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Volumn 174, Issue 10, 2005, Pages 6129-6136

Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CD40 ANTIGEN; CD69 ANTIGEN; DNA; INTERFERON; INTERLEUKIN 6; LIGAND; LIPID; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VERTEBRATE DNA;

EID: 18644383289     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.10.6129     Document Type: Article
Times cited : (233)

References (44)
  • 1
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner, H. 1999. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv. Immunol. 73: 329-368.
    • (1999) Adv. Immunol. , vol.73 , pp. 329-368
    • Wagner, H.1
  • 2
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20: 709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 7
    • 0027887302 scopus 로고
    • Functions for DNA methylation in vertebrates
    • Bird, A. P. 1993. Functions for DNA methylation in vertebrates. Cold Spring Harb. Symp. Quant. Biol. 58: 281-285.
    • (1993) Cold Spring Harb. Symp. Quant. Biol. , vol.58 , pp. 281-285
    • Bird, A.P.1
  • 8
    • 0030453827 scopus 로고    scopus 로고
    • DNA methylation: Biology and significance
    • Ramsahoye, B. H., C. S. Davies, and K. I. Mills. 1996. DNA methylation: biology and significance. Blood Rev. 10: 249-261.
    • (1996) Blood Rev. , vol.10 , pp. 249-261
    • Ramsahoye, B.H.1    Davies, C.S.2    Mills, K.I.3
  • 10
    • 6344262317 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-γ- and IL-12-mediated signaling
    • Shirota, H., M. Gursel, and D. M. Klinman. 2004. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-γ- and IL-12-mediated signaling. J. Immunol. 173: 5002-5007.
    • (2004) J. Immunol. , vol.173 , pp. 5002-5007
    • Shirota, H.1    Gursel, M.2    Klinman, D.M.3
  • 12
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
    • Lee, J., T. H. Chuang, V. Redecke, L. She, P. M. Pitha, D. A. Carson, E. Raz, and H. B. Cottam. 2003. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 100: 6646-6651.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6    Raz, E.7    Cottam, H.B.8
  • 14
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad, P., H. Hacker, M. Rutz, S. Bauer, R. M. Vabulas, and H. Wagner. 2002. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32: 1958-1968.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 17
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule, M. W., C. Broughton, F. Mackay, S. Akira, A. Marshak-Rothstein, and I. R. Rifkin. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199: 1631-1640.
    • (2004) J. Exp. Med. , vol.199 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 18
    • 0033485756 scopus 로고    scopus 로고
    • Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-α inducer in systemic lupus erythematosus
    • Vallin, H., A. Perers, G. V. Alm, and L. Ronnblom. 1999. Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-α inducer in systemic lupus erythematosus. J. Immunol. 163: 6306-6313.
    • (1999) J. Immunol. , vol.163 , pp. 6306-6313
    • Vallin, H.1    Perers, A.2    Alm, G.V.3    Ronnblom, L.4
  • 19
    • 0035708710 scopus 로고    scopus 로고
    • Importance of CpG dinucleotides in activation of natural IFN-α-producing cells by a lupus-related oligodeoxynucleotide
    • Magnusson, M., S. Magnusson, H. Vallin, L. Ronnblom, and G. V. Alm. 2001. importance of CpG dinucleotides in activation of natural IFN-α-producing cells by a lupus-related oligodeoxynucleotide. Scand. J. Immunol. 54: 543-550.
    • (2001) Scand. J. Immunol. , vol.54 , pp. 543-550
    • Magnusson, M.1    Magnusson, S.2    Vallin, H.3    Ronnblom, L.4    Alm, G.V.5
  • 20
    • 2942618418 scopus 로고    scopus 로고
    • Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides
    • Wang, Y., and A. M. Krieg. 2004. Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides. Vaccine 22: 2641-2650.
    • (2004) Vaccine , vol.22 , pp. 2641-2650
    • Wang, Y.1    Krieg, A.M.2
  • 22
    • 0141886170 scopus 로고    scopus 로고
    • Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs
    • Elias, F., J. Flo, R. A, Lopez, J. Zorzopulos, A. Montaner, and J. M. Rodriguez. 2003. Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs. J. Immunol. 171: 3697-3704.
    • (2003) J. Immunol. , vol.171 , pp. 3697-3704
    • Elias, F.1    Flo, J.2    Lopez, R.A.3    Zorzopulos, J.4    Montaner, A.5    Rodriguez, J.M.6
  • 23
    • 4744368053 scopus 로고    scopus 로고
    • Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation
    • Vollmer, J., R. D. Weeratna, M. Jurk, U. Samulowitz, M. J. McCluskie, P. Payette, H. L. Davis, C. Schetter, and A. M. Krieg. 2004. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113: 212-223.
    • (2004) Immunology , vol.113 , pp. 212-223
    • Vollmer, J.1    Weeratna, R.D.2    Jurk, M.3    Samulowitz, U.4    McCluskie, M.J.5    Payette, P.6    Davis, H.L.7    Schetter, C.8    Krieg, A.M.9
  • 24
    • 2942679083 scopus 로고    scopus 로고
    • The immunobiology of the TLR9 subfamily
    • Wagner, H. 2004. The immunobiology of the TLR9 subfamily. Trends Immunol. 25: 381-386.
    • (2004) Trends Immunol. , vol.25 , pp. 381-386
    • Wagner, H.1
  • 26
    • 0036289475 scopus 로고    scopus 로고
    • Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes
    • Yasuda, K., Y. Ogawa, M. Kishimoto, T. Takagi, M. Hashida, and Takakura Y. 2002. Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes. Biochem. Biophys. Res. Commun. 293: 344-348.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 344-348
    • Yasuda, K.1    Ogawa, Y.2    Kishimoto, M.3    Takagi, T.4    Hashida, M.5    Takakura, Y.6
  • 27
    • 0345447639 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
    • Spies, B., H. Hochrein, M. Vabulas, K. Huster, D. H. Busch, F. Schmitz, A. Heit, and H. Wagner. 2003. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J. Immunol. 171: 5908-5912.
    • (2003) J. Immunol. , vol.171 , pp. 5908-5912
    • Spies, B.1    Hochrein, H.2    Vabulas, M.3    Huster, K.4    Busch, D.H.5    Schmitz, F.6    Heit, A.7    Wagner, H.8
  • 29
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira, and Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa5
  • 30
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17: 6230-6240.
    • (1998) EMBO J. , vol.17 , pp. 6230-6240
    • Hacker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 31
    • 0037100526 scopus 로고    scopus 로고
    • B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12
    • Shirota, H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, and G. Tamura. 2002. B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12. J. Immunol. 169: 787-794.
    • (2002) J. Immunol. , vol.169 , pp. 787-794
    • Shirota, H.1    Sano, K.2    Hirasawa, N.3    Terui, T.4    Ohuchi, K.5    Hattori, T.6    Tamura, G.7
  • 32
    • 0037443413 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells
    • Heit, A., T. Maurer, H. Hochrein, S. Bauer, K. M. Huster, D. H. Busch, and H. Wagner. 2003. Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J. Immunol. 170: 2802-2805.
    • (2003) J. Immunol. , vol.170 , pp. 2802-2805
    • Heit, A.1    Maurer, T.2    Hochrein, H.3    Bauer, S.4    Huster, K.M.5    Busch, D.H.6    Wagner, H.7
  • 35
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
    • Verthelyi, D., K. J. Ishii, M. Gursel, F. Takeshita, and D. M. Klinman. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166: 2372-2377.
    • (2001) J. Immunol. , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 37
    • 1342311435 scopus 로고    scopus 로고
    • Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors
    • Zhao, H., H. Hemmi, S. Akira, S. H. Cheng, R. K. Scheule, and N. S. Yew. 2004. Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors. Mol. Ther. 9: 241-248.
    • (2004) Mol. Ther. , vol.9 , pp. 241-248
    • Zhao, H.1    Hemmi, H.2    Akira, S.3    Cheng, S.H.4    Scheule, R.K.5    Yew, N.S.6
  • 38
    • 0141760526 scopus 로고    scopus 로고
    • Cationic lipids and cationic ligands induce DNA helix denaturation: Detection of single stranded regions by KMnO4 probing
    • Prasad, T. K., V. Gopal, and N. M. Rao. 2003. Cationic lipids and cationic ligands induce DNA helix denaturation: detection of single stranded regions by KMnO4 probing. FEBS Lett. 552: 199-206.
    • (2003) FEBS Lett. , vol.552 , pp. 199-206
    • Prasad, T.K.1    Gopal, V.2    Rao, N.M.3
  • 39
    • 4644330955 scopus 로고    scopus 로고
    • Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
    • Rutz, M., J. Metzger, T. Gellert, P. Luppa, G. B. Lipford, H. Wagner, and S. Bauer. 2004. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 34: 2541-2550.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2541-2550
    • Rutz, M.1    Metzger, J.2    Gellert, T.3    Luppa, P.4    Lipford, G.B.5    Wagner, H.6    Bauer, S.7
  • 41
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA
    • Yoshida, H., Y, Okabe, K. Kawane, H. Fukuyama, and S. Nagata. 2005. Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA. Nat. Immunol. 6: 49-56.
    • (2005) Nat. Immunol. , vol.6 , pp. 49-56
    • Yoshida, H.Y.1    Okabe2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 42
    • 0036676975 scopus 로고    scopus 로고
    • Roles of Fc receptors in autoimmunity
    • Takai, T. 2002. Roles of Fc receptors in autoimmunity. Nat. Rev. Immunol. 2: 580-592.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 580-592
    • Takai, T.1
  • 43
    • 0032932445 scopus 로고    scopus 로고
    • CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro
    • Sato, Y., M. Miyata, Y. Sato, T. Nishimaki, H. Kochi, and R. Kasukawa. 1999. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J. Rheumatol. 26: 294-301.
    • (1999) J. Rheumatol. , vol.26 , pp. 294-301
    • Sato, Y.1    Miyata, M.2    Sato, Y.3    Nishimaki, T.4    Kochi, H.5    Kasukawa, R.6
  • 44
    • 0037237628 scopus 로고    scopus 로고
    • Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential Toll-like receptor ligation
    • Boonstra, A., C. Asselin-Paturel, M. Gilliet, C. Crain, G. Trinchieri, Y. J. Liu, and A. O'Garra. 2003. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J. Exp. Med. 197: 101-109.
    • (2003) J. Exp. Med. , vol.197 , pp. 101-109
    • Boonstra, A.1    Asselin-Paturel, C.2    Gilliet, M.3    Crain, C.4    Trinchieri, G.5    Liu, Y.J.6    O'Garra, A.7


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