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Volumn 12, Issue 4, 2002, Pages 499-510

Mechanistic approaches to Parkinson's disease pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETOGENIN; ALPHA SYNUCLEIN; ANTIBIOTIC AGENT; BENZIMIDAZOLE; CYHALOTHRIN; HEAVY METAL; HERBICIDE; MANGANESE; MITOCHONDRIAL DNA; PESTICIDE; PROTEASOME; REACTIVE OXYGEN METABOLITE; RHEIN; ROTENONE; UBIQUITIN;

EID: 0036793929     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2002.tb00468.x     Document Type: Conference Paper
Times cited : (128)

References (101)
  • 1
    • 0030805622 scopus 로고    scopus 로고
    • A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
    • Alam ZI, Daniel SE, Lees AJ, Marsden DC, Jenner P, Halliwell B (1997) A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem 69:1326-1329.
    • (1997) J Neurochem , vol.69 , pp. 1326-1329
    • Alam, Z.I.1    Daniel, S.E.2    Lees, A.J.3    Marsden, D.C.4    Jenner, P.5    Halliwell, B.6
  • 2
    • 0026609559 scopus 로고
    • Alternative excitotoxic hypotheses
    • Albin RL, Greenamyre JT (1992) Alternative excitotoxic hypotheses. Neurology 42:733-738.
    • (1992) Neurology , vol.42 , pp. 733-738
    • Albin, R.L.1    Greenamyre, J.T.2
  • 3
    • 0024450903 scopus 로고
    • The functional anatomy of basal ganglia disorders
    • Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375.
    • (1989) Trends Neurosci , vol.12 , pp. 366-375
    • Albin, R.L.1    Young, A.B.2    Penney, J.B.3
  • 4
    • 0022408175 scopus 로고
    • Ecogenetics of Parkinson's disease: 4-Hydroxylation of debrisoquine
    • Barbeau A, Cloutier T, Roy M, Plasse L, Paris S, Poirier J (1985) Ecogenetics of Parkinson's disease: 4-Hydroxylation of debrisoquine. Lancet 2:1213-1216.
    • (1985) Lancet , vol.2 , pp. 1213-1216
    • Barbeau, A.1    Cloutier, T.2    Roy, M.3    Plasse, L.4    Paris, S.5    Poirier, J.6
  • 5
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-1237.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 9
    • 0035074475 scopus 로고    scopus 로고
    • Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease
    • Blandini F, Nappi G, Greenamyre JT (2001) Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Ann Neurol 49:525-529.
    • (2001) Ann Neurol , vol.49 , pp. 525-529
    • Blandini, F.1    Nappi, G.2    Greenamyre, J.T.3
  • 11
    • 0034007822 scopus 로고    scopus 로고
    • Pathoanatomy of Parkinson's disease
    • Braak H, Braak E (2000) Pathoanatomy of Parkinson's disease. J Neurol 247 Suppl 2:113-10.
    • (2000) J Neurol , vol.247 , Issue.SUPPL. 2 , pp. 113-110
    • Braak, H.1    Braak, E.2
  • 14
    • 0024500857 scopus 로고
    • Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence
    • Cadet JL, Katz M, Jackson-Lewis V, Fahn S (1989) Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence. Brain Res 476:10-15.
    • (1989) Brain Res , vol.476 , pp. 10-15
    • Cadet, J.L.1    Katz, M.2    Jackson-Lewis, V.3    Fahn, S.4
  • 18
    • 0026598930 scopus 로고
    • Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement
    • Cleeter MW, Cooper JM, Schapira AH (1992) Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 58:786-789.
    • (1992) J Neurochem , vol.58 , pp. 786-789
    • Cleeter, M.W.1    Cooper, J.M.2    Schapira, A.H.3
  • 19
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 4:1318-1320.
    • (1998) Nat Med , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 20
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway KA, Rochet JC, Bieganski RM Lansbury PT, Jr, (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294:1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury P.T., Jr.4
  • 21
    • 0024379639 scopus 로고
    • Neural mechanisms in disorders of movement
    • Crossman AR (1989) Neural mechanisms in disorders of movement. Comp Biochem Physiol A 93:141-149.
