Tirapazamine-cisplatin: The synergy

British Journal of Cancer

Volumn 77, Issue SUPPL. 4, 1998, Pages 15-17

  Gatzemeier, U ^a   Rodriguez, G ^b   Treat, J ^b   Miller, V ^b   Von Roemeling, R ^b   Viallet, J ^b   Rey, A ^c  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b Tirapazamine Study Group   (United States)

^c NONE

Author keywords

Cisplatin; Non small cell lung cancer; Reversible ototoxicity; Tirapazamine

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX; CISPLATIN; RADIOSENSITIZING AGENT; TIRAPAZAMINE;

CLINICAL TRIAL; CONFERENCE PAPER; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; GASTROINTESTINAL SYMPTOM; HEARING LOSS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG NON SMALL CELL CANCER; MUSCLE CRAMP; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; DRUG SYNERGISM; HUMANS; LUNG NEOPLASMS; MULTICENTER STUDIES; TRIAZINES;

EID: 0031809546     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.431     Document Type: Article

References (6)

1. Dorie MJ and Brown JM (1993) Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res 53: 4633-4636
2. Graham MA, Senan S, Robin H, Jr, Eckhardt N, Lendrem D, Hincks J, Greenslade D, Rampling R, Kaye SB, von Roemeling R and Workman P (1997) Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial. Cancer Chemother Pharmacol 40: 1-10
3. Miller VA, Ng KK, Grant SC, Kindler H, Pizzo B, Heelan RT, von Roemeling R and Kris MG (1997) Phase II study of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer. Ann Oncol 8: 1269-1271
4. Rodriguez GJ, Valdivieso M, von Hoff DD, Kraut M, Burris HA, Eckhardt JR, Lockwood G, Kennedy H and von Roemeling R (1996) A phase I/II trial of the combination of tirapazamine and cisplatin in patients with non-small cell lung cancer. Proc Am Soc Clin Oncol 15: abstract 1144
5. Treat J, Haynes B, Johnson E, Belani C, Greenberg R, Rodriguez R, Drobbins P, Muller, Jr., W, Meechan L and von Roemeling R (1997) Proc Am Soc Clin Oncol 16: abstract 1633
6. Wozniak AJ, Crowley JJ, Belcerzak SP, Weiss GR, Laufman LR, Baker LH, Fisher RI, Bearman SI, Taylor SA and Livingston RB (1996) Randomized phase II trial of cisplatin versus CDDP plus navelbine in treatment of advanced non-small cell lung cancer: report of a Southwest Oncology Group Study. Proc Am Soc Clin Oncol 15: abstract 1110