메뉴 건너뛰기




Volumn 99, Issue 4, 2006, Pages 1062-1072

Parkinsonism genes: Culprits and clues

Author keywords

DJ 1; LRRK2 Synuclein; Parkin; Parkinson's disease; PINK1

Indexed keywords

ALPHA SYNUCLEIN; CYTOPLASM PROTEIN; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN PINK1; RAS PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 33750459730     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04102.x     Document Type: Review
Times cited : (98)

References (118)
  • 1
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A., Schmitz. Y., Farinas I. et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252.
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3
  • 2
    • 0037244211 scopus 로고    scopus 로고
    • The identification of pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum
    • Abysalh J. C., Kuchnicki L. L. and Larochelle D. A. (2003) The identification of pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum. Mol Biol. Cell 14, 14-25.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 14-25
    • Abysalh, J.C.1    Kuchnicki, L.L.2    Larochelle, D.A.3
  • 3
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • Beal M. F. (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. N Y Acad. Sci. 991, 120-131.
    • (2003) Ann. N Y Acad. Sci. , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 6
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., Rizzu P., van Baren M. J. et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259.
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1    Rizzu, P.2    Van Baren, M.J.3
  • 7
    • 33646451063 scopus 로고    scopus 로고
    • Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization
    • Bosco D. A., Fowler D. M., Zhang Q., Nieva J., Powers E. T., Wentworth P., Lerner R. A. and Kelly J. W. (2006) Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem. Biol. 2, 249-253.
    • (2006) Nat Chem. Biol. , vol.2 , pp. 249-253
    • Bosco, D.A.1    Fowler, D.M.2    Zhang, Q.3    Nieva, J.4    Powers, E.T.5    Wentworth, P.6    Lerner, R.A.7    Kelly, J.W.8
  • 9
    • 0037109727 scopus 로고    scopus 로고
    • Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    • Cabin D. E., Shimazu K., Murphy D. et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22, 8797-8807.
    • (2002) J. Neurosci. , vol.22 , pp. 8797-8807
    • Cabin, D.E.1    Shimazu, K.2    Murphy, D.3
  • 12
    • 27544507306 scopus 로고    scopus 로고
    • Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    • Chandra S., Gallardo G., Fernandez-Chacon R., Schluter O. M. and Sudhof T. C. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123, 383-396.
    • (2005) Cell , vol.123 , pp. 383-396
    • Chandra, S.1    Gallardo, G.2    Fernandez-Chacon, R.3    Schluter, O.M.4    Sudhof, T.C.5
  • 13
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin- 1: Implications for Lewy-body formation in Parkinson disease
    • Chung K. K., Zhang Y., Lim K. L., Tanaka Y., Huang H., Gao J., Ross C. A., Dawson V. L. and Dawson T. M. (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin- 1: implications for Lewy-body formation in Parkinson disease. Nat Med. 7, 1144-1150.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 15
    • 33645558938 scopus 로고    scopus 로고
    • Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy
    • von Coelln R., Thomas B., Andrabi S. A. et al. (2006) Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. J. Neurosci. 26, 3685-3696.
    • (2006) J. Neurosci. , vol.26 , pp. 3685-3696
    • Von Coelln, R.1    Thomas, B.2    Andrabi, S.A.3
  • 16
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
    • Conway K. A., Lee S. J., Rochet J. C., Ding T. T., Williamson R. E. and Lansbury P. T. Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl Acad. Sci. U S A 97, 571-576.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury Jr., P.T.6
  • 17
    • 33746533924 scopus 로고    scopus 로고
    • Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    • Cooper A. A., Gitler A. D., Cashikar A. et al. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324-328.
    • (2006) Science , vol.313 , pp. 324-328
    • Cooper, A.A.1    Gitler, A.D.2    Cashikar, A.3
  • 18
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo A. M., Stefanis L., Fredenburg R., Lansbury P. T. and Sulzer D. (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 19
    • 0037338634 scopus 로고    scopus 로고
    • Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
    • Darios F., Corti O., Lucking C. B. et al. (2003) Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet 12, 517-526.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 517-526
    • Darios, F.1    Corti, O.2    Lucking, C.B.3
  • 20
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta S. R., Brunet A. and Greenberg M. E. (1999) Cellular survival: a play in three Akts. Genes Dev 13, 2905-2927.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 21
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H., Bignell G. R., Cox C. et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417, 949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 22
    • 19944431081 scopus 로고    scopus 로고
    • A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease
    • Di Fonzo A., Rohe C. F., Ferreira J. et al. (2005) A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet 365, 412-415.
