Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress

Eukaryotic Cell

Volumn 2, Issue 5, 2003, Pages 1018-1024

  Chauhan, Neeraj ^a   Inglis, Diane ^b   Roman, Elvira ^c   Pla, Jesus ^c   Li, Dongmei ^a   Calera, Jose A ^d   Calderone, Richard ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION, PHYSIOLOGICAL; CANDIDA ALBICANS; CELL DIVISION; CELL WALL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, REGULATOR; HEAT-SHOCK RESPONSE; HYDROGEN PEROXIDE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHOSPHORYLATION; SODIUM CHLORIDE; SUPEROXIDES; TERT-BUTYLHYDROPEROXIDE; UP-REGULATION; VITAMIN K 3;

CANDIDA; CANDIDA ALBICANS; EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0142247063     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.2.5.1018-1024.2003     Document Type: Article

References (54)

1. Alex, L. A., C. Korch, C. P. Selitrennikof, and M. I. Simon. 1998. COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen, Candida albicans. Proc. Natl. Acad. Sci. USA 95:7069-7073.
2. Alonso-Monge, R., F. Navarro-García, E. Roman, A. I. Negredo, B. Eisman, C. Nombela, and J. Pla. 2003. The Hog1 MAP kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans. Eukaryot. Cell 2:351-361.
3. Alonso-Monge, R., F. Navarro-García, G. Molero, R. Diez-Orejas, M. Gustin, J. Pla, M. Sánchez, and C. Nombela. 1999. Role of mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J. Bacteriol. 181:3058-3068.
4. Alvarez-Peral, F. J, O. Zaragoza, Y. Pedreño, and J.-C. Argüelles. 2002. Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans. Microbiology 148:2599-2606.
5. Barrett, J. F., and J. A. Hoch. 1998. Two-component signal transduction as a target for microbial anti-infective therapy. Antimicrob. Agents Chemother. 42:1529-1536.
6. Bernhardt, J., D. Herman, M. Sheridan, and R. Calderone. 2001. Adherence and invasion studies of Candida albicans strains utilizing in vitro models of esophageal candidiasis. J. Infect. Dis. 184:1170-1175.
7. Black, C. A., F. M. Eyers, A. Russel, M. L. Dunkley, R. L. Clancy, and K. W. Beagley. 1998. Acute neutropenia decreases inflammation associated with murine vaginal candidiasis but has no effect on the course of infection. Infect. Immun. 66:1273-1275.
8. Bodey, C. A., M. Buckley, Y. S. Sathe, and E. J. Freirich. 1986. Quantitative relationship between circulating leukocytes and infections in patients with acute leukemia. Ann. Intern. Med. 64:328-340.
9. Calderone, R. A., and W. A. Fonzi. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9:327-335.
10. Calera, J. A., and R. A. Calderone. 1999. Histidine kinase, two-component signal transduction proteins of Candidia albicans and the pathogenesis of candidosis. Mycoses 42(Suppl.):49-53.
11. Calera, J. A., G. Cho, and R. A. Calderone. 1998. Identification of a putative histidine kinase two-component phosphorelay gene (CaCHK1) in Candida albicans. Yeast 14:665-674.
12. Calera, J. A., and R. A. Calderone. 1999. Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiology 145:1431-1442.
13. Calera, J. A. X.-J. Zhao, M. Sheridan, and R. A. Calderone. 1999. Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis. Infect. Immun. 67:4280-4284.
14. Calera, J. A., and R. A. Calderone. 1999. Identification of a putative response regulator, two-component phosphorelay gene (CaSSK1) from Candida albicans. Yeast 15:1243-1254.
15. Calera, J. A., X.-J. Zhao, and R. A. Calderone. 2000. Defective hyphal formation and avirulence caused by a deletion of the CSSK1 response regulator gene in Candida albicans. Infect. Immun. 68:518-525.
