메뉴 건너뛰기




Volumn 21, Issue 6, 1998, Pages 1243-1257

Hedgehog and patched in neural development and disease

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA; GENE TARGETING; GENETIC TRANSCRIPTION; HEDGEHOG; NERVE GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0032409157     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80645-5     Document Type: Review
Times cited : (218)

References (210)
  • 2
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., and Hooper, J.E. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 3
    • 0029858774 scopus 로고    scopus 로고
    • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
    • Alexandre, C., Jacinto, A., and Ingham, P.W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013.
    • (1996) Genes Dev. , vol.10 , pp. 2003-2013
    • Alexandre, C.1    Jacinto, A.2    Ingham, P.W.3
  • 4
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc, P., Ramirez-Weber, F.A., Laget, M.P., Schwartz, C., and Kornberg, T.B. (1997). Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3    Schwartz, C.4    Kornberg, T.B.5
  • 5
    • 0029075802 scopus 로고
    • Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain
    • Barth, K.A., and Wilson, S.W. (1995). Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development 121, 1755-1768.
    • (1995) Development , vol.121 , pp. 1755-1768
    • Barth, K.A.1    Wilson, S.W.2
  • 6
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler, K., and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 7
    • 0027386246 scopus 로고
    • Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
    • Bejsovec, A., and Wieschaus, E. (1993). Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119, 501-517.
    • (1993) Development , vol.119 , pp. 501-517
    • Bejsovec, A.1    Wieschaus, E.2
  • 9
    • 0029793645 scopus 로고    scopus 로고
    • The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis
    • Bhat, K.M. (1996). The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis. Development 122, 2921-2932.
    • (1996) Development , vol.122 , pp. 2921-2932
    • Bhat, K.M.1
  • 10
    • 0030949261 scopus 로고    scopus 로고
    • Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis
    • Bhat, K.M., and Schedl, P. (1997). Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development 124, 1675-1688.
    • (1997) Development , vol.124 , pp. 1675-1688
    • Bhat, K.M.1    Schedl, P.2
  • 11
    • 0030111258 scopus 로고    scopus 로고
    • Seitoli cell signaling by Desert hedgehog regulates the male germllne
    • Bitgood, M.J., Shen, L., and McMahon, A.P. (1996). Seitoli cell signaling by Desert hedgehog regulates the male germllne. Curr. Biol. 6, 298-304.
    • (1996) Curr. Biol. , vol.6 , pp. 298-304
    • Bitgood, M.J.1    Shen, L.2    McMahon, A.P.3
  • 12
    • 1842314819 scopus 로고
    • Type-C Niemann-Pick disease: Low density lipoproteln uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes
    • Blanchette-Mackle, E.J., Dwyer, N.K., Amende, L.M., Kruth, H.S., Butler, J.D., Sokol, J., Comly, M.E., Vanler, M.T., August, J.T., Brady, R.O., et al. (1988). Type-C Niemann-Pick disease: low density lipoproteln uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes. Proc. Natl. Acad. Sci. USA 85, 8022-8026.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8022-8026
    • Blanchette-Mackle, E.J.1    Dwyer, N.K.2    Amende, L.M.3    Kruth, H.S.4    Butler, J.D.5    Sokol, J.6    Comly, M.E.7    Vanler, M.T.8    August, J.T.9    Brady, R.O.10
  • 13
    • 15844390388 scopus 로고    scopus 로고
    • The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila
    • Bokor, P., and DiNardo, S. (1996). The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila. Development 122, 1083-1092.
    • (1996) Development , vol.122 , pp. 1083-1092
    • Bokor, P.1    DiNardo, S.2
  • 15
    • 0028966517 scopus 로고
    • Proteolytic processing yields two secreted forms of Sonic hedgehog
    • Bumcrot, D.A., Takada, R. and McMahon, A.P. (1995). Proteolytic processing yields two secreted forms of Sonic hedgehog. Mol. Cell. Biol. 15, 2294-2303.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2294-2303
    • Bumcrot, D.A.1    Takada, R.2    McMahon, A.P.3
  • 16
    • 0031964117 scopus 로고    scopus 로고
    • Expression profile of Gli family members and Shh in normal and mutant mouse limb development
    • Buscher, D., and Ruther, U. (1998). Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev. Dyn. 211, 88-96.
    • (1998) Dev. Dyn. , vol.211 , pp. 88-96
    • Buscher, D.1    Ruther, U.2
  • 17
    • 0040976312 scopus 로고    scopus 로고
    • Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
    • Buscher, D., Bosse, B., Heymer, J., and Ruther, U. (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62, 175-182.
    • (1997) Mech. Dev. , vol.62 , pp. 175-182
    • Buscher, D.1    Bosse, B.2    Heymer, J.3    Ruther, U.4
  • 18
    • 0027983638 scopus 로고
    • Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
    • Capdevila, J., and Guerrero, I. (1994). Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
    • (1994) EMBO J. , vol.13 , pp. 4459-4468
    • Capdevila, J.1    Guerrero, I.2
  • 19
    • 0028208698 scopus 로고
    • Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
    • Capdevila, J., Pariente, F., Sampedro, J., Alonso, J.L., and Guerrero, I. (1994a). Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development 120, 987-998.
    • (1994) Development , vol.120 , pp. 987-998
    • Capdevila, J.1    Pariente, F.2    Sampedro, J.3    Alonso, J.L.4    Guerrero, I.5
  • 20
    • 0028032065 scopus 로고
    • The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
    • Capdevila, J., Estrada, M.P., Sánchez-Herrero, E., and Guerrero, I. (1994b). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J. 13, 71-82.
    • (1994) EMBO J. , vol.13 , pp. 71-82
    • Capdevila, J.1    Estrada, M.P.2    Sánchez-Herrero, E.3    Guerrero, I.4
  • 22
    • 0029791915 scopus 로고    scopus 로고
    • A spinal cord fate map in the avian embryo: While regressing, Hensen's node lays down the notochord and floor plate, thus joining the spinal cord lateral walls
    • Catala, M., Teillet, M.A., Robertis, E.M.D., and Douarin, N.L.L. (1996). A spinal cord fate map in the avian embryo: while regressing, Hensen's node lays down the notochord and floor plate, thus joining the spinal cord lateral walls. Development 122, 2599-2610.
    • (1996) Development , vol.122 , pp. 2599-2610
    • Catala, M.1    Teillet, M.A.2    Robertis, E.M.D.3    Douarin, N.L.L.4
  • 23
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen, Y., and Struhl, G. (1996). Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 24
    • 0032478107 scopus 로고    scopus 로고
    • Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
    • Chen, Y., Gallaher, N., Goodman, R.H., and Smolik, S.M. (1998). Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-2354.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2349-2354
    • Chen, Y.1    Gallaher, N.2    Goodman, R.H.3    Smolik, S.M.4
  • 25
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • Chiang, C., Litingtung, Y., Lee, E., Young, K.E., Corden, J.L., Westphal, H., and Beachy, P.A. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6    Beachy, P.A.7
  • 27
    • 0029791854 scopus 로고    scopus 로고
    • Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning
    • Concordet, J.-P., Lewis, K.E., Moore, J.W., Goodrich, L.V., Johnson, R.L., Scott, M.P., and Ingham, P.W. (1996). Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122, 2835-2846.
