Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs

Chemical Research in Toxicology

Volumn 11, Issue 12, 1998, Pages 1586-1595

  Naisbitt, Dean J ^a   Williams, Dominic P ^a   O'Neill, Paul M ^a   Maggs, James L ^a   Willock, David J ^b   Pirmohamed, Munir ^a   Kevin Park, B ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPHENOL; AMODIAQUINE; ANTIMALARIAL AGENT; CHLOROQUINE; GLUTATHIONE; PYRONARIDINE; TEBUQUINE;

AGRANULOCYTOSIS; ARTICLE; CYTOTOXICITY; DRUG METABOLISM; HUMAN; HUMAN CELL; LIVER TOXICITY; MALARIA; NEUTROPHIL; PATIENT MONITORING;

ADULT; AMODIAQUINE; ANTIMALARIALS; BIOTRANSFORMATION; CELL SURVIVAL; GLUTATHIONE; HORSERADISH PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; NAPHTHYRIDINES; NEUTROPHILS; OXIDATION-REDUCTION;

ARMORACIA RUSTICANA;

EID: 0032410803     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980148k     Document Type: Article

References (3)

1. Peters, W. (1970) Chemotherapy and drug resistance in malaria, Academic Press, London.
2. Burckhalter, J. H., Tendwick, J. H., Jones, F. H., Jones, P. A., Holcome, W. F., and Rawlins, A. L. (1948) Aminoalkylphenols as antimalarials II (heterocyclic-amino)-α-amino-o-cresols: The synthesis of camoquine. J. Am. Chem. Soc. 70, 1363-1373.
3. Neftel, K. A., Woodtly, W., Schnid, M., Frick, P. G., and Fehr, J. (1986) Amodiaquine induced agranulocytosis and liver damage. Br. Med. J. 292, 721-723.