16. Calera, J. A., D. Herman, and R. A. Calderone. 2000. Identification of YPD1, a gene of Candida albicans which encodes a two-component phospho-histidine intermediate protein. Yeast 16:1053-1059.
17. Cole, G. T., K. R. Seshan, K. T. Lynn, and M. Franco. 1993. Gastrointestinal candidiasis: histopathology of Candida-host interactions in a murine model. Mycol. Res. 97:385-408.
18. Cowen, L. E., A. Nantel, M. S. Whiteway, D. Y. Thomas, D. C. Tessler, L. M. Kohn, and J. B. Anderson. 2002. Population genomics of drug resistance on Candida albicans. Proc. Natl. Acad. Sci. USA 99:9284-9289.
19. Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863-14868.
20. Enjalbert, B., A. Nantel, and M. Whiteway. 2003. Stress-induced gene expression in Candida albicans: absence of a general stress response. Mol. Biol. Cell 14:1460-1467.
21. Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
22. Grant, C. M. 2001. Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol. Microbiol. 39:533-541.
23. Hohmann, S. 2002. Osmotic stress signaling and osmoadaptation in yeasts. Microbiol. Mol. Biol. Rev. 66:300-372.
24. Jamieson, D. J., W. S. S Duncan, and E. C. Terriere. 1996. Analysis of the adaptive oxidative response of Candida albicans. FEMS Microbiol. Lett. 138:83-88.
25. Kapteyn, J. C., L. L. Hoyer, J. E. Hecht, W. H. Muller, A. Andel, A. J. Verldeij, M. Makarow, H. Van Den Ende, and F. M. Klis. 2000. The cell wall architecture of Candida albicans wild-type cells and cell wall-deficient mutants. Mol. Microbiol. 35:601-611.
26. Koretke, K. K., A. N. Lupas, P. V. Warren, M. Rosenberg, and J. R. Brown. 2000. Evolution of two-component signal transduction. Mol. Biol. Evol. 17:1956-1970.
27. Kruppa, M., T. Goins, D. Williams, D. Li, N. Chauhan, P. Singh, J. Cutler, and R. Calderone. 2003. FEMS Yeast Res. 3:289-299.
28. Lengeler, K. B., R. C. Davidson, C. D'Souza, T. Harashima, W.-C. Shen, P. Wang, X. Pan, M. Waugh, and J. Heitman. 2000. Signal transduction cascades regulating fungal development and virulence. Microbiol. Mol. Biol. Rev. 64:746-785.
29. Li, D., J. Bernhardt, and R. Calderone. 2002. Temporal expression of the Candida albicans genes CHK1 and CSSK1: adherence and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect. Immun. 70:1558-1565.
30. Martin, H., J. M. Rodriguez-Pachon, C. Ruiz, C. Nombela, and M. Molina. 2000. Regulatory mechanisms for modulation of signalling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae. J. Biol. Chem. 275:1511-1519.
31. Nagahashi, S., T. Mio, N. Ono, T. Yamada-Okabe, M. Arisawa, H. Bussey, and H. Yamada-Okabe. 1998. Isolation of CaSLN1 and CaN1K1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus, Candida albicans. Microbiology 144:425-432.
32. Navarro-Garcia, F., M. Sanchez, C. Nombela, and J. Pla. 2001. Virulence genes in the pathogenic yeast Candida albicans. FEMS Microbiol. Rev. 25:245-268.
33. Navarro-Garcia, F., R. Alonso-Monge, H. Rico, J. Pla, R. Sentandreu, and C. Nombela. 1998. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans. Microbiology 144:411-424.
34. Navarro-Garcia, F., M. Sanchez, J. Pla, and C. Nombela. 1995. Functional characterisitics of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity. Mol. Cell Biol. 15:2197-2206.
35. Odami, T., Y.-I. Shimma, X.-H. Wang, and Y. Jigami. 1997. Mannosyl phosphate transfer to cell wall mannan is regulated by the transcriptional level of the MNN4 gene in Saccharomyces cerevisiae. FEBS Lett. 420:186-190.
