Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

Cell Calcium

Volumn 32, Issue 5-6, 2002, Pages 413-420

  Ferrari, D ^a   Pinton, P ^a   Szabadkai, G ^a   Chami, M ^a   Campanella, M ^a   Pozzan, T ^b   Rizzuto, Rosario ^a  

^a Section of General Pathology   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CYTOCHROME C; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DEATH; CELL ORGANELLE; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHODGKIN LYMPHOMA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

EID: 0036878819     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143416002002014     Document Type: Review

References (73)

1. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 2000; 1: 11-21.
2. Schanne FA, Kane AB, Young EE, Farber JL. Calcium dependence of toxic cell death: a final common pathway. Science 1979; 206: 700-702.
3. Leonard JP, Salpeter MM. Agonist-induced myopathy at the neuromuscular junction is mediated by calcium. J Cell Biol 1979; 82: 811-819.
4. Choi DW. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 1988; 11: 465-469.
5. Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physiol Rev 2000; 80: 315-360.
6. Halestrap AP, Doran E, Gillespie JP, O'Toole A. Mitochondria and cell death. Biochem Soc Trans 2000; 28: 170-177.
7. Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol 2002; 38: 713-721.
8. Wang KK. Calpain and caspase: can you tell the difference? Trends Neurosci 2000; 23: 20-26.
9. Capper EA, Marshall LA. Mammalian phospholipases A(2): mediators of inflammation, proliferation and apoptosis. Prog Lipid Res 2001; 40: 167-197.
10. Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke 1998; 29: 705-718.
11. Kataoka A, Kubota M, Wakazono Y et al. Association of high molecular weight DNA fragmentation with apoptotic or non-apoptotic cell death induced by calcium ionophore. FEBS Lett 1995; 364: 264-267.
12. Strasser A, O'Connor L, Dixit VM. Apoptosis signaling. Ann Rev Biochem 2000; 69: 217-245.
13. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3: E255-E263.
14. Pinton P, Ferrari D, Di Virgilio F, Pozzan T, Rizzuto R. Molecular machinery and signalling events in apoptosis. Drug Dev Res 2001; 52: 558-570.
15. Kruman I, Guo Q, Mattson MP. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 1998; 51: 293-308.
16. i in avian cochlear nucleus neurons: roles of protein kinases A and C and relation to cell death. J Neurophysiol 1998; 79: 2288-2302.
17. Shen HM, Dong SY, Ong CN. Critical role of calcium overloading in cadmium-induced apoptosis in mouse thymocytes. Toxicol Appl Pharmacol 2001; 171: 12-19.
18. Gallo V, Kingsbury A, Balazs R, Jorgensen OS. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987; 7: 2203-2213.
19. Ikonomidou C, Stefovska V, Turski L. Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proc Natl Acad Sci USA 2000; 97: 12885-12890.
20. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995; 92: 7162-7166.
21. Martikainen P, Kyprianou N, Tucker RW, Isaacs JT. Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Res 1991; 51: 4693-4700.
22. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 2001; 20: 2690-2701.
23. Lynch K, Fernandez G, Pappalardo A, Peluso JJ. Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase C delta-dependent pathway. Endocrinology 2000; 141: 4209-4217.
24. Guo Q, Christakos S, Robinson N, Mattson MP. Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function. Proc Natl Acad Sci USA 1998; 95: 3227-3232.
25. 2+ release: an intimate connection. Trends Biochem Sci 2000; 25: 215-221.
26. Duchen MR. Mitochondria and calcium: from cell signalling to cell death. J Physiol 2000; 529: 57-68.
27. Martinou JC, Desagher S, Antonsson B. Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2000; 2: E41-E43.
28. Joza N, Susin SA, Daugas E et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001; 410: 549-554.
29. Verhagen AM, Ekert PG, Pakusch M et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000; 102: 43-53.
30. Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 2001; 412: 90-94.
31. Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease: a novel therapeutic target? FASEB J 2002; 16: 135-146.
32. Mbebi C, See V, Mercken L, Pradier L, Muller U, Loeffler JP. Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J Biol Chem 2002; 277: 20979-20990.
33. 2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999; 284: 339-343.