    • (1996) Development , vol.122 , pp. 2835-2846
    • Concordet, J.-P.1    Lewis, K.E.2    Moore, J.W.3    Goodrich, L.V.4    Johnson, R.L.5    Scott, M.P.6    Ingham, P.W.7
  • 28
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper, M.K., Porter, J.A., Young, K.E., and Beachy, P.A. (1998). Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280, 1603-1607.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 29
    • 0027155888 scopus 로고
    • Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: A cytochemical freeze-fracture study
    • Coxey, R.A., Pentchev, P.G., Campbell, G., and Blanchette-Mackie, E.J. (1993). Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study. J. Lipid Res. 34, 1165-1176.
    • (1993) J. Lipid Res. , vol.34 , pp. 1165-1176
    • Coxey, R.A.1    Pentchev, P.G.2    Campbell, G.3    Blanchette-Mackie, E.J.4
  • 30
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signaling pathway in skin tumours
    • Dahmane, N., Lee, J., Robins, P., Heller, P., and Ruiz i Altaba, A. (1997). Activation of the transcription factor Gli1 and the Sonic hedgehog signaling pathway in skin tumours. Nature 389, 876-881.
    • (1997) Nature , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3    Heller, P.4    Ruiz I Altaba, A.5
  • 31
    • 0030840943 scopus 로고    scopus 로고
    • Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
    • Dale, J.K., Vesque, C., Lints, T.J., Sampath, T.K., Furley, A., Dodd, J., and Placzek, M. (1997). Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell 90, 257-269.
    • (1997) Cell , vol.90 , pp. 257-269
    • Dale, J.K.1    Vesque, C.2    Lints, T.J.3    Sampath, T.K.4    Furley, A.5    Dodd, J.6    Placzek, M.7
  • 32
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • in press
    • Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J., and Hui, C.-C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development, in press.
    • (1998) Development
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.-C.7
  • 33
    • 0029930495 scopus 로고    scopus 로고
    • Neurogenesis in the insect central nervous system
    • Doe, C.Q., and Skeath, J.B. (1996). Neurogenesis in the insect central nervous system. Curr. Opin. Neurobiol. 6, 18-24.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , pp. 18-24
    • Doe, C.Q.1    Skeath, J.B.2
  • 34
    • 0029896212 scopus 로고    scopus 로고
    • Sending and receiving the hedgehog signal: Control by the Drosophila gli protein Cubitus interruptus
    • Domínguez, M., Brunner, M., Hafen, E., and Basler, K. (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.
    • (1996) Science , vol.272 , pp. 1621-1625
    • Domínguez, M.1    Brunner, M.2    Hafen, E.3    Basler, K.4
  • 35
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative secreted signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard, Y., Epstein, D.J., St.-Jacques, B., Shen, L., Mohler, J., McMahon, J.A., and McMahon, A.P. (1993). Sonic hedgehog, a member of a family of putative secreted signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St.-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 37
    • 0030888522 scopus 로고    scopus 로고
    • Oroshigane, a new segment polarity gene of Drosophila melanogaster, functions in hedgehog signal transduction
    • Epps, J.L., Jones, J.B., and Tanda, S. (1997). oroshigane, a new segment polarity gene of Drosophila melanogaster, functions in hedgehog signal transduction. Genetics 145, 1041-1052.
    • (1997) Genetics , vol.145 , pp. 1041-1052
    • Epps, J.L.1    Jones, J.B.2    Tanda, S.3
  • 38
    • 0029821890 scopus 로고    scopus 로고
    • Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    • Epstein, D.J., Martí, E., Scott, M.P., and McMahon, A.P. (1996). Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-2894.
    • (1996) Development , vol.122 , pp. 2885-2894
    • Epstein, D.J.1    Martí, E.2    Scott, M.P.3    McMahon, A.P.4
  • 39
    • 0029068123 scopus 로고
    • Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
    • Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T.M., and Edlund, T. (1995). Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.
    • (1995) Cell , vol.81 , pp. 747-756
    • Ericson, J.1    Muhr, J.2    Placzek, M.3    Lints, T.4    Jessell, T.M.5    Edlund, T.6
  • 40
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity
    • Ericson, J., Morton, S., Kawakami, A., Roelink, H., and Jessell, T.M. (1996). Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.
    • (1996) Cell , vol.87 , pp. 661-673
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 44
    • 0028630689 scopus 로고
    • Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
    • Fan, C., and Tessier-Lavigne, M. (1994). Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79, 1175-1186.
    • (1994) Cell , vol.79 , pp. 1175-1186
    • Fan, C.1    Tessier-Lavigne, M.2
  • 45
    • 0029041177 scopus 로고
    • Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
    • Fan, C.M., Porter, J.A., Chiang, C., Chang, D.T., Beachy, P.A., and Tessier-Lavigne, M. (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81, 457-465.
    • (1995) Cell , vol.81 , pp. 457-465
    • Fan, C.M.1    Porter, J.A.2    Chiang, C.3    Chang, D.T.4    Beachy, P.A.5    Tessier-Lavigne, M.6
  • 46
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
    • Fan, H., Oro, A.E., Scott, M.P., and Khavari, P.A. (1997). Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat. Med. 3, 788-792.
    • (1997) Nat. Med. , vol.3 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3    Khavari, P.A.4
  • 47
    • 0028341745 scopus 로고
    • Holoprosencephaly and septo-optic dysplasia
    • Fitz, C.R. (1994). Holoprosencephaly and septo-optic dysplasia. Neuroimaging Clin. N. Am. 4, 263-281.
    • (1994) Neuroimaging Clin. N. Am. , vol.4 , pp. 263-281
    • Fitz, C.R.1
  • 50
    • 0031573882 scopus 로고    scopus 로고
    • Novel segment polarity gene interactions during embryonic head development in Drosophila
    • Gallitano-Mendel, A., and Finkelstein, R. (1997). Novel segment polarity gene interactions during embryonic head development in Drosophila. Dev. Biol. 192, 599-613.
    • (1997) Dev. Biol. , vol.192 , pp. 599-613
    • Gallitano-Mendel, A.1    Finkelstein, R.2
  • 52
    • 0027132479 scopus 로고
    • With apologies to Scheherazade: Tails of 1001 kinesin motors
    • Goldstein, L.S. (1993). With apologies to Scheherazade: tails of 1001 kinesin motors. Annu. Rev. Genet. 27, 319-351.
    • (1993) Annu. Rev. Genet. , vol.27 , pp. 319-351
    • Goldstein, L.S.1
  • 53
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by hedgehog
    • Goodrich, L.V., Johnson, R.L., Milenkovic, L., McMahon, J., and Scott, M.P. (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by hedgehog. Genes Dev. 10, 301-312.
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.4    Scott, M.P.5
  • 54
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich, L.V., Milenkovic, L., Higgins, K.M., and Scott, M.P. (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 55
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin, R.J. (1987). Nevoid basal-cell carcinoma syndrome. Medicine 66, 98-109.
    • (1987) Medicine , vol.66 , pp. 98-109
    • Gorlin, R.J.1
  • 58
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn, H., Wajnowski, L., Zimmer, A.M., Hall, J., Miller, G., and Zimmer, A. (1998). Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat. Med. 4, 619-622.
