Molecular biological characterization of an azole-resistant Candida glabrata isolate

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 10, 1997, Pages 2229-2237

  Marichal, Patrick ^a   Vanden Bossche, Hugo ^a   Odds, Frank C ^a   Nobels, Geert ^a   Warnock, David W ^c   Timmerman, Vincent ^b   Van Broeckhoven, Christine ^b   Fay, Stephen ^d   Mose Larsen, Peter ^d  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c NHS BLOOD AND TRANSPLANT   (United Kingdom)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE; ITRACONAZOLE;

ARTICLE; CANDIDA GLABRATA; CANDIDIASIS; CHROMOSOME DUPLICATION; DRUG SENSITIVITY; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; VIRULENCE;

EID: 0030812876     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.10.2229     Document Type: Article

References (39)

1. Arif, S., T. Barkham, E. G. Power, and S. A. Howell. 1996. Techniques for investigation of an apparent outbreak of infections with Candida glabrata. J. Clin. Microbiol. 34:2205-2209.
2. Cannon, R. D., M. Niimi, G. D. Albertson, and H. F. Jenkinson. 1996. CDR1-mediated fluconazole resistance in Candida albicans. ASM Conference on Candida and Candidiasis: Biology, pathogenesis, and management march 24-27, 1996, San Diego, California.
3. Chen, C., T. G. Turi, D. Sanglard, and J. C. Loper. 1987. Isolation of the Candida tropicalis gene for P450 lanosterol demethylase and its expression in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 146:1311-1317.
4. Clark, F. S., T. Parkinson, C. A. Hitchcock, and N. A. R. Gow. 1996. Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance. Antimicrob. Agents Chemother. 40:419-425.
5. Crombie, T., D. J. Falconer, and C. A. Hitchcock. 1995. Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata. Antimicrob. Agents Chemother. 39:1696-1699.
6. Den Dunnen, J. T., P. Liang, G. J. B. Van Ommen, and C. Van Broeckhoven. 1995. Mutation, detection and diagnosis using PFGE, p. 46-67. In A. P. Monaco (ed.), Pulsed field gel electrophoresis, a practical approach. Oxford University Press, New York, N.Y.
7. Doi, M., M. Homma, A. Chindamporn, and K. Tanaka. 1992. Estimation of chromosome number and size by pulsed-field gel electrophoresis (PFGE) in medically important Candida species. J. Gen. Microbiol. 138:2243-2251.
8. Fling, M. E., J. Kopf, A. Tamarkin, J. A. Gorman, H. A. Smith, and Y. Koltin. 1991. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol. Gen. Genet. 227:318-329.
9. Hitchcock, C. A., K. Barett-Bee, and N. J. Russell. 1986. The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans. J. Gen. Microbiol. 132:2421-2431.
10. Hitchcock, C. A. 1993. Resistance of Candida albicans to antifungal agents. Biochem. Soc. Trans. 41:1039-1047.
11. Jandrositz, A., F. Turnowsky, and G. Högenauer. 1991. The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization. Gene 107:155-160.
12. Kelly, S. L., D. C. Lamb, A. J. Corran, B. C. Baldwin, and E. D. Kelly. 1995. Mode of action and resistance to azole antifungals associated with the formation of 14α-methyl-ergosta-8,24(28)-dien-3 β-6 α-diol. Biochem. Biophys. Res. Commun. 207:910-915.
13. Kosuga, K., S. Hata, T. Osumi, J. Sakakibara, and T. Ono. 1995. Nucleotide sequence of cDNA for mouse squalene epoxidase. Biochim. Biophys. Acta 1260:345-348.
14. Lee, L. G., C. R. Connell, S. L. Woo, R. D. Cheng, B. T. McArdle, C. W. Fuller, N. D. Halloran, and R. K. Wilson. 1992. DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effects of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments. Nucleic Acids Res. 20:2471-2483.
15. Marichal, P., and H. Vanden Bossche. 1995. Mechanisms of resistance to azole antifungals. Acta Biochim. Pol. 42:509-516.
