Fungal heat-shock proteins in human disease

FEMS Microbiology Reviews

Volumn 30, Issue 1, 2006, Pages 53-88

  Burnie, James P ^a,b   Carter, Tracey L ^b   Hodgetts, Samantha J ^b   Matthews, Ruth C ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Fungi; Heat shock proteins; Moulds; Mycograb; Pathogenesis; Yeast

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BCG VACCINE; BRUCELLA VACCINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DNA VACCINE; FLUCONAZOLE; FUNGAL PROTEIN; GELDANAMYCIN; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 104; HEAT SHOCK PROTEIN 12; HEAT SHOCK PROTEIN 30; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 78; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MANNOPROTEIN; MYCOGRAB; NITRIC OXIDE; RECOMBINANT ANTIBODY; REGULATOR PROTEIN; SUBUNIT VACCINE; TREHALOSE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABSENCE OF SIDE EFFECTS; ACHLYA; ACHLYA AMBISEXUALIS; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANGIONEUROTIC EDEMA; ANTIBODY RESPONSE; ANTIMALARIAL ACTIVITY; ASCARIASIS; ASPERGILLUS; ASPERGILLUS FUMIGATUS; BRUCELLOSIS; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CATTLE DISEASE; CHAGAS DISEASE; COCCIDIOIDES IMMITIS; CONSTRICTIVE PERICARDITIS; CORYNEBACTERIUM; CORYNEBACTERIUM JEIKEIUM; CRYPTOCOCCUS NEOFORMANS; DNA MODIFICATION; DRUG TARGETING; EPITOPE MAPPING; EXPERIMENTAL MOUSE; FERMENTATION; FUNGAL GENETICS; FUNGAL VIRULENCE; FUSARIUM OXYSPORUM; GENOMICS; HISTOPLASMA CAPSULATUM; HUMAN; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOTHERAPY; INFECTION PREVENTION; INTENSIVE CARE; LEISHMANIA DONOVANI; LEISHMANIASIS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MUCOCUTANEOUS CANDIDIASIS; MYCOSIS; NEUROSPORA CRASSA; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS; PERIODONTITIS; PHYCOMYCES BLAKESLEANUS; PLASMODIUM FALCIPARUM; PNEUMOCYSTIS JIROVECI; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEOMICS; RABBIT; REVIEW; SACCHAROMYCES CEREVISIAE; SCHISTOSOMA MANSONI; SEPSIS; SEPTICEMIA; SEQUENCE HOMOLOGY; SOUTH AMERICAN BLASTOMYCOSIS; SURGICAL INFECTION; THRUSH; TOXOPLASMOSIS; TRICHINELLA SPIRALIS; TRICHINOSIS; TRICHOPHYTON RUBRUM; VISCERAL LEISHMANIASIS; FUNGUS; GENE EXPRESSION REGULATION; METABOLISM; MICROBIOLOGY; PATHOGENICITY;

ACHLYA; ACHLYA AMBISEXUALIS; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AJELLOMYCES CAPSULATUS; ASPERGILLUS; ASPERGILLUS FUMIGATUS; BOS TAURUS; BRUCELLA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; COCCIDIOIDES IMMITIS; CORYNEBACTERIUM; CORYNEBACTERIUM JEIKEIUM; FILOBASIDIELLA NEOFORMANS; FUNGI; FUSARIUM OXYSPORUM; ISSATCHENKIA ORIENTALIS; LEISHMANIA DONOVANI; LISTERIA MONOCYTOGENES; NEUROSPORA CRASSA; ORYCTOLAGUS CUNICULUS; PARACOCCIDIOIDES BRASILIENSIS; PHYCOMYCES; PHYCOMYCES BLAKESLEEANUS; PLASMODIUM FALCIPARUM; PNEUMOCYSTIS JIROVECII; PORPHYROMONAS GINGIVALIS; SACCHAROMYCES CEREVISIAE; SCHISTOSOMA MANSONI; TRICHINELLA SPIRALIS; TRICHOPHYTON RUBRUM;

FUNGAL PROTEINS; FUNGI; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK PROTEINS; HUMANS; MYCOSES;

EID: 33644888842     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/j.1574-6976.2005.00001.x     Document Type: Review

References (420)

1. Abbas-Terki T Donze O Briand PA Picard D 2001 Hsp104 interacts with Hsp90 cochaperones in respiring yeast Mol Cell Biol 21 7569 7575
2. Agarwal AK Rogers PD Baerson SR Jacob MR Barker KS Cleary JD Walker LA Nagle DG Clark AM 2003 Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae J Biol Chem 278 34998 35015
3. Albarrag AM 2004 Cellular localization of heat shock protein 90 in Candida albicans. MSc Project, University of Manchester.
4. Allendoerfer R Maresca B Deepe GS Jr. 1996 Cellular immune responses to recombinant heat shock protein 70 from Histoplasma capsulatum Infect Immun 64 4123 4128
5. Alloush HM Lopez-Ribot JL Chaffin WL 1996 Dynamic expression of cell wall proteins of Candida albicans revealed by probes from cDNA clones J Med Vet Mycol 34 91 97
6. Amoros M Estruch F 2001 Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene- and stress type-dependent manner Mol Microbiol 39 1523 1532
7. de Andrade CR Kirchhoff LV Donelson JE Otsu K 1992 Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients J Clin Microbiol 30 330 335
8. Angiolella L Micocci MM D'Alessio S Girolamo A Maras B Cassone A 2002 Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance Antimicrob Agents Chemother 46 1688 1694
9. Arancia S Sandini S Cassone A De Bernardis F La Valle R 1997 Construction and use of PCR primers from a 70 kDa heat shock protein gene for identification of Candida albicans Mol Cell Probes 11 329 336
10. Au-Young JK Troy FA Goldstein E 1985 Serologic analysis of antigen-specific reactivity in patients with systemic candidiasis Diagn Microbiol Infect Dis 3 419 432
11. de Backer MD Van Dijck P 2003 Progress in functional genomics approaches to antifungal drug target discovery Trends Microbiol 11 470 478
12. de Backer MD Ilyina T Ma XJ Vandoninck S Luyten WH Vanden Bossche H 2001a Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray Antimicrob Agents Chemother 45 1660 1670
13. de Backer MD Nelissen B Logghe M et al 2001b An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans Nat Biotechnol 19 235 241
14. Bali M Zhang B Morano KA Michels CA 2003 The Hsp90 molecular chaperone complex regulates maltose Induction and stability of the saccharomyces MALgene transcription activator Mal63p J Biol Chem 278 47441 47448
15. Banumathy G Singh V Pavithra SR Tatu U 2003 Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes J Biol Chem 278 18336 18345
16. Bardwell JC Craig EA 1987 Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli Proc Natl Acad Sci USA 84 5177 5181
17. Basu S Binder RJ Suto R Anderson KM Srivastava PK 2000 Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway Int Immunol 12 1539 1546
18. Basu S Binder RJ Ramalingam T Srivastava PK 2001 CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin Immunity 14 303 313
19. Baumann F Milisav I Neupert W Herrmann JM 2000 Ecm10, a novel hsp70 homolog in the mitochondrial matrix of the yeast Saccharomyces cerevisiae FEBS Lett 487 307 312
20. de Belder MA Walker JD Burnie JP Rothman MT 1989 Survival after rupture of the oesophagus and subsequent candidal endocarditis use of new serological methods in management Eur Heart J 10 858 862
21. Bennett RJ Uhl MA Miller MG Johnson AD 2003 Identification and characterization of a Candida albicans mating pheromone Mol Cell Biol 23 8189 8201
22. Bente M Harder S Wiesgigl M Heukeshoven J Gelhaus C Krause E Clos J Bruchhaus I 2003 Developmentally induced changes of the proteome in the protozoan parasite Leishmania donovani Proteomics 3 1811 1829
23. Bentley NJ Fitch IT Tuite MF 1992 The small heat-shock protein Hsp26 of Saccharomyces cerevisiae assembles into a high molecular weight aggregate Yeast 8 95 106
24. Bergman A Siegal ML 2003 Evolutionary capacitance as a general feature of complex gene networks Nature 424 549 552
25. Bohen SP 1998 Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins Mol Cell Biol 18 3330 3339
26. Bonnefoy S Gysin J Blisnick T Guillotte M Carcy B Pereira da Silva L Mercereau-Puijalon O 1994 Immunogenicity and antigenicity of a Plasmodium falciparum protein fraction (90-110 kDa) able to protect squirrel monkeys against asexual blood stages Vaccine 12 32 40
27. Bonner JJ Carlson T Fackenthal DL Paddock D Storey K Lea K 2000 Complex regulation of the yeast heat shock transcription factor Mol Biol Cell 11 1739 1751
28. Boreham DR Mitchel RE 1994 Regulation of heat and radiation stress responses in yeast by hsp-104 Radiat Res 137 190 195
29. Borkovich KA Farrelly FW Finkelstein DB Taulien J Lindquist S 1989 hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures Mol Cell Biol 9 3919 3930
30. Bossier P Fitch IT Boucherie H Tuite MF 1989 Structure and expression of a yeast gene encoding the small heat-shock protein Hsp26 Gene 78 323 330
31. Braley R Piper PW 1997 The C-terminus of yeast plasma membrane H+-ATPase is essential for the regulation of this enzyme by heat shock protein Hsp30, but not for stress activation FEBS Lett 418 123 126
32. Bromuro C La Valle R Sandini S Urbani F Ausiello CM Morelli L Fe d'Ostiani C Romani L Cassone A 1998 A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis Infect Immun 66 2154 2162
33. Brosnan MP Donnelly D James TC Bond U 2000 The stress response is repressed during fermentation in brewery strains of yeast J Appl Microbiol 88 746 755
34. Brown CR McCann JA Chiang HL 2000 The heat shock protein Ssa2p is required for import of fructose-1, 6-bisphosphatase into Vid vesicles J Cell Biol 150 65 76
35. Bruneau JM Maillet I Tagat E Legrand R Supatto F Fudali C Caer JP Labas V Lecaque D Hodgson J 2003 Drug induced proteome changes in Candida albicans comparison of the effect of beta(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole Proteomics 3 325 336
36. Brunt SA Silver JC 1986 Cellular localization of steroid hormone-regulated proteins during sexual development in Achlya Exp Cell Res 165 306 319