    • (2005) Lancet , vol.365 , pp. 412-415
    • Di Fonzo, A.1    Rohe, C.F.2    Ferreira, J.3
  • 23
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M. B. and Bender W. W. (2000) A Drosophila model of Parkinson's disease. Nature 404, 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 26
    • 0033539664 scopus 로고    scopus 로고
    • Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein
    • Galvin J. E., Uryu K., Lee V. M. and Trojanowski J. Q. (1999) Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc. Natl Acad. Sci. U S A 96, 13 450-13 455.
    • (1999) Proc. Natl. Acad. Sci. U S A , vol.96 , pp. 13450-13455
    • Galvin, J.E.1    Uryu, K.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 27
    • 0032937059 scopus 로고    scopus 로고
    • Diagnostic criteria for Parkinson disease
    • Gelb D. J., Oliver E. and Gilman S. (1999) Diagnostic criteria for Parkinson disease. Arch. Neurol. 56, 33-39.
    • (1999) Arch. Neurol. , vol.56 , pp. 33-39
    • Gelb, D.J.1    Oliver, E.2    Gilman, S.3
  • 28
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson B. I., Duda J. E., Quinn S. M., Zhang B., Trojanowski J. Q. and Lee V. M. (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34, 521-533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 30
    • 19944432921 scopus 로고    scopus 로고
    • A common LRRK2 mutation in idiopathic Parkinson's disease
    • Gilks W. P., Abou-Sleiman P. M., Gandhi S. et al. (2005) A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 356, 415-416.
    • (2005) Lancet , vol.356 , pp. 415-416
    • Gilks, W.P.1    Abou-Sleiman, P.M.2    Gandhi, S.3
  • 31
    • 10744221260 scopus 로고    scopus 로고
    • Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
    • Gispert S., Del Turco D., Garrett L. et al. (2003) Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci. 24, 419-429.
    • (2003) Mol. Cell Neurosci. , vol.24 , pp. 419-429
    • Gispert, S.1    Del Turco, D.2    Garrett, L.3
  • 33
    • 0032214501 scopus 로고    scopus 로고
    • Tau mutations cause frontotemporal dementias
    • Goedert M., Crowther R. A. and Spillantini M. G. (1998) Tau mutations cause frontotemporal dementias. Neuron 21, 955-958.
    • (1998) Neuron , vol.21 , pp. 955-958
    • Goedert, M.1    Crowther, R.A.2    Spillantini, M.G.3
  • 34
    • 0141891953 scopus 로고    scopus 로고
    • Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    • Goldberg M. S., Fleming S. M., Palacino J. J. et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278, 43 628-43 635.
    • (2003) J. Biol. Chem. , vol.278 , pp. 43628-43635
    • Goldberg, M.S.1    Fleming, S.M.2    Palacino, J.J.3
  • 35
    • 13844253723 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    • Goldberg M. S., Pisani A., Haburcak M. et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45, 489-496.
    • (2005) Neuron , vol.45 , pp. 489-496
    • Goldberg, M.S.1    Pisani, A.2    Haburcak, M.3
  • 37
    • 33746267531 scopus 로고    scopus 로고
    • Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
    • Greggio E., Jain S., Kingsbury A. et al. (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis 23, 329-341.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 329-341
    • Greggio, E.1    Jain, S.2    Kingsbury, A.3
  • 38
    • 0032551656 scopus 로고    scopus 로고
    • Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
    • Hashimoto M., Hsu L. J., Sisk A., Xia Y., Takeda A., Sundsmo M. and Masliah E. (1998) Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Brain Res. 799, 301-306.