    • (1989) Comp Biochem Physiol A , vol.93 , pp. 141-149
    • Crossman, A.R.1
  • 22
    • 0032490114 scopus 로고    scopus 로고
    • Inhibitors of NADH-ubiquinone reductase: An overview
    • Degli Esposti M (1998) Inhibitors of NADH-ubiquinone reductase: an overview. Biochim Biophys Acta 1364:222-235.
    • (1998) Biochim Biophys Acta , vol.1364 , pp. 222-235
    • Degli Esposti, M.1
  • 23
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13:281-285.
    • (1990) Trends Neurosci , vol.13 , pp. 281-285
    • DeLong, M.R.1
  • 26
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany MB, Bender WW (2000) A Drosophila model of Parkinson's disease. Nature 404:394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 27
    • 0031962268 scopus 로고    scopus 로고
    • Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay
    • Floor E, Wetzel MG (1998) Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. Journal of Neurochemistry 70:268-275.
    • (1998) Journal of Neurochemistry , vol.70 , pp. 268-275
    • Floor, E.1    Wetzel, M.G.2
  • 29
    • 0025273787 scopus 로고
    • Follow-up study of early-life protective and risk factors in Parkinson's disease
    • Golbe LI, Farrell TM, Davis PH (1990) Follow-up study of early-life protective and risk factors in Parkinson's disease. Mov Disord 5:66-70.
    • (1990) Mov Disord , vol.5 , pp. 66-70
    • Golbe, L.I.1    Farrell, T.M.2    Davis, P.H.3
  • 31
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ (1998) The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50:1346-1350.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 33
    • 0027160043 scopus 로고
    • Glutamate-dopamine interactions in the basal ganglia: Relationship to Parkinson's disease
    • Greenamyre JT (1993) Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease. J Neural Transm Gen Sect 91:255-269.
    • (1993) J Neural Transm Gen Sect , vol.91 , pp. 255-269
    • Greenamyre, J.T.1
  • 34
    • 0029992108 scopus 로고    scopus 로고
    • Bioenergetics and glutamate excitotoxicity
    • Greene JG, Greenamyre JT (1996) Bioenergetics and glutamate excitotoxicity. Prog Neurobiol 48:613-634.
    • (1996) Prog Neurobiol , vol.48 , pp. 613-634
    • Greene, J.G.1    Greenamyre, J.T.2
  • 35
    • 0031859395 scopus 로고    scopus 로고
    • Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease
    • Gu M, Cooper JM, Taanman JW, Schapira AH (1998) Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol 44:177-186.
    • (1998) Ann Neurol , vol.44 , pp. 177-186
    • Gu, M.1    Cooper, J.M.2    Taanman, J.W.3    Schapira, A.H.4
  • 36
    • 0024997609 scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP-) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
    • Hasegawa E, Takeshige K, Oishi T, Murai Y, Minakami S (1990) 1-Methyl-4-phenylpyridinium (MPP-) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochem Biophys Res Commun 170:1049-1055.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 1049-1055
    • Hasegawa, E.1    Takeshige, K.2    Oishi, T.3    Murai, Y.4    Minakami, S.5
  • 38
    • 0031771518 scopus 로고    scopus 로고
    • Interaction of alphaphenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site
    • Hensley K, Pye QN, Maidt ML, Stewart CA, Robinson KA, Jaffrey F, Floyd RA (1998) Interaction of alphaphenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J Neurochem 71:2549-2557.
    • (1998) J Neurochem , vol.71 , pp. 2549-2557
    • Hensley, K.1    Pye, Q.N.2    Maidt, M.L.3    Stewart, C.A.4    Robinson, K.A.5    Jaffrey, F.6    Floyd, R.A.7
  • 39
    • 0025230379 scopus 로고
    • Parkinson's disease: A case-control study of occupational and environmental risk factors
    • Hertzman C, Wiens M, Bowering D, Snow B, Calne D (1990) Parkinson's disease: a case-control study of occupational and environmental risk factors. Am J Ind Med 17:349-355.
    • (1990) Am J Ind Med , vol.17 , pp. 349-355
    • Hertzman, C.1    Wiens, M.2    Bowering, D.3    Snow, B.4    Calne, D.5
  • 41
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A 82:2173-2177.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 42
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner P (1998) Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 13:24-34.
    • (1998) Mov Disord , vol.13 , pp. 24-34
    • Jenner, P.1
  • 43
    • 0032500599 scopus 로고    scopus 로고
    • Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    • Jensen PH, Nielsen MS, Jakes R, Dotti CG, Goedert M (1998) Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J Biol Chem 273:26292-26294.
    • (1998) J Biol Chem , vol.273 , pp. 26292-26294
    • Jensen, P.H.1    Nielsen, M.S.2    Jakes, R.3    Dotti, C.G.4    Goedert, M.5
  • 44
    • 0034714346 scopus 로고    scopus 로고
    • Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease
    • Jha N, Jurma O, Lalli G, Liu Y, Pettus EH, Greenamyre JT, Liu RM, Forman HJ, Andersen JK (2000) Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. J Biol Chem 275:26096-260101.
    • (2000) J Biol Chem , vol.275 , pp. 26096-260101
    • Jha, N.1    Jurma, O.2    Lalli, G.3    Liu, Y.4    Pettus, E.H.5    Greenamyre, J.T.6    Liu, R.M.7    Forman, H.J.8    Andersen, J.K.9
  • 45
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: A cellular response to misfolded proteins
    • Johnston JA, Ward CL, Kopito RR (1998) Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143:1883-1898.
    • (1998) J Cell Biol , vol.143 , pp. 1883-1898
    • Johnston, J.A.1    Ward, C.L.2    Kopito, R.R.3
  • 46
    • 0034008852 scopus 로고    scopus 로고
    • Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
    • Kanda S, Bishop JF, Eglitis MA, Yang Y, Mouradian MM (2000) Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation. Neuroscience 97:279-284.
    • (2000) Neuroscience , vol.97 , pp. 279-284
    • Kanda, S.1    Bishop, J.F.2    Eglitis, M.A.3    Yang, Y.4    Mouradian, M.M.5
  • 48
    • 0024713802 scopus 로고
    • Excitatory amino acids and the basal ganglia: Implications for the therapy of Parkinson's disease
    • Klockgether T, Turski L (1989) Excitatory amino acids and the basal ganglia: implications for the therapy of Parkinson's disease. Trends Neurosci 12:285-286.
    • (1989) Trends Neurosci , vol.12 , pp. 285-286
    • Klockgether, T.1    Turski, L.2
  • 49
    • 0022964709 scopus 로고
    • The pharmacology of (-)deprenyl
    • Knoll J (1986) The pharmacology of (-)deprenyl. J Neural Transm Suppl 22:75-89.
    • (1986) J Neural Transm Suppl , vol.22 , pp. 75-89
    • Knoll, J.1
  • 50
    • 0033773403 scopus 로고    scopus 로고
    • Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein
    • Ko L, Mehta ND, Farrer M, Easson C, Hussey J, Yen S, Hardy J, Yen SH (2000) Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein [In Process Citation]. J Neurochem 75:2546-2554.
    • (2000) J Neurochem , vol.75 , pp. 2546-2554
    • Ko, L.1    Mehta, N.D.2    Farrer, M.3    Easson, C.4    Hussey, J.5    Yen, S.6    Hardy, J.7    Yen, S.H.8
  • 51
    • 0034578389 scopus 로고    scopus 로고
    • Aggresomes, inclusion bodies and protein aggregation
    • Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10:524-530.
    • (2000) Trends Cell Biol , vol.10 , pp. 524-530
    • Kopito, R.R.1
  • 52
    • 0028916715 scopus 로고
    • Free radical-generated neurotoxicity of 6-hydroxydopamine
    • Kumar R, Agarwal AK, Seth PK (1995) Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem 64:1703-1707.
    • (1995) J Neurochem , vol.64 , pp. 1703-1707
    • Kumar, R.1    Agarwal, A.K.2    Seth, P.K.3
  • 53
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidineanalog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic Parkinsonism in humans due to a product of meperidineanalog synthesis. Science 219:979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 54
    • 0037016741 scopus 로고    scopus 로고
    • Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
    • Lee HJ, Choi C, Lee SJ (2002(a)) Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem 277:671-676.
    • (2002) J Biol Chem , vol.277 , pp. 671-676
    • Lee, H.J.1    Choi, C.2    Lee, S.J.3
  • 55
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee HJ, Shin SY, Choi C, Lee YH, Lee SJ (2002(b)) Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem 277:5411-5417.
