In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity

Chemical Research in Toxicology

Volumn 17, Issue 2, 2004, Pages 137-143

  Joshi, Elizabeth M ^a   Heasley, Brian H ^a   Chordia, Mahendra D ^a   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLBENZOTHIOPHENE; 2 ACETYLBENZOTHIOPHENE OXIDE; ACETYLCYSTEINE; CYTOCHROME P450; DRUG METABOLITE; GLUTATHIONE; LEUKOTRIENE; LIPOXYGENASE INHIBITOR; OXIDE; UNCLASSIFIED DRUG; WATER; ZILEUTON;

ACIDITY; ADDITION REACTION; ANIMAL EXPERIMENT; AROMATIZATION; ASTHMA; CELL ASSAY; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPATHOGENIC EFFECT; DRUG EFFECT; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; DRUG URINE LEVEL; ELIMINATION REACTION; ELUTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER TOXICITY; LYMPHOBLAST; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PATHOPHYSIOLOGY; RAT; STRUCTURE ANALYSIS; URINALYSIS;

ANIMALS; CELL LINE; GLUTATHIONE; HALF-LIFE; HUMANS; HYDROXYUREA; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOPHENES;

ANIMALIA;

EID: 1342310597     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0341409     Document Type: Conference Paper

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