37. Brunt SA Silver JC 1991 Molecular cloning and characterization of two distinct hsp85 sequences from the steroid responsive fungus Achlya ambisexualis Curr Genet 19 383 388
38. Brunt SA Silver JC 2004 Molecular cloning and characterization of two different cDNAs encoding the molecular chaperone Hsp90 in the Oomycete Achlya ambisexualis Fungal Genet Biol 41 239 252
39. Brunt SA Borkar M Silver JC 1998a Regulation of hsp90 and hsp70 genes during antheridiol-induced hyphal branching in the oomycete Achlya ambisexualis Fungal Genet Biol 24 310 324
40. Brunt SA Perdew GH Toft DO Silver JC 1998b Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya Cell Stress Chaperones 3 44 56
41. Brunt SA Riehl R Silver JC 1990 Steroid hormone regulation of the Achlya ambisexualis 85-kilodalton heat shock protein, a component of the Achlya steroid receptor complex Mol Cell Biol 10 273 281
42. Bukau B Horwich AL 1998 The Hsp70 and Hsp60 chaperone machines Cell 92 351 366
43. Bulman AL Hubl ST Nelson HC 2001 The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains J Biol Chem 276 40254 40262
44. Burford-Mason AP Matthews RC Williams JR 1987 Transient abrogation of immunosuppression in a patient with chronic mucocutaneous candidiasis following vaccination with Candida albicans J Infect 14 147 157
45. Burnie J Matthews R 2003 The role of antibodies against hsp90 in the treatment of fungal infections Drug News Perspect 16 205 210
46. Burnie J Matthews R 2004 Genetically recombinant antibodies new therapeutics against candidiasis Expert Opin Biol Ther 4 233 241
47. Burnie JP 1995 Allergic and invasive aspergillosis J R Soc Med 88 Suppl 25 41 45
48. Burnie JP Matthews RC 1991 Heat shock protein 88 and Aspergillus infection J Clin Microbiol 29 2099 2106
49. Burt ET O'Connor C Larsen B 1999 Isolation and identification of a 92-kDa stress induced protein from Candida albicans Mycopathologia 147 13 20
50. Burt ET Daly R Hoganson D Tsirulnikov Y Essmann M Larsen B 2003 Isolation and partial characterization of Hsp90 from Candida albicans Ann Clin Lab Sci 33 86 93
51. Cabiscol E Belli G Tamarit J Echave P Herrero E Ros J 2002 Mitochondrial Hsp60, resistance to oxidative stress, the labile iron pool are closely connected in Saccharomyces cerevisiae J Biol Chem 277 44531 44538
52. Caplan AJ Douglas MG 1991 Characterization of YDJ1 a yeast homologue of the bacterial dnaJ protein J Cell Biol 114 609 621
53. Carmelo V Sa-Correia I 1997 HySP26 gene transcription is strongly induced during Saccharomyces cerevisiae growth at low pH FEMS Microbiol Lett 149 85 88
54. Carratu L Franceschelli S Pardini CL Kobayashi GS Horvath I Vigh L Maresca B 1996 Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast Proc Natl Acad Sci USA 93 3870 3875
55. Caruso M Sacco M Medoff G Maresca B 1987 Heat shock 70 gene is differentially expressed in Histoplasma capsulatum strains with different levels of thermotolerance and pathogenicity Mol Microbiol 1 151 158
56. Chang HC Lindquist S 1994 Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae J Biol Chem 269 24983 24988
57. Chang HC Nathan DF Lindquist S 1997 In vivo analysis of the Hsp90 cochaperone Sti1 (p60) Mol Cell Biol 17 318 325
58. Chaturvedi V Fan J Stein B Behr MJ Samsonoff WA Wickes BL Chaturvedi S 2002 Molecular genetic analyses of mating pheromones reveal intervariety mating or hybridization in Cryptococcus neoformans Infect Immun 70 5225 5235
59. Chauhan N Inglis D Roman E Pla J Li D Calera JA Calderone R 2003 Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress Eukaryot Cell 2 1018 1024
60. Chen J Pederson DS 1993 A distal heat shock element promotes the rapid response to heat shock of the HSP26 gene in the yeast Saccharomyces cerevisiae J Biol Chem 268 7442 7448
61. Chen J Lane S Liu H 2002 A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicans Mol Microbiol 46 1335 1344
62. Chen T Parker CS 2002 Dynamic association of transcriptional activation domains and regulatory regions in Saccharomyces cerevisiae heat shock factor Proc Natl Acad Sci USA 99 1200 1205
63. Cheng MY Hartl FU Horwich AL 1990 The mitochondrial chaperonin hsp60 is required for its own assembly Nature 348 455 458
64. Cheng MY Hartl FU Martin J Pollock RA Kalousek F Neupert W Hallberg EM Hallberg RL Horwich AL 1989 Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria Nature 337 620 625
65. Chernoff YO Newnam GP Kumar J Allen K Zink AD 1999 Evidence for a protein mutator in yeast role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion Mol Cell Biol 19 8103 8112
66. Chiang S Azizzadeh B Buga G Ignarro L Calcaterra T Blackwell K 2003 Local administration of nitric oxide donor significantly impacts microvascular thrombosis Laryngoscope 113 406 409
67. Chiller T Farrokhshad F Brummer E Stevens DA 2000 Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus Antimicrob Agents Chemother 44 3302 3305
68. Cho T Toyoda M Sudoh M Nakashima Y Calderone RA Kaminishi H 2003 Isolation and sequencing of the Candida albicans MSI3, a putative novel member of the HSP70 family Yeast 20 149 156
69. Choi W Yoo YJ Kim M Shin D Jeon HB 2003 Identification of proteins highly expressed in the hyphae of Candida albicans by two-dimensional electrophoresis Yeast 20 1053 1060
70. Chughtai ZS Rassadi R Matusiewicz N Stochaj U 2001 Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells J Biol Chem 276 20261 20266
71. Clark I Burnie JP Coke AP Matthews RC Oppenheim BA 1990 Characterization of the antibody response in Corynebacterium jeikeium septicaemias Epidemiol Infect 105 229 236
72. Cohen IR 1992 The cognitive paradigm and the immunological homunculus Immunol Today 13 490 494
73. Cohen IR 2002 Peptide therapy for Type I diabetes the immunological homunculus and the rationale for vaccination Diabetologia 45 1468 1474
74. Colonna-Romano S Porta A Franco A Kobayashi GS Maresca B 1998 Identification and isolation by DDRT-PCR of genes differentially expressed by Histoplasma capsulatum during macrophages infection Microb Pathog 25 55 66
75. Coogan MM Challacombe SJ 2000 Serum and salivary antibodies to a mycobacterial 65-kDa stress protein are elevated in HIV-positive patients and modified by oral candidiasis Oral Microbiol Immunol 15 284 289
76. Corrochano LM 2002 Photomorphogenesis in Phycomyces differential display of gene expression by PCR with arbitrary primers Mol Genet Genomics 267 424 428
77. Costantino PJ Franklyn KM Gare NF Warmington JR 1994 Production of antibodies to antigens of Candida albicans in CBA/H mice Infect Immun 62 1400 1405
78. Cox MB Miller CA III. 2002 The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system Toxicol Lett 129 13 21
79. Craig E Baxter B Becker J Hallady J Ziegelhoffer T 1994 Heat Shock Proteins: Structure, Function and Regulation Cold Spring Harbour Lab Cold Spring Harbor, NY
80. Cunha DA Zancope-Oliveira RM Sueli M Felipe S Salem-Izacc SM Deepe Jr. GS Soares CM 2002 Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis Clin Diagn Lab Immunol 9 374 377
81. Dabrowa N Howard DH 1984 Heat shock and heat stroke proteins observed during germination of the blastoconidia of Candida albicans Infect Immun 44 537 539
82. Dabrowa N Zeuthen ML Howard DH 1990 Nutritional stress proteins in Candida albicans J Gen Microbiol 136 Part 7 1387 1391
83. Daniels CJ McKee AHZ Doolittle WF 1984 Archaebacterial heat shock proteins EMBO J 3 745 749
84. Deepe GS Jr. Gibbons R 2001 V beta 6+ T cells are obligatory for vaccine-induced immunity to Histoplasma capsulatum J Immunol 167 2219 2226
85. Deepe GS Jr. Gibbons RS 2002a Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum J Infect Dis 186 815 822
86. Deepe GS Jr. Gibbons RS 2002b Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum Infect Immun 70 3759 3767
87. Deepe GS Jr. Gibbons R Brunner GD Gomez FJ 1996 A protective domain of heat-shock protein 60 from Histoplasma capsulatum J Infect Dis 174 828 834
88. Deegenaars ML Watson K 1997 Stress proteins and stress tolerance in an Antarctic, psychrophilic yeast, Candida psychrophila FEMS Microbiol Lett 151 191 196
89. Dehner A Furrer J Richter K Schuster I Buchner J Kessler H 2003 NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol Chembiochem 4 870 877
90. van Deventer HJ Goessens WH van Vliet AJ Verbrugh HA 1996 Anti-enolase antibodies partially protective against systemic candidiasis in mice Clin Microbiol Infect 2 36 43
91. Diez S Gomez BL Restrepo A Hay RJ Hamilton AJ 2002 Paracoccidioides brasiliensis 87-kilodalton antigen, a heat shock protein useful in diagnosis characterization, purification, and detection in biopsy material via immunohistochemistry J Clin Microbiol 40 359 365
92. Dolinski KJ Cardenas ME Heitman J 1998 CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90 Mol Cell Biol 18 7344 7352
93. Donalies UE Stahl U 2001 Phase-specific gene expression in Saccharomyces cerevisiae, using maltose as carbon source under oxygen-limiting conditions Curr Genet 39 150 155
