Use of the glucose starvation-inducible glucose-regulated protein 78 promoter suicide gene therapy of murine fibrosarcoma

Cancer Research

Volumn 59, Issue 13, 1999, Pages 3100-3106

  Gazit, Gadi ^a   Hung, Gene ^a   Chen, Xinke ^a   Anderson, W French ^a   Lee, Amy S ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; GLUCOSE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL KILLING; FIBROSARCOMA; GENE EXPRESSION; GENE INDUCTION; GENE THERAPY; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SUICIDE GENE;

ANIMALS; ANOXIA; ANTIVIRAL AGENTS; CARRIER PROTEINS; CELL SURVIVAL; FIBROSARCOMA; GANCICLOVIR; GENE THERAPY; GLUCOSE; HEAT-SHOCK PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR CHAPERONES; PROMOTER REGIONS (GENETICS); RETROVIRIDAE; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 0033168065     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Moolten, F. L., and Wells, J. M. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst., 82: 297-300, 1990.
2. Singhal, S., and Kaiser, L. R. Cancer chemotherapy using suicide genes. Surg. Oncol. Clin. N. Am., 7: 505-536, 1998.
3. Freeman, S. M., Abboud, C. N., Whartenby, K. A., Packman, C. H., Koeplin, D. S., Moolten, F. L., and Abraham, G. N. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53: 5274-5283, 1993.
4. Barba, D., Hardin, J., Sadelain, M., and Gage, F. H. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc. Natl. Acad. Sci. USA, 91: 4348-4352, 1994.
5. Vile, R. G., Nelson, J. A., Castleden, S., Chong, H., and Hart, I. R. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res., 54: 6228-6234, 1994.
6. Mullen, C. A., Coale, M. M., Lowe, R., and Blaese, R. M. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. Cancer Res., 54: 1503-1506, 1994.
7. Consalvo, M., Mullen, C. A., Modesti, A., Musiani, P., Allione, A., Cavallo, F., Giovarelli, M., and Forni, G. 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory. J. Immunol., 154: 5302-5312, 1995.
8. Nanni, P., de Giovanni, C., Nicoletti, G., Landuzzi, L., Rossi, I., Frabetti, F., Giovarelli, M., Forni, G., Cavallo, F., di Carlo, E., Musiani, P., and Lollini, P. L. The immune response elicited by mammary adenocarcinoma cells transduced with interferon-γ and cytosine deaminase genes cures lung metastases by parental cells. Hum. Gene Ther., 9: 217-224, 1998.
9. Ram, Z., Culver, K. W., Oshiro, E. M., Viola, J. J., DeVroom, H. L., Otto, E., Long, Z., Chiang, Y., McGarrity, G. J., Muul, L. M., Katz, D., Blaese, R. M., and Oldfield, E. H. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat. Med., 3: 1354-1361, 1997.
10. Anderson, W. F. Human gene therapy. Nature (Lond.), 392 (Suppl.): 25-30, 1998.
11. Dachs, G. U., Dougherty, G. J., Stratford, I. J., and Chaplin, D. J. Targeting gene therapy to cancer: a review. Oncol. Res., 9: 313-325, 1997.
12. Clary, B. M., and Lyerly, H. K. Transcriptional targeting for cancer gene therapy. Surg. Oncol. Clin. N. Am., 7: 565-574, 1998.
13. Vile, R. G., and Hart, I. R. In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res., 53: 962-967, 1993.
14. Macri, P., and Gordon, J. W. Delayed morbidity and mortality of albumin/SV40 T-antigen transgenic mice after insertion of an α-fetoprotein/Herpes virus thymidine kinase transgene and treatment with ganciclovir. Hum. Gene Ther., 5: 175-182, 1994.
15. Hwang, J. J., Scuric, Z., and Anderson, W. F. Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system. J. Virol., 70: 8138-8141, 1996.
16. Palmer, T. D., Rosman, G. J., Osborne, W. R., and Miller, A. D. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc. Natl. Acad. Sci. USA, 88: 1330-1334, 1991.
17. Gazit, G., Kane, S. E., Nichols, P., and Lee, A. S. Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo. Cancer Res., 55: 1660-1663, 1995.
18. Tong, X., Engehausen, D. G., Freund, C. T., Agoulnik, I., Guo, Z., Oehler, M. K., Kim, T. E., Hasenburg, A., Contant, C. F., Woo, S. L., and Kieback, D. G. The efficacy of adenovirus-mediated gene therapy of ovarian cancer is enhanced by using the cytomegalovirus promoter. Anticancer Res., 18: 719-725, 1998.
19. Hallahan, D. E., Mauceri, H. J., Seung, L. P., Dunphy, E. J., Wayne, J. D., Hanna, N. N., Toledano, A., Hellman, S., Kufe, D. W., and Weichselbaum, R. R. Spatial and temporal control of gene therapy using ionizing radiation. Nat. Med., 1: 786-791, 1995.
20. Dachs, G. U., Patterson, A. V., Firth, J. D., Ratcliffe, P. J., Townsend, K. M., Stratford, I. J., and Harris, A. L. Targeting gene expression to hypoxic tumor cells. Nat. Med., 3: 515-520, 1997.