    • (1998) Brain Res. , vol.799 , pp. 301-306
    • Hashimoto, M.1    Hsu, L.J.2    Sisk, A.3    Xia, Y.4    Takeda, A.5    Sundsmo, M.6    Masliah, E.7
  • 40
    • 0033103726 scopus 로고    scopus 로고
    • Identification and characterization of a novel protein that regulates RNA-protein interaction
    • Hod Y., Pentyala S. N., Whyard T. C. and El-Maghrabi M. R. (1999) Identification and characterization of a novel protein that regulates RNA-protein interaction. J. Cell Biochem. 72, 435-444.
    • (1999) J. Cell Biochem. , vol.72 , pp. 435-444
    • Hod, Y.1    Pentyala, S.N.2    Whyard, T.C.3    El-Maghrabi, M.R.4
  • 41
    • 0141995596 scopus 로고    scopus 로고
    • The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
    • Huynh D. P., Scoles D. R., Nguyen D. and Pulst S. M. (2003) The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Hum Mol Genet 12, 2587-2597.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2587-2597
    • Huynh, D.P.1    Scoles, D.R.2    Nguyen, D.3    Pulst, S.M.4
  • 42
    • 0036345454 scopus 로고    scopus 로고
    • CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
    • Imai Y., Soda M., Hatakeyama S., Akagi T., Hashikawa T., Nakayama K. I. and Takahashi R. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 10, 55-67.
    • (2002) Mol. Cell , vol.10 , pp. 55-67
    • Imai, Y.1    Soda, M.2    Hatakeyama, S.3    Akagi, T.4    Hashikawa, T.5    Nakayama, K.I.6    Takahashi, R.7
  • 43
    • 0035967883 scopus 로고    scopus 로고
    • An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
    • Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y. and Takahashi R. (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105, 891-902.
    • (2001) Cell , vol.105 , pp. 891-902
    • Imai, Y.1    Soda, M.2    Inoue, H.3    Hattori, N.4    Mizuno, Y.5    Takahashi, R.6
  • 44
    • 0034680913 scopus 로고    scopus 로고
    • Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
    • Imai Y., Soda M. and Takahashi R. (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J. Biol. Chem. 275, 35 661-35 664.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35661-35664
    • Imai, Y.1    Soda, M.2    Takahashi, R.3
  • 45
    • 10744221310 scopus 로고    scopus 로고
    • Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
    • Itier J. M., Ibanez. P., Mena M. A. et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum Mol Genet 12, 2277-2291.
    • (2003) Hum Mol Genet , vol.12 , pp. 2277-2291
    • Itier, J.M.1    Ibanez, P.2    Mena, M.A.3
  • 46
    • 4444327827 scopus 로고    scopus 로고
    • Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
    • Jiang H., Ren Y., Zhao J. and Feng J. (2004) Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum Mol Genet 13, 1745-1754.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 1745-1754
    • Jiang, H.1    Ren, Y.2    Zhao, J.3    Feng, J.4
  • 47
    • 0035191413 scopus 로고    scopus 로고
    • Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    • Kahle P. J., Neumann M., Ozmen L. et al. (2001) Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am. J. Pathol 159, 2215-2225.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2215-2225
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 48
    • 20144389422 scopus 로고    scopus 로고
    • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress
    • Kim R. H., Smith P. D., Aleyasin H. et al. (2005a) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl Acad. Sci. U S A 102, 5215-5220.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 5215-5220
    • Kim, R.H.1    Smith, P.D.2    Aleyasin, H.3
  • 49
    • 20244365801 scopus 로고    scopus 로고
    • DJ-1, a novel regulator of the tumor suppressor PTEN
    • Kim R. H., Peters M., Jang Y. et al. (2005b) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7, 263-273.
    • (2005) Cancer Cell , vol.7 , pp. 263-273
    • Kim, R.H.1    Peters, M.2    Jang, Y.3
  • 51
    • 33745220302 scopus 로고    scopus 로고
    • Identification of far up stream element binding protein-1 as an authentic parkin substrate
    • Ko H. S., Kim S. W., Sriram S. R., Dawson V. L. and Dawson T. M. (2006) Identification of far up stream element binding protein-1 as an authentic parkin substrate. J Biol Chem.
    • (2006) J. Biol. Chem.
    • Ko, H.S.1    Kim, S.W.2    Sriram, S.R.3    Dawson, V.L.4    Dawson, T.M.5
  • 52
    • 24144497601 scopus 로고    scopus 로고
    • Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death
    • Ko H. S., von Coelln R., Sriram S. R. et al. (2005) Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neurosci. 25, 7968-7978.