94. Dragon EA Brothers VM Wrightsman RA Manning J 1985 A Mr 90 000 surface polypeptide of Trypanosoma cruzi as a candidate for a Chagas' disease diagnostic antigen Mol Biochem Parasitol 16 213 229
95. Dubaquie Y Looser R Rospert S 1997 Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60 Proc Natl Acad Sci USA 94 9011 9016
96. Dubaquie Y Looser R Funfschilling U Jeno P Rospert S 1998 Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10 EMBO J 17 5868 5876
97. al-Dughaym AM Matthews RC Burnie JP 1994 Epitope mapping human heat shock protein 90 with sera from infected patients FEMS Immunol Med Microbiol 8 43 48
98. Duina AA Chang HC Marsh JA Lindquist S Gaber RF 1996a A cyclophilin function in Hsp90-dependent signal transduction Science 274 1713 1715
99. Duina AA Marsh JA Gaber RF 1996b Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth Yeast 12 943 952
100. Duttagupta R Vasudevan S Wilusz CJ Peltz SW 2003 A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3′ untranslated region Mol Cell Biol 23 2623 2632
101. Elahi S Pang G Ashman RB Clancy R 2001 Nitric oxide-enhanced resistance to oral candidiasis Immunology 104 447 454
102. Erkine AM Adams CC Diken T Gross DS 1996 Heat shock factor gains access to the yeast HSC82 promoter independently of other sequence-specific factors and antagonizes nucleosomal repression of basal and induced transcription Mol Cell Biol 16 7004 7017
103. Eroles P Sentandreu M Elorza MV Sentandreu R 1995 Cloning of a DNA fragment encoding part of a 70-kDa heat shock protein of Candida albicans FEMS Microbiol Lett 128 95 100
104. Eroles P Sentandreu M Elorza MV Sentandreu R 1997 The highly immunogenic enolase and Hsp70p are adventitious Candida albicans cell wall proteins Microbiology 143 Part 2 313 320
105. Estruch F 2000 Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast FEMS Microbiol Rev 24 469 486
106. Fang YC Cheng M 2002 The effect of C-terminal mutations of HSP60 on protein folding J Biomed Sci 9 223 233
107. Ferreira RP Yu B Niki Y Armstrong D 1990 Detection of Candida antigenuria in disseminated candidiasis by immunoblotting J Clin Microbiol 28 1075 1078
108. Fillinger S Chaveroche MK van Dijck P de Vries R Ruijter G Thevelein J d'Enfert C 2001 Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans Microbiology 147 1851 1862
109. Finkelstein DB Strausberg S 1983 Identification and expression of a cloned yeast heat shock gene J Biol Chem 258 1908 1913
110. Firon A Villalba F Beffa R D'Enfert C 2003 Identification of essential genes in the human fungal pathogen Aspergillus fumigatus by transposon mutagenesis Eukaryot Cell 2 247 255
111. Fontana J Fulton D Chen Y Fairchild TA McCabe TJ Fujita N Tsuruo T Sessa WC 2002 Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release Circ Res 90 866 873
112. Fracella F Scholle C Kallies A Hafker T Schroder T Rensing L 1997 Differential HSC70 expression during asexual development of Neurospora crassa Microbiology 143 Part 11 3615 3624
113. Fradin C Kretschmar M Nichterlein T Gaillardin C d'Enfert C Hube B 2003 Stage-specific gene expression of Candida albicans in human blood Mol Microbiol. 47 1523 1543
114. Franklyn KM Warmington JR 1994 The expression of Candida albicans enolase is not heat shock inducible FEMS Microbiol Lett 118 219 225
115. Freeman BC Felts SJ Toft DO Yamamoto KR 2000 The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies Genes Dev 14 422 434
116. Freitag DG Ouimet PM Girvitz TL Kapoor M 1997 Heat shock protein 80 of Neurospora crassa, a cytosolic molecular chaperone of the eukaryotic stress 90 family, interacts directly with heat shock protein 70 Biochemistry 36 10221 10229
117. Friedrich KL Giese KC Buan NR Vierling E 2004 Interactions between small heat shock protein subunits and substrate in small heat shock protein-substrate complexes J Biol Chem 279 1080 1089
118. Frydman J 2001 Folding of newly translated proteins in vivo the role of molecular chaperones Annu Rev Biochem 70 603 647
119. Galdiero E Romano Carratelli C Vitiello M Nuzzo I. Del Vecchio E. Bentivoglio C. Perillo G. Galdiero F 2000 HSP and apoptosis in leukocytes from infected or vaccinated animals by Brucella abortus New Microbiol 23 271
120. Garcia-Cardena G Fan R Shah V Sorrentino R Cirino G Papapetropoulos A Sessa WC 1998 Dynamic activation of endothelial nitric oxide synthase by Hsp90 Nature 392 821 824
121. Gargano S Di Lallo G Kobayashi GS Maresca B 1995 A temperature-sensitive strain of Histoplasma capsulatum has an altered delta 9-fatty acid desaturase gene Lipids 30 899 906
122. Garnier C Lafitte D Tsvetkov PO Barbier P Leclerc-Devin J Millot JM Briand C Makarov AA Catelli MG Peyrot V 2002 Binding of ATP to heat shock protein 90 evidence for an ATP-binding site in the C-terminal domain J Biol Chem. 277 12208 12214
123. Gautschi M Mun A Ross S Rospert S 2002 A functional chaperone triad on the yeast ribosome Proc Natl Acad Sci USA 99 4209 4214
124. Geissler A Krimmer T Schonfisch B Meijer M Rassow J 2000 Biogenesis of the yeast frataxin homologue Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria Eur J Biochem 267 3167 3180
125. Geissler A Rassow J Pfanner N Voos W 2001 Mitochondrial import driving forces enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins Mol Cell Biol 21 7097 7104
126. van Gemeren IA Punt PJ Drint-Kuyvenhoven A Broekhuijsen MP van't Hoog A Beijersbergen A Verrips CT van den Hondel CA 1997 The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins Gene 198 43 52
127. Germaniuk A Liberek K Marszalek J 2002 A bichaperone (Hsp70-Hsp78) system restores mitochondrial DNA synthesis following thermal inactivation of Mip1p polymerase J Biol Chem 277 27801 27808
128. Ghaemmaghami S Huh WK Bower K Howson RW Belle A Dephoure N O'Shea EK JSWeissman JS 2003 Global analysis of protein expression in yeast Nature 425 737 741
129. Giaever G Chu AM Ni L et al 2002 Functional profiling of the Saccharomyces cerevisiae genome Nature 418 387 391
130. Giraldo P Neuer A Korneeva IL Ribeiro-Filho A Simoes JA Witkin SS 1999a Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis Am J Obstet Gynecol 180 524 529
131. Giraldo P Neuer A Ribeiro-Filho A Linhares I Witkin SS 1999b Detection of the human 70-kD and 60-kD heat shock proteins in the vagina relation to microbial flora, vaginal pH, and method of contraception Infect Dis Obstet Gynecol 7 23 25
132. Giraldo PC Ribeiro-Filho AD Simoes JA Neuer A Feitosa SB Witkin SS 1999c Circulating heat shock proteins in women with a history of recurrent vulvovaginitis Infect Dis Obstet Gynecol 7 128 132
133. Girvitz TL Ouimet PM Kapoor M 2000 Heat shock protein 80 of Neurospora crassa sequence analysis of the gene and expression during the asexual phase Can J Microbiol 46 981 991
134. Gitlits VM Toh BH Sentry JW 2001 Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase J Investig Med 49 138 145
135. Glover JR Lindquist S 1998 Hsp104, Hsp70, and Hsp40 a novel chaperone system that rescues previously aggregated proteins 94 73 82
136. Goes FS Martin J 2001 Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1 Eur J Biochem 268 2281 2289
137. Goldman GH dos Reis Marques E Duarte Ribeiro DC et al 2003 Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: identification of putative homologues of Candida albicans virulence and pathogenicity genes Eukaryot Cell 2 34 48
138. Gomez FJ Gomez AM Deepe GS Jr. 1992 An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice Infect Immun 60 2565 2571
139. Gomez FJ Allendoerfer R Deepe GS Jr. 1995 Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis Infect Immun 63 2587 2595
140. Grably MR Stanhill A Tell O Engelberg D 2002 HSF and Msn2/4p can exclusively or cooperatively activate the yeast HSP104 gene Mol Microbiol 44 21 35
141. Graefe SE Wiesgigl M Gaworski I Macdonald A Clos J 2002 Inhibition of HSP90 in Trypanosoma cruzi induces a stress response but no stage differentiation Eukaryot Cell 1 936 943
142. Grandin N Charbonneau M 2001 Hsp90 levels affect telomere length in yeast Mol Genet Genomics 265 126 134
143. Grenert JP Sullivan WP Fadden P et al 1997 The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation J Biol Chem 272 23843 23850
144. de Groot E Bebelman JP Mager WH Planta RJ 2000 Very low amounts of glucose cause repression of the stress-responsive gene HSP12 in Saccharomyces cerevisiae Microbiology 146 Part 2 367 375
145. Gross C Watson K 1998 Application of mRNA differential display to investigate gene expression in thermotolerant cells of Saccharomyces cerevisiae Yeast 14 431 442
146. Hafker T Techel D Steier G Rensing L 1998 Differential expression of glucose-regulated (grp78) and heat-shock-inducible (hsp70) genes during asexual development of Neurospora crassa Microbiology 144 Part 1 37 43
147. Hahn JS Thiele DJ 2004 Activation of the S. cerevisiae heat shock transcription factor under glucose starvation conditions by Snf1 protein kinase J Biol Chem 279 5169 5176
148. Hallberg EM Shu Y Hallberg RL 1993 Loss of mitochondrial hsp60 function nonequivalent effects on matrix-targeted and intermembrane-targeted proteins Mol Cell Biol 13 3050 3057
