Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

Journal of Biological Chemistry

Volumn 280, Issue 47, 2005, Pages 39515-39523

  Krawitz, Peter ^a   Haffner, Christof ^a   Fluhrer, Regina ^a   Steiner, Harald ^a   Schmid, Bettina ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; PHYSIOLOGICAL MODELS; POLYPEPTIDES;

ASPARTYL PROTEASE; C-TERMINAL CATALYTIC CENTER; ENDOPLASMIC RETICULUM (ER); NON-REDUNDANT PROTEOLYTIC FUNCTIONS; PROTEOLYTIC ACTIVITY;

ENZYMES;

ASPARTIC ACID; ASPARTIC PROTEINASE; PEPTIDASE; PRESENILIN 1; SIGNAL PEPTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL FUNCTION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; COMPLEX FORMATION; ENDOSOME; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; ZEBRA FISH;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; CATALYTIC DOMAIN; CELL LINE; DNA, COMPLEMENTARY; ENDOPLASMIC RETICULUM; ENDOSOMES; GENE TARGETING; HUMANS; LYSOSOMES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PRESENILIN-1; PROTEIN SORTING SIGNALS; RECOMBINANT PROTEINS; RNA, ANTISENSE; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 28244456207     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501645200     Document Type: Article

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