    • (2002) J Biol Chem , vol.277 , pp. 5411-5417
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 58
    • 0034309848 scopus 로고    scopus 로고
    • Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation
    • Lopiano L, Fasano M, Giraudo S, Digilio G, Koenig SH, Torre E, Bergamasco B, Aime S (2000) Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation. Neurochem Int 37:331-336.
    • (2000) Neurochem Int , vol.37 , pp. 331-336
    • Lopiano, L.1    Fasano, M.2    Giraudo, S.3    Digilio, G.4    Koenig, S.H.5    Torre, E.6    Bergamasco, B.7    Aime, S.8
  • 59
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity
    • Lotharius J, O'Malley KL (2000) The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J Biol Chem 275:38581-38588.
    • (2000) J Biol Chem , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 60
    • 0032564235 scopus 로고    scopus 로고
    • Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism
    • The European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study Group [letter]
    • Lucking CB, Abbas N, Durr A, Bonifati V, Bonnet AM, de Broucker T, De Michele G, Wood NW, Agid Y, Brice A (1998) Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study Group [letter]. Lancet 352:1355-1356.
    • (1998) Lancet , vol.352 , pp. 1355-1356
    • Lucking, C.B.1    Abbas, N.2    Durr, A.3    Bonifati, V.4    Bonnet, A.M.5    De Broucker, T.6    De Michele, G.7    Wood, N.W.8    Agid, Y.9    Brice, A.10
  • 61
    • 0032490090 scopus 로고    scopus 로고
    • Complex I inhibitors as insecticides and acaricides
    • Lummen P (1998) Complex I inhibitors as insecticides and acaricides. Blochim Biophys Acta 1364:287-296.
    • (1998) Blochim Biophys Acta , vol.1364 , pp. 287-296
    • Lummen, P.1
  • 62
    • 0026718086 scopus 로고
    • Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease
    • Mann VM, Cooper JM, Krige D, Daniel SE, Schapira AH, Marsden CD (1992) Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease. Brain 115:333-342.
    • (1992) Brain , vol.115 , pp. 333-342
    • Mann, V.M.1    Cooper, J.M.2    Krige, D.3    Daniel, S.E.4    Schapira, A.H.5    Marsden, C.D.6
  • 63
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: Paraquat and alpha-synuclein
    • Manning-Bog AB, McCormack AL, Li J, Uversky VN, Fink AL, Di Monte DA (2002) The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem 277:1641-1644.
    • (2002) J Biol Chem , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1    McCormack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.A.6
  • 66
    • 0035910634 scopus 로고    scopus 로고
    • Proteasomal function is impaired in substantia nigra in Parkinson's disease
    • McNaught KS, Jenner P (2001) Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett 297:191-194.
    • (2001) Neurosci Lett , vol.297 , pp. 191-194
    • McNaught, K.S.1    Jenner, P.2
  • 68
    • 0032564134 scopus 로고    scopus 로고
    • Parkinson's disease, pesticides, and glutathione transferase polymorphisms
    • Menegon A, Board PG, Blackburn AC, Mellick GD, Le Couteur DG (1998) Parkinson's disease, pesticides, and glutathione transferase polymorphisms [see comments]. Lancet 352:1344-1346.
    • (1998) Lancet , vol.352 , pp. 1344-1346
    • Menegon, A.1    Board, P.G.2    Blackburn, A.C.3    Mellick, G.D.4    Le Couteur, D.G.5
  • 70
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36:2503-2508.
    • (1985) Life Sci , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 71
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker WD, Jr., Boyson SJ, Parks JK (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker W.D., Jr.1    Boyson, S.J.2    Parks, J.K.3
  • 72
    • 0026446062 scopus 로고
    • Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain
    • Perumal AS, Gopal VB, Tordzro WK, Cooper TB, Cadet JL (1992) Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain. Brain Res Bull 29:699-701.
    • (1992) Brain Res Bull , vol.29 , pp. 699-701
    • Perumal, A.S.1    Gopal, V.B.2    Tordzro, W.K.3    Cooper, T.B.4    Cadet, J.L.5
  • 73
    • 0029897501 scopus 로고    scopus 로고
    • Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioural and immunohistochemical studies
    • Piallat B, Benazzouz A, Benabid AL (1996) Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies. Eur J Neurosci 8:1408-1414.
