Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3591-3597

  Sparwasser, Tim ^a   Vabulas, Ramunas M ^b   Villmow, Brigitte ^b   Lipford, Grayson B ^a   Wagner, Hermann ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b VILNIUS UNIVERSITY   (Lithuania)

Author keywords

Antigen presentation; Cytotoxic T lymphocyte; Dendritic cell; Vaccination

Indexed keywords

BACTERIAL DNA; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 12; OLIGONUCLEOTIDE; OVALBUMIN; PROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; HELPER CELL; IMMUNOSTIMULATION; IN VIVO STUDY; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VACCINATION;

ANIMALS; ANTIGENS, CD40; CD40 LIGAND; DENDRITIC CELLS; DINUCLEOSIDE PHOSPHATES; DNA, BACTERIAL; FEMALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OVALBUMIN; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0034532681     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200012)30:12<3591::AID-IMMU3591>3.0.CO;2-J     Document Type: Article

References (38)

1. + T-helper and a T-killer cell
2. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
3. CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
4. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
5. CD40 and CD154 in cell-mediated immunity
6. + T cell help
7. Host response to Sendal virus in mice lacking class II major histocompatibility complex glycoproteins
8. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells
9. Immunology. Licence to kill
10. Bacterial CpG DNA activates immune cells to signal infectious danger
11. Innate immunity: The virtues of a nonclonal system of recognition
12. The Toll-receptor family and control of innate immunity
13. Immune cell activation by bacterial CpG-DNA through MyD88 and TRAF6
14. A novel Toll-like receptor that recognizes bacterial DNA
15. Macrophages ingest and are activated by bacterial DNA
16. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
17. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
18. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
19. DNA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen
20. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
21. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
22. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
23. + T cell responses to infectious agents, tumors, transplants, and vaccines
24. A new foreign policy: MHC class I molecules monitor the outside world
25. MHC class I-restricted CTL responses to exogenous antigens
26. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
27. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
28. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
29. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization
30. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
31. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
32. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
33. + T cell dependent
34. Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
35. Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens
36. In vivo CTL induction with point-substituted ovalbumin peptides: Immunogenicity correlates with peptide-induced MHC class stability
37. Exact prediction of a natural T cell epitope
38. Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes