Reactive metabolite screen for reducing candidate attrition in drug discovery

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 521-524

  Chen, Weichao G ^a   Zhang, Chenghong ^a   Avery, Michael J ^a   Fouda, Hassan G ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ISOPROPYLPHENOL; ACETYLSALICYLIC ACID; AMPICILLIN; CAFFEINE; CARBAMAZEPINE; CITRIC ACID; CLOZAPINE; DRUG METABOLITE; IBUPROFEN; INDOMETACIN; ISONIAZID; LEVODOPA; MEQUINOL; META CRESOL; PARA CRESOL; PARACETAMOL; PHENOL DERIVATIVE; PHENYTOIN; QUINIDINE; SULFADIMIDINE; UNCLASSIFIED DRUG; VALPROIC ACID; VERAPAMIL;

CONFERENCE PAPER; CONTROLLED STUDY; DRUG SAFETY; DRUG SCREENING; HUMAN; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL; TOXICITY TESTING;

EID: 0035699746     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0667-6_79     Document Type: Conference Paper

References (13)

1. Metabolic activation and drug toxicity
2. Idiosyncratic drug reactions
3. Reactive metabolites as a cause of hepatotoxicity
4. Metabolic activation of carcinogens
5. Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptal issues: Implications for embryotoxicity and teratogenesis
6. The role of reactive drug metabolites in immunemediated adverse drug reactions
7. Mass spectrometry in the analysis of glutathione conjugates
8. Automated sample preparation using membrane microtiter extraction for bioanalytical mass spectrometry
9. Oxidation of a metabolite of indomethacin (desmethyldeschlorobenzoylindomethacin) to reactive intermediates by activated neutrophils, hypochlorous acid, and the myeloperoxidase system
10. Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and independent processes
11. Metabolism of phenytoin and covalent binding of reactive intermediates in activated human neutrophils