISSN: 00325791     EISSN: None     Source Type: Journal    
DOI: 10.1093/ps/81.9.1317     Document Type: Article

References (29)

1. Agrawal, S. 1999. Importance of oligonucleotide sequence and chemical modifications of antisense nucleotides. Biochem. Biophys. Acta 1498:53-68.
2. Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840-1845.
3. Bianchi A. T., J. W. Scholten, B. H. Moonen-Leusen, and W. J. Boersma. 1999. Development of the natural response of immunoglobulin secreting cells in the pig as a function of organ, age and housing. Dev. Comp. Immunol. 23:511-520.
4. Bianchi, A. T., R. J. Zwart, S. H. Jeurissen, and B. H. Moonen-Leusen. 1992. Development of the B- and T-cell compartments in porcine lymphoid organs from birth to adult life: an immunohistological approach. Vet. Immunol. Immunopathol. 33:201-221.
5. Cowdery, J. S., J. H. Chase, A.-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increase the toxicity of lipopolysaccharides. J. Immunol. 156:4570-4575.
6. Davis, H. L., I. I. Suparto, R. R. Weeratna, Jumintarto, D. D. Iskandriati, S. S. Chamzah, A. A. Ma'ruf, C. C. Nente, D. D. Pawitri, A. M. Krieg, Heriyanto, W. Smits, and D. D. Sajuthi. 2000. CpG DNA overcomes hyporesponsiveness to a hepatitis B vaccine in Orangutans. Vaccine 18:1920-1924.
7. Davis, H. L., R. Weeratna, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg, 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870-876.
8. Hartmann, G., and A. M. Krieg. 1999. CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Ther. 6:893-903.
9. Hartmann, G., R. D. Weeratna, Z. K. Ballas, P. Payette, S. Blackwell, I. Suparto, W. L. Rasmussen, M. Waldschmidt, D. Sajuthi, R. H. Purcell, H. L. Davis, and A. M. Krieg. 2000. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J. Immunol. 164:1617-1624.
10. Hassett, D. E., J. Zhang, and J. L. Whitton. 1999. Plasmid DNA vaccines are effective in the absence of IFN-γ. Virology 263:175-83.
11. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanyo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takesda, and S. Akira. 2000. A toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
12. Horner, A. A., A. Ronaghy, P. M. Cheng, M. D. Nguyen, H. J. Cho, D. Broide, and E. Raz. 1998. Immunostimulatory DNA is a potent mucosal adjuvant. Cell. Immunol. 190:77-82.
13. Jones, T. R., N. Obaldia III, R. A. Gramzinski, Y. Charoenvit, N. Kolodny, S. Kitov, H. L. Davis, A. M. Krieg, and S. L. Hoffman. 1999. Synthetic oligonucleotieds containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus Monkey. Vaccine 17:3065-3071.
14. Klinman, D. M., A-K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin-6, interleukin-12, and IFN-γ. Proc. Natl. Acad. Sci. USA 93:2879-2883.
15. Krieg, A.M. 1999. Mechanisms and applications of immune stimulatory CpG oligonucleotides. Biochem. Biophys. Acta 1489:107-116.
16. Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love-Homan, L. Zhang, L. Yang, A-K. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631-12636.
17. Krieg, A. M., A.-K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bischop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B cell activation. Nature 374:546-549.
18. Kundu, T. K., and M. R. Rao. 1999. CpG islands in chromatin organization and gene expression. J. Biochem. (Tokyo) 125:217-222.
19. Leitner, W. W., H. Ying, and N. P. Restifo. 2000. DNA and RNA-based vaccines:principles, progress and prospects. Vaccine 18:765-777.
20. Lipford, G. B., T. Sparwasser, M. Bauer, S. Zimmerman, E. S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: Sequence dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420-3424.
21. Manzel, J., and D. E. McFarlane. 1999. Lack of immunostimulation by immobilised CpG oligonuceotides. Antisense Nucleic Acid Drug Dev. 9:459-464.
22. Mast, J., M. Desmidt, C. Martin, R. Ducatelle, S. Haesebrouck, T. F. Davison, B. Kaspers, and B. M. Goddeeris. 1997. Different methods of bursectomy induce different effects on leucocyte distribution and reactivitiy. Arch. Geflügelkd. 61:238-246.
23. Mast, J., and B. M. Goddeeris. 1999. Development of immunocompetence of broiler chickens. Vet. Immunol. Immunopathol. 70:245-256.
24. McCluskie, M. J., R. D. Weeratna, A. M. Krieg, and H. L. Davis. 2000. CpG DNA is an effective oral adjuvant to protein antigens in mice. Vaccine 22:950-957.
25. Pisetsky, D. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303-310.
26. Sato Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization, Science 273:352-354.
27. Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Hacker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336-337.
28. Sparwasser, T., E. S. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, J. W. Ellart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activity of murine dendritic cells. Eur. J. Immunol. 28:2045-2054.
29. Weeratna, R. D., M. J. McCluskie, Y. Xu, and H. L. Davis. 2000. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 18:1755-1762.