    • (2005) J. Neurosci. , vol.25 , pp. 7968-7978
    • Ko, H.S.1    Von Coelln, R.2    Sriram, S.R.3
  • 54
    • 0021155228 scopus 로고
    • MPTP-induced parkinsonism in human and non-human primates - Clinical and experimental aspects
    • Langston J. W., Langston E. B. and Irwin I. (1984) MPTP-induced parkinsonism in human and non-human primates - clinical and experimental aspects. Acta Neurol. Scandsupplement 100, 49-54.
    • (1984) Acta Neurol. Scandsupplement , vol.100 , pp. 49-54
    • Langston, J.W.1    Langston, E.B.2    Irwin, I.3
  • 55
    • 0036415838 scopus 로고    scopus 로고
    • Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
    • Lashuel H. A., Petre B. M., Wall J., Simon M., Nowak R. J., Walz. T. and Lansbury P. T. Jr (2002) Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J. Mol Biol. 322, 1089-1102.
    • (2002) J. Mol. Biol. , vol.322 , pp. 1089-1102
    • Lashuel, H.A.1    Petre, B.M.2    Wall, J.3    Simon, M.4    Nowak, R.J.5    Walz, T.6    Lansbury Jr., P.T.7
  • 57
    • 0037173006 scopus 로고    scopus 로고
    • Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 - > Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
    • Lee M. K., Stirling W., Xu Y., Xu X., Qui D., Mandir A. S., Dawson T. M., Copeland N. G., Jenkins N. A. and Price D. L. (2002) Human alpha-synuclein- harboring familial Parkinson's disease-linked Ala-53 - > Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc. Natl Acad. Sci. U S A 99, 8968-8973.
    • (2002) Proc. Natl. Acad. Sci. U S A , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3    Xu, X.4    Qui, D.5    Mandir, A.S.6    Dawson, T.M.7    Copeland, N.G.8    Jenkins, N.A.9    Price, D.L.10
  • 59
    • 30644471051 scopus 로고    scopus 로고
    • Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
    • Martin L. J., Pan Y., Price A. C., Sterling W., Copeland N. G., Jenkins N. A., Price D. L. and Lee M. K. (2006) Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26, 41-50.
    • (2006) J. Neurosci. , vol.26 , pp. 41-50
    • Martin, L.J.1    Pan, Y.2    Price, A.C.3    Sterling, W.4    Copeland, N.G.5    Jenkins, N.A.6    Price, D.L.7    Lee, M.K.8
  • 60
    • 0035861048 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    • Martin E. R., Scott W. K., Nance M. A. et al. (2001) Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. Jama 286, 2245-2250.
    • (2001) Jama , vol.286 , pp. 2245-2250
    • Martin, E.R.1    Scott, W.K.2    Nance, M.A.3
  • 61
    • 13944279784 scopus 로고    scopus 로고
    • Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES- Derived cell model of primary parkinsonism
    • Martinat C., Shendelman S., Jonason A., Leete T., Beal M. F., Yang L., Floss T. and Abeliovich A. (2004) Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary parkinsonism. PLoS Biol 2, e327.
    • (2004) PLoS Biol. , vol.2
    • Martinat, C.1    Shendelman, S.2    Jonason, A.3    Leete, T.4    Beal, M.F.5    Yang, L.6    Floss, T.7    Abeliovich, A.8
  • 62
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
    • Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., Sagara Y., Sisk A. and Mucke L. (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Sagara, Y.7    Sisk, A.8    Mucke, L.9
  • 64
    • 24044506249 scopus 로고    scopus 로고
    • Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    • Menzies F. M., Yenisetti S. C. and Min K. T. (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 15, 1578-1582.
    • (2005) Curr. Biol. , vol.15 , pp. 1578-1582
    • Menzies, F.M.1    Yenisetti, S.C.2    Min, K.T.3
  • 65
  • 68
    • 0034906096 scopus 로고    scopus 로고
    • Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
    • Mitsumoto A., Nakagawa Y., Takeuchi A., Okawa K., Iwamatsu A. and Takanezawa Y. (2001) Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic Res. 35, 301-310.
