The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the hi-terminal domains

EMBO Journal

Volumn 19, Issue 16, 2000, Pages 4383-4392

  Prodromou, Chrisostomos ^a   Panaretou, Barry ^a,b   Chohan, Shahzad ^c   Siligardi, Giuliano ^d   O'Brien, Ronan ^b   Ladbury, John E ^b   Roe, S Mark ^a   Piper, Peter W ^b   Pearl, Laurence H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Chaperone; Conformational switch; Cross linking; Mutational analysis

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 90; MUTANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; ENZYME ACTIVITY; MISSENSE MUTATION; PRIORITY JOURNAL; TEMPERATURE SENSITIVE MUTANT;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; BACTERIAL PROTEINS; CIRCULAR DICHROISM; CROSS-LINKING REAGENTS; DIMERIZATION; DNA GYRASE; DNA TOPOISOMERASES, TYPE II; ESCHERICHIA COLI PROTEINS; FUNGAL PROTEINS; HSP90 HEAT-SHOCK PROTEINS; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PHENOTYPE; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; TIME FACTORS;

EID: 0034663806     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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