Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo

BioFactors

Volumn 21, Issue 1-4, 2004, Pages 223-232

  Ray, S D ^a,b   Lam, T S ^a   Rotollo, J A ^a   Phadke, S ^a   Patel, C ^a   Dontabhaktuni, A ^a   Mohammad, S ^a   Lee, H ^a   Strika, S ^a   Dobrogowska, A ^a   Bruculeri, C ^a   Chou, A ^a   Patel, S ^a   Patel, R ^a   Manolas, T ^a   Stohs, S ^b  

^a LONG ISLAND UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY   (United States)

Author keywords

Acetaminophen; Apoptosis; Basil; Chloroform; Doxorubicin; Furosemide; Grape seed extract; Kidney; Liver; Momordica; Necrosis; Oncotic necrosis; Oxidative stress; Thioacetamide

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CHLOROFORM; DNA; DOXORUBICIN; FUROSEMIDE; GLUTATHIONE; MOMORDICA CHARANTIA EXTRACT; PARACETAMOL; THIOACETAMIDE; VITIS VINIFERA EXTRACT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DNA CLEAVAGE; GRAPE; HOMEOSTASIS; KIDNEY; LIPID PEROXIDATION; LIVER; LIVER TOXICITY; MALE; MELON; MOMORDICA; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TOXICITY TESTING; ANIMAL; ARTICLE; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; PHYTOTHERAPY;

CUCUMIS; MOMORDICA; MOMORDICA CHARANTIA; OCIMUM BASILICUM; VITIS SP.;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL DEATH; FUROSEMIDE; LIVER; MALE; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 16444374717     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.552210144     Document Type: Conference Paper

References (17)

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2. 2+-Calmodulin Antagonist Chlorpromazine and Poly (ADP-Ribose) Polymerase Modulators 4-Aminobenzamide and Nicotinamide Influence Hepatic Expression of Bcl-XL and P53 and Protect against acetaminophen-induced programmed and unprogrammed cell death in mice, Free Radical Biology & Medicine 31 (2001), 277-291.
3. S.D. Ray, Oxidative stress orchestrates both apoptosis and necrosis in vivo: a new perspective from molecular toxicology. Proc. Soc. Free Rad. Res., Chemistry, Biochemistry and Pathophysiological Implications, D. Galaris, ed., Medimond S.r.l., Monduzzi Editore Int. Proc. Div., Italy, 2003, pp. 45-53.
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5. S.D. Ray and D. Bagchi, Roles of Polyphenoles, Flavonoids and Oligomeric Proanthocyanidins in Cancer Chemoprevention, Chapter 21, CRC Press, Boca Raton, FL, 2004, in press.
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15. S.D. Ray, D. Patel, V. Wong, A. Rinkovsky, M. Bagchi, R.R. Raje and D. Bagchi, Unique organoprotective properties of a novel a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine-induced spleenotoxicity, and mocap-induced neurotoxicity in mice, Res. Commu. Mol. Pathol. & Pharmacol. 107 (2000), 105-128.
16. S.D. Ray, D. Patel, V. Wong and D. Bagchi, In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen- induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract, Res. Commu. Mol. Pathol. & Pharmacol. 107 (2000), 137-166.
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