Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12

EMBO Journal

Volumn 19, Issue 14, 2000, Pages 3530-3541

  Yoon, Christina ^a   Johnston, Steven C ^b,c   Tang, Jin ^b   Stahl, Mark ^b   Tobin, James F ^a   Somers, William S ^b  

^a Dept of Musculoskeletal Sciences ^*  (United States)

^b PFIZER INC   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Cytokine receptor complex; Interleukin 12; Structure function; X ray crystallography

Indexed keywords

ARGININE; CYTOKINE; CYTOKINE RECEPTOR; DIMER; DISULFIDE; IMMUNOGLOBULIN; INTERLEUKIN 12; PROTEIN P40; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; HUMAN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALIA;

EID: 0034679726     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.14.3530     Document Type: Article

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