Fatal hepatotoxicity secondary to nimesulide

European Journal of Clinical Pharmacology

Volumn 57, Issue 4, 2001, Pages 321-326

  Merlani, Giorgio ^a   Fox, Mark ^b   Oehen, Hans Peter ^b   Cathomas, Gieri ^b   Renner, Eberhard L ^b   Fattinger, Karin ^b   Schneemann, Markus ^a   Kullak Ublick, Gerd A ^c  

^a Medizinische Klinik Zurich   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c NONE

Author keywords

Adverse drug reaction; Hepatitis; Non steroidal antiinflammatory drugs

Indexed keywords

CYCLOOXYGENASE 2; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONAMIDE;

ADULT; ARTICLE; CASE REPORT; ENZYME INHIBITION; EOSINOPHILIA; FEMALE; HUMAN; JAUNDICE; LIVER FAILURE; LIVER INJURY; LIVER TOXICITY; PRIORITY JOURNAL; RISK FACTOR; FATALITY; MIDDLE AGED; TOXIC HEPATITIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FATAL OUTCOME; FEMALE; HEPATITIS, TOXIC; HUMANS; MIDDLE AGED; SULFONAMIDES;

EID: 0034742510     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280100312     Document Type: Article

References (27)

1. Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
2. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
3. Drug-induced liver disease
4. Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors
5. Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention
6. Hepatic toxicity of nonsteroidal anti-inflammatory drugs
7. Liver disease associated with diclofenac, naproxen, and piroxicam
8. Safety of nonsteroidal anti-inflammatory drugs with respect to acute liver disease
9. Hepatotoxicity of non-narcotic analgesics
10. Update of hepatotoxicity due to classes of drugs in common clinical use: Non-steroidal drugs, anti-inflammatory drugs, antibiotics, antihypertensives, and cardiac and psychotropic agents
11. Efficacy and tolerability of nimesulide in elderly patients with osteoarthritis: Double-blind trial versus naproxen
12. An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy
13. Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee
14. Nimesulide: A multifactorial therapeutic approach to the inflammatory process? A 7-year clinical experience. Proceedings of an international congress, Berlin, 1-3 October 1992
15. Nimesulide-induced acute hepatitis: Evidence from six cases
16. Acute cholestatic hepatitis induced by nimesulide
17. Nimesulide acute hepatitis: Description of 3 cases
18. Fatal hepatitis and renal failure during treatment with nimesulide
19. COX 2 inhibitor and fulminant hepatic failure
20. Fatal hepatitis associated with nimesulide
21. Criteria of drug-induced liver disorders. Report of an international consensus meeting
22. Diclofenac hepatitis
23. Low-dose diclofenac, naproxen, and ibuprofen cohort study
24. Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis
25. Meloxicam-induced liver toxicity
26. Celecoxib-induced acute pancreatitis and hepatitis: A case report
27. Non-puerperal lactation associated with antidepressant drug use