149. Han KH Prade RA 2002 Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulans Mol Microbiol 43 1065 1078
150. Harris N MacLean M Hatzianthis K Panaretou B Piper PW 2001 Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells Mol Genet Genom 265 258 263
151. Haslbeck M Walke S Stromer T Ehrnsperger M. White HE Chen S Saibil HR Buchner J 1999 Hsp26 a temperature-regulated chaperone EMBO J 18 6744 6751
152. Hattendorf DA Lindquist SL 2002 Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants EMBO J 21 12 21
153. Hengel H Masihi KN 2003 Combinatorial immunotherapies for infectious diseases Int Immunopharmacol 3 1159 1167
154. Hernandez R Nombela C Diez-Orejas R Gil C 2004 Two-dimensional reference map of Candida albicans hyphal forms Proteomics 2 374 382
155. Heyrovska N Frydman J Hohfeld J Hartl FU 1998 Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein folding Biol Chem 379 301 309
156. Hiatt JS Martin DS 1946 Recovery from pulmonary moniliasis following serum therapy J Am Med Assoc 130 205 206
157. Hijarrubia MJ Casqueiro J Gutierrez S Fernandez FJ Martin JF 1997 Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion Curr Genet 32 139 146
158. Hjorth-Sorensen B Hoffmann ER Lissin NM Sewell AK Jakobsen BK 2001 Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins Mol Microbiol 39 914 923
159. Hodgetts S Matthews R Morrissey G Mitsutake K Piper P Burnie J 1996 Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice FEMS Immunol Med Microbiol 16 229 234
160. Hoos A Levey DL 2003 Vaccination with heat shock protein-peptide complexes from basic science to clinical applications Expert Rev Vaccines 2 369 379
161. Horton LE James P Craig EA Hensold JO 2001 The yeast hsp70 homologue Ssa is required for translation and interacts with Sis1 and Pab1 on translating ribosomes J Biol Chem 276 14426 14433
162. Hube B Naglik J 2001 Candida albicans proteinases resolving the mystery of a gene family Microbiology 147 Part 8 1997 2005
163. Ignarro LJ 2002 Nitric oxide as a unique signaling molecule in the vascular system a historical overview J Physiol Pharmacol 53 503 514
164. Ivanyi L Ivanyi J 1990 Elevated antibody levels to mycobacterial 65-kDa stress protein in patients with superficial candidiasis J Infect Dis 162 519 522
165. Ivorra C Perez-Ortin JE del Olmo M 1999 An inverse correlation between stress resistance and stuck fermentations in wine yeasts. A molecular study Biotechnol Bioeng 64 698 708
166. Iwahashi H Obuchi K Fujii S Komatsu Y 1997 Effect of temperature on the role of Hsp104 and trehalose in barotolerance of Saccharomyces cerevisiae FEBS Lett 416 1 5
167. Iwahashi H Nwaka S Obuchi K Komatsu Y 1998 Evidence for the interplay between trehalose metabolism and Hsp104 in yeast Appl Environ Microbiol 64 4614 4617
168. Izacc SM Gomez FJ Jesuino RS Fonseca CA Felipe MS Deepe GS Soares CM 2001 Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis Med Mycol 39 445 455
169. Jeavons L Hunt L Hamilton A 1994 Immunochemical studies of heat-shock protein 80 of Histoplasma capsulatum J Med Vet Mycol 32 47 57
170. Jesuino RS Azevedo MO Felipe MS Pereira M De Almeida Soares CM 2002 Characterization of a chaperone ClpB homologue of Paracoccidioides brasiliensis Yeast 19 963 972
171. Johnson JL Craig EA 2000 A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast Mol Cell Biol 20 3027 3036
172. Johnson J Craig E 2001 An essential role for the substrate-binding region of Hsp40s in Saccharomyces cerevisiae J Cell Biol 152 851 856
173. Johnson KS Wells K Bock JV Nene V Taylor DW Cordingley JS 1989 The 86-kilodalton antigen from Schistosoma mansoni is a heat-shock protein homologous to yeast HSP-90 Mol Biochem Parasitol 36 19 28
174. Jong AY Chen SH Stins MF Kim KS Tuan TL Huang SH 2003 Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells J Med Microbiol 52 615 622
175. Joseph K Tholanikunnel BG Kaplan AP 2002a Heat shock protein 90 catalyzes activation of the prekallikrein - kininogen complex in the absence of factor XII Proc Natl Acad Sci USA 99 896 900
176. Joseph K Tholanikunnel BG Kaplan AP 2002b Activation of the bradykinin-forming cascade on endothelial cells a role for heat shock protein 90 Int Immunopharmacol 2 1851 1859
177. Jung G Masison DC 2001 Guanidine hydrochloride inhibits Hsp104 activity in vivo a possible explanation for its effect in curing yeast prions Curr Microbiol 43 7 10
178. Kabani M Beckerich JM Brodsky JL 2002 Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p Mol Cell Biol 22 4677 4689
179. Kakeya H Udono H Ikuno N et al 1997 A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary cryptococcosis Infect Immun 65 1653 1658
180. Kakeya H Udono H Maesaki S et al 1999 Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis Clin Exp Immunol 115 485 490
181. Kapoor M Curle CA Runham C 1995 The hsp70 gene family of Neurospora crassa cloning, sequence analysis, expression, and genetic mapping of the major stress-inducible member J Bacteriol 177 212 221
182. Kaufmann SH 1990 Heat shock proteins and the immune response Immunol Today 11 129 136
183. Kawasaki L Sanchez O Shiozaki K Aguirre J 2002 SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans Mol Microbiol 45 1153 1163
184. Kim S Schilke B Craig EA Horwich AL 1998 Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins Proc Natl Acad Sci USA 95 12860 12865
185. Kobayashi H Debeaupuis JP Bouchara JP Latge JP 1993 An 88-kilodalton antigen secreted by Aspergillus fumigatus Infect Immun 61 4767 4771
186. Kraus PR Fox DS Cox GM Heitman J 2003 The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function Mol Microbiol 48 1377 1387
187. Krimmer T Rassow J Kunau WH Voos W Pfanner N 2000 Mitochondrial protein import motor the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role Mol Cell Biol 20 5879 5887
188. Krzewska J Konopa G Liberek K 2001a Importance of two ATP-binding sites for oligomerization, ATPase activity and chaperone function of mitochondrial Hsp78 protein J Mol Biol 314 901 910
189. Krzewska J Langer T Liberek K 2001b Mitochondrial Hsp78, a member of the Clp/Hsp100 family in Saccharomyces cerevisiae, cooperates with Hsp70 in protein refolding FEBS Lett 489 92 96
190. Kumar N Zhao Y Graves P Perez Folgar J Maloy L Zheng H 1990 Human immune response directed against Plasmodium falciparum heat shock-related proteins Infect Immun 58 1408 1414
191. Kumar A Reddy LV Sochanik A Kurup VP 1993 Isolation and characterization of a recombinant heat shock protein of Aspergillus fumigatus J Allergy Clin Immunol 91 1024 1030
192. Kumar R Musiyenko A Barik S 2003 The heat shock protein 90 of Plasmodiumfalciparum and antimalarial activity of its inhibitor, geldanamycin Malar J 2 30
193. Kumari S Lillibridge CD Bakeer M Lowrie RC Jr. Jayaraman K Philipp MT 1994 Brugia malayi the diagnostic potential of recombinant excretory/secretory antigens Exp Parasitol 79 489 505
194. Kusakabe T Koga K Sugimoto Y 1994 Isolation and characterization of cDNA and genomic promoter region for a heat shock protein 30 from Aspergillus nidulans Biochim Biophys Acta 1219 555 558
195. La Valle R Bromuro C Ranucci L Muller HM Crisanti A Cassone A 1995 Molecular cloning and expression of a 70-kilodalton heat shock protein of Candida albicans Infect Immun 63 4039 4045
196. Landry SJ Steede NK Garaudy AM Maskos K Viitanen PV 1999 Chaperonin function depends on structure and disorder in co-chaperonin mobile loops Pac Symp Biocomput 4 520 531
197. Lane S Birse C Zhou S Matson R Liu H 2001 DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans J Biol Chem 276 48988 48996
198. Lashkari DA DeRisi JL McCusker JH Namath AF Gentile C Hwang SY Brown PO Davis RW 1997 Yeast microarrays for genome wide parallel genetic and gene expression analysis Proc Natl Acad Sci USA 94 13057 13062
199. Latouch S Totet A Lacube P Bolognini J Nevez G Roux P 2001 Development of an RT-PCR on the heat shock protein 70 gene for viability detection of Pneumocystis carinii f. sp. hominis in patients with pneumocystosis and in air sample J Eukaryot Microbiol 48 Suppl 176S 177S
200. Lee DH Goldberg AL 1998 Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae Mol Cell Biol 18 30 38
201. Lee S Carlson T Christian N Lea K Kedzie J Reilly JP Bonner JJ 2000 The yeast heat shock transcription factor changes conformation in response to superoxide and temperature Mol Biol Cell 11 1753 1764
202. Lee S Fan CY Younger JM Ren H Cyr DM 2002 Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding J Biol Chem 277 21675 21682
203. Leonhardt SA Fearson K Danese PN Mason TL 1993 HSP78 encodes a yeast mitochondrial heat shock protein in the Clp family of ATP-dependent proteases Mol Cell Biol 13 6304 6313
204. Lewis RE Kontoyiannis DP 2001 Rationale for combination antifungal therapy Pharmacotherapy 21 149S 164S
205. Li K Yu JJ Hung CY Lehmann PF Cole GT 2001 Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice Infect Immun 69 2878 2887