    • (2001) Free Radic Res. , vol.35 , pp. 301-310
    • Mitsumoto, A.1    Nakagawa, Y.2    Takeuchi, A.3    Okawa, K.4    Iwamatsu, A.5    Takanezawa, Y.6
  • 71
    • 19944432606 scopus 로고    scopus 로고
    • Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
    • Nichols W. C., Pankratz N., Hernandez D. et al. (2005) Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet, 365, 410-412.
    • (2005) Lancet , vol.365 , pp. 410-412
    • Nichols, W.C.1    Pankratz, N.2    Hernandez, D.3
  • 72
    • 17644426350 scopus 로고    scopus 로고
    • Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders
    • Norris E. H. and Giasson B. I. (2005) Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxid Redox Signal 7, 672-684.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 672-684
    • Norris, E.H.1    Giasson, B.I.2
  • 74
    • 0345189364 scopus 로고    scopus 로고
    • Yeast cells provide insight into alpha-synuclein biology and pathobiology
    • Outeiro T. F. and Lindquist S. (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302, 1772-1775.
    • (2003) Science , vol.302 , pp. 1772-1775
    • Outeiro, T.F.1    Lindquist, S.2
  • 75
    • 31344439221 scopus 로고    scopus 로고
    • LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
    • Ozelius L. J., Senthil G., Saunders-Pullman R. et al. (2006) LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med 354, 424-425.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 424-425
    • Ozelius, L.J.1    Senthil, G.2    Saunders-Pullman, R.3
  • 76
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    • Paisan-Ruiz. C., Jain S., Evans E. W. et al. (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600.
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisan-Ruiz, C.1    Jain, S.2    Evans, E.W.3
  • 78
    • 27144519984 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
    • Park J., Kim S. Y., Cha G. H., Lee S. B., Kim S. and Chung J. (2005) Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361, 133-139.
    • (2005) Gene , vol.361 , pp. 133-139
    • Park, J.1    Kim, S.Y.2    Cha, G.H.3    Lee, S.B.4    Kim, S.5    Chung, J.6
  • 79
    • 33745602748 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    • Park J., Lee S. B., Lee S. et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature.
    • (2006) Nature
    • Park, J.1    Lee, S.B.2    Lee, S.3
  • 80
    • 13844313915 scopus 로고    scopus 로고
    • Parkin-deficient mice are not a robust model of parkinsonism
    • PereZ. F. A. and Palmiter R. D. (2005) Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl Acad. Sci. U S A 102, 2174-2179.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 2174-2179
    • Perez, F.A.1    Palmiter, R.D.2
  • 82
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with mutant alpha-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
    • Petrucelli L., O'Farrell C., Lockhart P. J. et al. (2002) Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36, 1007-1019.
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O'Farrell, C.2    Lockhart, P.J.3
  • 83
    • 0034528424 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Polymeropoulos M. H. (2000) Genetics of Parkinson's disease. Ann. N Y Acad. Sci. 920, 28-32.
    • (2000) Ann. N Y Acad. Sci. , vol.920 , pp. 28-32
    • Polymeropoulos, M.H.1
  • 84
    • 0034609561 scopus 로고    scopus 로고
    • Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein
    • Rochet J. C., Conway K. A. and Lansbury P. T. Jr (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39, 10 619-10 626.
    • (2000) Biochemistry , vol.39 , pp. 10619-10626
    • Rochet, J.C.1    Conway, K.A.2    Lansbury Jr., P.T.3
  • 85
    • 13944267769 scopus 로고    scopus 로고
    • DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    • Shendelman S., Jonason A., Martinat C., Leete T. and Abeliovich A. (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol 2, e362.
    • (2004) PLoS Biol. , vol.2
    • Shendelman, S.1    Jonason, A.2    Martinat, C.3    Leete, T.4    Abeliovich, A.5
  • 86
    • 0033933048 scopus 로고    scopus 로고
    • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
    • Shimura H., Hattori N., Kubo S. et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25, 302-305.
    • (2000) Nat. Genet. , vol.25 , pp. 302-305
    • Shimura, H.1    Hattori, N.2    Kubo, S.3
  • 89
    • 22144439077 scopus 로고    scopus 로고
    • Altered alpha-synuclein homeostasis causing Parkinson's disease: The potential roles of dardarin
    • Singleton A. B. (2005) Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin. Trends Neurosci. 28, 416-421.