16. Marichal, P., J. Gorrens, M.-C. Coene, L. Le Jeune, and H. Vanden Bossche. 1995. Origin of differences in susceptibility of Candida krusei to azole antifungal agents. Mycoses 38:111-117.
17. Mewes, H. W., K. Albermann, K. Heumann, S. Liebl, and F. Pfeiffer. 1997. MIPS - a database for protein sequences, homology data and yeast genome information. Nucleic Acids Res. 25:28-30.
18. Mieth, H. 1993. In vitro and in vivo activities of terbinafine, p. 137-149. In J. W. Rippon and R. A. Fromtling (ed.), Cutaneous antifungal agents, Marcel Dekker, New York, N.Y.
19. National Committee for Clinical Laboratory Standards. 1995. Reference method for broth dilution susceptibility testing of yeasts. Tentative standard M27-T. National Committee for Clinical Laboratory Standards, Villanova, Pa.
20. Ng, R., and J. Abelson. 1980. Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 77:3912-3916.
21. Odds, F. C. 1993. Resistance of yeasts to azole-derivative antifungals. J. Antimicrob. Chemother. 31:463-471.
22. Odds, F. C., L. Vranckx, and F. Woestenborghs. 1995. Antifungal susceptibility testing of yeasts: evaluation of technical variables for test automation. Antimicrob. Agents Chemother. 39:2051-2060.
23. Polak, A. 1988. Mode of action of morpholine derivatives. Ann. N. Y. Acad. Sci. 544:221-228.
24. Prasad, R., P. Dewegifosse, A. Goffeau, and E. Balzi. 1995. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27:320-329.
25. Rex, J. H., M. G. Rinaldi, and M. A. Pfaller. 1995. Resistance of Candida species to fluconazole. Antimicrob. Agents Chemother. 39:1-8.
26. Ryder, N. S. 1985. Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. Antimicrob. Agents Chemother. 27:252-256.
27. Sakakibara, J., R. Watanabe, Y. Kannai, and T. Ono. 1995. Molecular cloning and expression of rat squalene epoxidase. J. Biol. Chem. 270:17-20.
28. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
29. Sanglard, D., K. Kuchler, F. Isher, J. L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
30. Sanglard, D., F. Isher, M. Monod, and J. Bille. 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305.
31. Sanglard, D., F. Isher, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents; characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405-416.
32. Smith, K. J., D. W. Warnock, C. T. C. Kennedy, E. M. Johnson, V. Hopwood, J. Van Cutsem, and H. Vanden Bossche. 1986. Azole resistance in Candida albicans. J. Med. Vet. Mycol. 24:133-144.
33. Smith, R. A., C. A. Hitchcock, E. G. V. Evans, C. J. N. Lacey, and D. J. Adams. 1989. The identification of C. albicans strains by restriction fragment length polymorphism analysis of DNA. J. Med. Vet. Mycol. 27:431-434.
34. Thorvaldsen, J. L., R. K. Mehra, W. Yu, A. K. Sewell, and D. R. Winge. 1995. Analysis of copper-induced metallothionein expression using autonomously replicating plasmids in Candida glabrata. Yeast 11:1501-1511.
35. Vanden Bossche, H., P. Marichal, J. Gorrens, D. Bellens, H. Moereels, and P. A. J. Janssen. 1990. Mutation in cytochrome P450-dependent 14α-lanosterol demethylase results in decreased affinity for azole antifungals. Biochem. Soc. Trans. 18:56-59.
36. Vanden Bossche, H., P. Marichal, F. C. Odds, L. Le Jeune, and M.-C. Coene. 1992. Characterization of an azole-resistant Candida glabrata isolate. Antimicrob. Agents Chemother. 36:2602-2610.
37. Vanden Bossche, H., P. Marichal, and F. C. Odds. 1994. Molecular mechanisms of drug resistance in fungi. Trends Microbiol. 2:393-400.
38. Warnock, D. W., J. Burke, N. J. Cope, E. M. Johnson, N. A. Van Fraunhofer, and E. W. Williams. 1988. Fluconazole resistance in Candida glabrata. Lancet ii:1310.
39. Zhou, P., and D. J. Thiele. 1993. Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification. Genes Dev. 7:1824-1835.