Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the ATPase cycle

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10328-10333

  Richter, Klaus ^a   Muschler, Paul ^a   Hainzl, Otmar ^a   Reinstein, Jochen ^b   Buchner, Johannes ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERS; HORMONES; HYDROLYSIS; MOLECULAR BIOLOGY; PROTEINS;

HORMONE RECEPTORS;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATASE; CHAPERONE; HEAT SHOCK PROTEIN 90; HORMONE RECEPTOR; STEROID RECEPTOR; FUNGAL PROTEIN; POTASSIUM CHLORIDE; SACCHAROMYCES CEREVISIAE PROTEIN; STRESS INDUCIBLE PROTEIN 1, FUNGAL; STRESS-INDUCIBLE PROTEIN 1, FUNGAL;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DIMERIZATION; ENZYME ACTIVITY; ENZYME METABOLISM; HYDROLYSIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY;

ANIMALIA; HUMULUS; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; DIMERIZATION; FUNGAL PROTEINS; HSP90 HEAT-SHOCK PROTEINS; POTASSIUM CHLORIDE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0037518202     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M213094200     Document Type: Article

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