34. Yano S, Tokumitsu H, Soderling TR. Calcium promotes cell survival through CaM-K kinase activation of the protein kinase B pathway. Nature 1998; 396: 584-587.
35. Majumder PK, Pandey P, Sun X et al. Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. J Biol Chem 2000; 275: 21793-21796.
36. Ruvolo PP, Deng X, Carr BK, May WS. A functional role for mitochondrial protein kinase C alpha in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 1998; 273: 25436-25442.
37. Juin P, Pelletier M, Oliver L et al. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. J Biol Chem 1998; 273: 17559-17564.
38. Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 2000; 150: 887-894.
39. Pozzan T, Rizzuto R, Volpe P, Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 1994; 74: 595-636.
40. Pahl HL, Baeuerle PA. The ER-overload response: activation of NF-kappa B. Trends Biochem Sci 1997; 22: 63-67.
41. Kaufman RJ. Molecular chaperones and the heat shock response. Biochim Biophys Acta 1999; 1423: R13-R27.
42. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000; 1: 120-129.
43. Miyake H, Hara I, Arakawa S, Kamidono S. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. J Cell Biochem 2000; 77: 396-408.
44. Jamora C, Dennert G, Lee AS. Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc Natl Acad Sci USA 1996; 93: 7690-7694.
45. Johnson S, Michalak M, Opas M, Eggleton P. The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol 2001; 11: 122-129.
46. Nicotera P, Orrenius S. The role of calcium in apoptosis. Cell Calcium 1998; 23: 173-180.
47. 3 and ryanodine receptor driven calcium signals. Cell Calcium 2000; 28: 349-363.
48. Jayaraman T, Marks AR. T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol Cell Biol 1997; 17: 3005-3012.
49. Khan AA, Soloski MJ, Sharp AH et al. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science 1996; 273: 503-507.
50. 2+ stores in induction and suppression of apoptosis in S49 cells. Am J Physiol 1997; 272: C1241-C1249.
51. 2+ current in human prostate cancer LNCaP cells: involvement in apoptosis. J Physiol 2000; 527: 71-83.
52. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the Bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440-1443.
53. Chao DT, Korsmeyer SJ. Bcl-2 family: regulators of cell death. Ann Rev Immunol 1998; 16: 395-419.
54. Yang J, Liu X, Bhalla K et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
55. Lithgow T, van Driel R, Bertram JF, Strasser A. The protein product of the oncogene Bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ 1994; 5: 411-417.
56. Susin SA, Zamzami N, Castedo M et al. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 1996; 184: 1331-1341.
57. Knudson CM, Korsmeyer SJ. Bcl-2 and Bax function independently to regulate cell death. Nat Genet 1997; 16: 358-363.
58. Schendel SL, Xie Z, Montal MO, Matsuyama S, Montal M, Reed JC. Channel formation by anti-apoptotic protein Bcl-2. Proc Natl Acad Sci USA 1997; 94: 5113-5118.
59. He H, Lam M, McCormick TS, Distelhorst CW. Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2. J Cell Biol 1997; 138: 1219-1228.
60. Kuo TH, Kim HR, Zhu L, Yu Y, Lin HM, Tsang W. Modulation of endoplasmic reticulum calcium pump by Bcl-2. Oncogene 1998; 17: 1903-1910.
61. 2+ influx in Bcl-2-overexpressing cells. J Cell Biol 2000; 148: 857-862.
62. 2+ concentration within the endoplasmic reticulum. Proc Natl Acad Sci USA 2000; 97: 5723-5728.
63. Chiesa A, Rapizzi E, Tosello V et al. Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling. Biochem J 2001; 355: 1-12.
64. Ma TS, Mann DL, Lee JH, Gallinghouse GJ. SR compartment calcium and cell apoptosis in SERCA overexpression. Cell Calcium 1999; 26: 25-36.
65. 2+]. J Cell Biol 1998; 140: 325-334.
66. 2+ pool.
67. 2+ signalling. EMBO J 2000; 19: 4926-4935.
68. Fasolato C, Pizzo P, Pozzan T. Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells. Mol Biol Cell 1998; 9: 1513-1522.
69. Nakamura K, Bossy-Wetzel E, Burns K et al. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol 2000; 150: 731-740.
70. 2+ release from the endoplasmic reticulum and suppressing Bcl-2 expression. J Biol Chem 2002.
71. Lilliehook C, Chan S, Choi EK et al. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci 2002; 19: 552-559.
72. 2+ permeation through the outer mitochondrial membrane. EMBO J 2002; 21: 2198-2206.
73. 2+ influx in Bcl-2-overexpressing cells. J Cell Biol 2000;