206. Li XS Reddy MS Baev D Edgerton M 2003 Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5 J Biol Chem 278 28553 28561
207. Lim JH Martin F Guiard B Pfanner N Voos W 2001 The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation EMBO J 20 941 950
208. Lindquist S Craig EA 1988 The heat-shock proteins Annu Rev Genet 22 631 677
209. Liu XD Liu PC Santoro N Thiele DJ 1997 Conservation of a stress response human heat shock transcription factors functionally substitute for yeast HSF EMBO J 16 6466 6477
210. Long KH Gomez FJ Morris RE Newman SL 2003 Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages J Immunol 170 487 494
211. Lopatin DE Jaramillo E Edwards CA Van Poperin N Combs A Shelburne CE 1999 Cellular localization of a Hsp90 homologue in Porphyromonas gingivalis FEMS Microbiol Lett 181 9 16
212. Lopatin DE Combs A Sweier DG Fenno JC Dhamija S 2000 Characterization of heat-inducible expression and cloning of HtpG (Hsp90 homologue) of Porphyromonas gingivalis Infect Immun 68 1980 1987
213. Lopez N Aron R Craig EA 2003 Specificity of Class II Hsp40 Sis1 maintenance of yeast prion [RNQ+] Mol Biol Cell 14 1172 1181
214. Lopez-Buesa P Pfund C Craig EA 1998 The biochemical properties of the ATPase activity of a 70-kDa heat shock protein (Hsp70) are governed by the C-terminal domains Proc Natl Acad Sci USA 95 15253 15258
215. Lopez-Ribot JL Alloush HM Masten BJ Chaffin WL 1996 Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family Infect Immun 64 3333 3340
216. Lotz GP Lin H Harst A Obermann WM 2003 Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone J Biol Chem 278 17228 17235
217. Louvion JF Abbas-Terki T Picard D 1998 Hsp90 is required for pheromone signaling in yeast Mol Biol Cell 9 3071 3083
218. Louvion JF Warth R Picard D 1996 Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast Proc Natl Acad Sci USA 93 13937 13942
219. Luke MM Sutton A Arndt KT 1991 Characterization of SIS1, a Saccharomyces cerevisiae homolgue of bacterial dnaJ proteins J Cell Biol 114 623 638
220. Malloy PJ Zhao X Madani ND Feldman D 1993 Cloning and expression of the gene from Candida albicans that encodes a high-affinity corticosteroid-binding protein Proc Natl Acad Sci USA 90 1902 1906
221. Maneu V Cervera AM Martinez JP Gozalbo D 1997 Molecular cloning of a Candida albicans gene (SSB1) coding for a protein related to the Hsp70 family Yeast 13 677 681
222. Maneu V Roig P Gozalbo D 2000 Complementation of Saccharomyces cerevisiae mutations in genes involved in translation and protein folding (EFB1 and SSB1) with Candida albicans cloned genes Res Microbiol 151 739 746
223. Maresca B Kobayashi G 1993 Changes in membrane fluidity modulate heat shock gene expression and produced attenuated strains in the dimorphic fungus Histoplasma capsulatum Arch Med Res 24 247 249
224. Marichal P Vanden Bossche H Odds FC Nobels G Warnock DW Timmerman V Van Broeckhoven C Fay S Mose-Larsen P 1997 Molecular biological characterization of an azole-resistant Candida glabrata isolate Antimicrob Agents Chemother 41 2229 2237
225. Marsh JA Kalton HM Gaber RF 1998 Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells Mol Cell Biol 18 7353 7359
226. Martin J Horwich AL Hartl FU 1992 Prevention of protein denaturation under heat stress by the chaperonin Hsp60 Science 258 995 998
227. Martinez J Perez-Serrano J Bernadina WE Rodriguez-Caabeiro F 2001 HSP60, HSP70 and HSP90 from Trichinella spiralis as targets of humoral immune response in rats Parasitol Res 87 453 458
228. Mason AB Brandt M Buckley HR 1989 Enolase activity associated with a C. albicans cytoplasmic antigen Yeast 5 S231 239
229. Mason CA Dunner J Indra P Colangelo T 1999 Heat-induced expression and chemically induced expression of the Escherichia coli stress protein HtpG are affected by the growth environment Appl Environ Microbiol 65 3433 3440
230. Matsumoto S Tanaka E Nemoto TK et al 2002 Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperone 277 34959 34966
231. Matthews RC 1991 HSP 90, yeasts and Corynebacterium jeikeium Epidemiol Infect 107 273 283
232. Matthews RC 1992 The 14th C. L. Oakley Lecture. Candida albicans HSP 90 link between protective and auto immunity J Med Microbiol 36 367 370
233. Matthews R Burnie J 1989 Cloning of a DNA sequence encoding a major fragment of the 47 kilodalton stress protein homologue of Candida albicans FEMS Microbiol Lett 51 25 30
234. Matthews R Burnie JP 1995 Heat Shock Proteins in Fungal Infections Landes Austin, TX, USA
235. Matthews R Burnie JP 2004 Recombinant antibodies a natural partner in combinatorial antifungal therapy Vaccine 22 865 871
236. Matthews RC Burnie JP Tabaqchali S 1984 Immunoblot analysis of the serological response in systemic candidosis Lancet ii 1415 1418
237. Matthews R Burnie JP Fox A Tabaqchali S 1985 Immunoblot analysis of serological responses in invasive aspergillosis J Clin Pathol 38 1300 1303
238. Matthews RC Burnie JP Tabaqchali S 1987 Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans J Clin Microbiol 25 230 237
239. Matthews R Burnie J Smith D Clark I Midgley J Conolly M Gazzard B 1988a Candida and AIDS evidence for protective antibody Lancet 2 263 266
240. Matthews R Wells C Burnie JP 1988b Characterisation and cellular localisation of the immunodominant 47-KDa antigen of Candida albicans J Med Microbiol 27 227 232
241. Matthews RC Lee W Donohoe MS Damani NN Burnie JP 1990 Torulopsis glabrata fungaemia clinical features and antibody responses Serodiagn Immunothern Infect Dis 4 209 216
242. Matthews RC Burnie JP Howat D Rowland T Walton F 1991a Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis Immunology 74 20 24
243. Matthews R Burnie JP Lee W 1991b The application of epitope mapping in the development of a new serological test for systemic candidosis J Immunol Methods 143 73 79
244. Matthews R Hodgetts S Burnie J 1995 Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis J Infect Dis 171 1668 1671
245. Matthews RC Rigg G Hodgetts S Carter T Chapman C Gregory C Illidge C Burnie J 2003 Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90 Antimicrob Agents Chemother 47 2208 2216
246. Matzinger P 2002 The danger model a renewed sense of self Science 296 301 305
247. Mayr C Richter K Lilie H Buchner J 2000 Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties J Biol Chem 275 34140 34146
248. Meacham GC Browne BL Zhang W Kellermayer R Bedwell DM Cyr DM 1999 Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing J Biol Chem 274 34396 34402
249. Meyer U Monnerjahn C Techel D Rensing L 2000 Interaction of the Neurospora crassa heat shock factor with the heat shock element during heat shock and different developmental stages FEMS Microbiol Lett 185 255 261
250. Meyer P Prodromou C Hu B Vaughan C Roe SM Panaretou B Piper PW Pearl LH 2003 Structural and functional analysis of the middle segment of hsp90 implications for ATP hydrolysis and client protein and cochaperone interactions Mol Cell 11 647 658
251. Minchiotti G Gargano S Maresca B 1991 The intron-containing hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatum is properly spliced in severe heat shock conditions Mol Cell Biol 11 5624 5630
252. Minchiotti G Gargano S Maresca B 1992 Molecular cloning and expression of hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatum Biochim Biophys Acta 1131 103 107
253. Mizutani S Endo M Ino-Ue T Kurasawa M Uno Y Saito H Kato I Takesako K 2000 Immunization with the Candida albicans membrane fraction and in combination with fluconazole protects against systemic fungal infections Antimicrob Agents Chemother 44 243 247
254. Moczko M Schonfisch B Voos W Pfanner N Rassow J 1995 The mitochondrial ClpB homolog Hsp78 cooperates with matrix Hsp70 in maintenance of mitochondrial function J Mol Biol 254 538 543
255. Monnerjahn C Techel D Meyer U Rensing L 2001 The grp78 promoter of Neurospora crassa constitutive, stress and differentiation-dependent protein-binding patterns Curr Genet 39 319 326
256. Motshwene P Karreman R Kgari G Brandt W Lindsey G 2004 LEA (late embryonic abundant)-like protein hsp 12 (heat-shock protein 12) is present in the cell wall and enhances the barotolerance of the yeast Saccharomyces cerevisiae Biochem J 377 769 774
257. Mtwisha L Brandt W McCready S Lindsey GG 1998 HSP 12 is a LEA-like protein in Saccharomyces cerevisiae Plant Mol Biol 37 513 521
258. Munoz MJ Bejarano ER Daga RR Jimenez J 1999 The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts Genetics 153 1561 1572
259. Murali PS Kurup VP Bansal NK Fink JN Greenberger PA 1998 IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis J Lab Clin Med 131 228 235
260. Murray HW Brooks EB DeVecchio JL Heinzel FP 2003 Immunoenhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis Antimicrob Agents Chemother 47 2513 2517
261. Nascimento FR Calich VL Rodriguez D Russo M 2002 Dual role for nitric oxide in paracoccidioidomycosis essential for resistance, but overproduction associated with susceptibility J Immunol 168 4593 4600
262. Nathan C Shiloh MU 2000 Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens Proc Natl Acad Sci USA 97 8841 8848
