-
1
-
-
0034129629
-
Signaling and transcription in T helper development
-
Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL (2000) Signaling and transcription in T helper development. Annu Rev Immunol 18:451
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 451
-
-
Murphy, K.M.1
Ouyang, W.2
Farrar, J.D.3
Yang, J.4
Ranganath, S.5
Asnagli, H.6
Afkarian, M.7
Murphy, T.L.8
-
2
-
-
0034661356
-
Lineage commitment in the immune system: The T helper lymphocyte grows up
-
Glimcher LH, Murphy KM (2000) Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev 14:1693
-
(2000)
Genes Dev
, vol.14
, pp. 1693
-
-
Glimcher, L.H.1
Murphy, K.M.2
-
3
-
-
0024467154
-
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
-
Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827
-
(1989)
J Exp Med
, vol.170
, pp. 827
-
-
Kobayashi, M.1
Fitz, L.2
Ryan, M.3
Hewick, R.M.4
Clark, S.C.5
Chan, S.6
Loudon, R.7
Sherman, F.8
Perussia, B.9
Trinchieri, G.10
-
4
-
-
0025028960
-
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
-
Stern AS, Podlaski FJ, Hulmes JD, et al (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87:6808
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6808
-
-
Stern, A.S.1
Podlaski, F.J.2
Hulmes, J.D.3
-
5
-
-
0025808629
-
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
-
Gubler U, Chua AO, Schoenhaut DS, et al (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 88:4143
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 4143
-
-
Gubler, U.1
Chua, A.O.2
Schoenhaut, D.S.3
-
6
-
-
0025875022
-
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
-
Wolf SF, Temple PA, Kobayashi M, et al (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 146:3074
-
(1991)
J Immunol
, vol.146
, pp. 3074
-
-
Wolf, S.F.1
Temple, P.A.2
Kobayashi, M.3
-
7
-
-
0030790652
-
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
-
Cooper AM, Magram J, Ferrante J, Orme IM (1997) Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 186:39
-
(1997)
J Exp Med
, vol.186
, pp. 39
-
-
Cooper, A.M.1
Magram, J.2
Ferrante, J.3
Orme, I.M.4
-
8
-
-
0035884846
-
IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18
-
Müller U, Köhler G, Mossmann H, Schaub GA, Alber G, Di Santo JP, Brombacher F, Hölscher C (2001) IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18. J Immunol 167:3346
-
(2001)
J Immunol
, vol.167
, pp. 3346
-
-
Müller, U.1
Köhler, G.2
Mossmann, H.3
Schaub, G.A.4
Alber, G.5
Di Santo, J.P.6
Brombacher, F.7
Hölscher, C.8
-
9
-
-
0030002111
-
Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
-
Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Behin R, Gately MK, Louis JA, Alber G (1996) Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 26:1553
-
(1996)
Eur J Immunol
, vol.26
, pp. 1553
-
-
Mattner, F.1
Magram, J.2
Ferrante, J.3
Launois, P.4
Di Padova, K.5
Behin, R.6
Gately, M.K.7
Louis, J.A.8
Alber, G.9
-
10
-
-
16044363695
-
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
-
Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu CY, Ferrante J, Stewart C, Sarmiento U, Faherty DA, Gately MK (1996) IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4:471
-
(1996)
Immunity
, vol.4
, pp. 471
-
-
Magram, J.1
Connaughton, S.E.2
Warrier, R.R.3
Carvajal, D.M.4
Wu, C.Y.5
Ferrante, J.6
Stewart, C.7
Sarmiento, U.8
Faherty, D.A.9
Gately, M.K.10
-
11
-
-
0030970867
-
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
-
Scharton-Kersten TM, Yap G, Magram J, Sher A (1997) Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med 185:1261
-
(1997)
J Exp Med
, vol.185
, pp. 1261
-
-
Scharton-Kersten, T.M.1
Yap, G.2
Magram, J.3
Sher, A.4
-
12
-
-
0030466329
-
IL-12-deficient mice are defective but not devoid of type 1 cytokine responses
-
Magram J, Sfarra J, Connaughton S, Faherty D, Warrier R, Carvajal D, Wu CY, Stewart C, Sarmiento U, Gately MK (1996) IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann N Y Acad Sci 795:60
-
(1996)
Ann N Y Acad Sci
, vol.795
, pp. 60
-
-
Magram, J.1
Sfarra, J.2
Connaughton, S.3
Faherty, D.4
Warrier, R.5
Carvajal, D.6
Wu, C.Y.7
Stewart, C.8
Sarmiento, U.9
Gately, M.K.10
-
13
-
-
0031571205
-
Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor
-
Wu C, Ferrante J, Gately MK, Magram J (1997) Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. J Immunol 159:1658
-
(1997)
J Immunol
, vol.159
, pp. 1658
-
-
Wu, C.1
Ferrante, J.2
Gately, M.K.3
Magram, J.4
-
14
-
-
0034541139
-
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
-
Wu C, Wang X, Gadina M, O'Shea JJ, Presky DH, Magram J (2000) IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol 165:6221
-
(2000)
J Immunol
, vol.165
, pp. 6221
-
-
Wu, C.1
Wang, X.2
Gadina, M.3
O'Shea, J.J.4
Presky, D.H.5
Magram, J.6
-
15
-
-
0036467445
-
Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
-
Cooper AM, Kipnis A, Turner J, Magram J, Ferrante J, Orme IM (2002) Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168:1322
-
(2002)
J Immunol
, vol.168
, pp. 1322
-
-
Cooper, A.M.1
Kipnis, A.2
Turner, J.3
Magram, J.4
Ferrante, J.5
Orme, I.M.6
-
16
-
-
0031707741
-
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
-
Decken K, Kohler G, Palmer-Lehmann K, Wunderlin A, Mattner F, Magram J, Gately MK, Alber G (1998) Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 66:4994
-
(1998)
Infect Immun
, vol.66
, pp. 4994
-
-
Decken, K.1
Kohler, G.2
Palmer-Lehmann, K.3
Wunderlin, A.4
Mattner, F.5
Magram, J.6
Gately, M.K.7
Alber, G.8
-
17
-
-
0036127059
-
In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70
-
Elkins KL, Cooper A, Colombini SM, Cowley SC, Kieffer TL (2002) In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect Immun 70:1936
-
(2002)
Infect Immun
, vol.70
, pp. 1936
-
-
Elkins, K.L.1
Cooper, A.2
Colombini, S.M.3
Cowley, S.C.4
Kieffer, T.L.5
-
18
-
-
0035892749
-
A protective and agonistic function of IL-12p40 in mycobacterial infection
-
Hölscher C, Atkinson RA, Arendse B, Brown N, Myburgh E, Alber G, Brombacher F (2001) A protective and agonistic function of IL-12p40 in mycobacterial infection. J Immunol 167:6957
-
(2001)
J Immunol
, vol.167
, pp. 6957
-
-
Hölscher, C.1
Atkinson, R.A.2
Arendse, B.3
Brown, N.4
Myburgh, E.5
Alber, G.6
Brombacher, F.7
-
19
-
-
0035500298
-
IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis
-
Lehmann J, Bellmann S, Werner C, Schroder R, Schutze N, Alber G (2001) IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J Immunol 167:5304
-
(2001)
J Immunol
, vol.167
, pp. 5304
-
-
Lehmann, J.1
Bellmann, S.2
Werner, C.3
Schroder, R.4
Schutze, N.5
Alber, G.6
-
20
-
-
0026588207
-
Cloning and expression of murine IL-12
-
Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, Familletti PC, Gately MK, Gubler U (1992) Cloning and expression of murine IL-12. J Immunol 148:3433
-
(1992)
J Immunol
, vol.148
, pp. 3433
-
-
Schoenhaut, D.S.1
Chua, A.O.2
Wolitzky, A.G.3
Quinn, P.M.4
Dwyer, C.M.5
McComas, W.6
Familletti, P.C.7
Gately, M.K.8
Gubler, U.9
-
21
-
-
0025783528
-
Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor
-
Gearing DP, Cosman D (1991) Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66:9
