Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice

FEMS Immunology and Medical Microbiology

Volumn 16, Issue 3-4, 1996, Pages 229-234

  Hodgetts, Samantha ^a   Matthews, Ruth ^a   Morrissey, Graham ^a   Mitsutake, Kotaro ^a   Piper, Peter ^b   Burnie, James ^a  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

hsp90; Saccharomyces cerevisiae; yeast virulence

Indexed keywords

HEAT SHOCK PROTEIN; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; VIRULENCE;

ANIMALS; COLONY COUNT, MICROBIAL; FEMALE; HSP90 HEAT-SHOCK PROTEINS; KIDNEY; LIVER; MICE; MYCOSES; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SPLEEN; VIRULENCE;

EID: 0030608465     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(96)00088-0     Document Type: Article

References (24)

1. [1] Oriol, A., Ribera, J.M., Arnal, J., Milla, F., Batlle, M. and Feliu, E. (1993) Saccharomyces cerevisiae septicaemia in a patient with myelodysplastic syndrome. Am. J. Hematol. 43, 325-326.
2. [2] Nielson, H., Stenderup, J. and Bruun, B. (1990) Fungemia with Saccharomycetaceae. Scand. J. Infect. Dis. 22, 581-584.
3. [3] Aucott, J.N., Fayen, H., Grossnicklas, H., Morrissey, A., Lederman, M.M. and Salata, R.A. (1990) Invasive infection with Saccharomyces cerevisiae: report of three cases and review. Rev. Infect. Dis. 12, 406-411
4. [4] Doyle, M.G., Pickering, L.K., O'Brien, N. and Hoots, K. (1990) Saccharomyces cerevisiae infection in a patient with acquired immunodeficiency syndrome. Pediatr. Infect. Dis. J. 9, 850-851.
5. [5] Tawfik, O.W., Papsian, C.J., Dixon, A.Y. and Potter, L.M. (1989) Saccharomyces cerevisiae pneumonia in a patient with acquired immune deficiency syndrome. J. Clin. Microbiol. 27, 1689-1691.
6. [6] Cimolai, N., Gill, M.J. and Church, D. (1987) Saccharomyces cerevisiae fungemia: case report and review of the literature. Diagn. Microbiol. Infect. Dis. 8, 113-117.
7. [7] Eng, R.H.K., Drehmel, R., Smith, S.M. and Goldstein, E.J.C. (1984) Saccharomyces cerevisiae infections in man. Sabouraudia J. Med. Vet. Mycol. 22, 403-407.
8. [8] Eschete, M.L. and West, B.C. (1980) Saccharomyces cerevisiae septicaemia. Arch. Intern. Med. 140, 1539.
9. [9] Sobel, J.D., Schmitt, C.A., Lynch, M., Vazquez, J. and Zervos, M. (1993) Emerging problem of vaginitis due to Saccharomyces cerevisiae. Clin. Infect. Dis. 16, 93-99.
10. [10] Holzschu, D.L., Chandler, F.W., Ajello, L. and Ahearn, D.G. (1979) Evaluation of industrial yeasts for pathogenicity. Sabouraudia 17, 71-78.
11. [11] Maejima, K., Shimoda, K., Morita, C., Fujiwara, T. and Kitamura, T. (1980) Colonization and pathogenicity of Saccharomyces cerevisiae, MC16, in mice and cynomolgus monkeys after oral and intravenous administration. Jpn. J. Med. Sci. Biol. 33, 271-276.
12. [12] Pecquet, S., Guillaumin, D., Tancrede, C. and Andremont, A. (1991) Kinetics of Saccharomyces cerevisiae elimination from the intestines of human volunteers and effect of this yeast on resistance to microbial colonization in gnotobiotic mice. Appl. Environ. Microbiol. 57, 3049-3051.
13. [13] Clemons, K.V., McCusker, J.H., Davis, R.W. and Stevens, D.A. (1994) Comparative pathogenesis of clinical and non-clinical isolates of Saccharomyces cerevisiae. J. Infect. Dis. 169, 859-867.
14. [14] McCusker, J.H., Clemons, K.V., Stevens, D.A. and Davis, R. (1994) Saccharomyces cerevisiae virulence phenotype as determined with CD-1 mice is associated with the ability to grow at 42°C and form pseudohyphae. Infect. Immun. 5447-5455.
15. [15] Borkovich, K.A., Farrelly, F.W., Finkelstein, D.B., Taulien, J. and Lindquist, S. (1989) hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol. Cell. Biol. 9, 3919-3930.
16. [16] Cheng, L., Hirst, K. and Piper, P.W. (1992) Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector. Influences of overexpression of hsp90 protein on high temperature growth and thermotolerance. Biochim. Biophys. Acta 1132, 26-34.
17. [17] Cheng, L., Kirk, N. and Piper, P.W. (1993) A small influence of hsp90 levels on the trehalose and heat shock element inductions of the yeast heat shock response. Biochem. Biophys. Res. Commun. 195, 201-207.
18. [18] Leunk, R.D. and Moon, R.J. (1979) Physiological and metabolic alterations accompanying systemic candidiasis in mice. Infect. Immun. 26, 1035-1041.
19. [19] Matthews, R.C. and Burnie, P. (1995) Heat Shock Proteins in Fungal Infections, pp. 1-92. Springer, London.
20. [20] Matthews, R.C. and Burnie, P. (1989) Cloning of a DNA sequence encoding a major fragment of the 47 kilodalton stress protein homologue of Candida albicans. FEMS Microbiol, Lett. 60, 25-30.
21. [21] Swoboda, R.K., Bertram, G., Budge, S., Gooday, G.W., Gow, N.A.R. and Brown, A.J.P. (1995) Structure and regulation of the hsp90 gene from the pathogenic fungus Candida albicans. Infect. Immun. 63, 4506-4514.
22. [22] Matthews, R.C., Burnie, P. And Tabaqchali, S. (1984) Immunoblot analysis of the serological response in systemic candidiasis. Lancet ii, 1415-1418.
23. [23] Matthews, R.C., Burnie, P., Howat, D., Rowland, T. and Wallon, F. (1991) Autoantibody to heat shock protein 90 can mediate protection against systemic candidiasis. Immunology 74, 20-24.
24. [24] Matthews, R.C., Hodgetts, S. and Burnie, J.P. (1995) Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis. J. Infect. Dis. 171, 1668-1671.