263. Nathan DF Vos MH Lindquist S 1997 In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone Proc Natl Acad Sci USA 94 12949 12956
264. Neale TJ Muir JC Drake B 1987 The immunochemical characterisation of circulating immune complex constituents in Candida albicans osteomyelitis by isoelectric focusing, immunoblot, and immunoprint Aust N Z J Med 17 201 209
265. Nemoto TK Ono T Kobayakawa T Tanaka E Baba TT Tanaka K Takagi T Gotoh T 2001a Domain - domain interactions of HtpG, an Escherichia coli homologue of eukaryotic HSP90 molecular chaperone Eur J Biochem 268 5258 5269
266. Nemoto TK Ono T Tanaka K 2001b Substrate-binding characteristics of proteins in the 90 kDa heat shock protein family Biochem J 354 663 670
267. Ng TT Strang JI Wilkins EG 1994 Humoral response to mycobacterial heat shock proteins in patients with constrictive pericarditis caused by tuberculosis and its implications for pathogenesis Clin Diagn Lab Immunol 1 552 555
268. Ngosuwan J Wang NM Fung KL Chirico WJ 2003 Roles of cytosolic Hsp70 and Hsp40 molecular chaperones in post-translational translocation of presecretory proteins into the endoplasmic reticulum J Biol Chem 278 7034 7042
269. de Nobel H Lawrie L Brul S Klis F Davis M Alloush H Coote P 2001 Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae Yeast 18 1413 1428
270. Nooney L Matthews RC Burnie JP 2005 Evaluation of Mycograb, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill methodologies Diagn Microbiol Infect Dis 51 19 29
271. Noventa-Jordao MA Couto RM Goldman MH Aguirre J Iyer S Caplan A Terenzi HF Goldman GH 1999 Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings Microbiology 145 Part 11 3229 3234
272. Ouimet PM Kapoor M 1998 Analysis of complex formation between Hsp80 and Hsp70, cytosolic molecular chaperones of Neurospora crassa, by enzyme-linked immunosorbent assays (ELISA) Biochem Cell Biol 76 97 106
273. Palmer G Louvion JF Tibbetts RS Engman DM Picard D 1995 Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast Mol Biochem Parasitol 70 199 202
274. Panaretou B Piper PW 1992 The plasma membrane of yeast acquires a novel heat-shock protein (hsp30) and displays a decline in proton-pumping ATPase levels in response to both heat shock and the entry to stationary phase Eur J Biochem 206 635 640
275. Panaretou B Sinclair K Prodromou C Johal J Pearl L Piper PW 1999 The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections Microbiology 145 Part 12 3455 3463
276. Panwar SL Legrand M Dignard D Whiteway M Magee PT 2003 MFalpha1, the gene encoding the alpha mating pheromone of Candida albicans Eukaryot Cell 2 1350 1360
277. Pardo M Monteoliva L Pla J Sanchez M Gil C Nombela C 1999 Two-dimensional analysis of proteins secreted by Saccharomyces cerevisiae regenerating protoplasts a novel approach to study the cell wall Yeast 15 459 472
278. Parissi V Calmels C De Soultrait VR Caumont A Fournier M Chaignepain S Litvak S 2001 Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60 J Virol 75 11344 11353
279. Parsell DA Kowal AS Lindquist S 1994 Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes J Biol Chem 269 4480 4487
280. Passinen S Valkila J Manninen T Syvala H Ylikomi T 2001 The C-terminal half of Hsp90 is responsible for its cytoplasmic localization Eur J Biochem 268 5337 5342
281. Perlman J Feldman JF 1982 Cycloheximide and heat shock induce new polypeptide synthesis in Neurospora crassa Mol Cell Biol 2 1167 1173
282. Peterson P Perheentupa J Krohn KJ 1996 Detection of candidal antigens in autoimmune polyglandular syndrome type I Clin Diagn Lab Immunol 3 290 294
283. Pfund C Huang P Lopez-Hoyo N Craig EA 2001 Divergent functional properties of the ribosome-associated molecular chaperone Ssb compared with other Hsp70s Mol Biol Cell 12 3773 3782
284. Piper PW Ortiz-Calderon C Holyoak C Coote P Cole M 1997 Hsp30, the integral plasma membrane heat shock protein of Saccharomyces cerevisiae, is a stress-inducible regulator of plasma membrane H(+)-ATPase Cell Stress Chaperones 2 12 24
285. Piper PW Millson SH Mollapour M Panaretou B Siligardi G Pearl LH Prodromou C 2003a Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast Eur J Biochem 270 4689 4695
286. Piper PW Panaretou B Millson SH Trumana A Mollapour M Pearl LH Prodromou C 2003b Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors Gene 302 165 170
287. Pirkl F Buchner J 2001 Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40 J Mol Biol 308 795 806
288. Pitarch A Pardo M Jimenez A Pla J Gil C Sanchez M Nombela C 1999 Two-dimensional gel electrophoresis as analytical tool for identifying Candida albicans immunogenic proteins Electrophoresis 20 1001 1010
289. Pitarch A Diez-Orejas R Molero G Pardo M Sanchez M Gil C Nombela C 2001 Analysis of the serologic response to systemic Candida albicans infection in a murine model Proteomics 1 550 559
290. Pitarch A Sanchez M Nombela C Gil C 2002 Sequential fractionation and two-dimensional gel analysis unravels the complexity of the dimorphic fungus Candida albicans cell wall proteome Mol Cell Proteomics 1 967 982
291. Pitarch A Sanchez M Nombela C Gil C 2003a Analysis of the Candida albicans proteome. II. Protein information technology on the Net (update 2002) J Chromatogr B Analyt Technol Biomed Life Sci 787 129 148
292. Pitarch A Sanchez M Nombela C Gil C 2003b Analysis of the Candida albicans proteome. I. Strategies and applications J Chromatogr B Analyt Technol Biomed Life Sci 787 101 128
293. Pitzurra L Polonelli L Cantelli C Gerloni M Ponton J Bikandi J Blasi E 1996 Candida albicans stress mannoprotein, SMP200, enhances tumour necrosis factor secretion in the murine macrophage cell line ANA-1 J Med Vet Mycol 34 219 222
294. Plesofsky N Brambl R 1999 Glucose metabolism in Neurospora is altered by heat shock and by disruption of HSP30 Biochim Biophys Acta 1449 73 82
295. Plesofsky N Brambl R 2002 Analysis of interactions between domains of a small heat shock protein, Hsp30 of Neurospora crassa Cell Stress Chaperones 7 374 386
296. Plesofsky N Gardner N Lill R Brambl R 1999 Disruption of the gene for Hsp30, an alpha-crystallin-related heat shock protein of Neurospora crassa, causes defects in import of proteins into mitochondria Biol Chem 380 1231 1236
297. Plesofsky-Vig N Brambl R 1985 Heat shock response of Neurospora crassa protein synthesis and induced thermotolerance J Bacteriol 162 1083 1091
298. Plesofsky-Vig N Brambl R 1987 Two developmental stages of Neurospora crassa utilize similar mechanisms for responding to heat shock but contrasting mechanisms for recovery Mol Cell Biol 7 3041 3048
299. Plesofsky-Vig N Brambl R 1995 Disruption of the gene for hsp30, an alpha-crystallin-related heat shock protein of Neurospora crassa, causes defects in thermotolerance Proc Natl Acad Sci USA 92 5032 5036
300. Plesofsky-Vig N Brambl R 1998 Characterization of an 88-kDa heat shock protein of Neurospora crassa that interacts with Hsp30 J Biol Chem 273 11335 11341
301. Poggeler S 2002 Genomic evidence for mating abilities in the asexual pathogen Aspergillus fumigatus Curr Genet 42 153 160
302. Polonelli L Gerloni M Conti S Fisicaro P Cantelli C Portincasa P Almondo F Barea PL Hernando FL Ponton J 1994 Heat-shock mannoproteins as targets of secretory IgA in Candida albicans J Infect Dis 169 1401 1405
303. Ponton J Hernando FL Moragues MD Barea PL Gerloni M Conti S Fisicaro P Cantelli C Polonelli L 1996 Candida albicans stress mannoproteins expression in superficial and systemic candidiasis. Stress mannoproteins in Candida albicans Mycopathologia 133 89 94
304. Porsius JC van Vliet HJ van Zeijl JH Goessens WH Michel MF 1990 Detection of an antibody response in immunocompetent patients with systemic candidiasis or Candida albicans colonisation Eur J Clin Microbiol Infect Dis 9 352 355
305. Prigneau O Porta A Poudrier JA Colonna-Romano S Noel T Maresca B 2003 Genes involved in beta-oxidation, energy metabolism and glyoxylate cycle are induced by Candida albicans during macrophage infection Yeast 20 723 730
306. Prodromou C Siligardi G O'Brien R Woolfson DN Regan L Panaretou B Ladbury JE Piper PW Pearl LH 1999 Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones EMBO J 18 754 762
307. Prodromou C Panaretou B Chohan S Siligardi G O'Brien R Ladbury JE Roe SM Piper PW Pearl LH 2000 The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains EMBO J 19 4383 4392
308. Punt PJ van Gemeren IA Drint-Kuijvenhoven J Hessing JG van Muijlwijk-Harteveld GM Beijersbergen A Verrips CT van den Hondel CA 1998 Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli Appl Microbiol Biotechnol 50 447 454
309. Qian X Hou W Zhengang Li Sha B 2002 Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40 yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1 Biochem J 361 27 34
310. Ramage L Junne T Hahne K Lithgow T Schatz G 1993 Functional cooperation of mitochondrial protein import receptors in yeast EMBO J 12 4115 4123