-
(1991)
Cell
, vol.66
, pp. 9
-
-
Gearing, D.P.1
Cosman, D.2
-
22
-
-
0026559308
-
Molecular characterization of interleukin 12
-
Podlaski FJ, Nanduri VB, Hulmes JD, Pan YC, Levin W, Danho W, Chizzonite R, Gately MK, Stern AS (1992) Molecular characterization of interleukin 12. Arch Biochem Biophys 294:230
-
(1992)
Arch Biochem Biophys
, vol.294
, pp. 230
-
-
Podlaski, F.J.1
Nanduri, V.B.2
Hulmes, J.D.3
Pan, Y.C.4
Levin, W.5
Danho, W.6
Chizzonite, R.7
Gately, M.K.8
Stern, A.S.9
-
23
-
-
0026693587
-
Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5
-
Sieburth D, Jabs EW, Warrington JA, Li X, Lasota J, LaForgia S, Kelleher K, Huebner K, Wasmuth JJ, Wolf SF (1992) Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14:59
-
(1992)
Genomics
, vol.14
, pp. 59
-
-
Sieburth, D.1
Jabs, E.W.2
Warrington, J.A.3
Li, X.4
Lasota, J.5
Laforgia, S.6
Kelleher, K.7
Huebner, K.8
Wasmuth, J.J.9
Wolf, S.F.10
-
24
-
-
0030137680
-
Genetic mapping of the IL-12 alpha chain gene (I112a) on mouse chromosome 3
-
Schweitzer PA, Noben-Trauth N, Pelsue SC, Johnson KR, Wolf SF, Shultz LD (1996) Genetic mapping of the IL-12 alpha chain gene (I112a) on mouse chromosome 3. Mamm Genome 7:394
-
(1996)
Mamm Genome
, vol.7
, pp. 394
-
-
Schweitzer, P.A.1
Noben-Trauth, N.2
Pelsue, S.C.3
Johnson, K.R.4
Wolf, S.F.5
Shultz, L.D.6
-
25
-
-
0028043326
-
Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
-
Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008
-
(1994)
Blood
, vol.84
, pp. 4008
-
-
Trinchieri, G.1
-
26
-
-
0030137655
-
The interleukin-12 beta subunit (p40) maps to mouse chromosome 11
-
Noben-Trauth N, Schweitzer PA, Johnson KR, Wolf SF, Knowles BB, Shultz LD (1996) The interleukin-12 beta subunit (p40) maps to mouse chromosome 11. Mamm Genome 7:392
-
(1996)
Mamm Genome
, vol.7
, pp. 392
-
-
Noben-Trauth, N.1
Schweitzer, P.A.2
Johnson, K.R.3
Wolf, S.F.4
Knowles, B.B.5
Shultz, L.D.6
-
27
-
-
0026567028
-
Sequence similarity between NKSF and the IL-6/G-CSF family
-
Merberg DM, Wolf SF, Clark SC (1992) Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol Today 13:77
-
(1992)
Immunol Today
, vol.13
, pp. 77
-
-
Merberg, D.M.1
Wolf, S.F.2
Clark, S.C.3
-
28
-
-
0028819316
-
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
-
Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J (1995) Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 154:116
-
(1995)
J Immunol
, vol.154
, pp. 116
-
-
Ling, P.1
Gately, M.K.2
Gubler, U.3
Stern, A.S.4
Lin, P.5
Hollfelder, K.6
Su, C.7
Pan, Y.C.8
Hakimi, J.9
-
29
-
-
0028967287
-
Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
-
Gillessen S, Carvajal D, Ling P, Podlaski FJ, Stremlo DL, Familletti PC, Gubler U, Presky DH, Stern AS, Gately MK (1995) Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 25:200
-
(1995)
Eur J Immunol
, vol.25
, pp. 200
-
-
Gillessen, S.1
Carvajal, D.2
Ling, P.3
Podlaski, F.J.4
Stremlo, D.L.5
Familletti, P.C.6
Gubler, U.7
Presky, D.H.8
Stern, A.S.9
Gately, M.K.10
-
30
-
-
17544399131
-
Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo
-
Gately MK, Carvajal DM, Connaughton SE, Gillessen S, Warrier RR, Kolinsky KD, Wilkinson VL, Dwyer CM, Higgins GF Jr, Podlaski FJ, Faherty DA, Familletti PC, Stern AS, Presky DH (1996) Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann N Y Acad Sci 795:1
-
(1996)
Ann N Y Acad Sci
, vol.795
, pp. 1
-
-
Gately, M.K.1
Carvajal, D.M.2
Connaughton, S.E.3
Gillessen, S.4
Warrier, R.R.5
Kolinsky, K.D.6
Wilkinson, V.L.7
Dwyer, C.M.8
Higgins Jr., G.F.9
Podlaski, F.J.10
Faherty, D.A.11
Familletti, P.C.12
Stern, A.S.13
Presky, D.H.14
-
31
-
-
0031940203
-
Alloantigen-reactive Th1 development in IL-12-deficient mice
-
Piccotti JR, Li K, Chan SY, Ferrante J, Magram J, Eichwald EJ, Bishop DK (1998) Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol 160:1132
-
(1998)
J Immunol
, vol.160
, pp. 1132
-
-
Piccotti, J.R.1
Li, K.2
Chan, S.Y.3
Ferrante, J.4
Magram, J.5
Eichwald, E.J.6
Bishop, D.K.7
-
32
-
-
0026605457
-
IL-12 receptor. II. Distribution and regulation of receptor expression
-
Desai BB, Quinn PM, Wolitzky AG, Mongini PK, Chizzonite R, Gately MK (1992) IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol 148:3125
-
(1992)
J Immunol
, vol.148
, pp. 3125
-
-
Desai, B.B.1
Quinn, P.M.2
Wolitzky, A.G.3
Mongini, P.K.4
Chizzonite, R.5
Gately, M.K.6
-
33
-
-
0028235663
-
Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to ap130
-
Chua AO, Chizzonite R, Desai BB, et al (1994) Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to ap130. J Immunol 153:128
-
(1994)
J Immunol
, vol.153
, pp. 128
-
-
Chua, A.O.1
Chizzonite, R.2
Desai, B.B.3
-
34
-
-
0028892869
-
Cloning and characterization of a mouse IL-12 receptor-beta component
-
Chua AO, Wilkinson VL, Presky DH, Gubler U (1995) Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol 155:4286
-
(1995)
J Immunol
, vol.155
, pp. 4286
-
-
Chua, A.O.1
Wilkinson, V.L.2
Presky, D.H.3
Gubler, U.4
-
35
-
-
0030445948
-
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
-
Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 93:14002
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14002
-
-
Presky, D.H.1
Yang, H.2
Minetti, L.J.3
Chua, A.O.4
Nabavi, N.5
Wu, C.Y.6
Gately, M.K.7
Gubler, U.8
-
36
-
-
4243599873
-
Functional characterization of mouse IL-12 receptors
-
Wilkinson VL, Carvajal D, Minetti LJ, Chua AO, Gubler U, Gately MK, Presky DH (1997) Functional characterization of mouse IL-12 receptors. J.Allergy Clin Immunol 99:852
-
(1997)
J. Allergy Clin Immunol
, vol.99
, pp. 852
-
-
Wilkinson, V.L.1
Carvajal, D.2
Minetti, L.J.3
Chua, A.O.4
Gubler, U.5
Gately, M.K.6
Presky, D.H.7
-
37
-
-
0029039610
-
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells
-
Zou JP, Yamamoto N, Fujii T, Takenaka H, Kobayashi M, Herrmann SH, Wolf SF, Fujiwara H, Hamaoka T (1995) Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells. Int Immunol 7:1135
-
(1995)
Int Immunol
, vol.7
, pp. 1135
-
-
Zou, J.P.1
Yamamoto, N.2
Fujii, T.3
Takenaka, H.4
Kobayashi, M.5
Herrmann, S.H.6
Wolf, S.F.7
Fujiwara, H.8
Hamaoka, T.9
-
38
-
-
0028910222
-
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
-
Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA (1995) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 181:399
-
(1995)
J Exp Med
, vol.181
, pp. 399
-
-
Bacon, C.M.1
McVicar, D.W.2
Ortaldo, J.R.3
Rees, R.C.4
O'Shea, J.J.5
Johnston, J.A.6
-
39
-
-
0029116336
-
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
-
Bacon CM, Petricoin EF 3rd, Ortaldo JR, Rees RC, Larner AC, Johnston JA, O'Shea JJ (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci USA 92:7307
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7307
-
-
Bacon, C.M.1
Petricoin III, E.F.2
Ortaldo, J.R.3
Rees, R.C.4
Larner, A.C.5
Johnston, J.A.6
O'Shea, J.J.7
-
40
-
-
0028943484
-
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
-
Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy KM (1995) Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 181:1755
-
(1995)
J Exp Med
, vol.181
, pp. 1755