21. Brown, J. M., and Giaccia, A. J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res., 58: 1408-1416, 1998.
22. Sciandra, J. J., Subjeck, J. R., and Hughes, C. S. Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation. Proc. Natl. Acad. Sci. USA, 81: 4843-4847, 1984.
23. Whelan, S. A., and Hightower, L. E. Differential induction of glucose-regulated and heat shock proteins: effects of pH and sulfhydryl-reducing agents on chicken embryo cells. J. Cell. Physiol., 125: 251-258, 1985.
24. Lee, A. S. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem. Sci., 12: 20-23, 1987.
25. Lee, A. S. Mammalian stress response: induction of the glucose-regulated protein family. Curr. Opin. Cell Biol., 4: 267-273, 1992.
26. Koong, A. C., Chen, E. Y., Lee, A. S., Brown, J. M., and Giaccia, A. J. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int. J. Radiat. Oncol. Biol. Phys., 28: 661-666, 1994.
27. r 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. Cancer Res., 47: 6220-6224, 1987.
28. Lyons, R. M., Forry-Schaudies, S., Otto, E., Wey, C., Patil-Koota, V., Kaloss, M., McGarrity, G. J., and Chiang, Y. L. An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo. Cancer Gene Ther., 2: 273-280, 1995.
29. Hung, G., Skotzko, M. J., Chang, M., Parekh, D., Stain, S. C., Hall, F. L., Gordon, E., and Anderson, W. F. Intratumoral injection of a concentrated antisense cyclin G1 retroviral vector inhibits growth of undifferentiated carcinoma in nude mice. Int. J. Pediatr. Oncol., 4: 317-325, 1997.
30. Chang, S. C., Wooden, S. K., Nakaki, T., Kim, Y. K., Lin, A. Y., Kung, L., Attenello, J. W., and Lee, A. S. Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression. Proc. Natl. Acad. Sci. USA, 84: 680-684, 1987.
31. Zhou, Y., and Lee, A. S. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J. Natl. Cancer Inst., 90: 381-388, 1998.
32. 2+-ATPase inhibitor thapsigargin. J. Biol. Chem., 268: 12003-12009, 1993.
33. Roy, B., Li, W. W., and Lee, A. S. Calcium-sensitive transcriptional activation of the proximal CCAAT regulatory element of the grp78/BiP promoter by the human nuclear factor CBF/NF-Y. J. Biol. Chem., 271: 28995-29002, 1996.
34. 2+ depletion and formation of aberrant proteins: activation of the conserved stress-inducible grp core promoter element by the human nuclear factor YY1. Mol. Cell. Biol., 17: 54-60, 1997.
35. Roy, B., and Lee, A. S. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress inducible complex. Nucleic Acids Res., 27: 1437-1443, 1999.
36. Macejak, D. G., and Sarnow, P. Internal initiation of translation mediated by the 5′ leader of a cellular mRNA. Nature (Lond.), 353: 90-94, 1991.
37. Jamora, C., Dennert, G., and Lee, A. S. Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc. Natl. Acad. Sci. USA, 93: 7690-7694, 1996.
38. Shen, J., Hughes, C., Chao, C., Cai, J., Bartels, C., Gessner, T., and Subjeck, J. Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. Proc. Natl. Acad. Sci. USA, 84: 3278-3282, 1987.
39. Chatterjee, S., Cheng, M. F., Berger, R. B., Berger, S. J., and Berger, N. A. Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide. Cancer Res., 55: 868-873, 1995.
40. Attenello, J. W., and Lee, A. S. Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts. Science (Washington DC), 226: 187-190, 1984.
41. Cai, J. W., Henderson, B. W., Shen, J. W., and Subjeck, J. R. Induction of glucose regulated proteins during growth of a murine tumor. J. Cell. Physiol., 154: 229-237, 1993.
42. Pavlovic, J., Nawrath, M., Tu, R., Heinicke, T., and Moelling, K. Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras (G12V). Gene Ther., 3: 635-643, 1996.
43. Felzmann, T., Ramsey, W. J., and Blaese, R. M. Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1. Gene Ther., 4: 1322-1329, 1997.
44. Santodonato, L., D'Agostino, G., Santini, S. M., Carlei, D., Musiani, P., Modesti, A., Signorelli, P., Belardelli, F., and Ferrantini, M. Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-α and HSVtk: perspectives for the generation of cancer vaccines. Gene Ther., 4: 1246-1255, 1997.
45. Vile, R. G., Castleden, S., Marshall, J., Camplejohn, R., Upton, C., and Chong, H. Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int. J. Cancer, 71: 267-274, 1997.
46. Cher, S. H., Kosai, K., Xu, B., Pham-Nguyen, K., Contant, C., Finegold, M. J., and Woo, S. L. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res., 56: 3758-3762, 1996.