311. Regnacq M Boucherie H 1993 Isolation and sequence of HSP30, a yeast heat-shock gene coding for a hydrophobic membrane protein Curr Genet 23 435 442
312. de Repentigny L Kilanowski E Pedneault L Boushira M 1991 Immunoblot analyses of the serologic response to Aspergillus fumigatus antigens in experimental invasive aspergillosis J Infect Dis 163 1305 1311
313. Rezaie S Ban M Mildner J Poitschek C Brna C Tschachler E 2000 Characterization of a cDNA clone, encoding a 70 kDa heat shock protein from the dermatophyte pathogen Trichophyton rubrum Gene 241 27 33
314. Richter K Muschler P Hainzl O Buchner J 2001 Coordinated ATP hydrolysis by the Hsp90 dimer J Biol Chem 276 33689 33696
315. Richter K Reinstein J Buchner J 2002 N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle J Biol Chem 277 44905 44910
316. Richter K Muschler P Hainzl O Reinstein J Buchner J 2003 Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the ATPase cycle J Biol Chem 278 10328 10333
317. Rico AI Girones N Fresno M Alonso C Requena JM 2002 The heat shock proteins, Hsp70 and Hsp83, of Leishmania infantum are mitogens for mouse B cells Cell Stress Chaperones 7 339 346
318. Riou C Nicaud JM Barre P Gaillardin C 1997 Stationary-phase gene expression in Saccharomyces cerevisiae during wine fermentation Yeast 13 903 915
319. Roemer T Jiang B Davison J et al 2003 Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery Mol Microbiol 50 167 181
320. Rojas PA Martin V Nigro M Echeverria PC Guarnera EA Pszenny V Angel SO 2000 Expression of a cDNA encoding a Toxoplasma gondii protein belonging to the heat-shock 90 family and analysis of its antigenicity FEMS Microbiol Lett 190 209 213
321. Rottgers K Zufall N Guiard B Voos W 2002 The ClpB homolog Hsp78 is required for the efficient degradation of proteins in the mitochondrial matrix J Biol Chem 277 45829 45837
322. Roychowdhury HS Kapoor M 1988 Ethanol and carbon-source starvation enhance the accumulation of HSP80 in Neurospora crassa Can J Microbiol 34 162 168
323. Roychowdhury HS Kapoor M 1990 Heat shock response in Neurospora crassa purification and some properties of HSP 80 Biochem Cell Biol 68 1218 1221
324. Roychowdhury HS Wong D Kapoor M 1992 HSP80 of Neurospora crassa cDNA cloning, gene mapping, and studies of mRNA accumulation under stress Biochem Cell Biol 70 1356 1367
325. Russell KS Haynes MP Caulin-Glaser T Rosneck J Sessa WC Bender JR 2000 Oestrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells Effects on calcium sensitivity and NO release J Biol Chem 275 5026 5030
326. Saito T Mitsui K Hamada Y Tsurugi K 2002 Regulation of the Gts1p level by the ubiquitination system to maintain metabolic oscillations in the continuous culture of yeast J Biol Chem 277 33624 33631
327. Sanchez Y Taulien J Borkovich KA Lindquist S 1992 Hsp104 is required for tolerance to many forms of stress EMBO J 11 2357 2364
328. Sanchez Y Parsell DA Taulien J Vogel JL Craig EA Lindquist S 1993 Genetic evidence for a functional relationship between Hsp104 and Hsp70 J Bacteriol 175 6484 6491
329. Sandini S Melchionna R Bromuro C La Valle R 2002 Gene expression of 70 kDa heat shock protein of Candida albicans transcriptional activation and response to heat shock Med Mycol 40 471 478
330. Santhanam J Burnie JP 2000 A PCR-based approach to sequence the Candida tropicalis HSP90 gene FEMS Immunol Med Microbiol 29 35 38
331. Satyanarayana C Schroder-Kohne S Craig EA Schu PV Horst M 2000 Cytosolic Hsp70s are involved in the transport of aminopeptidase 1 from the cytoplasm into the vacuole FEBS Lett 470 232 238
332. Savolainen J Kortekangas-Savolainen O Nermes M Viander M Koivikko A Kalimo K Terho EO 1998 IgE, IgA, and IgG responses to common yeasts in atopic patients Allergy 53 506 512
333. Scheckelhoff M Deepe GS Jr. 2002 The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells J Immunol 169 5818 5826
334. Scheibel T Weikl T Rimerman R Smith D Lindquist S Buchner J 1999 Contribution of N- and C-terminal domains to the function of Hsp90 in Saccharomyces cerevisiae Mol Microbiol 34 701 713
335. Scheufler C Brinker A Bourenkov G Pegoraro S Moroder L Bartunik H Hartl FU Moarefi I 2000 Structure of TPR domain-peptide complexes critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine Cell 101 199 210
336. Schirmer EC Lindquist S 1997 Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP Proc Natl Acad Sci USA 94 13932 13937
337. Schwartz JA Mizukami H 1991 A metal-linked gapped zipper model is proposed for the 90 kDa heat shock protein-oestrogen receptor interface Med Hypotheses 35 140 145
338. Schwartz JA Mizukami H Skafar DF 1993 A metal-linked gapped zipper model is proposed for the hsp90-glucocorticoid receptor interaction FEBS Lett 315 109 113
339. Schwartz M Cohen IR 2000 Autoimmunity can benefit self-maintenance Immunol Today 21 265 268
340. Seymour IJ Piper PW 1999 Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors Microbiology 145 Part 1 231 239
341. Shah V Wiest R Garcia-Cardena G Cadelina G Groszmann RJ Sessa WC 1999 Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension Am J Physiol 277 G463 468
342. Shariat-Madar Z Mahdi F Schmaier AH 2002 Assembly and activation of the plasma kallikrein/kinin system a new interpretation Int Immunopharmacol 2 1841 1849
343. Sharma SA Miller GG Peek Jr. RA Perez-Perez G Blaser MJ 1997 T-cell, antibody, and cytokine responses to homologs of the 60-kilodalton heat shock protein in Helicobacter pylori infection Clin Diagn Lab Immunol 4 440 446
344. Shastry SJM 2002 Geldananmycin attenuates No-mediated dilation in human skin AM J Physiol Heart Circ Physiol 282 232 236
345. Shearer G Jr. Birge CH Yuckenberg PD Kobayashi GS Medoff G 1987 Heat-shock proteins induced during the mycelial-to-yeast transitions of strains of Histoplasma capsulatum J Gen Microbiol 133 Part 12 3375 3382
346. Shen HD Au LC Lin WL Liaw SF Tsai JJ Han SH 1997 Molecular cloning and expression of a Penicillium citrinum allergen with sequence homology and antigenic crossreactivity to a hsp 70 human heat shock protein Clin Exp Allergy 27 682 690
347. Siligardi G Panaretou B Meyer P Singh S Woolfson DN Piper PW Pearl LH Prodromou C 2002 Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37 J Biol Chem 277 20151 20159
348. Simola M Hanninen AL Stranius SM Makarow M 2000 Trehalose is required for conformational repair of heat-denatured proteins in the yeast endoplasmic reticulum but not for maintenance of membrane traffic functions after severe heat stress Mol Microbiol 37 42 53
349. Sims TJ Lernmark A Mancl LA Schifferle RE Page RC Persson GR 2002 Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis J Clin Periodontol 29 551 562
350. Skinner MA Buddle BM Wedlock DN et al 2003 A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis Infect Immun 71 4901 4907
351. Smulian AG Sesterhenn T Tanaka R Cushion MT 2001 The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes Genetics 157 991 1002
352. Soti C Racz A Csermely P 2002 A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket J Biol Chem 277 7066 7075
353. Soti C Vermes A Haystead TA Csermely P 2003 Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage a distinct nucleotide specificity of the C-terminal ATP-binding site Eur J Biochem 270 2421 2428
354. Spence J Cegielska A Georgopoulos C 1990 Role of Escherichia coli heat shock proteins DnaK and HtpG (C62.5) in response to nutritional deprivation J Bacteriol 172 7157 7166
355. Sreedhar AS Mihaly K Pato B Schnaider T Stetak A Kis-Petik K Fidy J Simonics T Maraz A Csermely P 2003 Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events J Biol Chem 278 35231 35240
356. Stearns SC 2003 Theoretical biology safeguards and spurs Nature 424 501 504
357. Stedman TT Buck GA 1996 Identification, characterization, and expression of the BiP endoplasmic reticulum resident chaperonins in Pneumocystis carinii Infect Immun 64 4463 4471
358. Stedman TT Butler DR Buck GA 1998 The HSP70 gene family in Pneumocystis carinii molecular and phylogenetic characterization of cytoplasmic members J Eukaryot Microbiol 45 589 599
359. Steen BR Lian T Zuyderduyn S MacDonald WK Marra M Jones SJ Kronstad JW 2002 Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans Genome Res 12 1386 1400
360. Steen BR Zuyderduyn S Toffaletti DL Marra M Jones SJ Perfect JR Kronstad J 2003 Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis Eukaryot Cell 2 1336 1349
361. Steger HF Sollner T Kiebler M Dietmeier KA Pfaller R Trulzsch KS Tropschug M Neupert W Pfanner N 1990 Import of ADP/ATP carrier into mitochondria two receptors act in parallel J Cell Biol 111 2353 2363
362. Stemmann O Neidig A Kocher T Wilm M Lechner J 2002 Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore Proc Natl Acad Sci USA 99 8585 8590
363. Streit JA Donelson JE Agey MW Wilson ME 1996 Developmental changes in the expression of Leishmania chagasi gp63 and heat shock protein in a human macrophage cell line Infect Immun 64 1810 1818
364. Strockbine NA Largen MT Zweibel SM Buckley HR 1984 Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera Infect Immun 43 715 721