-
-
Jacobson, N.G.1
Szabo, S.J.2
Weber-Nordt, R.M.3
Zhong, Z.4
Schreiber, R.D.5
Darnell Jr., J.E.6
Murphy, K.M.7
-
41
-
-
0033593445
-
Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
-
Naeger LK, McKinney J, Salvekar A, Hoey T (1999) Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. J Biol Chem 274:1875
-
(1999)
J Biol Chem
, vol.274
, pp. 1875
-
-
Naeger, L.K.1
McKinney, J.2
Salvekar, A.3
Hoey, T.4
-
43
-
-
0030063347
-
IL-12 expression in AIDS-related lymphoma B cell lines
-
Benjamin D, Sharma V, Kubin M, Klein JL, Sartori A, Holliday J, Trinchieri G (1996) IL-12 expression in AIDS-related lymphoma B cell lines. J Immunol 156:1626
-
(1996)
J Immunol
, vol.156
, pp. 1626
-
-
Benjamin, D.1
Sharma, V.2
Kubin, M.3
Klein, J.L.4
Sartori, A.5
Holliday, J.6
Trinchieri, G.7
-
44
-
-
0030892136
-
Selective expression of an interleukin-12 receptor component by human T helper 1 cells
-
Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 185:825
-
(1997)
J Exp Med
, vol.185
, pp. 825
-
-
Rogge, L.1
Barberis-Maino, L.2
Biffi, M.3
Passini, N.4
Presky, D.H.5
Gubler, U.6
Sinigaglia, F.7
-
45
-
-
0031030398
-
Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells
-
Wu C, Warrier RR, Wang X, Presky DH, Gately MK (1997) Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. Eur J Immunol 27:147
-
(1997)
Eur J Immunol
, vol.27
, pp. 147
-
-
Wu, C.1
Warrier, R.R.2
Wang, X.3
Presky, D.H.4
Gately, M.K.5
-
46
-
-
0033532294
-
Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
-
Diefenbach A, Schindler H, Rollinghoff M, Yokoyama WM, Bogdan C (1999) Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 284:951
-
(1999)
Science
, vol.284
, pp. 951
-
-
Diefenbach, A.1
Schindler, H.2
Rollinghoff, M.3
Yokoyama, W.M.4
Bogdan, C.5
-
47
-
-
0028970060
-
Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251
-
(1995)
Annu Rev Immunol
, vol.13
, pp. 251
-
-
Trinchieri, G.1
-
48
-
-
0036784614
-
Cutting edge: Toll-like receptor (TLR)2- And TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
-
Reiling N, Hölscher C, Fehrenbach A, Kröger S, Kirschning CJ, Goyert S, Ehlers S (2002) Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169:3480
-
(2002)
J Immunol
, vol.169
, pp. 3480
-
-
Reiling, N.1
Hölscher, C.2
Fehrenbach, A.3
Kröger, S.4
Kirschning, C.J.5
Goyert, S.6
Ehlers, S.7
-
49
-
-
0031050034
-
Innate immunity: Impact on the adaptive immune response
-
Medzhitov R, Janeway CA Jr (1997) Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9:4
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 4
-
-
Medzhitov, R.1
Janeway Jr., C.A.2
-
50
-
-
0034763143
-
Regulation of interleukin-12 production in antigen-presenting cells
-
Ma X, Trinchieri G (2001) Regulation of interleukin-12 production in antigen-presenting cells. Adv Immunol 79:55
-
(2001)
Adv Immunol
, vol.79
, pp. 55
-
-
Ma, X.1
Trinchieri, G.2
-
51
-
-
0032577295
-
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
-
De Jong R, Altare F, Haagen IA, Elferink DG, Boer T, Breda Vriesman PJ van, Kabel PJ, Draaisma JM, Dissel JT van, Kroon FP, Casanova JL, Ottenhoff TH (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435
-
(1998)
Science
, vol.280
, pp. 1435
-
-
De Jong, R.1
Altare, F.2
Haagen, I.A.3
Elferink, D.G.4
Boer, T.5
Van Breda Vriesman, P.J.6
Kabel, P.J.7
Draaisma, J.M.8
Van Dissel, J.T.9
Kroon, F.P.10
Casanova, J.L.11
Ottenhoff, T.H.12
-
52
-
-
18244428735
-
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
-
Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Doffinger R, Bernaudin F, Jeppsson O, Gollob JA, Meinl E, Segal AW, Fischer A, Kumararatne D, Casanova JL (1998) Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280:1432
-
(1998)
Science
, vol.280
, pp. 1432
-
-
Altare, F.1
Durandy, A.2
Lammas, D.3
Emile, J.F.4
Lamhamedi, S.5
Le Deist, F.6
Drysdale, P.7
Jouanguy, E.8
Doffinger, R.9
Bernaudin, F.10
Jeppsson, O.11
Gollob, J.A.12
Meinl, E.13
Segal, A.W.14
Fischer, A.15
Kumararatne, D.16
Casanova, J.L.17
-
53
-
-
0035424542
-
Immune responses to intracellular bacteria
-
Raupach B, Kaufmann SH (2001) Immune responses to intracellular bacteria. Curr Opin Immunol 13:417
-
(2001)
Curr Opin Immunol
, vol.13
, pp. 417
-
-
Raupach, B.1
Kaufmann, S.H.2
-
54
-
-
0031913243
-
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
-
Hölscher C, Köhler G, Müller U, Mossmann H, Schaub GA, Brombacher F (1998) Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun 66:1208
-
(1998)
Infect Immun
, vol.66
, pp. 1208
-
-
Hölscher, C.1
Köhler, G.2
Müller, U.3
Mossmann, H.4
Schaub, G.A.5
Brombacher, F.6
-
55
-
-
0344958627
-
IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytocenes
-
Brombacher F, Dorfmuller A, Magram J, Dai WJ, Kohler G, Wunderlin A, Palmer-Lehmann K, Gately MK, Alber G (1999) IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytocenes. Int Immunol 11:325
-
(1999)
Int Immunol
, vol.11
, pp. 325
-
-
Brombacher, F.1
Dorfmuller, A.2
Magram, J.3
Dai, W.J.4
Kohler, G.5
Wunderlin, A.6
Palmer-Lehmann, K.7
Gately, M.K.8
Alber, G.9
-
56
-
-
0032534672
-
The role of Stat4 in species-specific regulation of Th cell development by type I IFNs
-
Rogge L, D'Ambrosio D, Biffi M, Penna G, Minetti LJ, Presky DH, Adorini L, Sinigaglia F (1998) The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J Immunol 161:6567
-
(1998)
J Immunol
, vol.161
, pp. 6567
-
-
Rogge, L.1
D'Ambrosio, D.2
Biffi, M.3
Penna, G.4
Minetti, L.J.5
Presky, D.H.6
Adorini, L.7
Sinigaglia, F.8
-
57
-
-
0033583516
-
Two roads diverged: Interferon alpha/beta- And interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
-
Consens LP, Peterson R, Hsu S, Dorner A, Altman JD, Ahmed R, Biron CA (1999) Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med 189:1315
-
(1999)
J Exp Med
, vol.189
, pp. 1315
-
-
Consens, L.P.1
Peterson, R.2
Hsu, S.3
Dorner, A.4
Altman, J.D.5
Ahmed, R.6
Biron, C.A.7
-
58
-
-
18844481515
-
Defective NK cell activity and Th1 response in IL-18-deficient mice
-
Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383
-
(1998)
Immunity
, vol.8
, pp. 383
-
-
Takeda, K.1
Tsutsui, H.2
Yoshimoto, T.3
Adachi, O.4
Yoshida, N.5
Kishimoto, T.6
Okamura, H.7
Nakanishi, K.8
Akira, S.9
-
59
-
-
0028845730
-
Cloning of a new cytokine that induces IFN-gamma production by T cells
-
Okamura H, Tsutsi H, Komatsu T, et al. (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88
-
(1995)
Nature
, vol.378
, pp. 88
-
-
Okamura, H.1
Tsutsi, H.2
Komatsu, T.3
-
60
-
-
0037103254
-
Cutting edge: A murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
-
Freudenberg MA, Merlin T, Kalis C, Chvatchko Y, Stubig H, Galanos C (2002) Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. J Immunol 169:1665
-
(2002)
J Immunol
, vol.169
, pp. 1665
-
-
Freudenberg, M.A.1
Merlin, T.2
Kalis, C.3
Chvatchko, Y.4
Stubig, H.5
Galanos, C.6
-
61
-
-
0033999966
-
IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology
-
Satoskar AR, Rodig S, Telford SR 3rd, Satoskar AA, Ghosh SK, Lichtenberg F von, David JR (2000) IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology. Eur J Immunol 30:834
-