    • (1998) Nat. Med. , vol.4 , pp. 619-622
    • Hahn, H.1    Wajnowski, L.2    Zimmer, A.M.3    Hall, J.4    Miller, G.5    Zimmer, A.6
  • 59
    • 0028841677 scopus 로고
    • A potential catalytic site revealed by the 1.7 Å crystal structure of the amino-terminal signaling domain of Sonic hedgehog
    • Hall, T.M.T., Porter, J.A., Beachy, P.A., and Leahy, D.J. (1995). A potential catalytic site revealed by the 1.7 Å crystal structure of the amino-terminal signaling domain of Sonic hedgehog. Nature 378, 212-216.
    • (1995) Nature , vol.378 , pp. 212-216
    • Hall, T.M.T.1    Porter, J.A.2    Beachy, P.A.3    Leahy, D.J.4
  • 60
    • 0342813091 scopus 로고    scopus 로고
    • Crystal structure of a hedgehog autoprocessing domain: Homology between hedgehog and self-splicing proteins
    • Hall, T.M., Porter, J.A., Young, K.E., Koonin, E.V., Beachy, P.A., and Leahy, D.J. (1997). Crystal structure of a hedgehog autoprocessing domain: homology between hedgehog and self-splicing proteins. Cell 91, 85-97.
    • (1997) Cell , vol.91 , pp. 85-97
    • Hall, T.M.1    Porter, J.A.2    Young, K.E.3    Koonin, E.V.4    Beachy, P.A.5    Leahy, D.J.6
  • 61
    • 0027423420 scopus 로고
    • Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
    • Halpern, M.E., Ho, R.K., Walker, C., and Kimmel, C.B. (1993). Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell 75, 99-111.
    • (1993) Cell , vol.75 , pp. 99-111
    • Halpern, M.E.1    Ho, R.K.2    Walker, C.3    Kimmel, C.B.4
  • 62
    • 0029879687 scopus 로고    scopus 로고
    • Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
    • Hammerschmidt, M., Bitgood, M.J., and McMahon, A.P. (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev. 10, 647-658.
    • (1996) Genes Dev. , vol.10 , pp. 647-658
    • Hammerschmidt, M.1    Bitgood, M.J.2    McMahon, A.P.3
  • 63
    • 0028956797 scopus 로고
    • Mechanisms of neural patterning and specification in the developing cerebellum
    • Hatten, M.E., and Heintz, N. (1995). Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci. 18, 385-408.
    • (1995) Annu. Rev. Neurosci. , vol.18 , pp. 385-408
    • Hatten, M.E.1    Heintz, N.2
  • 64
    • 0027788042 scopus 로고
    • The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
    • Heberlein, U., Wolff, T., and Rubin, G.M. (1993). The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell 75, 913-926.
    • (1993) Cell , vol.75 , pp. 913-926
    • Heberlein, U.1    Wolff, T.2    Rubin, G.M.3
  • 65
    • 0028910516 scopus 로고
    • Growth and differentation in the Drosophila eye coordinated by hedgehog
    • Heberlein, U., Singh, C.M., Luk, A.Y., and Donohoe, T.J. (1995). Growth and differentation in the Drosophila eye coordinated by hedgehog. Nature 373, 709-711.
    • (1995) Nature , vol.373 , pp. 709-711
    • Heberlein, U.1    Singh, C.M.2    Luk, A.Y.3    Donohoe, T.J.4
  • 66
    • 0028008784 scopus 로고
    • Drosophila hedgehog acts as a morphogen in cellular patterning
    • Heemskerk, J., and DiNardo, S. (1994). Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76, 449-460.
    • (1994) Cell , vol.76 , pp. 449-460
    • Heemskerk, J.1    DiNardo, S.2
  • 67
    • 0031040287 scopus 로고    scopus 로고
    • Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
    • Hepker, J., Wang, Q.T., Motzny, C.Z., Holmgren, R., and Orenic, T.V. (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.
    • (1997) Development , vol.124 , pp. 549-558
    • Hepker, J.1    Wang, Q.T.2    Motzny, C.Z.3    Holmgren, R.4    Orenic, T.V.5
  • 68
    • 0025072659 scopus 로고
    • Cell patterning in the Drosophila segment: Spatial regulation of the segment polarity gene patched
    • Hidalgo, A., and Ingham, P.W. (1990). Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development 110, 291-301.
    • (1990) Development , vol.110 , pp. 291-301
    • Hidalgo, A.1    Ingham, P.W.2
  • 69
    • 0028077841 scopus 로고
    • Distinct pathways for autocrine and paracrine Wingless signaling in Drosophila embryos
    • Hooper, J.E. (1994). Distinct pathways for autocrine and paracrine Wingless signaling in Drosophila embryos. Nature 372, 461-464.
    • (1994) Nature , vol.372 , pp. 461-464
    • Hooper, J.E.1
  • 70
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper, J.E., and Scott, M.P. (1989). The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 71
    • 0030298339 scopus 로고    scopus 로고
    • Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
    • Hua, X., Nohturfft, A., Goldstein, J.L., and Brown, M.S. (1996). Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 87, 415-426.
    • (1996) Cell , vol.87 , pp. 415-426
    • Hua, X.1    Nohturfft, A.2    Goldstein, J.L.3    Brown, M.S.4
  • 72
    • 0028281306 scopus 로고
    • Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
    • Hui, C.-C, Slusarski, D., Platt, K.A., Holmgren, R., and Joyner, A.L. (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162, 402-413.
    • (1994) Dev. Biol. , vol.162 , pp. 402-413
    • Hui, C.-C.1    Slusarski, D.2    Platt, K.A.3    Holmgren, R.4    Joyner, A.L.5
  • 74
    • 0028833793 scopus 로고
    • Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons
    • Hynes, M., Poulsen, K., Tessier-Lavigne, M., and Rosenthal, A. (1995b). Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell 80, 95-101.
    • (1995) Cell , vol.80 , pp. 95-101
    • Hynes, M.1    Poulsen, K.2    Tessier-Lavigne, M.3    Rosenthal, A.4
  • 75
    • 0030795109 scopus 로고    scopus 로고
    • Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene gli-1
    • Hynes, M., Stone, D.M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A., and Rosenthal, A. (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene gli-1. Neuron 19, 15-26.
    • (1997) Neuron , vol.19 , pp. 15-26
    • Hynes, M.1    Stone, D.M.2    Dowd, M.3    Pitts-Meek, S.4    Goddard, A.5    Gurney, A.6    Rosenthal, A.7
  • 76
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
    • Incardona, J.P., Gaffield, W., Kapur, R.P., and Roelink, H. (1998). The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction. Development 125, 3553-3562.
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3    Roelink, H.4
  • 77
    • 0027761917 scopus 로고
    • Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
    • Ingham, P.W. (1993). Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560-562.
    • (1993) Nature , vol.366 , pp. 560-562
    • Ingham, P.W.1
  • 78
    • 0029278749 scopus 로고
    • Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
    • Ingham, P.W., and Fietz, M.J. (1995). Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr. Biol. 5, 432-440.