    • (2005) Trends Neurosci. , vol.28 , pp. 416-421
    • Singleton, A.B.1
  • 90
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-Synuclein locus triplication causes Parkinson's disease
    • Singleton A. B., Farrer M., Johnson J. et al. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 92
    • 0037422010 scopus 로고    scopus 로고
    • Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
    • Staropoli J. F., McDermott C., Martinat C., Schulman B., Demireva E. and Abeliovich A. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37, 735-749.
    • (2003) Neuron , vol.37 , pp. 735-749
    • Staropoli, J.F.1    McDermott, C.2    Martinat, C.3    Schulman, B.4    Demireva, E.5    Abeliovich, A.6
  • 93
    • 0035894855 scopus 로고    scopus 로고
    • Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
    • Stefanis L., Larsen K. E., Rideout H. J., Sulzer D. and Greene L. A. (2001) Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci. 21, 9549-9560.
    • (2001) J. Neurosci. , vol.21 , pp. 9549-9560
    • Stefanis, L.1    Larsen, K.E.2    Rideout, H.J.3    Sulzer, D.4    Greene, L.A.5
  • 95
    • 0035813135 scopus 로고    scopus 로고
    • DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    • Takahashi K., Taira T., Niki T., Seino C., Iguchi-Ariga S. M. and Ariga H. (2001) DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 276, 37 556-37 563.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37556-37563
    • Takahashi, K.1    Taira, T.2    Niki, T.3    Seino, C.4    Iguchi-Ariga, S.M.5    Ariga, H.6
  • 96
    • 0035870881 scopus 로고    scopus 로고
    • Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
    • Tanaka Y., Engelender S., Igarashi S., Rao R. K., Wanner T., Tanzi R. E., Sawa A. V. L. D., Dawson T. M. and Ross C. A. (2001) Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 10, 919-926.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 919-926
    • Tanaka, Y.1    Engelender, S.2    Igarashi, S.3    Rao, R.K.4    Wanner, T.5    Tanzi, R.E.6    Sawa, A.V.L.D.7    Dawson, T.M.8    Ross, C.A.9
  • 97
    • 33744760852 scopus 로고    scopus 로고
    • Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
    • Tang B., Xiong H., Sun P. et al. (2006) Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum Mol Genet 15, 1816-1825.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1816-1825
    • Tang, B.1    Xiong, H.2    Sun, P.3
  • 98
    • 0027479150 scopus 로고
    • Altered tau and neurofilament proteins in neuro-degenerative diseases: Diagnostic implications for Alzheimer's disease and Lewy body dementias
    • Trojanowski J. Q., Schmidt M. L., Shin R. W., Bramblett G. T., Rao D. and Lee V. M. (1993) Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias. Brain Pathol 3, 45-54.
    • (1993) Brain Pathol. , vol.3 , pp. 45-54
    • Trojanowski, J.Q.1    Schmidt, M.L.2    Shin, R.W.3    Bramblett, G.T.4    Rao, D.5    Lee, V.M.6
  • 99
    • 0035958558 scopus 로고    scopus 로고
    • Growth-suppressive effects of BPOZ. and EGR2, two genes involved in the PTEN signaling pathway
    • Unoki M. and Nakamura Y. (2001) Growth-suppressive effects of BPOZ. and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 20, 4457-4465.
    • (2001) Oncogene , vol.20 , pp. 4457-4465
    • Unoki, M.1    Nakamura, Y.2
  • 102
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb P. H., Zhen W., Poon A. W., Conway K. A. and Lansbury P. T. Jr (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13 709-13 715.
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury Jr., P.T.5
  • 104
    • 20344369560 scopus 로고    scopus 로고
    • Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
    • Whitworth A. J., Theodore D. A., Greene J. C., Benes H., Wes P. D. and Pallanck L. J. (2005) Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc. Natl Acad. Sci. U S A 102, 8024-8029.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 8024-8029
    • Whitworth, A.J.1    Theodore, D.A.2    Greene, J.C.3    Benes, H.4    Wes, P.D.5    Pallanck, L.J.6
  • 106
    • 0036959481 scopus 로고    scopus 로고
    • Activation of the c-Jun N terminal kinase pathway in an animal model of Parkinson's disease
    • Willesen M. G., Gammeltoft S. and Vaudano E. (2002) Activation of the c-Jun N terminal kinase pathway in an animal model of Parkinson's disease. Ann. N Y Acad. Sci. 973, 237-240.