(2000)
Eur J Immunol
, vol.30
, pp. 834
-
-
Satoskar, A.R.1
Rodig, S.2
Telford III, S.R.3
Satoskar, A.A.4
Ghosh, S.K.5
Von Lichtenberg, F.6
David, J.R.7
-
62
-
-
0033136323
-
+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection
-
+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162:5449
-
(1999)
J Immunol
, vol.162
, pp. 5449
-
-
Ely, K.H.1
Kasper, L.H.2
Khan, I.A.3
-
63
-
-
0034662234
-
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells
-
Kawakami K, Koguchi Y, Qureshi MH, Miyazato A, Yara S, Kinjo Y, Iwakura Y, Takeda K, Akira S, Kurimoto M, Saito A (2000) IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 165:941
-
(2000)
J Immunol
, vol.165
, pp. 941
-
-
Kawakami, K.1
Koguchi, Y.2
Qureshi, M.H.3
Miyazato, A.4
Yara, S.5
Kinjo, Y.6
Iwakura, Y.7
Takeda, K.8
Akira, S.9
Kurimoto, M.10
Saito, A.11
-
64
-
-
0032526925
-
Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guerin in IL-12-deficient mice
-
Wakeham J, Wang J, Magram J, Croitoru K, Harkness R, Dunn P, Zganiacz A, Xing Z (1998) Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guerin in IL-12-deficient mice. J Immunol 160:6101
-
(1998)
J Immunol
, vol.160
, pp. 6101
-
-
Wakeham, J.1
Wang, J.2
Magram, J.3
Croitoru, K.4
Harkness, R.5
Dunn, P.6
Zganiacz, A.7
Xing, Z.8
-
65
-
-
0032522640
-
Mice lacking IL-12 develop polarized Th1 cells during viral infection
-
Schijns VE, Haagmans BL, Wierda CM, Kruithof B, Heijnen IA, Alber G, Horzinek MC (1998) Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160:3958
-
(1998)
J Immunol
, vol.160
, pp. 3958
-
-
Schijns, V.E.1
Haagmans, B.L.2
Wierda, C.M.3
Kruithof, B.4
Heijnen, I.A.5
Alber, G.6
Horzinek, M.C.7
-
66
-
-
0033556145
-
IL-12 is not required for induction of type 1 cytokine responses in viral infections
-
Oxenius A, Karrer U, Zinkernagel RM, Hengartner H (1999) IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol 162:965
-
(1999)
J Immunol
, vol.162
, pp. 965
-
-
Oxenius, A.1
Karrer, U.2
Zinkernagel, R.M.3
Hengartner, H.4
-
67
-
-
0034163312
-
IL-12-independent Th1-type immune responses to respiratory viral infection: Requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes
-
Xing Z, Zganiacz A, Wang J, Divangahi M, Nawaz F (2000) IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol 164:2575
-
(2000)
J Immunol
, vol.164
, pp. 2575
-
-
Xing, Z.1
Zganiacz, A.2
Wang, J.3
Divangahi, M.4
Nawaz, F.5
-
68
-
-
0034682553
-
The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
-
Stobie L, Gurunathan S, Prussin C, Sacks DL, Glaichenhaus N, Wu CY, Seder RA (2000) The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc Natl Acad Sci USA 97:8427
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8427
-
-
Stobie, L.1
Gurunathan, S.2
Prussin, C.3
Sacks, D.L.4
Glaichenhaus, N.5
Wu, C.Y.6
Seder, R.A.7
-
69
-
-
0031826253
-
The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis
-
Constantinescu CS, Hondowicz BD, Elloso MM, Wysocka M, Trinchieri G, Scott P (1998) The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis. Eur J Immunol 28:2227
-
(1998)
Eur J Immunol
, vol.28
, pp. 2227
-
-
Constantinescu, C.S.1
Hondowicz, B.D.2
Elloso, M.M.3
Wysocka, M.4
Trinchieri, G.5
Scott, P.6
-
70
-
-
0037218610
-
Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta1 deficiency
-
Cleary AM, Tu W, Enright A, Giffon T, Dewaal-Malefyt R, Gutierrez K, Lewis DB (2003) Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta1 deficiency. J Immunol 170:597
-
(2003)
J Immunol
, vol.170
, pp. 597
-
-
Cleary, A.M.1
Tu, W.2
Enright, A.3
Giffon, T.4
Dewaal-Malefyt, R.5
Gutierrez, K.6
Lewis, D.B.7
-
71
-
-
0037261363
-
Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta 1-deficient patients and evidence for the existence of partial receptor beta 1 deficiencies
-
Elgin GR (2003) Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta 1-deficient patients and evidence for the existence of partial receptor beta 1 deficiencies. Eur J Immunol 33:59
-
(2003)
Eur J Immunol
, vol.33
, pp. 59
-
-
Elgin, G.R.1
-
72
-
-
0034698827
-
Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): Evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells
-
Verhagen CE, Boer T de, Smits HH, Verreck FA, Wierenga EA, Kurimoto M, Lammas DA, Kumararatne DS, Sanal O, Kroon FP, Dissel JT van, Sinigaglia F, Ottenhoff TH (2000) Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells. J Exp Med 192:517
-
(2000)
J Exp Med
, vol.192
, pp. 517
-
-
Verhagen, C.E.1
De Boer, T.2
Smits, H.H.3
Verreck, F.A.4
Wierenga, E.A.5
Kurimoto, M.6
Lammas, D.A.7
Kumararatne, D.S.8
Sanal, O.9
Kroon, F.P.10
Van Dissel, J.T.11
Sinigaglia, F.12
Ottenhoff, T.H.13
-
74
-
-
0026701132
-
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
-
D'Andrea A, Rengaraju M, Valiante NM, et al (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176:1387
-
(1992)
J Exp Med
, vol.176
, pp. 1387
-
-
D'Andrea, A.1
Rengaraju, M.2
Valiante, N.M.3
-
76
-
-
0030817861
-
Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock
-
Mattner F, Ozmen L, Podlaski FJ, Wilkinson VL, Presky DH, Gately MK, Alber G (1997) Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect Immun 65:4734
-
(1997)
Infect Immun
, vol.65
, pp. 4734
-
-
Mattner, F.1
Ozmen, L.2
Podlaski, F.J.3
Wilkinson, V.L.4
Presky, D.H.5
Gately, M.K.6
Alber, G.7
-
77
-
-
0029808332
-
Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection
-
Kato K, Shimozato O, Hoshi K, Wakimoto H, Hamada H, Yagita H, Okumura K (1996) Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc Natl Acad Sci USA 93:9085
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9085
-
-
Kato, K.1
Shimozato, O.2
Hoshi, K.3
Wakimoto, H.4
Hamada, H.5
Yagita, H.6
Okumura, K.7
-
78
-
-
0031041596
-
Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases
-
Zou J, Presky DH, Wu CY, Gubler U (1997) Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. J Biol Chem 272:6073
-
(1997)
J Biol Chem
, vol.272
, pp. 6073
-
-
Zou, J.1
Presky, D.H.2
Wu, C.Y.3
Gubler, U.4
-
79
-
-
0032565598
-
Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit
-
Kawashima T, Kawasaki H, Kitamura T, Nojima Y, Morimoto C (1998) Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit. Cell Immunol 186:39
-
(1998)
Cell Immunol
, vol.186
, pp. 39
-
-
Kawashima, T.1
Kawasaki, H.2
Kitamura, T.3
Nojima, Y.4
Morimoto, C.5
-
80
-
-
0037238897
-
A unique role for IL-23 in promoting cellular immunity
-
Lankford CS, Frucht DM (2003) A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol 73:49
-
(2003)
J Leukoc Biol
, vol.73
, pp. 49
-
-
Lankford, C.S.1
Frucht, D.M.2
-
81
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, Waal-Malefyt R de, Hannum C, Bazan JF, Kastelein RA (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715
-
(2000)
Immunity
, vol.13
, pp. 715
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
Vega, F.7
Yu, N.8
Wang, J.9
Singh, K.10
Zonin, F.11
Vaisberg, E.12
Churakova, T.13
Liu, M.14
Gorman, D.15
Wagner, J.16
Zurawski, S.17
Liu, Y.18
Abrams, J.S.19
Moore, K.W.20
Rennick, D.21
De Waal-Malefyt, R.22
Hannum, C.23
Bazan, J.F.24
Kastelein, R.A.25
more..
