Autoimmunity can benefit self-maintenance

Immunology Today

Volumn 21, Issue 6, 2000, Pages 265-268

  Schwartz, Michal ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DISEASE RESISTANCE; IMMUNE RESPONSE; IMMUNITY; INFLAMMATION; MACROPHAGE; MOUSE; NERVE FIBER DEGENERATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; T LYMPHOCYTE; TISSUE INJURY; WOUND HEALING;

EID: 0034112239     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01633-9     Document Type: Note

References (46)

1. Moalem G.et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5:1999;49-55.
2. Hauben E.et al. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet. 355:2000;286-287.
3. Schwartz M.et al. Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci. 22:1999;295-299.
4. Cohen I.R., Schwartz M. Autoimmune maintenance and neuroprotection of the central nervous system. J. Neuroimmunol. 100:1999;111-114.
5. Cohen I.R. The cognitive principle challenges clonal selection. Immunol. Today. 13:1992;441-444.
6. Cohen I.R. Tending Adam's Garden: Evolving the Cognitive Immune Self. 2000;Academic Press.
7. Cohen I.R. Discrimination and dialogue in the immune system. Semin. Immol. 2000;. (in press).
8. Rapalino O.et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4:1998;814-821.
9. Schwartz M., Lazarov-Spiegler O. The role of immune system in central nervous system recovery. an evolutionary perspective Curr. Top. Neurochem. 1:1998;123-132.
10. Lazarov-Spiegler O.et al. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J. 10:1996;1296-1302.
11. Lazarov-Spiegler O.et al. Restricted inflammatory reaction in the CNS. A key impediment to axonal regeneration Mol. Med. Today. 4:1998;337-342.
12. Schwartz M.et al. Potential treatment modalities for glaucomatous neuropathy. neuroprotection and neuroregeneration J. Glaucoma. 5:1996;427-432.
13. Burnet M. Self and Not-Self. 1959;Cambridge University Press.
14. Yoles E., Schwartz M. Degeneration of spared axons following partial white matter lesion. implications for optic nerve neuropathies Exp. Neurol. 153:1998;1-7.
15. McIntosh T.K. Novel pharmacologic therapies in the treatment of experimental traumatic brain injury. a review J. Neurotrauma. 10:1993;215-261.
16. Lynch D.R., Dawson T.M. Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7:1994;510-516.
17. Faden A.I., Salzman S. Pharmacological strategies in CNS trauma. Trends. Pharmacol. Sci. 13:1992;29-35.
18. Hovda D.A.et al. Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat. a cytochrome oxidase histochemistry study Brain Res. 567:1991;1-10.
19. Bazan N.G.et al. Mediators of injury in neurotrauma. intracellular signal transduction and gene expression J. Neurotrauma. 12:1995;791-814.
20. Eitan S.et al. Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science. 264:1994;1764-1768.
21. Yoles E.et al. Alpha-2-adrenoreceptor agonists are neuroprotective in an experimental model of optic nerve degeneration in the rat. Invest. Ophthalmol. Vis. Sci. 40:1999;65-73.
22. Elias D.et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. U. S. A. 88:1991;3088-3091.
23. Mor F., Cohen I.R. Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 90:1992;2447-2455.
24. Hickey W.F.et al. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:1991;254-260.
25. Hirschberg D.L.et al. Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma. Neuroimmunol. 89:1998;88-96.
26. Moalem G.et al. Differential T cell response in central and peripheral nerve injury. connection to immune privilege FASEB J. 13:1999;1207-1217.
27. Moalem G.et al. Autoimmune T cells retard the loss of function in injured rat optic nerves. J. Neuroimmunol. 2000;. (in press).
28. Fisher J.et al. Active immunization with nonencephalitogenic myelin-associated peptides slows-down degeneration of retinal ganglion cells in severely injured optic nerves of mice. Society for Neurosci. 25:1999;1775.
29. Santambrogio L.et al. Nerve growth factor production by lymphocytes. J. Immunol. 153:1994;4488-4495.
30. Ehrhard P.B.et al. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10984-10988.
31. Kerschensteiner M.et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J. Exp. Med. 189:1999;865-870.
32. Yarom Y.et al. Immunospecific inhibition of nerve conduction by T lymphocytes reactive to basic protein of myelin. Nature. 303:1983;246-247.
33. Popovich P.G.et al. Concept of autoimmunity following spinal cord injury. possible roles for T lymphocytes in the traumatized central nervous system J. Neurosci. Res. 45:1996;349-363.
34. Streilein J.W. Unraveling immune privilege. Science. 270:1995;1158-1159.
35. Barker C.F., Billingham R.E. Immunologically privileged sites. Adv. Immunol. 25:1977;1-54.
36. Lotan M., Schwartz M. Cross talk between the immune system and the nervous system in response to injury. Implications for regeneration FASEB J. 8:1994;1026-1033.
37. Schwartz M.et al. Central nervous system regeneration and the immune system. Mol. Med. Today. 1:1995;60-61.
38. Avrameas S. Natural autoantibodies. from 'horror autotoxicus' to 'gnothi seauton' Immunol. Today. 12:1991;154-159.
39. Cohen I.R., Young D.B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol. Today. 12:1991;105-110.
40. Cohen I.R. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:1992;490-494.
41. Haury M.et al. The repertoire of serum IgM in normal mice is largely independent of external antigenic contact. Eur. J. Immunol. 27:1997;1557-1563.
42. Lacroix-Desmazes S.et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods. 216:1998;117-137.
43. Birk O.et al. The 60-kDa heat shock protein modulates allograft rejection. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5159-5163.
44. Konen-Waisman S.et al. Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection. J. Infect. Dis. 179:1999;403-413.
45. Atlan H., Cohen I.R. Immune information, self-organization and meaning. Int. Immunol. 10:1998;711-717.
46. Schwartz M. Autoimmune involvement in CNS trauma is beneficial if well controlled. Progress in Brain Res. 2000;. (in press).