    • (1996) Eur J Neurosci , vol.8 , pp. 1408-1414
    • Piallat, B.1    Benazzouz, A.2    Benabid, A.L.3
  • 77
    • 0029064518 scopus 로고
    • Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
    • Reynolds IJ, Hastings TG (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 15:3318-27.
    • (1995) J Neurosci , vol.15 , pp. 3318-3327
    • Reynolds, I.J.1    Hastings, T.G.2
  • 78
    • 0016411549 scopus 로고
    • Mechanisms of action of 6-hydroxydopamine
    • Sachs C, Jonsson G (1975) Mechanisms of action of 6-hydroxydopamine. Biochem Pharmacol 24:1-8.
    • (1975) Biochem Pharmacol , vol.24 , pp. 1-8
    • Sachs, C.1    Jonsson, G.2
  • 80
    • 0028978106 scopus 로고
    • Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity
    • Schulz JB, Henshaw DR, Matthews RT, Beal MF (1995) Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp Neurol 132:279-283.
    • (1995) Exp Neurol , vol.132 , pp. 279-283
    • Schulz, J.B.1    Henshaw, D.R.2    Matthews, R.T.3    Beal, M.F.4
  • 81
    • 0027256104 scopus 로고
    • Parkinson's disease: A test of the multifactorial etiologic hypothesis
    • Semchuk KM, Love EJ, Lee RG (1993) Parkinson's disease: a test of the multifactorial etiologic hypothesis. Neurology 43:1173-1180.
    • (1993) Neurology , vol.43 , pp. 1173-1180
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.G.3
  • 82
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's Disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT (2002) An in vitro model of Parkinson's Disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22:7006-7015.
    • (2002) J Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 84
    • 0026091344 scopus 로고
    • Mitochondrial oxidative phosphorylation defects in Parkinson's disease
    • Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC (1991) Mitochondrial oxidative phosphorylation defects in Parkinson's disease [see comments]. Ann Neurol 30:332-339.
    • (1991) Ann Neurol , vol.30 , pp. 332-339
    • Shoffner, J.M.1    Watts, R.L.2    Juncos, J.L.3    Torroni, A.4    Wallace, D.C.5
  • 85
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, Jenner P, Marsden CD (1994) Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 36:348-355.
    • (1994) Ann Neurol , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3    Daniel, S.4    Agid, Y.5    Javoy-Agid, F.6    Jenner, P.7    Marsden, C.D.8
  • 86
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza JM, Giasson BI, Chen Q, Lee VM, Ischiropoulos H (2000) Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J Biol Chem 275:18344-18349.
    • (2000) J Biol Chem , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 88
    • 0031036391 scopus 로고    scopus 로고
    • Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice
    • Sriram K, Pal KS, Boyd MR, Ravindranath V (1997) Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res 749:44-52.
    • (1997) Brain Res , vol.749 , pp. 44-52
    • Sriram, K.1    Pal, K.S.2    Boyd, M.R.3    Ravindranath, V.4
  • 93
    • 0034671469 scopus 로고    scopus 로고
    • The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease
    • Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA (2000) The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci 20:9207-9214.
    • (2000) J Neurosci , vol.20 , pp. 9207-9214
    • Thiruchelvam, M.1    Richfield, E.K.2    Baggs, R.B.3    Tank, A.W.4    Cory-Slechta, D.A.5
  • 94
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton KF, Singer TP (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 61:1191-1206.
    • (1993) J Neurochem , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 95
    • 0019083215 scopus 로고
    • Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
    • Turrens JF, Boveris A (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 191:421-427.
    • (1980) Biochem J , vol.191 , pp. 421-427
    • Turrens, J.F.1    Boveris, A.2
  • 96
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of alpha-synuclein fibril formation: A possible factor in Parkinson's disease
    • Uversky VN, Li J, Fink AL (2001) Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett 500:105-108.
    • (2001) FEBS Lett , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 98
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein upregulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S (2000) Alpha-synuclein upregulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem 74:721-729.
    • (2000) J Neurochem , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 101
    • 0033993476 scopus 로고    scopus 로고
    • Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice
    • Zou L, Xu J, Jankovic J, He Y, Appel SH, Le W (2000) Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice. Neurosci Lett 281:167-170.
    • (2000) Neurosci Lett , vol.281 , pp. 167-170
    • Zou, L.1    Xu, J.2    Jankovic, J.3    He, Y.4    Appel, S.H.5    Le, W.6


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