-
82
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
-
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, Waal Malefyt R de, Moore KW (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168:5699
-
(2002)
J Immunol
, vol.168
, pp. 5699
-
-
Parham, C.1
Chirica, M.2
Timans, J.3
Vaisberg, E.4
Travis, M.5
Cheung, J.6
Pflanz, S.7
Zhang, R.8
Singh, K.P.9
Vega, F.10
To, W.11
Wagner, J.12
O'Farrell, A.M.13
McClanahan, T.14
Zurawski, S.15
Hannum, C.16
Gorman, D.17
Rennick, D.M.18
Kastelein, R.A.19
De Waal Malefyt, R.20
Moore, K.W.21
more..
-
83
-
-
0035313701
-
The Stat family in cytokine signaling
-
Ihle JN (2001) The Stat family in cytokine signaling. Curr Opin Cell Biol 13:211
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 211
-
-
Ihle, J.N.1
-
84
-
-
0030840464
-
STATs and gene regulation
-
Darnell JE Jr (1997) STATs and gene regulation. Science 277:1630
-
(1997)
Science
, vol.277
, pp. 1630
-
-
Darnell Jr., J.E.1
-
85
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski MT, Leach MW, Evans EW, Sullivan L, Chen SC, Vassileva G, Bazan JF, Gorman DM, Kastelein RA, Narula S, Lira SA (2001) Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol 166:7563
-
(2001)
J Immunol
, vol.166
, pp. 7563
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
Sullivan, L.4
Chen, S.C.5
Vassileva, G.6
Bazan, J.F.7
Gorman, D.M.8
Kastelein, R.A.9
Narula, S.10
Lira, S.A.11
-
86
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744
-
(2003)
Nature
, vol.421
, pp. 744
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
Zurawski, S.11
Wiekowski, M.12
Lira, S.A.13
Gorman, D.14
Kastelein, R.A.15
Sedgwick, J.D.16
-
87
-
-
0035904851
-
Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
-
Ehlers S, Benini J, Held HD, Roeck C, Alber G, Uhlig S (2001) Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology. J Exp Med 194:1847
-
(2001)
J Exp Med
, vol.194
, pp. 1847
-
-
Ehlers, S.1
Benini, J.2
Held, H.D.3
Roeck, C.4
Alber, G.5
Uhlig, S.6
-
88
-
-
0035472079
-
IFN-gamma production by antigen-presenting cells: Mechanisms emerge
-
Frucht DM, Fukao T, Bogdan C, Schindler H, O'Shea JJ, Koyasu S (2001) IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol 22:556
-
(2001)
Trends Immunol
, vol.22
, pp. 556
-
-
Frucht, D.M.1
Fukao, T.2
Bogdan, C.3
Schindler, H.4
O'Shea, J.J.5
Koyasu, S.6
-
89
-
-
0035313545
-
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses
-
Fukao T, Frucht DM, Yap G, Gadina M, O'Shea JJ, Koyasu S (2001) Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol 166:4446
-
(2001)
J Immunol
, vol.166
, pp. 4446
-
-
Fukao, T.1
Frucht, D.M.2
Yap, G.3
Gadina, M.4
O'Shea, J.J.5
Koyasu, S.6
-
90
-
-
0036604062
-
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
-
Belladonna ML, Renauld JC, Bianchi R, Vacca C, Fallarino F, Orabona C, Fioretti MC, Grohmann U, Puccetti P (2002) IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 168:5448
-
(2002)
J Immunol
, vol.168
, pp. 5448
-
-
Belladonna, M.L.1
Renauld, J.C.2
Bianchi, R.3
Vacca, C.4
Fallarino, F.5
Orabona, C.6
Fioretti, M.C.7
Grohmann, U.8
Puccetti, P.9
-
91
-
-
0012654169
-
IL-12-independent mechanisms of resistance during T. gondii infection: A role for IL-23?
-
Liebermann LA, Cardillo F, Rennick D, Hunter CA (2002) IL-12-independent mechanisms of resistance during T. gondii infection: a role for IL-23? FASEB J 16:Q1068
-
(2002)
FASEB J
, vol.16
-
-
Liebermann, L.A.1
Cardillo, F.2
Rennick, D.3
Hunter, C.A.4
-
92
-
-
0030067819
-
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
-
Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (1996) A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 70:1143
-
(1996)
J Virol
, vol.70
, pp. 1143
-
-
Devergne, O.1
Hummel, M.2
Koeppen, H.3
Le Beau, M.M.4
Nathanson, E.C.5
Kieff, E.6
Birkenbach, M.7
-
93
-
-
18444385868
-
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
-
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, Waal Malefyt R de, Rennick D, Kastelein RA (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16:779
-
(2002)
Immunity
, vol.16
, pp. 779
-
-
Pflanz, S.1
Timans, J.C.2
Cheung, J.3
Rosales, R.4
Kanzler, H.5
Gilbert, J.6
Hibbert, L.7
Churakova, T.8
Travis, M.9
Vaisberg, E.10
Blumenschein, W.M.11
Mattson, J.D.12
Wagner, J.L.13
To, W.14
Zurawski, S.15
McClanahan, T.K.16
Gorman, D.M.17
Bazan, J.F.18
De Waal Malefyt, R.19
Rennick, D.20
Kastelein, R.A.21
more..