    • (1995) Curr. Biol. , vol.5 , pp. 432-440
    • Ingham, P.W.1    Fietz, M.J.2
  • 79
    • 0027408032 scopus 로고
    • Regulation of wingless transcription in the Drosophila embryo
    • Ingham, P.W., and Hidalgo, A. (1993). Regulation of wingless transcription in the Drosophila embryo. Development 117, 283-291.
    • (1993) Development , vol.117 , pp. 283-291
    • Ingham, P.W.1    Hidalgo, A.2
  • 80
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signaling
    • Ingham, P.W., Taylor, A.M., and Nakano, Y. (1991). Role of the Drosophila patched gene in positional signaling. Nature 353, 184-187.
    • (1991) Nature , vol.353 , pp. 184-187
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 81
    • 0031046842 scopus 로고    scopus 로고
    • Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
    • Jensen, A.M., and Wallace, V.A. (1997). Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development 124, 363-371.
    • (1997) Development , vol.124 , pp. 363-371
    • Jensen, A.M.1    Wallace, V.A.2
  • 82
    • 0028918468 scopus 로고
    • Protein kinase A and hedgehog signaling in Drosophila limb development
    • Jiang, J., and Struhl, G. (1995). Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
    • (1995) Cell , vol.80 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 83
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang, J., and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 85
    • 0029417009 scopus 로고
    • Patched overexpression alters wing disc size and pattern: Transcriptional and posttranscriptional effects on hedgehog targets
    • Johnson, R.L., Grenier, J.K., and Scott, M.P. (1995). patched overexpression alters wing disc size and pattern: transcriptional and posttranscriptional effects on hedgehog targets. Development 121, 4161-4170.
    • (1995) Development , vol.121 , pp. 4161-4170
    • Johnson, R.L.1    Grenier, J.K.2    Scott, M.P.3
  • 88
    • 0014786872 scopus 로고
    • Teratogenic compounds in Veratrum californicum (Durand)
    • Keeler, R.F. (1970). Teratogenic compounds in Veratrum californicum (Durand). Teratology 3, 169-174.
    • (1970) Teratology , vol.3 , pp. 169-174
    • Keeler, R.F.1
  • 89
    • 0016693302 scopus 로고
    • Teratogenic effects of cyclopamine and jervine in rats, mice and hamsters
    • Keeler, R.F. (1975). Teratogenic effects of cyclopamine and jervine in rats, mice and hamsters. Proc. Soc. Exp. Biol. Med. 149, 302-306.
    • (1975) Proc. Soc. Exp. Biol. Med. , vol.149 , pp. 302-306
    • Keeler, R.F.1
  • 92
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • Kinzler, K.W., Ruppert, J.M., Bigner, S.H., and Vogelstein, B. (1988). The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332, 371-374.
    • (1988) Nature , vol.332 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 93
    • 0030664545 scopus 로고    scopus 로고
    • Cholesterol biosynthesis inhibited by BM15.766 induces holoprosencephaly in the rat
    • Kolf-Clauw, M., Chevy, F., Siliart, B., Wolf, C., Mulliez, N., and Roux, C. (1997). Cholesterol biosynthesis inhibited by BM15.766 induces holoprosencephaly in the rat. Teratology 56, 188-200.
    • (1997) Teratology , vol.56 , pp. 188-200
    • Kolf-Clauw, M.1    Chevy, F.2    Siliart, B.3    Wolf, C.4    Mulliez, N.5    Roux, C.6
  • 95
    • 0027749249 scopus 로고
    • A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    • Krauss, S., Concordet, J.-P., and Ingham, P.W. (1993). A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444.
    • (1993) Cell , vol.75 , pp. 1431-1444
    • Krauss, S.1    Concordet, J.-P.2    Ingham, P.W.3
  • 96
    • 0031436999 scopus 로고    scopus 로고
    • Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase
    • Krishnan, V., Pereira, F.A., Qiu, Y., Chen, C.H., Beachy, P.A., Tsai, S.Y., and Tsai, M.J. (1997). Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278, 1947-1950.
    • (1997) Science , vol.278 , pp. 1947-1950
    • Krishnan, V.1    Pereira, F.A.2    Qiu, Y.3    Chen, C.H.4    Beachy, P.A.5    Tsai, S.Y.6    Tsai, M.J.7
  • 97
    • 0025553130 scopus 로고
    • Medulloblastoma in the nevoid basal-cell carcinoma syndrome: Case reports and review of the literature
    • Lacombe, D., Chateil, J.F., Fontan, D., and Battin, J. (1990). Medulloblastoma in the nevoid basal-cell carcinoma syndrome: case reports and review of the literature. Genet. Couns. 1, 273-277.
    • (1990) Genet. Couns. , vol.1 , pp. 273-277
    • Lacombe, D.1    Chateil, J.F.2    Fontan, D.3    Battin, J.4
  • 98
    • 0029028990 scopus 로고
    • Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
    • Lai, C.J., Ekker, S.C., Beachy, P.A., and Moon, R.T. (1995). Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. Development 121, 2349-2360.
    • (1995) Development , vol.121 , pp. 2349-2360
    • Lai, C.J.1    Ekker, S.C.2    Beachy, P.A.3    Moon, R.T.4
  • 99
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • Lee, J.J., von Kessler, D.P., Parks, S., and Beachy, P.A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.
    • (1992) Cell , vol.71 , pp. 33-50
    • Lee, J.J.1    Von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 101
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee, J., Platt, K.A., Censullo, P., and Ruiz i Altaba, A. (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz I Altaba, A.4
  • 102
    • 0028952718 scopus 로고
    • Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
    • Lepage, T., Cohen, S.M., Diaz-Benjumea, F.J., and Parkhurst, S.M. (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.
    • (1995) Nature , vol.373 , pp. 711-715
    • Lepage, T.1    Cohen, S.M.2    Diaz-Benjumea, F.J.3    Parkhurst, S.M.4
  • 103
    • 0031866079 scopus 로고    scopus 로고
    • Expression of wingless in the Drosophila embryo: A conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression
    • Lessing, D., and Nusse, R. (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125, 1469-1476.
    • (1998) Development , vol.125 , pp. 1469-1476
    • Lessing, D.1    Nusse, R.2
  • 104
    • 0030797144 scopus 로고    scopus 로고
    • Sonic hedgehog promotes rod photo-receptor differentiation in mammalian retinal cells in vitro
    • Levine, E.M., Roelink, H., Turner, J., and Reh, T.A. (1997). Sonic hedgehog promotes rod photo-receptor differentiation in mammalian retinal cells in vitro. J. Neurosci. 17, 6277-6288.
    • (1997) J. Neurosci. , vol.17 , pp. 6277-6288
    • Levine, E.M.1    Roelink, H.2    Turner, J.3    Reh, T.A.4
  • 105
    • 0028897883 scopus 로고
    • Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
    • Li, W., Ohlmeyer, J.T., Lane, M.E., and Kalderon, D. (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
    • (1995) Cell , vol.80 , pp. 553-562
    • Li, W.1    Ohlmeyer, J.T.2    Lane, M.E.3    Kalderon, D.4
  • 106
    • 0029162584 scopus 로고
    • Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
    • Liem, K., Jr., Tremml, G., Roelink, H., and Jessell, T.M. (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979.
