Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid

Chemical Research in Toxicology

Volumn 10, Issue 4, 1997, Pages 414-419

  Miyamoto, Gohachiro ^a,b   Zahid, Nasir ^a   Uetrecht, Jack P ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; DICLOFENAC DERIVATIVE; GLUTATHIONE; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; QUINONE DERIVATIVE;

ARTICLE; BONE MARROW TOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER TOXICITY; NEUTROPHIL; NONHUMAN; OXIDATION; RAT; SPECTROSCOPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; GLUTATHIONE; HUMANS; HYPOCHLOROUS ACID; MASS SPECTROMETRY; MICROSOMES, LIVER; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; RATS;

EID: 0030989616     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960190k     Document Type: Article

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