-
94
-
-
17944377950
-
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
-
Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, Mu S, Xia M, Wakeham AC, Nishina H, Potter J, Saris CJ, Mak TW (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15:569
-
(2001)
Immunity
, vol.15
, pp. 569
-
-
Yoshida, H.1
Hamano, S.2
Senaldi, G.3
Covey, T.4
Faggioni, R.5
Mu, S.6
Xia, M.7
Wakeham, A.C.8
Nishina, H.9
Potter, J.10
Saris, C.J.11
Mak, T.W.12
-
95
-
-
0034687402
-
Development of Th1-type immune responses requires the type I cytokine receptor TCCR
-
Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407:916
-
(2000)
Nature
, vol.407
, pp. 916
-
-
Chen, Q.1
Ghilardi, N.2
Wang, H.3
Baker, T.4
Xie, M.H.5
Gurney, A.6
Grewal, I.S.7
De Sauvage, F.J.8
-
96
-
-
0032495990
-
Cloning and characterization of a novel class I cytokine receptor
-
Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998) Cloning and characterization of a novel class I cytokine receptor. Biochem Biophys Res Commun 246:82
-
(1998)
Biochem Biophys Res Commun
, vol.246
, pp. 82
-
-
Sprecher, C.A.1
Grant, F.J.2
Baumgartner, J.W.3
Presnell, S.R.4
Schrader, S.K.5
Yamagiwa, T.6
Whitmore, T.E.7
O'Hara, P.J.8
Foster, D.F.9
-
97
-
-
0038326688
-
Cutting edge: Role of IL-27/WSX-1 signaling for induction of t-bet through activation of STAT1 during initial Th1 commitment
-
in press
-
Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of t-bet through activation of STAT1 during initial Th1 commitment. J. Immunol 170 (in press)
-
(2003)
J. Immunol
, vol.170
-
-
Takeda, A.1
Hamano, S.2
Yamanaka, A.3
Hanada, T.4
Ishibashi, T.5
Mak, T.W.6
Yoshimura, A.7
Yoshida, H.8
-
98
-
-
0037168543
-
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
-
Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS (2002) Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci USA 99:16951
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16951
-
-
Nieuwenhuis, E.E.1
Neurath, M.F.2
Corazza, N.3
Iijima, H.4
Trgovcich, J.5
Wirtz, S.6
Glickman, J.7
Bailey, D.8
Yoshida, M.9
Galle, P.R.10
Kronenberg, M.11
Birkenbach, M.12
Blumberg, R.S.13
-
99
-
-
0029847368
-
Functional diversity of helper T lymphocytes
-
Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383:787
-
(1996)
Nature
, vol.383
, pp. 787
-
-
Abbas, A.K.1
Murphy, K.M.2
Sher, A.3
-
100
-
-
0029987839
-
The instructive role of innate immunity in the acquired immune response
-
Fearon DT, Locksley RM (1996) The instructive role of innate immunity in the acquired immune response. Science 272:50
-
(1996)
Science
, vol.272
, pp. 50
-
-
Fearon, D.T.1
Locksley, R.M.2
-
101
-
-
0036850908
-
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
-
Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W (2002) Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17:629
-
(2002)
Immunity
, vol.17
, pp. 629
-
-
Heller, F.1
Fuss, I.J.2
Nieuwenhuis, E.E.3
Blumberg, R.S.4
Strober, W.5
-
102
-
-
0032538915
-
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
-
Boirivant M, Fuss IJ, Chu A, Strober W (1998) Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188:1929
-
(1998)
J Exp Med
, vol.188
, pp. 1929
-
-
Boirivant, M.1
Fuss, I.J.2
Chu, A.3
Strober, W.4
-
103
-
-
0035156672
-
Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: Involvement of syncytiotrophoblasts and extravillous trophoblasts
-
Devergne O, Coulomb-L'Hermine A, Capel F, Moussa M, Capron F (2001) Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am J Pathol 159:1763
-
(2001)
Am J Pathol
, vol.159
, pp. 1763
-
-
Devergne, O.1
Coulomb-L'Hermine, A.2
Capel, F.3
Moussa, M.4
Capron, F.5
-
104
-
-
0030064036
-
Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
-
Snijders A, Hilkens CM, Pouw Kraan TC van der, Engel M, Aarden LA, Kapsenberg ML (1996) Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 156:1207
-
(1996)
J Immunol
, vol.156
, pp. 1207
-
-
Snijders, A.1
Hilkens, C.M.2
Van Der, P.K.T.C.3
Engel, M.4
Aarden, L.A.5
Kapsenberg, M.L.6
-
105
-
-
0028021595
-
Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ
-
Bette M, Jin SC, Germann T, Schafer MK, Weihe E, Rude E, Fleischer B (1994) Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur J Immunol 24:2435
-
(1994)
Eur J Immunol
, vol.24
, pp. 2435
-
-
Bette, M.1
Jin, S.C.2
Germann, T.3
Schafer, M.K.4
Weihe, E.5
Rude, E.6
Fleischer, B.7
-
106
-
-
0000060327
-
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
-
Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A (1997) In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med 186:1819
-
(1997)
J Exp Med
, vol.186
, pp. 1819
-
-
Reis E Sousa, C.1
Hieny, S.2
Scharton-Kersten, T.3
Jankovic, D.4
Charest, H.5
Germain, R.N.6
Sher, A.7
-
107
-
-
0030294163
-
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
-
Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A (1996) In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157:4045
-
(1996)
J Immunol
, vol.157
, pp. 4045
-
-
Scharton-Kersten, T.M.1
Wynn, T.A.2
Denkers, E.Y.3
Bala, S.4
Grunvald, E.5
Hieny, S.6
Gazzinelli, R.T.7
Sher, A.8
-
108
-
-
0027939611
-
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii
-
Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S, Caspar P, Trinchieri G, Sher A (1994) Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153:2533
-
(1994)
J Immunol
, vol.153
, pp. 2533
-
-
Gazzinelli, R.T.1
Wysocka, M.2
Hayashi, S.3
Denkers, E.Y.4
Hieny, S.5
Caspar, P.6
Trinchieri, G.7
Sher, A.8
-
109
-
-
0035886848
-
C-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription
-
Grumont R, Hochrein H, O'Keeffe M, Gugasyan R, White C, Caminschi I, Cook W, Gerondakis S (2001) c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J Exp Med 194:1021
-
(2001)
J Exp Med
, vol.194
, pp. 1021
-
-
Grumont, R.1
Hochrein, H.2
O'Keeffe, M.3
Gugasyan, R.4
White, C.5
Caminschi, I.6
Cook, W.7
Gerondakis, S.8
-
110
-
-
0034653895
-
Selective suppression of IL-12 production by chemoattractants
-
Braun MC, Lahey E, Kelsall BL (2000) Selective suppression of IL-12 production by chemoattractants. J Immunol 164:3009
-
(2000)
J Immunol
, vol.164
, pp. 3009
-
-
Braun, M.C.1
Lahey, E.2
Kelsall, B.L.3
-
111
-
-
0037111202
-
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages
-
Pirhonen J, Matikainen S, Julkunen I (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 169:5673
-
(2002)
J Immunol
, vol.169
, pp. 5673
-
-
Pirhonen, J.1
Matikainen, S.2
Julkunen, I.3
-
112
-
-
0035813157
-
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
-
Re F, Strominger JL (2001) Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276:37692
-
(2001)
J Biol Chem
, vol.276
, pp. 37692
-
-
Re, F.1
Strominger, J.L.2
-
113
-
-
0031839740
-
Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells
-
Hayes MP, Murphy FJ, Burd PR (1998) Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells. Blood 91:4645
-
(1998)
Blood
, vol.91
, pp. 4645
-
-
Hayes, M.P.1
Murphy, F.J.2
Burd, P.R.3
-
114
-
-
0030064148
-
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
-
Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dzialo R, Trinchieri G (1996) The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 183:147
-
(1996)
J Exp Med
, vol.183
, pp. 147
-
-
Ma, X.1
Chow, J.M.2
Gri, G.3
Carra, G.4
Gerosa, F.5
Wolf, S.F.6
Dzialo, R.7
Trinchieri, G.8
-
115
-
-
0028911482
-
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production
-
D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G (1995) Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 181:537
