Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

EMBO Journal

Volumn 21, Issue 1-2, 2002, Pages 12-21

  Hattendorf, Douglas A ^a,b   Lindquist, Susan L ^c,d  

^a Stanford University ^*  (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

AAA superfamily; ATP hydrolysis; Hsp 104; Sensor 1; PSI

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 104; MONOMER; MUTANT PROTEIN; NUCLEOTIDE; OLIGOMER; PROTEIN AAA; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; ASSAY; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; HEAT TOLERANCE; HYDROLYSIS; IN VITRO STUDY; MUTATION; NONHUMAN; PHENOTYPE; PRION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; STEADY STATE; YEAST;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; DNA, FUNGAL; HEAT-SHOCK PROTEINS; HYDROLYSIS; KINETICS; MUTATION; OSMOLAR CONCENTRATION; PHENOTYPE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMATION, GENETIC;

EID: 0037080611     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.1.12     Document Type: Article

References (60)

1. Roles of homooligomerization and membrane association in ATPase and proteolytic activities of FtsH in vitro
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Review: Mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones
4. +]
5. Evidence for a protein mutator in yeast: Role of the Hsp70-related chaperone ssb in formation, stability and toxicity of the [PSI] prion
6. The psi factor of yeast: A problem in inheritance
7. Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae
8. Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery
9. +] prion by guanidine hydrochloride is the result of Hsp104 inactivation
10. Hsp104, Hsp70 and Hsp40: A novel chaperone system that rescues previously aggregated proteins
11. Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network
12. Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP
13. Review: Allostery in chaperonins
14. Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP
15. Translocation pathway of protein substrates in ClpAP protease
16. Mutational analysis of the functional motifs of RuvB, an AAA+ class helicase and motor protein for Holliday junction branch migration
17. Crystal structure of the processivity clamp loader gamma (γ) complex of E. coli DNA polymerase III
18. +] as a cellular stress
19. Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH
20. Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis
21. Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26S proteasome
22. Mutational analysis of the two ATP-binding sites in ClpB, a heat shock protein with protein-activated ATPase activity in Escherichia coli
23. Heptameric ring structure of the heat-shock protein ClpB, a protein-activated ATPase in Escherichia coli
24. Dynamics of substrate denaturation and translocation by the ClpXP degradation machine
25. Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein
26. Ras-catalyzed hydrolysis of GTP: A new perspective from model studies
27. Unraveling the mechanism of the vesicle transport ATPase NSF, the N-ethylmaleimide-sensitive factor
28. Identification of thermolabile Escherichia coli proteins: Prevention and reversion of aggregation by DnaK and ClpB
29. [URE3] prion propagation in Saccharomyces cerevisiae: Requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydjlp
30. AAA+: A class of chaperone-like ATPases associated with the assembly, operation and disassembly of protein complexes
31. Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing
32. AAA+ superfamily ATPases: Common structure-diverse function
33. Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP
34. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: Implications for the mechanism of GTP hydrolysis
35. Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes
36. Protein disaggregation mediated by heat-shock protein Hsp104
37. Support for the prion hypothesis for inheritance of a phenotypic trait in yeast
38. +] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor
39. Structure and mechanism of the ruvb Holliday junction branch migration motor
40. Structural bioenergetics and energy transduction mechanisms
41. Targeting, disruption, replacement and allele rescue: Integrative DNA transformation in yeast
42. HSP104 required for induced thermotolerance
43. Hsp104 is required for tolerance to many forms of stress
44. The ATPase activity of Hsp104, effects of environmental conditions and mutations
45. Subunit interactions influence the biochemical and biological properties of Hspl04
46. The chaperone function of ClpB from Thermus thermophilus depends on allosteric interactions of its two ATP-binding sites
47. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
48. Mutational analysis demonstrates different functional roles for the two ATP-binding sites in ClpAP protease from Escherichia coli
49. Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP
50. Rnql: An epigenetic modifier of protein function in yeast
51. +] prion
52. Crystal and solution structures of an HsIUV protease-chaperone complex
53. A screen for dominant negative mutants of SEC18 reveals a role for the AAA protein consensus sequence in ATP hydrolysis
54. DNA replication-coupled inactivation of DnaA protein in vitro: A role for DnaA arginine-334 of the AAA+ Box VIII motif in ATP hydrolysis
55. AAA proteins. Lords of the ring
56. Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
57. Mechanism of prion loss after Hsp104 inactivation in yeast
58. Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP
59. ClpB cooperates with DnaK, DnaJ and GrpE in suppressing protein aggregation. A novel multi-chaperone system from Escherichia coli