Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency

AIDS

Volumn 10, Issue 5, 1996, Pages 501-507

  Pirmohamed, Munir ^a   Williams, Dominic ^a   Tingle, Malcolm D ^a   Barry, Michael ^a   Khoo, Saye H ^a   O'Mahony, Colm ^b   Wilkins, Edmund G L ^c   Breckenridge, Alasdair M ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Chester Royal Infirmary   (United Kingdom)

^c NORTH MANCHESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

AIDS; Drug hypersensitivity; Glutathione; HIV; Methaemoglobinaemia; Trimethoprim sulphamethoxazole

Indexed keywords

BROMOBIMANE; GLUTATHIONE; N HYDROXYDAPSONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MALE; MASS SPECTROMETRY; METHEMOGLOBINEMIA; MONONUCLEAR CELL; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

EID: 0029933107     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199605000-00008     Document Type: Article

References (36)

1. Reed DJ: Glutathione: toxicological implications. Annu Rev Pharmacol Toxicol 1990, 30:603-631.
2. Meister A: Metabolism and function of glutathione. In Glutathione. Chemical, Biochemical and Medical Aspects. Edited by Dolphin D, Poulson R, Avramovic O. New York: John Wiley & Sons; 1989:367-474.
3. Moldeus P, Quanguan J: Importance of the glutathione cycle in drug metabolism. Pharmacol Ther 1987, 33:37-40.
4. Staal FJT, Ela SW, Roederer M, Anderson MT, Herzenberg LA, Herzenberg LA: Glutathione deficiency and human immunodeficiency virus infection. Lanet 1992, 339:909-912.
5. Buhl R, Holroyd KJ, Mastrangeli A, et al.: Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 1989, ii:1294-1298.
6. Eck H-P, Gmunder H, Hartmann M, Petzoldt D, Daniel V, Droge W: Low concentrations of acid-soluble thiol (cysteine) in the plasma of HIV-1 infected patients. Biol Chem Hoppe-Seyler 1989, 370:101-108.
7. de Quay B, Malinverni R, Lauterburg BH: Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine. AIDS 1992, 6:815-819.
8. Witschi A, Junker E, Schranz C, Speck RF, Lauterburg BH: Supplementation of N-acetylcysteine fails to increase glutathione in lymphocytes and plasma of patients with AIDS. AIDS Res Hum Retroviruses 1995, 11:141-143.
9. Roederer M, Staal FJT, Osada H, Herzenberg LA, Herzenberg LA: CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Int Immunol 1991, 3:933-937.
10. Staal FJT, Roederer M, Israelski DM, et al.: Intracellular glutathione levels in T-cell subsets decrease in HIV-infected individuals. AIDS Res Hum Retroviruses 1992, 8:305-311.
11. Staal FJT, Roederer M, Herzenberg LA, Herzenberg LA: Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 1990, 87:9943-9947.
12. Lederman MM, Georges D, Dando S, Schmelzer R, Averill L, Goldberg D: L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human-immunodeficiency-virus and expression of the interleukin-2 receptor-alpha chain. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 8:107-115.
13. Droge W, Schulzeosthoff K, Mihm S, et al.: Functions of glutathione and glutathione disulfide immunology and immunopathology. FASEB J 1994, 8:1131-1138.
14. Bayard PJ, Berger TG, Jacobson MA: Drug hypersensitivity reactions and human immunodeficiency virus disease. J Acquir Immune Defic Syndr 1992, 5:1237-1257.
15. Vanderven AJM, Koopmans PP, Vree TB, Vandermeer JWM: Drug intolerance in HIV disease. J Antimicrob Chemother 1994, 34:1-5.
16. van der Ven AJ, Koopmans PP, Vree TB, van der Meer JW: Adverse reactions to co-trimoxazole in HIV infection. Lancet 1991, ii:431-433.
17. Jung AC, Paauw DS: Management of adverse reactions to trimethoprim-sulfamethoxazole in human immunodeficiency virus-infected patients. Arch Intern Med 1994, 154:2402-2406.
18. Cribb AE, Miller M, Leeder JS, Hill J, Spielberg SP: Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Drug Metab Dispos 1991, 19:900-906.
19. Droge W: Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology 1993, 46:61-65.
20. Roederer M, Staal FJ, Ela SW, Herzenberg LA, Herzenberg LA: N-acetylcysteine: potential for AIDS therapy. Pharmacology 1993, 46:121-129.
21. Vanderven AJAM, Mier P, Peters WHM, et al.: Monochlorobimane does not selectively label glutathione in peripheral-blood mononuclear-cells. Anal Biochem 1994, 217:41-47.
22. Aukrust P, Svardal AM, Muller F, et al.: Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection. Blood 1995, 86:258-267.
23. Cotgreave IA, Moldeus P: Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems. J Biochem Biophys Methods 1986, 13:231-249.
24. Tingle MD, Coleman MD, Park BK: An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system. Br J Clin Pharmacol 1990, 30:829-838.
25. Centers for Disease Control: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987, 36(suppl 1):S1-S15.
26. Uetrecht J, Zahid N, Shear NH, Biggar WD: Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells. J Pharmacol Exp Ther 1988, 245:274-279.
27. Riley RJ, Lambert C, Maggs JL, Kitteringham NR, Park BK: An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil, and mianserin. Br J Clin Pharmacol 1988, 26:577-588.
28. Fahey RC, Newton GL: Determination of low-molecular-weight thiols using monobromobimane fluorescent labelling and high-performance liquid chromatography. Methods Enzymol 1987, 143:85-96.
29. Harrison JH, Jollow DJ: Role of aniline metabolites in aniline-induced haemolytic anaemia. J Pharmacol Exp Ther 1986, 238:1045-1054.
30. Fahey RC: Methods for determination of glutathione and derivatives using high-performance liquid chromatography. In Glutathione. Chemical, Biochemical and Medical Aspects. Edited by Dolphin D, Poulson R, Avramovic O. New York: John Wiley & Sons; 1989:303-337.
31. Koopmans PP, Van der Ven AJAM, Vree TB, Van der Meer JWM: Pathogenesis of hypersensitivity reactions to drugs in patients with HIV-infection: allergic or toxic? AIDS 1995, 9:217-222.
32. Rabin RL, Roederer M, Maldonado YA, Herzenberg LA, Herzenberg LA: Glutathione concentration is decreased in RBC and T-cells of infants and children most affected by HIV. AIDS Res Hum Retroviruses 1994, 10 (suppl):S38.
33. Beutler E, Gelbart T: Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med 1985, 105:581-584.
34. Meister A: A brief history of glutathione and a survey of its metabolism and functions. In Glutathione. Chemical, Biochemical and Medical Aspects. Edited by Dolphin D, Poulson R, Avramovic O. New York: John Wiley & Sons; 1989:1-48.
35. Smith GH: Treatment of infections in the patient with acquired immunodeficiency syndrome. Arch Intern Med 1994, 154:949-973.
36. Coleman MD, Breckenridge AM, Park BK: Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes. Br J Clin Pharmacol 1989, 28:389-395.