-
(1995)
J Exp Med
, vol.181
, pp. 537
-
-
D'Andrea, A.1
Ma, X.2
Aste-Amezaga, M.3
Paganin, C.4
Trinchieri, G.5
-
116
-
-
0029812593
-
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
-
Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184:747
-
(1996)
J Exp Med
, vol.184
, pp. 747
-
-
Cella, M.1
Scheidegger, D.2
Palmer-Lehmann, K.3
Lane, P.4
Lanzavecchia, A.5
Alber, G.6
-
117
-
-
0034663999
-
IL-4 is a mediator of IL-12p70 induction by human Th2 cells: Reversal of polarized Th2 phenotype by dendritic cells
-
Kalinski P, Smits HH, Schuitemaker JH, Vieira PL, Eijk M van, Jong EC de, Wierenga EA, Kapsenberg ML (2000) IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells. J Immunol 165:1877
-
(2000)
J Immunol
, vol.165
, pp. 1877
-
-
Kalinski, P.1
Smits, H.H.2
Schuitemaker, J.H.3
Vieira, P.L.4
Van Eijk, M.5
De Jong, E.C.6
Wierenga, E.A.7
Kapsenberg, M.L.8
-
118
-
-
0029014952
-
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells
-
Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh CS, Culpepper JA, Wysocka M, Trinchieri G, Murphy KM, O'Garra A (1995) Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154:5071
-
(1995)
J Immunol
, vol.154
, pp. 5071
-
-
Macatonia, S.E.1
Hosken, N.A.2
Litton, M.3
Vieira, P.4
Hsieh, C.S.5
Culpepper, J.A.6
Wysocka, M.7
Trinchieri, G.8
Murphy, K.M.9
O'Garra, A.10
-
119
-
-
0033697454
-
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
-
Schulz O, Edwards AD, Schito M, Aliberti J, Manickasingham S, Sher A, Reis e Sousa C (2000) CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453
-
(2000)
Immunity
, vol.13
, pp. 453
-
-
Schulz, O.1
Edwards, A.D.2
Schito, M.3
Aliberti, J.4
Manickasingham, S.5
Sher, A.6
Reis E Sousa, C.7
-
120
-
-
0033451474
-
Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription
-
Weinmann AS, Plevy SE, Smale ST (1999) Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. Immunity 11:665
-
(1999)
Immunity
, vol.11
, pp. 665
-
-
Weinmann, A.S.1
Plevy, S.E.2
Smale, S.T.3
-
121
-
-
0035221154
-
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
-
Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST (2001) Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat Immunol 2:51
-
(2001)
Nat Immunol
, vol.2
, pp. 51
-
-
Weinmann, A.S.1
Mitchell, D.M.2
Sanjabi, S.3
Bradley, M.N.4
Hoffmann, A.5
Liou, H.C.6
Smale, S.T.7
-
122
-
-
0035863730
-
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction
-
Eaves-Pyles T, Murthy K, Liaudet L, Virag L, Ross G, Soriano FG, Szabo C, Salzman AL (2001) Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol 166:1248
-
(2001)
J Immunol
, vol.166
, pp. 1248
-
-
Eaves-Pyles, T.1
Murthy, K.2
Liaudet, L.3
Virag, L.4
Ross, G.5
Soriano, F.G.6
Szabo, C.7
Salzman, A.L.8
-
123
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA Jr (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2:253
-
(1998)
Mol Cell
, vol.2
, pp. 253
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Kopp, E.3
Stadlen, A.4
Chen, C.5
Ghosh, S.6
Janeway Jr., C.A.7
-
124
-
-
0034650420
-
Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- And MyD88-dependent signaling pathway
-
Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Muhlradt PF, Akira S (2000) Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol 164:554
-
(2000)
J Immunol
, vol.164
, pp. 554
-
-
Takeuchi, O.1
Kaufmann, A.2
Grote, K.3
Kawai, T.4
Hoshino, K.5
Morr, M.6
Muhlradt, P.F.7
Akira, S.8
-
125
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115
-
(1999)
Immunity
, vol.11
, pp. 115
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
126
-
-
0034175632
-
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
-
Rudolph D, Yeh WC, Wakeham A, Rudolph B, Nallainathan D, Potter J, Elia AJ, Mak TW (2000) Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev 14:854
-
(2000)
Genes Dev
, vol.14
, pp. 854
-
-
Rudolph, D.1
Yeh, W.C.2
Wakeham, A.3
Rudolph, B.4
Nallainathan, D.5
Potter, J.6
Elia, A.J.7
Mak, T.W.8
-
127
-
-
0033638970
-
NEMO/IKK gamma-deficient mice model incontinentia pigmenti
-
Schmidt-Supprian M, Bloch W, Courtois G, Addicks K, Israel A, Rajewsky K, Pasparakis M (2000) NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell 5:981
-
(2000)
Mol Cell
, vol.5
, pp. 981
-
-
Schmidt-Supprian, M.1
Bloch, W.2
Courtois, G.3
Addicks, K.4
Israel, A.5
Rajewsky, K.6
Pasparakis, M.7
-
128
-
-
0033257795
-
JNK2 and IKKbeta are required for activating the innate response to viral infection
-
Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M (1999) JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity 11:721
-
(1999)
Immunity
, vol.11
, pp. 721
-
-
Chu, W.M.1
Ostertag, D.2
Li, Z.W.3
Chang, L.4
Chen, Y.5
Hu, Y.6
Williams, B.7
Perrault, J.8
Karin, M.9
-
129
-
-
0030872393
-
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
-
Plevy SE, Gemberling JH, Hsu S, Dorner AJ, Smale ST (1997) Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol Cell Biol 17:4572
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4572
-
-
Plevy, S.E.1
Gemberling, J.H.2
Hsu, S.3
Dorner, A.J.4
Smale, S.T.5
-
130
-
-
0029920849
-
Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acutephase response
-
An MR, Hsieh CC, Reisner PD, Rabek JP, Scott SG, Kuninger DT, Papaconstantinou J (1996) Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide- mediated acutephase response. Mol Cell Biol 16:2295
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2295
-
-
An, M.R.1
Hsieh, C.C.2
Reisner, P.D.3
Rabek, J.P.4
Scott, S.G.5
Kuninger, D.T.6
Papaconstantinou, J.7
-
131
-
-
0025936177
-
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
-
Descombes P, Schibler U (1991) A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569
-
(1991)
Cell
, vol.67
, pp. 569
-
-
Descombes, P.1
Schibler, U.2
-
132
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
-
Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285:732
-
(1999)
Science
, vol.285
, pp. 732
-
-
Brightbill, H.D.1
Libraty, D.H.2
Krutzik, S.R.3
Yang, R.B.4
Belisle, J.T.5
Bleharski, J.R.6
Maitland, M.7
Norgard, M.V.8
Plevy, S.E.9
Smale, S.T.10
Brennan, P.J.11
Bloom, B.R.12
Godowski, P.J.13
Modlin, R.L.14
-
133
-
-
0029024113
-
Lymphoproliferative disorder and unbalanced T-helper response in C/ EBP beta-deficient mice
-
Screpanti I, Romani L, Musiani P, et al. (1995) Lymphoproliferative disorder and unbalanced T-helper response in C/ EBP beta-deficient mice. EMBO J 14:1932
-
(1995)
EMBO J
, vol.14
, pp. 1932
-
-
Screpanti, I.1
Romani, L.2
Musiani, P.3
-
134
-
-
0028853334
-
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
-
Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T (1995) Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353
-
(1995)
Cell
, vol.80
, pp. 353
-
-
Tanaka, T.1
Akira, S.2
Yoshida, K.3
Umemoto, M.4
Yoneda, Y.5
Shirafuji, N.6
Fujiwara, H.7
Suematsu, S.8
Yoshida, N.9
Kishimoto, T.10
-
135
-
-
0037090244
-
C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages
-
Gorgoni B, Maritano D, Marthyn P, Righi M, Poli V (2002) C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages. J Immunol 168:4055
-
(2002)
J Immunol
, vol.168
, pp. 4055
-
-
Gorgoni, B.1
Maritano, D.2
Marthyn, P.3
Righi, M.4
Poli, V.5
-
136
-
-
0030891006
-
Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
-
Ma X, Neurath M, Gri G, Trinchieri G (1997) Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem 272:10389
-
(1997)
J Biol Chem
, vol.272