365. Stromer T Fischer E Richter K Haslbeck M Buchner J 2004 Analysis of the regulation of the molecular chaperone Hsp26 by temperature-induced dissociation the N-terminal domail is important for oligomer assembly and the binding of unfolding proteins J Biol Chem 279 11222 11228
366. Sturtevant J 2000 Applications of differential-display reverse transcription-PCR to molecular pathogenesis and medical mycology Clin Microbiol Rev 13 408 427
367. Svirshchevskaya EV Alekseeva LG Titov VM Frolova EG Sapozhnikov AM 1998 Determination of T and B cell epitopes of Aspergillus fumigatus ribotoxin and heat shock protein Russ J Immunol 3 61 68
368. Swan TM Watson K 1998 Stress tolerance in a yeast sterol auxotroph role of ergosterol, heat shock proteins and trehalose FEMS Microbiol Lett 169 191 197
369. Sweier DG Combs A Shelburne CE Fenno JC Lopatin DE 2003 Construction and characterization of a Porphyromonas gingivalis htpG disruption mutant FEMS Microbiol Lett 225 101 106
370. Swoboda R Miyasaki S Greenspan D Greenspan JS 1993 Heat-inducible ATP-binding proteins of Candida albicans are recognized by sera of infected patients J Gen Microbiol 139 Part 12 2995 3003
371. Swoboda RK Bertram G Budge S Gooday GW Gow NA Brown AJ 1995a Structure and regulation of the HSP 90 gene from the pathogenic fungus Candida albicans Infect Immun 63 4510 Erratum
372. Swoboda RK Bertram G Budge S Gooday GW Gow NA Brown AJ 1995b Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans Infect Immun 63 4506 4514
373. Tanaka E Nemoto TK Ono T 2001 Liberation of the intramolecular interaction as the mechanism of heat-induced activation of HSP90 molecular chaperone Eur J Biochem 268 5270 5277
374. Tavares D Ferreira P Arala-Chaves M 2003 Increased resistance in BALB/c mice to reinfection with Candida albicans is due to immunoneutralization of a virulence-associated immunomodulatory protein Microbiology 149 333 339
375. Tavares D Salvador A Ferreira P Arala-Chaves M 1993 Immunological activities of a Candida albicans protein which plays an important role in the survival of the microorganism in the host Infect Immun 61 1881 1888
376. Techel D Hafker T Muschner S Reimann M Li Y Monnerjahn C Rensing L 1998 Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa Biochim Biophys Acta 1397 21 26
377. Thanonkeo P Akiyama K Jain S Takata R 2000 Targeted disruption of sti35, a stress-responsive gene in phytopathogenic fungus Fusarium oxysporum Curr Microbiol 41 284 289
378. Thomas CF Park JG Limper AH Puri V 2001 Analysis of a pheromone receptor and MAP kinase suggest a sexual replicative cycle in Pneumocystis carinii J Eukaryot Microbiol 48 141S
379. Thomas JG Baneyx F 2000 ClpB and HtpG facilitate de novo protein folding in stressed Escherichia coli cells Mol Microbiol 36 1360 1370
380. Thomas PW Wyckoff EE Pishko EJ Yu JJ Kirkland TN Cole GT 1997 The hsp60 gene of the human pathogenic fungus Coccidioides immitis encodes a T-cell reactive protein Gene 199 83 91
381. Tomee JF van der Werf TS Latge JP Koeter GH Dubois AE Kauffman HF 1995 Serologic monitoring of disease and treatment in a patient with pulmonary aspergilloma Am J Respir Crit Care Med 151 199 204
382. Unno K Kishido T Okada S 1998 Effect of over-expressed hsp26 on cell growth of yeast Biol Pharm Bull 21 631 633
383. Urban C Sohn K Lottspeich F Brunner H Rupp S 2003 Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell FEBS Lett 544 228 235
384. Varela JC Praekelt UM Meacock PA Planta RJ Mager WH 1995 The Saccharomyces cerevisiae HSP12 gene is activated by the high-osmolarity glycerol pathway and negatively regulated by protein kinase A Mol Cell Biol 15 6232 6245
385. Vassilev AO Plesofsky-Vig N Brambl R 1992 Isolation, partial amino acid sequence, and cellular distribution of heat-shock protein hsp98 from Neurospora crassa Biochim Biophys Acta 1156 1 6
386. Verma R Chen S Feldman R Schieltz D Yates J Dohmen J Deshaies RJ 2000 Proteasomal proteomics identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes Mol Biol Cell 11 3425 3439
387. Versteeg S Escher A Wende A Wiegert T Schumann W 2003 Regulation of the Bacillus subtilis heat shock gene htpG is under positive control J Bacteriol 185 466 474
388. Vidotto V Polonelli L Conti S Ponton J Vieta I 1998 Factors influencing the expression in vitro of Candida albicans stress mannoproteins reactive with salivary secretory IgA Mycopathologia 141 1 6
389. Vohra PK Puri V Thomas CF Jr. 2003 Complementation and characterization of the Pneumocystis carinii MAPK, PCM FEBS Lett 551 139 146
390. Voisine C Craig EA Zufall N von Ahsen O Pfanner N Voos W 1999 The protein import motor of mitochondria unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70 Cell 97 565 574
391. Voisine C Schilke B Ohlson M Beinert H Marszalek J Craig EA 2000 Role of the mitochondrial Hsp70s, Ssc1 and Ssq1, in the maturation of Yfh1 Mol Cell Biol 20 3677 3684
392. Voit EO 2003 Biochemical and genomic regulation of the trehalose cycle in yeast review of observations and canonical model analysis J Theor Biol 223 55 78
393. Voos W Rottgers K 2002 Molecular chaperones as essential mediators of mitochondrial biogenesis Biochim Biophys Acta 1592 51 62
394. Wallin RP Lundqvist A More SH von Bonin A Kiessling R Ljunggren HG 2002 Heat-shock proteins as activators of the innate immune system Trends Immunol 23 130 135
395. Walsh TJ Hathorn JW Sobel JD et al 1991 Detection of circulating Candida enolase by immunoassay in patients with cancer and invasive candidiasis N Engl J Med 324 1026 1031
396. Wegele H Muschler P Bunck M Reinstein J Buchner J 2003 Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90 J Biol Chem 278 39303 39310
397. Wegrzyn RD Bapat K Newnam GP Zink AD Chernoff YO 2001 Mechanism of prion loss after Hsp104 inactivation in yeast Mol Cell Biol 21 4656 4669
398. Weis C Kappe R Sonntag HG 1997 Western blot analysis of the immune response to Candida albicans antigens in 391 long-term intensive care patients Mycoses 40 153 157
399. White TC Holleman S Dy F Mirels LF Stevens DA 2002 Resistance mechanisms in clinical isolates of Candida albicans Antimicrob Agents Chemother 46 1704 1713
400. Wiesgigl M Clos J 2001 Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani Mol Biol Cell 12 3307 3316
401. Wong S Fares MA Zimmermann W Butler G Wolfe KH 2003 Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata Genome Biol 4 R10
402. Wu Ke DJ Aris JP 2000 Expression and subcellular localization of a membrane protein related to Hsp30 in Saccharomyces cerevisiae Biochim Biophys Acta 1463 477 482
403. Yaguchi S Tsurugi K 2003 Gts1p activates SNF1-dependent derepression of HSP104 and TPS1 in the stationary phase of yeast growth J Biol Chem 278 29760 29768
404. Yamada S Ono T Mizuno A Nemoto TK 2003 A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone Eur J Biochem 270 146 154
405. Yan W Christians E 1999 The glycine-phenylalanine-rich region determines the specificity of the yeast HSP90 Sis1 Mol Cell Biol 19 7751 7758
406. Yazdanyar A Essmann M Larsen B 2001 Genistein effects on growth and cell cycle of Candida albicans J Biomed Sci 8 153 159
407. Yoshida M Xia Y 2003 Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase J Biol Chem 278 36953 36958
408. Young JC Obermann WM Hartl FU 1998 Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90 J Biol Chem 273 18007 18010
409. Young JC Hoogenraad NJ Hartl FU 2003 Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70 Cell 112 41 50
410. Zara S Antonio FG Budroni M Bakalinsky AT 2002 HSP12 is essential for biofilm formation by a Sardinian wine strain of S. cerevisiae Yeast 19 269 276
411. Zarzov P Boucherie H Mann C 1997 A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication J Cell Sci 110 Part 16 1879 1891
412. Zeuthen ML Howard DH 1989 Thermotolerance and the heat-shock response in Candida albicans J Gen Microbiol 135 Part 9 2509 2518
413. Zeuthen ML Dabrowa N Aniebo CM Howard DH 1988 Ethanol tolerance and the induction of stress proteins by ethanol in Candida albicans J Gen Microbiol 134 Part 5 1375 1384
414. Zhang X Essmann M Burt ET Larsen B 2000 Oestrogen effects on Candida albicans a potential virulence-regulating mechanism J Infect Dis 181 1441 1446
415. Zhang M Hisaeda H Kano S Matsumoto Y Hao YP Looaresuwan S Aikawa M Himeno K 2001 Antibodies specific for heat shock proteins in human and murine malaria Microbes Infect 3 363 367
416. Zhang L Zhang Y Zhou Y An S Cheng J 2002 Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays J Antimicrob Chemother 49 905 915
417. Zhu H Bilgin M Snyder M 2003 Proteomics Annu Rev Biochem 72 783 812
418. Zou J Guo Y Guettouche T Smith DF Voellmy R 1998 Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1 Cell 94 471 480
419. Zugel U Kaufmann SH 1999 Role of heat shock proteins in protection from and pathogenesis of infectious diseases Clin Microbiol Rev 12 19 39
420. Zugel U Sponaas AM Neckermann J Schoel B Kaufmann SH 2001 gp96-peptide vaccination of mice against intracellular bacteria Infect Immun 69 4164 4167