36. Park, S. G., M.-K. Cha, W. Jeong, and I.-H. Kim. 2000. Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae. J. Biol. Chem. 275:5723-5732.
37. Posas, F., S. M. Wurgler-Murphy, T. Maeda, E. A. Witten, T. C. Thai, and H. Saito. 1996. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 two-component osmosensor. Cell 86:865-875.
38. Pott, G. B., T. K. Miller, J. A. Bartlett, J. S. Palas, and C. P. Selitrennikoff. 2000. The isolation of FOS-1, a gene encoding a putative two-component histidine kinase from Aspergillus fumigatus. Fungal Genet. Biol. 31:55-67.
39. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Selitrennikoff, C. P., L. Alex, T. K. Miller, K. V. Clemons, M. I. Simon, and D. A. Stevens. 2001. COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor. Med. Mycol. 39:69-75.
41. Sherman, F., G. R. Fink, and J. B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
42. Singh, K. K. 2000. The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress in an oxidant-specific fashion. Free Radic. Biol. Med. 29:1043-1050.
43. Smail, E. H., B. N. Cronstein, T. Meshulam, A. L. Esposito, R. W. Ruggeri, and R. D. Diamond. 1992. In vitro, Candida albicans releases the immune modulator adenosine and a second, high molecular weight agent that blocks neutrophil killing. J. Immunol. 148:3588-3595.
44. Srikantha, T., L. Tsai, K. Daniels, L. Enger, K. Highley, and D. R. Soll. 1998. The two-component hybrid kinase regulator CaNIK1 of Candida albicans. Microbiology 144:2715-2729.
45. Stein, D. K., S. E. Malawista, G. Van Blaricom, D. Wysong, and R. D. Diamond. 1995. Cytoplasts generate oxidants but require added neutrophil granule constituents for fungicidal activity against Candida albicans hyphae. J. Infect. Dis. 172:511-520.
46. Stevenhagen, A., and R. van Furth. 1993. Interferon-gamma activates the oxidative killing of Candida albicans by human granulocytes. Clin. Exp. Immunol. 91:170-175.
47. Vasquez-Torres, A., J. Jones-Carson, and E. Balish. 1996. Peroxynitrite contributes to the candidacidal activity, of nitric oxide-producing macrophages. Infect. Immun. 64:3127-3133.
48. Vecchiarelli, A., C. Monari, F. Baldelli, D. Pietrella, C. Retini, C. Tascini, D. Francisci, and F. Bistoni. 1995. Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS. J. Infect. Dis. 171:1448-1454.
49. Voganatsi, A., A. Panyutich, K. T. Miyasaki, and R. K. Murthy. 2001. Mechanism of extracellular release of neutrophil calprotectin complex. J. Leukoc. Biol. 70:130-134.
50. Wenzel, R. P. 1995. Nosocomial candidiasis: risk factors and attributable mortality. Clin. Infect. Dis. 20:1531-1534.
51. Wohler Sunnarborg, S., S. P Miller, I. Unnikrishnan, and D. C. LaPorte. 2001. Expression of the yeast glycogen phosphorylase gene is regulated by stress-response dements and by the HOG MAP kinase pathway. Yeast 18:1505-1514.
52. Wright, C. D., J. U. Bowie, G. R. Gray, and R. D. Nelson. 1983. Candidacidal activity of myeloperoxidase: mechanisms of inhibitory influence of soluble cell wall mannan. Infect. Immun. 42:76-80.
53. Wysong, D. R., C. A. Lyman, and R. D. Diamond. 1989. Independence of neutrophil respiratory burst oxidant generation from the early cytosolic calcium response after stimulation with unopsonized Candida albicans hyphae. Infect. Immun. 57:1499-1505.
54. Yamada-Okabe, T., T. Mio, T. Ono, Y. Kashima, M. Arisawa, and Y. Yamada-Okabe. 1999. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus, Candida albicans. J. Bacteriol. 181:7243-7247.