    • (1995) Cell , vol.82 , pp. 969-979
    • Liem K., Jr.1    Tremml, G.2    Roelink, H.3    Jessell, T.M.4
  • 107
    • 0342684481 scopus 로고    scopus 로고
    • A role for the roof plate and its resident TGFβ- related proteins in neuronal patterning in the dorsal spinal cord
    • Liem, K.F., Tremml, G., and Jessell, T.M. (1997). A role for the roof plate and its resident TGFβ- related proteins in neuronal patterning in the dorsal spinal cord. Cell 91, 127-138.
    • (1997) Cell , vol.91 , pp. 127-138
    • Liem, K.F.1    Tremml, G.2    Jessell, T.M.3
  • 108
    • 0025872507 scopus 로고
    • Interactions between fused, a segment-polarity gene in Drosophila, and other segmentation genes
    • Limbourg-Bouchon, B., Bussen, D., and Lamour, I.C. (1991). Interactions between fused, a segment-polarity gene in Drosophila, and other segmentation genes. Development 112, 417-429.
    • (1991) Development , vol.112 , pp. 417-429
    • Limbourg-Bouchon, B.1    Bussen, D.2    Lamour, I.C.3
  • 109
    • 0023608155 scopus 로고
    • Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts
    • Liscum, L., and Faust, J.R. (1987). Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. J. Biol. Chem. 262, 17002-17008.
    • (1987) J. Biol. Chem. , vol.262 , pp. 17002-17008
    • Liscum, L.1    Faust, J.R.2
  • 111
    • 0029328583 scopus 로고
    • Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage
    • Lopez-Martinez, A., Chang, D.T., Chiang, C., Porter, J.A., Ros, M.A., Simandl, B.K., Beachy, P.A., and Fallon, J.F. (1995). Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage. Curr. Biol. 5, 791-796.
    • (1995) Curr. Biol. , vol.5 , pp. 791-796
    • Lopez-Martinez, A.1    Chang, D.T.2    Chiang, C.3    Porter, J.A.4    Ros, M.A.5    Simandl, B.K.6    Beachy, P.A.7    Fallon, J.F.8
  • 112
    • 0027741258 scopus 로고
    • The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
    • Ma, C., Zhou, Y., Beachy, P.A., and Moses, K. (1993). The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-938.
    • (1993) Cell , vol.75 , pp. 927-938
    • Ma, C.1    Zhou, Y.2    Beachy, P.A.3    Moses, K.4
  • 113
    • 0028864430 scopus 로고
    • Midline signaling is required for Pax gene regulation and patterning of the eyes
    • Macdonald, R., Barth, K.A., Xu, Q., Holder, N., Mikkola, I., and Wilson, S.W. (1995). Midline signaling is required for Pax gene regulation and patterning of the eyes. Development 121, 3267-3278.
    • (1995) Development , vol.121 , pp. 3267-3278
    • Macdonald, R.1    Barth, K.A.2    Xu, Q.3    Holder, N.4    Mikkola, I.5    Wilson, S.W.6
  • 114
    • 0029843937 scopus 로고    scopus 로고
    • Regulation of patched by sonic hedgehog in the developing neural tube
    • Marigo, V., and Tabin, C.J. (1996). Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. USA 93, 9346-9351.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9346-9351
    • Marigo, V.1    Tabin, C.J.2
  • 115
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo, V., Davey, R.A., Zuo, Y., Cunningham, J.M., and Tabin, C.J. (1996a). Biochemical evidence that patched is the Hedgehog receptor. Nature 384, 176-179.
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 116
    • 0030601955 scopus 로고    scopus 로고
    • Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    • Marigo, V., Johnson, R.L., Vortkamp, A., and Tabin, C.J. (1996b). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180, 273-283.
    • (1996) Dev. Biol. , vol.180 , pp. 273-283
    • Marigo, V.1    Johnson, R.L.2    Vortkamp, A.3    Tabin, C.J.4
  • 117
    • 0029975823 scopus 로고    scopus 로고
    • Conservation in hedgehog signaling: Sonic hedgehog controls the expression of a chicken patched homolog in the developing limb
    • Marigo, V., Scott, M.P., Johnson, R.L., Goodrich, L., and Tabin, C.J. (1996c). Conservation in hedgehog signaling: Sonic hedgehog controls the expression of a chicken patched homolog in the developing limb. Development 122, 1225-1233.
    • (1996) Development , vol.122 , pp. 1225-1233
    • Marigo, V.1    Scott, M.P.2    Johnson, R.L.3    Goodrich, L.4    Tabin, C.J.5
  • 118
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • Martí, E., Bumcrot, D.A., Takada, R., and McMahon, A.P. (1995a). Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.
    • (1995) Nature , vol.375 , pp. 322-325
    • Martí, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 119
    • 0029079893 scopus 로고
    • Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
    • Martí, E., Takada, R., Bumcrot, D.A., Sasaki, H., and McMahon, A.P. (1995b). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.
    • (1995) Development , vol.121 , pp. 2537-2547
    • Martí, E.1    Takada, R.2    Bumcrot, D.A.3    Sasaki, H.4    McMahon, A.P.5
  • 120
    • 0023895153 scopus 로고
    • Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
    • Martinez Arias, A., Baker, N.E., and Ingham, P.W. (1988). Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103, 157-170.
    • (1988) Development , vol.103 , pp. 157-170
    • Martinez Arias, A.1    Baker, N.E.2    Ingham, P.W.3
  • 121
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • in press
    • Matise, M.P., Epstein, D.J., Park, H.L., Platt, K.A., and Joyner, A.L. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development, in press.
    • (1998) Development
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 122
    • 0029905887 scopus 로고    scopus 로고
    • Hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNS
    • Matsuzaki, M., and Saigo, K. (1996). Hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNS. Development 122, 3567-3575.
    • (1996) Development , vol.122 , pp. 3567-3575
    • Matsuzaki, M.1    Saigo, K.2
  • 123
    • 0030793114 scopus 로고    scopus 로고
    • Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro
    • Miao, N., Wang, M., Ott, J.A., D'Alessandro, J.S., Woolf, T.M., Bumcrot, D.A., Mahanthappa, N.K., and Pang, K. (1997). Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro. J. Neurosci. 17, 5891-5899.
    • (1997) J. Neurosci. , vol.17 , pp. 5891-5899
    • Miao, N.1    Wang, M.2    Ott, J.A.3    D'Alessandro, J.S.4    Woolf, T.M.5    Bumcrot, D.A.6    Mahanthappa, N.K.7    Pang, K.8
  • 124
    • 0031944805 scopus 로고    scopus 로고
    • Holoprosencephaly: From Homer to Hedgehog
    • Ming, J.E., and Muenke, M. (1998). Holoprosencephaly: from Homer to Hedgehog. Clin. Genet. 53, 155-163.
    • (1998) Clin. Genet. , vol.53 , pp. 155-163
    • Ming, J.E.1    Muenke, M.2
  • 125
    • 0026474841 scopus 로고
    • Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
    • Mohler, J., and Vani, K. (1992). Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 8957-8971.
    • (1992) Development , vol.115 , pp. 8957-8971
    • Mohler, J.1    Vani, K.2
  • 126
    • 0028064476 scopus 로고
    • Primitive neuroectodermal tumors of the central nervous system in childhood: Tumor biological aspects
    • Molenaar, W.M., and Trojanowski, J.Q. (1994). Primitive neuroectodermal tumors of the central nervous system in childhood: tumor biological aspects. Crit. Rev. Oncol. Hematol. 17, 1-25.