, pp. 10389
-
-
Ma, X.1
Neurath, M.2
Gri, G.3
Trinchieri, G.4
-
137
-
-
0032513227
-
Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages
-
Gri G, Savio D, Trinchieri G, Ma X (1998) Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. J Biol Chem 273:6431
-
(1998)
J Biol Chem
, vol.273
, pp. 6431
-
-
Gri, G.1
Savio, D.2
Trinchieri, G.3
Ma, X.4
-
138
-
-
0033179698
-
IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice
-
Salkowski CA, Kopydlowski K, Blanco J, Cody MJ, McNally R, Vogel SN (1999) IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice. J Immunol 163:1529
-
(1999)
J Immunol
, vol.163
, pp. 1529
-
-
Salkowski, C.A.1
Kopydlowski, K.2
Blanco, J.3
Cody, M.J.4
McNally, R.5
Vogel, S.N.6
-
139
-
-
0035313284
-
Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation
-
Grazia Cappiello M, Sutterwala FS, Trinchieri G, Mosser DM, Ma X (2001) Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation. J Immunol 166:4498
-
(2001)
J Immunol
, vol.166
, pp. 4498
-
-
Grazia Cappiello, M.1
Sutterwala, F.S.2
Trinchieri, G.3
Mosser, D.M.4
Ma, X.5
-
140
-
-
0028316546
-
Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
-
Kubin M, Chow JM, Trinchieri G (1994) Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83:1847
-
(1994)
Blood
, vol.83
, pp. 1847
-
-
Kubin, M.1
Chow, J.M.2
Trinchieri, G.3
-
141
-
-
0029040855
-
Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
-
Hayes MP, Wang J, Norcross MA (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646
-
(1995)
Blood
, vol.86
, pp. 646
-
-
Hayes, M.P.1
Wang, J.2
Norcross, M.A.3
-
142
-
-
0030060242
-
Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes
-
Tone Y, Thompson SA, Babik JM, Nolan KF, Tone M, Raven C, Waldmann H (1996) Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur J Immunol 26:1222
-
(1996)
Eur J Immunol
, vol.26
, pp. 1222
-
-
Tone, Y.1
Thompson, S.A.2
Babik, J.M.3
Nolan, K.F.4
Tone, M.5
Raven, C.6
Waldmann, H.7
-
143
-
-
0030028619
-
Molecular cloning and characterization of murine IL-12 genes
-
Yoshimoto T, Kojima K, Funakoshi T, Endo Y, Fujita T, Nariuchi H (1996) Molecular cloning and characterization of murine IL-12 genes. J Immunol 156:1082
-
(1996)
J Immunol
, vol.156
, pp. 1082
-
-
Yoshimoto, T.1
Kojima, K.2
Funakoshi, T.3
Endo, Y.4
Fujita, T.5
Nariuchi, H.6
-
144
-
-
0033802387
-
Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
-
Hochrein H, O'Keeffe M, Luft T, Vandenabeele S, Grumont RJ, Maraskovsky E, Shortman K (2000) Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med 192:823
-
(2000)
J Exp Med
, vol.192
, pp. 823
-
-
Hochrein, H.1
O'Keeffe, M.2
Luft, T.3
Vandenabeele, S.4
Grumont, R.J.5
Maraskovsky, E.6
Shortman, K.7
-
145
-
-
0034194222
-
Biosynthesis and posttranslational regulation of human IL-12
-
Carra G, Gerosa F, Trinchieri G (2000) Biosynthesis and posttranslational regulation of human IL-12. J Immunol 164:4752
-
(2000)
J Immunol
, vol.164
, pp. 4752
-
-
Carra, G.1
Gerosa, F.2
Trinchieri, G.3
-
146
-
-
0034650811
-
Disparate intracellular processing of human IL-12 preprotein subunits: Atypical processing of the P35 signal peptide
-
Murphy FJ, Hayes MP, Burd PR (2000) Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide. J Immunol 164:839
-
(2000)
J Immunol
, vol.164
, pp. 839
-
-
Murphy, F.J.1
Hayes, M.P.2
Burd, P.R.3
-
147
-
-
0033773797
-
Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers
-
Martens E, Alloza I, Scott CJ, Billiau A, Vandenbroeck K (2000) Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers. Eur J Biochem 267:6679
-
(2000)
Eur J Biochem
, vol.267
, pp. 6679
-
-
Martens, E.1
Alloza, I.2
Scott, C.J.3
Billiau, A.4
Vandenbroeck, K.5
-
148
-
-
0032526338
-
Molecular mechanisms of the induction of IL-12 and its inhibition by 1L-10
-
Aste-Amezaga M, Ma X, Sartori A, Trinchieri G (1998) Molecular mechanisms of the induction of IL-12 and its inhibition by 1L-10. J Immunol 160:5936
-
(1998)
J Immunol
, vol.160
, pp. 5936
-
-
Aste-Amezaga, M.1
Ma, X.2
Sartori, A.3
Trinchieri, G.4
-
149
-
-
0027240219
-
Interleukin 10 (IL-10) inhibits human lymphocyte interferon
-
D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178:1041
-
(1993)
J Exp Med
, vol.178
, pp. 1041
-
-
D'Andrea, A.1
Aste-Amezaga, M.2
Valiante, N.M.3
Ma, X.4
Kubin, M.5
Trinchieri, G.6
-
150
-
-
0033949735
-
The role of interleukin-13 in infectious diseases and allergy
-
Brombacher F (2000) The role of interleukin-13 in infectious diseases and allergy. Bioessays 22:646
-
(2000)
Bioessays
, vol.22
, pp. 646
-
-
Brombacher, F.1
-
151
-
-
0031799002
-
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells
-
Du C, Sriram S (1998) Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells. J Leukoc Biol 64:92
-
(1998)
J Leukoc Biol
, vol.64
, pp. 92
-
-
Du, C.1
Sriram, S.2
-
152
-
-
0035089760
-
Regulation of interleukin-12 production by G-protein-coupled receptors
-
Braun MC, Kelsall BL (2001) Regulation of interleukin-12 production by G-protein-coupled receptors. Microbes Infect 3:99
-
(2001)
Microbes Infect
, vol.3
, pp. 99
-
-
Braun, M.C.1
Kelsall, B.L.2
-
153
-
-
0036199625
-
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
-
Jankovic D, Kullberg MC, Hieny S, Caspar P, Collazo CM, Sher A (2002) In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16:429
-
(2002)
Immunity
, vol.16
, pp. 429
-
-
Jankovic, D.1
Kullberg, M.C.2
Hieny, S.3
Caspar, P.4
Collazo, C.M.5
Sher, A.6
-
154
-
-
0035914841
-
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
-
Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL (2001) The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194:1497
-
(2001)
J Exp Med
, vol.194
, pp. 1497
-
-
Belkaid, Y.1
Hoffmann, K.F.2
Mendez, S.3
Kamhawi, S.4
Udey, M.C.5
Wynn, T.A.6
Sacks, D.L.7
-
155
-
-
0343081421
-
Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice
-
Hölscher C, Mohrs M, Dai WJ, Köhler G, Ryffel B, Schaub GA, Mossmann H, Brombacher F (2000) Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice. Infect Immun 68:4075
-
(2000)
Infect Immun
, vol.68
, pp. 4075
-
-
Hölscher, C.1
Mohrs, M.2
Dai, W.J.3
Köhler, G.4
Ryffel, B.5
Schaub, G.A.6
Mossmann, H.7
Brombacher, F.8
-
156
-
-
15944387892
-
Interleukin-13: Genes, receptors and signal transduction
-
Brombacher F (ed) Lands Bioscience, Georgetown
-
Hölscher C (2003) Interleukin-13: genes, receptors and signal transduction. In: Brombacher F (ed) Interleukin-13. Lands Bioscience, Georgetown, p 1
-
(2003)
Interleukin-13
, pp. 1
-
-
Hölscher, C.1
-
157
-
-
0035451798
-
Regulation of IL-12 p40 promoter activity in primary human monocytes: Roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2)
-
Becker C, Wirtz S, Ma X, Blessing M, Galle PR, Neurath MF (2001) Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2). J Immunol 167:2608
-
(2001)
J Immunol
, vol.167
, pp. 2608
-
-
Becker, C.1
Wirtz, S.2
Ma, X.3
Blessing, M.4
Galle, P.R.5
Neurath, M.F.6
-
158
-
-
0032033419
-
Cytokines induce the development of functionally heterogeneous T helper cell subsets
-
O'Garra A (1998) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275
-
(1998)
Immunity
, vol.8
, pp. 275
-
-
O'Garra, A.1
-
159
-
-
0034679726
-
Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
-
Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS (2000) Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J 19:3530
-
(2000)
EMBO J
, vol.19
, pp. 3530
-
-
Yoon, C.1
Johnston, S.C.2
Tang, J.3
Stahl, M.4
Tobin, J.F.5
Somers, W.S.6
|