    • (2002) Ann. N Y Acad. Sci. , vol.973 , pp. 237-240
    • Willesen, M.G.1    Gammeltoft, S.2    Vaudano, E.3
  • 107
    • 26244431890 scopus 로고    scopus 로고
    • The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: A close prokaryotic homologue of the Parkinsonism-associated protein DJ-1
    • Wilson M. A., Ringe D. and Petsko G. A. (2005) The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. J Mol Biol 353, 678-691.
    • (2005) J. Mol. Biol. , vol.353 , pp. 678-691
    • Wilson, M.A.1    Ringe, D.2    Petsko, G.A.3
  • 108
    • 2342605968 scopus 로고    scopus 로고
    • Autosomal dominant parkinsonism associated with variable synuclein and tau pathology
    • Wszolek Z. K., Pfeiffer R. F., Tsuboi Y. et al. (2004) Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology 62, 1619-1622.
    • (2004) Neurology , vol.62 , pp. 1619-1622
    • Wszolek, Z.K.1    Pfeiffer, R.F.2    Tsuboi, Y.3
  • 109
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • Xu J., Kao S. Y., Lee F. J., Song W., Jin L. W. and Yankner B. A. (2002) Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 8, 600-606.
    • (2002) Nat. Med. , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.3    Song, W.4    Jin, L.W.5    Yankner, B.A.6
  • 110
    • 20944437573 scopus 로고    scopus 로고
    • The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    • Xu J., Zhong N.,Wang H., Elias J. E., Kim C.Y.,Woldman I., Pifl C., Gygi S. P., Geula C. and Yankner B. A. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet 14, 1231-1241.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1231-1241
    • Xu, J.1    Zhong, N.2    Wang, H.3    Elias, J.E.4    Kim, C.Y.5    Woldman, I.6    Pifl, C.7    Gygi, S.P.8    Geula, C.9    Yankner, B.A.10
  • 111
    • 26444489693 scopus 로고    scopus 로고
    • Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    • Yang Y., Gehrke S., Haque M. E. et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl Acad. Sci. USA 102, 13 670-13 675.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13670-13675
    • Yang, Y.1    Gehrke, S.2    Haque, M.E.3
  • 114
    • 0034700158 scopus 로고    scopus 로고
    • Parkin functions as an E2-dependent ubiquitin- Protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    • Zhang Y., Gao J., Chung K. K., Huang H., Dawson V. L. and Dawson T. M. (2000) Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl Acad. Sci. U S A 97, 13 354-13 359.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.K.3    Huang, H.4    Dawson, V.L.5    Dawson, T.M.6
  • 115
    • 24944534660 scopus 로고    scopus 로고
    • Mitochondrial localization of the Parkinson's disease related protein DJ-1: Implications for pathogenesis
    • Zhang L., Shimoji M., Thomas B. et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet 14, 2063-2073.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2063-2073
    • Zhang, L.1    Shimoji, M.2    Thomas, B.3
  • 116
    • 30044449754 scopus 로고    scopus 로고
    • DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    • Zhou W. and Freed C. R. (2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J. Biol. Chem. 280, 43 150-43 158.
    • (2005) J. Biol. Chem. , vol.280 , pp. 43150-43158
    • Zhou, W.1    Freed, C.R.2
  • 117
    • 31344464179 scopus 로고    scopus 로고
    • The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    • Zhou W., Zhu M., Wilson M. A., Petsko G. A. and Fink A. L. (2006) The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol Biol. 356, 1036-1048.
    • (2006) J. Mol. Biol. , vol.356 , pp. 1036-1048
    • Zhou, W.1    Zhu, M.2    Wilson, M.A.3    Petsko, G.A.4    Fink, A.L.5
  • 118
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • Zimprich A., Biskup S., Leitner P. et al. (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607.
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1    Biskup, S.2    Leitner, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.