    • (1994) Crit. Rev. Oncol. Hematol. , vol.17 , pp. 1-25
    • Molenaar, W.M.1    Trojanowski, J.Q.2
  • 127
    • 0032492995 scopus 로고    scopus 로고
    • Suppressor of fused links fused and cubitus interruptus on the hedgehog signaling pathway
    • Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C., and Plessis, A. (1998). Suppressor of fused links fused and cubitus interruptus on the hedgehog signaling pathway. Curr. Biol. 8, 583-586.
    • (1998) Curr. Biol. , vol.8 , pp. 583-586
    • Monnier, V.1    Dussillol, F.2    Alves, G.3    Lamour-Isnard, C.4    Plessis, A.5
  • 128
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
    • Motoyama, J., Takabatake, T., Takeshima, K., and Hui, C.-C. (1998). Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat. Genet. 18, 104-106.
    • (1998) Nat. Genet. , vol.18 , pp. 104-106
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3    Hui, C.-C.4
  • 129
    • 0029126148 scopus 로고
    • The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
    • Motzny, C.K., and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-150.
    • (1995) Mech. Dev. , vol.52 , pp. 137-150
    • Motzny, C.K.1    Holmgren, R.2
  • 130
    • 0024440611 scopus 로고
    • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
    • Nakano, Y., Guerrero, I., Hidalgo, A., Taylor, A., Whittle, J.R.S., and Ingham, P.W. (1989). A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513.
    • (1989) Nature , vol.341 , pp. 508-513
    • Nakano, Y.1    Guerrero, I.2    Hidalgo, A.3    Taylor, A.4    Whittle, J.R.S.5    Ingham, P.W.6
  • 131
    • 0029894568 scopus 로고    scopus 로고
    • Direct and long-range action of a dpp morphogen gradient
    • Nellen, D., Burke, R., Struhl, G., and Basler, K. (1996). Direct and long-range action of a dpp morphogen gradient. Cell 85, 357-368.
    • (1996) Cell , vol.85 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Struhl, G.3    Basler, K.4
  • 133
    • 0028172168 scopus 로고
    • U. S. Childhood cancer survival, 1973-1987
    • Novakovic, B. (1994). U. S. childhood cancer survival, 1973-1987. Med. Pediatr. Oncol. 23, 480-486.
    • (1994) Med. Pediatr. Oncol. , vol.23 , pp. 480-486
    • Novakovic, B.1
  • 134
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard, C., and Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 136
    • 0030984470 scopus 로고    scopus 로고
    • Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
    • Ohlmeyer, J.T., and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250-2258.
    • (1997) Genes Dev. , vol.11 , pp. 2250-2258
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 137
    • 0030734649 scopus 로고    scopus 로고
    • Epidemiology of holoprosencephaly and phenotypic characteristics of affected children: New York State, 1984-1989
    • Olsen, C.L., Hughes, J.P., Youngblood, L.G., and Sharpe-Stimac, M. (1997). Epidemiology of holoprosencephaly and phenotypic characteristics of affected children: New York State, 1984-1989. Am. J. Med. Genet. 73, 217-226.
    • (1997) Am. J. Med. Genet. , vol.73 , pp. 217-226
    • Olsen, C.L.1    Hughes, J.P.2    Youngblood, L.G.3    Sharpe-Stimac, M.4
  • 138
    • 0025331133 scopus 로고
    • Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
    • Orenic, T.V., Slusarski, D.C., Kroll, K.L., and Holmgren, R.A. (1990). Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. 4, 1053-1067.
    • (1990) Genes Dev. , vol.4 , pp. 1053-1067
    • Orenic, T.V.1    Slusarski, D.C.2    Kroll, K.L.3    Holmgren, R.A.4
  • 141
    • 0028911915 scopus 로고
    • cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
    • Pan, D., and Rubin, G.M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
    • (1995) Cell , vol.80 , pp. 543-552
    • Pan, D.1    Rubin, G.M.2
  • 142
    • 0024689395 scopus 로고
    • The role of segment polarity genes during Drosophila neurogenesis
    • Patel, N.H., Schafer, B., Goodman, C.S., and Holmgren, R. (1989). The role of segment polarity genes during Drosophila neurogenesis. Genes Dev. 3, 890-904.
    • (1989) Genes Dev. , vol.3 , pp. 890-904
    • Patel, N.H.1    Schafer, B.2    Goodman, C.S.3    Holmgren, R.4
  • 143
    • 0000815355 scopus 로고
    • Niemann-Pick Disease type C: A cellular cholesterol lipidosis
    • C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds. (Philadelphia: McGraw-Hill)
    • Pentchev, P.G., Vanier, M.T., Suzuki, K., and Patterson, M.C. (1995). Niemann-Pick Disease type C: a cellular cholesterol lipidosis. In The Metabolic and Molecular Basis of Inherited Diseases, C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds. (Philadelphia: McGraw-Hill), pp. 2625-2639.
    • (1995) The Metabolic and Molecular Basis of Inherited Diseases , pp. 2625-2639
    • Pentchev, P.G.1    Vanier, M.T.2    Suzuki, K.3    Patterson, M.C.4
  • 147
    • 0025030276 scopus 로고
    • The Drosophila segment polarity gene patched is involved in a position-signaling mechanism in imaginal discs
    • Phillips, R.G., Roberts, I.J.H., Ingham, P.W., and Whittle, J.R.S. (1990). The Drosophila segment polarity gene patched is involved in a position-signaling mechanism in imaginal discs. Development 110, 105-114.
    • (1990) Development , vol.110 , pp. 105-114
    • Phillips, R.G.1    Roberts, I.J.H.2    Ingham, P.W.3    Whittle, J.R.S.4
  • 149
    • 0026339029 scopus 로고
    • Control of dorsoventral pattern in vertebrate neural development: Induction and polarizing properties of the floor plate
    • Placzek, M., Yamada, T., Tessier-Lavigne, M., Jessell, T., and Dodd, J. (1991). Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate. Development 2 (suppl.), 105-122.
    • (1991) Development , vol.2 , Issue.SUPPL. , pp. 105-122
    • Placzek, M.1    Yamada, T.2    Tessier-Lavigne, M.3    Jessell, T.4    Dodd, J.5
  • 150
    • 0025598254 scopus 로고
    • Mesodermal control of neural cell identity: Floor plate induction by the notochord
    • Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessell, T., and Dodd, J. (1990). Mesodermal control of neural cell identity: floor plate induction by the notochord. Science 250, 985-988.
    • (1990) Science , vol.250 , pp. 985-988
    • Placzek, M.1    Tessier-Lavigne, M.2    Yamada, T.3    Jessell, T.4    Dodd, J.5
  • 151
    • 0027400583 scopus 로고
    • Induction of floor plate differentiation by contact-dependent, homeogenetic signals
    • Placzek, M., Jessell, T.M., and Dodd, J. (1993). Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development 117, 205-218.
