Reactive intermediates and the pathogenesis of adverse drug reactions: The toxicology perspective

Current Drug Metabolism

Volumn 7, Issue 3, 2006, Pages 219-229

  Amacher, David E ^a  

^a PFIZER INC   (United States)

Author keywords

Adverse drug reactions; Biologically reactive intermediates; Electrophilic metabolites; Free radicals; Risk factors

Indexed keywords

AMITRIPTYLINE; AMODIAQUINE; ANTIINFECTIVE AGENT; ANTIOXIDANT; ANTIRETROVIRUS AGENT; ANTITHROMBOCYTIC AGENT; BROMOBENZENE; CARBAMAZEPINE; CLOZAPINE; COTRIMOXAZOLE; DICLOFENAC; FELBAMATE; FREE RADICAL; HAPTEN; INDOMETACIN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; NORTRIPTYLINE; OLANZAPINE; PARACETAMOL; RADICAL; RALOXIFENE; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; TERBINAFINE; TOLCAPONE; TRIMETHOPRIM; TUBERCULOSTATIC AGENT; UNINDEXED DRUG; XENOBIOTIC AGENT;

AGRANULOCYTOSIS; APLASTIC ANEMIA; AUTOIMMUNE DISEASE; BLOOD DYSCRASIA; BLOOD TOXICITY; BONE MARROW TOXICITY; CHEMICAL REACTION; CHOLESTASIS; CONJUGATION; DETOXIFICATION; DISEASE PREDISPOSITION; DRUG ACTIVATION; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG METABOLISM; DRUG SCREENING; DRUG TOLERANCE; EOSINOPHILIA; FEVER; GASTROINTESTINAL TOXICITY; HEPATITIS; HUMAN; HYPERSENSITIVITY REACTION; IDIOPATHIC DISEASE; IMMUNE RESPONSE; IN VITRO STUDY; LIVER DISEASE; LIVER INJURY; LUPUS LIKE SYNDROME; MACROMOLECULE; MEDICAL LITERATURE; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENESIS; PREDICTION; PROBABILITY; REVIEW; RISK FACTOR; SKIN DISEASE; SKIN TOXICITY; STEVENS JOHNSON SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; TARGET ORGAN; TOXIC EPIDERMAL NECROLYSIS;

ANIMALS; ANTIOXIDANTS; BIOTRANSFORMATION; FREE RADICALS; HUMANS; PHARMACEUTICAL PREPARATIONS; REACTIVE OXYGEN SPECIES; RISK FACTORS; TOXICOGENETICS;

EID: 33645983649     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006776359284     Document Type: Review

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