메뉴 건너뛰기




Volumn 44, Issue 5, 1997, Pages 439-446

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

Author keywords

Clozapine; CYP1A2; CYP3A4; Human liver microsomes

Indexed keywords

ANTIBODY; CLOZAPINE; CYTOCHROME P450 ISOENZYME; FLUVOXAMINE; KETOCONAZOLE; QUINIDINE; TROLEANDOMYCIN;

EID: 0030656425     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1997.t01-1-00605.x     Document Type: Article
Times cited : (205)

References (38)
  • 1
    • 0025599851 scopus 로고
    • Clozapine: A review of its pharmacological properties, and therapeutic use in schizophrenia
    • Fitton A, Heel RC. Clozapine: a review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs 1990; 5: 722-747.
    • (1990) Drugs , vol.5 , pp. 722-747
    • Fitton, A.1    Heel, R.C.2
  • 3
    • 0028201801 scopus 로고
    • A reevaluation of the clinical characteristics of clozapine-induced agranulocytosis in light of the United States experience
    • Alvir JMJ, Lieberman JA. A reevaluation of the clinical characteristics of clozapine-induced agranulocytosis in light of the United States experience. J Clin Psychopharmacol 1994; 14: 87-89.
    • (1994) J Clin Psychopharmacol , vol.14 , pp. 87-89
    • Alvir, J.M.J.1    Lieberman, J.A.2
  • 5
    • 0009404019 scopus 로고    scopus 로고
    • Pharmacokinetics of clozapine and risperidone: A review of recent literature
    • Byerly MJ, DeVane CL. Pharmacokinetics of clozapine and risperidone: A review of recent literature. J Clin Psychopharmacol 1996; 16: 177-187.
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 177-187
    • Byerly, M.J.1    DeVane, C.L.2
  • 7
    • 0029979414 scopus 로고    scopus 로고
    • Polymorphic drug oxidation-Relevance to the treatment of psychiatric disorders
    • Bertilsson L, Dahl ML. Polymorphic drug oxidation-Relevance to the treatment of psychiatric disorders. CNS Drugs 1996; 5: 200-223.
    • (1996) CNS Drugs , vol.5 , pp. 200-223
    • Bertilsson, L.1    Dahl, M.L.2
  • 8
    • 0026666976 scopus 로고
    • The anripsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6
    • Fischer V, Vogels B, Maurer G, Tynes RE. The anripsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6. J Pharmacol Exp Ther 1992; 260: 1355-1360.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 1355-1360
    • Fischer, V.1    Vogels, B.2    Maurer, G.3    Tynes, R.E.4
  • 10
    • 0028307888 scopus 로고
    • Disposition of clozapine in man: Lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
    • Dahl ML, Llerena A, Bondesson U, Lindström L, Bertilsson L. Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms. Br J Clin Pharmacol 1994; 37: 71-74.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 71-74
    • Dahl, M.L.1    Llerena, A.2    Bondesson, U.3    Lindström, L.4    Bertilsson, L.5
  • 11
    • 0028318482 scopus 로고
    • Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: Evidence from therapeutic drug monitoring service
    • Jerling M, Lindström L, Bondesson U, Bertilsson L. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from therapeutic drug monitoring service. Ther Drug Monit 1994; 37: 368-374.
    • (1994) Ther Drug Monit , vol.37 , pp. 368-374
    • Jerling, M.1    Lindström, L.2    Bondesson, U.3    Bertilsson, L.4
  • 15
    • 0027985726 scopus 로고
    • Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test
    • Bertilsson L, Carrillo JA, Dahl ML et al. Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol 1994; 38: 471-473.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 471-473
    • Bertilsson, L.1    Carrillo, J.A.2    Dahl, M.L.3
  • 16
    • 0020446078 scopus 로고
    • Microsomal enzyme induction in children: The influence of carbamazepine treatment on antipyrine kinetics, 6β-hydroxycortisol excretion and plasma γ-glutanyltranspeptidase activity
    • Moreland TA, Park BK, Rylance GW. Microsomal enzyme induction in children: The influence of carbamazepine treatment on antipyrine kinetics, 6β-hydroxycortisol excretion and plasma γ-glutanyltranspeptidase activity. Br J Clin Pharmacol 1982; 14: 861-865.
    • (1982) Br J Clin Pharmacol , vol.14 , pp. 861-865
    • Moreland, T.A.1    Park, B.K.2    Rylance, G.W.3
  • 19
    • 0028858960 scopus 로고
    • Cytochrome P450 inhibitors: Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
    • Newton DJ, Wang RW, Lu AYH. Cytochrome P450 inhibitors: Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metab Dispos 1995; 23: 154-158.
    • (1995) Drug Metab Dispos , vol.23 , pp. 154-158
    • Newton, D.J.1    Wang, R.W.2    Lu, A.Y.H.3
  • 20
    • 0030056594 scopus 로고    scopus 로고
    • Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
    • Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsu M. Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica 1996; 26: 681-693.
    • (1996) Xenobiotica , vol.26 , pp. 681-693
    • Ono, S.1    Hatanaka, T.2    Hotta, H.3    Satoh, T.4    Gonzalez, F.J.5    Tsutsu, M.6
  • 21
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehlin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehlin, T.2    Gordon, J.3
  • 23
    • 0027983085 scopus 로고
    • Pharmacogenetic phenotyping and genotyping
    • Gonzalez FJ, Idle JR. Pharmacogenetic phenotyping and genotyping. Clin Pharmacokinet 1994; 26: 59-70.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 59-70
    • Gonzalez, F.J.1    Idle, J.R.2
  • 24
    • 0029671175 scopus 로고    scopus 로고
    • Human cytochromes P450 expressed in Escherichia coli: Production of specific antibodies
    • Belloc C, Baird S, Cosine J, et al. Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies. Toxicology 1996; 106: 207-219.
    • (1996) Toxicology , vol.106 , pp. 207-219
    • Belloc, C.1    Baird, S.2    Cosine, J.3
  • 26
    • 0024999601 scopus 로고
    • Maximizing the expression of mammalian cytochrome P-450 monooxygenase activities in yeast cells
    • Urban P, Cullin C, Pompon D. Maximizing the expression of mammalian cytochrome P-450 monooxygenase activities in yeast cells. Biochimie 1990; 72: 463-472.
    • (1990) Biochimie , vol.72 , pp. 463-472
    • Urban, P.1    Cullin, C.2    Pompon, D.3
  • 27
    • 0023887868 scopus 로고
    • Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast of Saccaromyces cerevisae
    • Cullin C, Pompon D. Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast of Saccaromyces cerevisae. Gene 1988; 65: 203-217.
    • (1988) Gene , vol.65 , pp. 203-217
    • Cullin, C.1    Pompon, D.2
  • 28
    • 0028109728 scopus 로고
    • Chimeras of the human cytochrome P450 IA family produced in yeast. Accumulation in microsomal membranes, enzyme kinetics and stability
    • Bellamine A, Gautier JC, Urban P, Pompon D. Chimeras of the human cytochrome P450 IA family produced in yeast. Accumulation in microsomal membranes, enzyme kinetics and stability. Eur J Biochem 1994; 225: 1005-1013.
    • (1994) Eur J Biochem , vol.225 , pp. 1005-1013
    • Bellamine, A.1    Gautier, J.C.2    Urban, P.3    Pompon, D.4
  • 29
    • 78651165715 scopus 로고
    • The carbon monoxide binding pigment of liver microsomes
    • Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes, J Biol Chem 1964; 239: 2370-2378.
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 30
    • 0020601426 scopus 로고
    • Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450 -binding of phenoxazone and a homologous series of its n-alkyl-ethers (alkoxyresorufins)
    • Burke MD, Mayer RT. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450 -binding of phenoxazone and a homologous series of its n-alkyl-ethers (alkoxyresorufins). Chem Biol Interactions 1983; 45: 243-258.
    • (1983) Chem Biol Interactions , vol.45 , pp. 243-258
    • Burke, M.D.1    Mayer, R.T.2
  • 32
    • 0028114740 scopus 로고
    • Use of in vitro human metabolism studies in drug development
    • Rodrigues AD. Use of in vitro human metabolism studies in drug development. Biochem Pharmacol 1994; 48: 2147-2156.
    • (1994) Biochem Pharmacol , vol.48 , pp. 2147-2156
    • Rodrigues, A.D.1
  • 33
    • 0031038936 scopus 로고    scopus 로고
    • Clozapine drug-drug interactions: A review of the literature
    • Edge SC, Markowitz JS, Devane CL. Clozapine drug-drug interactions: a review of the literature. Human Psychopharmacol 1997; 12: 5-20.
    • (1997) Human Psychopharmacol , vol.12 , pp. 5-20
    • Edge, S.C.1    Markowitz, J.S.2    Devane, C.L.3
  • 35
    • 0000981191 scopus 로고
    • Mechanisms of catalysis and substrate specificity of human cytochrome P450 enzymes
    • Guengerich FP. Mechanisms of catalysis and substrate specificity of human cytochrome P450 enzymes. Falk Symp 1991; 57: 85-96.
    • (1991) Falk Symp , vol.57 , pp. 85-96
    • Guengerich, F.P.1
  • 37
    • 0029860967 scopus 로고    scopus 로고
    • Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity
    • Carnllo JA, Dahl ML, Svensson JO, Aim C, Rodriguez I, Bertilsson L. Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity, Clin Pharmacol Ther 1996; 60: 183-190.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 183-190
    • Carnllo, J.A.1    Dahl, M.L.2    Svensson, J.O.3    Aim, C.4    Rodriguez, I.5    Bertilsson, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.