    • (1993) Development , vol.117 , pp. 205-218
    • Placzek, M.1    Jessell, T.M.2    Dodd, J.3
  • 152
    • 0030913610 scopus 로고    scopus 로고
    • Expression of the mouse gli and ptc genes is adjacent to embryonic sources of hedgehog signals, suggesting a conservation of pathways between flies and mice
    • Platt, K.A., Michaud, J., and Joyner, A.L. (1997). Expression of the mouse gli and ptc genes is adjacent to embryonic sources of hedgehog signals, suggesting a conservation of pathways between flies and mice. Mech. Dev. 62, 121-135.
    • (1997) Mech. Dev. , vol.62 , pp. 121-135
    • Platt, K.A.1    Michaud, J.2    Joyner, A.L.3
  • 153
    • 0028948811 scopus 로고
    • The product of hedgehog autoproteolytic cleavage active in local and long-range signaling
    • Porter, J.A., von Kessler, D.P., Ekker, S.C., Young, K.E., Lee, J.J., Moses, K., and Beachy, P.A. (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signaling. Nature 374, 363-366.
    • (1995) Nature , vol.374 , pp. 363-366
    • Porter, J.A.1    Von Kessler, D.P.2    Ekker, S.C.3    Young, K.E.4    Lee, J.J.5    Moses, K.6    Beachy, P.A.7
  • 155
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter, J.A., Young, K.E., and Beachy, P.A. (1996b). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 157
    • 0027383291 scopus 로고
    • Segmental polarity in Drosophila melanogaster. Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
    • Préat, T., Thérond, P., Limbourg-Bouchon, B., Pham, A., Tricoire, H., Busson, D., and Lamour-Isnard, C. (1993). Segmental polarity in Drosophila melanogaster. genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 135, 1047-1062.
    • (1993) Genetics , vol.135 , pp. 1047-1062
    • Préat, T.1    Thérond, P.2    Limbourg-Bouchon, B.3    Pham, A.4    Tricoire, H.5    Busson, D.6    Lamour-Isnard, C.7
  • 158
    • 0027362452 scopus 로고
    • Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization
    • Puelles, L., and Rubenstein, J.L.R. (1993). Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 16, 472-479.
    • (1993) Trends Neurosci. , vol.16 , pp. 472-479
    • Puelles, L.1    Rubenstein, J.L.R.2
  • 160
    • 0030457125 scopus 로고    scopus 로고
    • Descriptive epidemiology of holoprosencephaly and arhinencephaly in metropolitan Atlanta, 1968-1992
    • Rasmussen, S.A., Moore, C.A., Khoury, M.J., and Cordero, J.F. (1996). Descriptive epidemiology of holoprosencephaly and arhinencephaly in metropolitan Atlanta, 1968-1992. Am. J. Med. Genet. 66, 320-333.
    • (1996) Am. J. Med. Genet. , vol.66 , pp. 320-333
    • Rasmussen, S.A.1    Moore, C.A.2    Khoury, M.J.3    Cordero, J.F.4
  • 161
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger, J., Wolter, M., Weber, R.G., Megahed, M., Ruzicka, T., Lichter, P., and Reifenberger, G. (1998). Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58, 1798-1803.
    • (1998) Cancer Res. , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3    Megahed, M.4    Ruzicka, T.5    Lichter, P.6    Reifenberger, G.7
  • 162
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle, R.D., Johnson, R.L., Laufer, E., and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 163
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., and Therond, P.P. (1997). Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90, 225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 165
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink, H., Porter, J.A., Chiang, C., Tanabe, Y., Chang, D.T., Beachy, P.A., and Jessell, T.M. (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 168
    • 0031820135 scopus 로고    scopus 로고
    • Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    • Ruiz i Altaba, A. (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212.
    • (1998) Development , vol.125 , pp. 2203-2212
    • Ruiz I Altaba, A.1
  • 170
    • 0025172883 scopus 로고
    • GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity
    • Ruppert, J.M., Vogelstein, B., Arheden, K., and Kinzler, K.W. (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol. 10, 5408-5415.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5408-5415
    • Ruppert, J.M.1    Vogelstein, B.2    Arheden, K.3    Kinzler, K.W.4
  • 171
    • 0028051239 scopus 로고
    • Convergence and divergence in the evolution of transport proteins
    • Saier, M.H. (1994). Convergence and divergence in the evolution of transport proteins. Bioessays 16, 23-29.
    • (1994) Bioessays , vol.16 , pp. 23-29
    • Saier, M.H.1
  • 172
    • 0025767994 scopus 로고
    • Unrestricted expression of the Drosophila gene patched allows a normal segment polarity
    • Sampedro, J., and Guerrero, I. (1991). Unrestricted expression of the Drosophila gene patched allows a normal segment polarity. Nature 353, 187-190.
    • (1991) Nature , vol.353 , pp. 187-190
    • Sampedro, J.1    Guerrero, I.2
  • 173
    • 0030005248 scopus 로고    scopus 로고
    • The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs
    • Sánchez-Herrero, E., Couso, J.P., Capdevila, J., and Guerrero, I. (1996). The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mech. Dev. 55, 159-170.
    • (1996) Mech. Dev. , vol.55 , pp. 159-170
    • Sánchez-Herrero, E.1    Couso, J.P.2    Capdevila, J.3    Guerrero, I.4
  • 174
    • 0028874275 scopus 로고
    • Drawing a stripe in Drosophila imaginal disks: Negative regulation of decapentaplegic and patched expression by engrailed
    • Sanicola, M., Sekelsky, J., Elson, S., and Gelbart, W.M. (1995). Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.
    • (1995) Genetics , vol.139 , pp. 745-756
    • Sanicola, M.1    Sekelsky, J.2    Elson, S.3    Gelbart, W.M.4
  • 175
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3b floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki, H., Hui, C.-C., Nakafuku, M., and Kondoh, H. (1997). A binding site for Gli proteins is essential for HNF-3b floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.-C.2    Nakafuku, M.3    Kondoh, H.4
  • 176
    • 0028168791 scopus 로고
    • Patched overexpression causes loss of wingless expression in Drosophila embryos
    • Schuske, K., Hooper, J.E., and Scott, M.P. (1994). patched overexpression causes loss of wingless expression in Drosophila embryos. Dev. Biol. 164, 300-311.
    • (1994) Dev. Biol. , vol.164 , pp. 300-311
    • Schuske, K.1    Hooper, J.E.2    Scott, M.P.3
  • 177
    • 0025857365 scopus 로고
    • Fate mapping and cell lineage analysis of Hensen's node in the chick embryo
    • Selleck, M.A., and Stern, C.D. (1991). Fate mapping and cell lineage analysis of Hensen's node in the chick embryo. Development 112, 615-626.
    • (1991) Development , vol.112 , pp. 615-626
    • Selleck, M.A.1    Stern, C.D.2
  • 178
    • 0030796030 scopus 로고    scopus 로고
    • Inductive interactions direct early regionalization of the mouse forebrain
    • Shimamura, K., and Rubenstein, J.L. (1997). Inductive interactions direct early regionalization of the mouse forebrain. Development 124, 2709-2718.
    • (1997) Development , vol.124 , pp. 2709-2718
    • Shimamura, K.1    Rubenstein, J.L.2
  • 179
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the hedgehog/patched signaling pathway
    • Sisson, J.C., Ho, K.S., Suyama, K., and Scott, M.P. (1997). Costal2, a novel kinesin-related protein in the Hedgehog/patched signaling pathway. Cell 90, 235-245.
    • (1997) Cell , vol.90 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 182
    • 0030663064 scopus 로고    scopus 로고
    • A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    • Strigini, M., and Cohen, S.M. (1997). A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705.
    • (1997) Development , vol.124 , pp. 4697-4705
    • Strigini, M.1    Cohen, S.M.2
  • 183
    • 0030795569 scopus 로고    scopus 로고
    • Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen
    • Struhl, G., Barbash, D.A., and Lawrence, P.A. (1997). Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen. Development 124, 2155-2165.
    • (1997) Development , vol.124 , pp. 2155-2165
    • Struhl, G.1    Barbash, D.A.2    Lawrence, P.A.3
  • 184
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata, T., and Kornberg, T. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.2
  • 185
    • 0027096741 scopus 로고
    • The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
    • Tabata, T., Eaton, S., and Kornberg, T.B. (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6, 2635-2645.
    • (1992) Genes Dev. , vol.6 , pp. 2635-2645
    • Tabata, T.1    Eaton, S.2    Kornberg, T.B.3
  • 188
    • 0029860502 scopus 로고    scopus 로고
    • Diversity and pattern in the developing spinal cord
    • Tanabe, Y., and Jessell, T.M. (1996). Diversity and pattern in the developing spinal cord. Science 274, 1115-1123.
    • (1996) Science , vol.274 , pp. 1115-1123
    • Tanabe, Y.1    Jessell, T.M.2
  • 189
    • 0029311276 scopus 로고
    • Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
    • Tanabe, Y., Roelink, H., and Jessell, T.M. (1995). Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Curr. Biol. 5, 651-658.
    • (1995) Curr. Biol. , vol.5 , pp. 651-658
    • Tanabe, Y.1    Roelink, H.2    Jessell, T.M.3
  • 190
    • 0025330489 scopus 로고
    • cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
    • Taylor, S.S., Buechler, J.A., and Yonemoto, W. (1990). cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59, 971-1005.
    • (1990) Annu. Rev. Biochem. , vol.59 , pp. 971-1005
    • Taylor, S.S.1    Buechler, J.A.2    Yonemoto, W.3
  • 191
    • 0027200833 scopus 로고
    • Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
    • Taylor, A.M., Nakano, Y., Mohler, J., and Ingham, P.W. (1993). Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech. Dev. 42, 89-96.
    • (1993) Mech. Dev. , vol.42 , pp. 89-96
    • Taylor, A.M.1    Nakano, Y.2    Mohler, J.3    Ingham, P.W.4
  • 194
    • 0029961659 scopus 로고    scopus 로고
    • Phosphorylation of the fused protein kinase in response to signaling from hedgehog
    • Thérond, P.P., Knight, J.D., Kornberg, T.B., and Bishop, J.M. (1996b). Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl. Acad. Sci. USA 93, 4224-4228.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4224-4228
    • Thérond, P.P.1    Knight, J.D.2    Kornberg, T.B.3    Bishop, J.M.4
  • 195
    • 0030990735 scopus 로고    scopus 로고
    • Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
    • Unden, A.B., Zaphiropoulos, P.G., Bruce, K., Toftgard, R., and Stahle-Backdahl, M. (1997). Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res. 57, 2336-2340.
    • (1997) Cancer Res. , vol.57 , pp. 2336-2340
    • Unden, A.B.1    Zaphiropoulos, P.G.2    Bruce, K.3    Toftgard, R.4    Stahle-Backdahl, M.5
  • 196
    • 0030601349 scopus 로고    scopus 로고
    • Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wildtype and cyclops mutant embryos
    • Ungar, A.R., and Moon, R.T. (1996). Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wildtype and cyclops mutant embryos. Dev. Biol. 178, 186-191.
    • (1996) Dev. Biol. , vol.178 , pp. 186-191
    • Ungar, A.R.1    Moon, R.T.2
  • 197
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signaling
    • van den Heuvel, M., and Ingham, P.W. (1996). smoothened encodes a receptor-like serpentine protein required for hedgehog signaling. Nature 382, 547-551.
    • (1996) Nature , vol.382 , pp. 547-551
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 198
    • 0031437362 scopus 로고    scopus 로고
    • Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer
    • Von Ohlen, T., and Hooper, J.E. (1997). Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer. Mech. Dev. 68, 149-156.
    • (1997) Mech. Dev. , vol.68 , pp. 149-156
    • Von Ohlen, T.1    Hooper, J.E.2
  • 199
    • 0030975697 scopus 로고    scopus 로고
    • Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
    • Von Ohlen, T., Lessing, D., Nusse, R., and Hooper, J.E. (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. USA 94, 2404-2409.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2404-2409
    • Von Ohlen, T.1    Lessing, D.2    Nusse, R.3    Hooper, J.E.4
  • 200
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M., and Tabin, C.J. (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 201
  • 202
  • 203
    • 12844276949 scopus 로고    scopus 로고
    • Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident
    • Wicking, C., Shanley, S., Smyth, I., Gillies, S., Negus, K., Graham, S., Suthers, G., Haites, N., Edwards, M., Wainwright, B., and Chenevix-Trench, G. (1997). Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. Am. J. Hum. Genet. 60, 21-26.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 21-26
    • Wicking, C.1    Shanley, S.2    Smyth, I.3    Gillies, S.4    Negus, K.5    Graham, S.6    Suthers, G.7    Haites, N.8    Edwards, M.9    Wainwright, B.10    Chenevix-Trench, G.11
  • 204
    • 0030738693 scopus 로고    scopus 로고
    • Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Wolter, M., Reifenberger, J., Sommer, C., Ruzicka, T., and Reifenberger, G. (1997). Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 57, 2581-2585.
    • (1997) Cancer Res. , vol.57 , pp. 2581-2585
    • Wolter, M.1    Reifenberger, J.2    Sommer, C.3    Ruzicka, T.4    Reifenberger, G.5
  • 208
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    • Ye, W., Shimamura, K., Rubenstein, J.L.R., Hynes, M.A., and Rosenthal, A. (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.1    Shimamura, K.2    Rubenstein, J.L.R.3    Hynes, M.A.4    Rosenthal, A.5
  • 209
    • 15144354319 scopus 로고    scopus 로고
    • GLI activates transcription through a herpes simplex viral protein 16-like activation domain
    • Yoon, J.W., Liu, C.Z., Yang, J.T., Swart, R., Iannoaccone, P., and Walterhouse, D. (1998). GLI activates transcription through a herpes simplex viral protein 16-like activation domain. J. Biol. Chem. 273, 3496-3501.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3496-3501
    • Yoon, J.W.1    Liu, C.Z.2    Yang, J.T.3    Swart, R.4    Iannoaccone, P.5    Walterhouse, D.6
  • 210
    • 0030606264 scopus 로고    scopus 로고
    • Direct and long-range action of a wingless morphogen gradient
    • Zecca, M., Basler, K., and Struhl, G. (1996). Direct and long-range action of a wingless morphogen gradient. Cell 87, 833-844.
    • (1996) Cell , vol.87 , pp. 833-844
    • Zecca, M.1    Basler, K.2    Struhl, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.