Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor β1 deficiency

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 597-603

  Cleary, Aileen M ^a   Tu, Wenwei ^a   Enright, Andrea ^a   Giffon, Thierry ^a   Dewaal Malefyt, Rene ^b   Gutierrez, Kathleen ^a   Lewis, David B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 23; MESSENGER RNA; MONOCLONAL ANTIBODY; RECEPTOR SUBUNIT; RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; MEMORY CELL; PRIORITY JOURNAL; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA ENTERITIDIS; T LYMPHOCYTE SUBPOPULATION;

EID: 0037218610     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.597     Document Type: Article

References (50)

1. Reiner, S. L. 2001. Helper T cell differentiation, inside and out. Curr. Opin. Immunol. 13:351.
2. Murphy, K. M., J. Ouyang, J. D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T. L. Murphy. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18:451.
3. Sprent, J., and C. D. Surh. 2001. Generation and maintenance of memory T cells. Curr. Opin. Immunol. 13:248.
4. Lanzavecchia, A., and F. Sallusto. 2000. Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells. Science 290:92.
5. Beverley, P. C. 1992. Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin. Immunol. 4:35.
6. Sallusto, F., D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708.
7. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23.
8. Sallusto, F., C. R. Mackay, and A. Lanzavecchia. 2000. The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18:593.
9. Kim, C. H., L. Rott, E. J. Kunkel, M. C. Genovese, D. P. Andrew, L. Wu, and E. C. Butcher. 2001. Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Invest. 108:1331.
10. Ma, X., and G. Trinchieri. 2001. Regulation of IL-12 production in antigen-presenting cells. Adv. Immunol. 79:55.
11. Presky, D. H., L. J. Minetti, S. Gillessen, V. L. Wilkinson, C. Y. Wu, U. Gubler, R. Chizzonite, and M. K. Gately. 1998. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 160:2174.
12. Bacon, C. M., E. F. Petricoin III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
13. Bacon, C. B., D. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin-12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IIL-2 and IL-12. J. Exp. Med. 181:399.
14. Zou, J., D. H. Presky, C. Y. Wu, and U. Gubler. 1997. Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases. J. Biol. Chem. 272:6073.
15. Naeger, L. K., J. McKinney, A. Salvekar, and T. Hoey. 1999. Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. J. Biol. Chem. 274:1875.
16. Kaplan, M. H., A. L. Wurster, and M. J. Grusby. 1998. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J. Exp. Med. 188:1191.
17. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715.
18. Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:5699.
19. Jouanguy, E., R. Doffinger, S. Dupuis, A. Pallier, F. Altare, and J. L. Casanova. 1999. IL-12 and IFN-γ in host defense against mycobacteria of mice and men. Curr. Opin. Immunol. 11:346.
20. Piccotti, J. R., K. Li, S. Y. Chan, J. Ferrante, J. Magram, E. J. Eichwald, and D. K. Bishop. 1998. Alloantigen-reactive Th1 development in IL-12-deficient mice. J. Immunol. 160:1132.
21. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrente, C. Stewart, U. Sarmiento, D. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses. Immunity 4:471.
22. Wakeham, J., J. Wang, J. Magram, K. Croitoru, R. Harkness, P. Dunn, A. Zganiacz, and L. Xing. 1998. Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guerin in IL-12-deficient mice. J. Immunol. 160:6101.
23. de Jong, R., F. Altare, I. A. Haagen, D. G. Elferink, T. Boer, P. J. van Breda Vriesman, P. J. Kabel, J. M. Draaisma, J. T. van Dissel, F. P. Kroon, et al. 1998. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435.
24. Ottenhoff, T. H., D. Kumararatne, and J. L. Casanova. 1998. Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria. Immunol. Today 19:491.
25. Sakai, T., M. Matsuoka, M. Aoki, K. Nosaka, and H. Mitsuya. 2001. Missense mutation of the interleukin-12 receptor beta1 is associated with impaired immunity against Mycobacterium avium complex infection. Blood 97:2688.
26. Touw, I. P., J. P. De Koning, A. C. Ward, and M. H. Hermans. 2000. Signaling mechanisms of cytokine receptors and their perturbances in disease. Mol. Cell. Endocrinol. 160:1.
27. Verhagen, C. E., T. de Boer, H. H. Smits, F. A. Verreck, E. A. Wierenga, M. Kurimoto, D. A. Lammas, D. A. Kumararatne, O. Sanal, F. P. Kroon, et al. 2000. Residual type 1 immunity in patients genetically deficient for 12 receptor β1 (IL-12Rβ1): Evidence for an IL-12β1-independent pathway of IL-12 responsiveness in human T cells. J. Exp. Med. 192:517.
28. Picard, C., C. Fieschi, F. Altare, S. Al-Jumaah, S. Al-Hajjar, J. Feinberg, S. Dupuis, C. Soudais, I. Z. Al-Mohsen, E. Genin, et al. 2002. Inherited interleukin-12 deficiency: IL-12B genotype and clinical phenotype of 13 patients from six kindreds. Am. J. Hum. Genet. 70:336.
29. Lewis, D. B., C. C. Yu, J. Meyer, B. K. English, S. J. Kahn, and C. B. Wilson. 1991. Cellular and molecular mechanisms for reduced interleukin 4 and interfer-on-γ production by neonatal T cells. J. Clin. Invest. 87:194.
30. + T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J. Exp. Med. 191:651.
31. Wang, K. S., D. A. Frank, and J. Ritz. 2000. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95:3183.
32. Chua, A. O., R. Chizzonite, B. B. Desai, T. P. Truitt, P. Nunes, L. J. Minetti, R. R. Warrier, D. H. Presky, J. F. Levine, M. K. Gately, et al. 1994. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153:128.
33. Ottenhoff, T. H., T. de Boer, C. E. Verhagen, F. A. Verreck, and J. T. van Dissel. 2000. Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria. Microbes Infect. 2:1559.
34. Dorman, S. E., and S. M. Holland. 2000. Interferon-γ and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev. 11:321.
35. Joneja, B., and D. M. Wojchowski. 1997. Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain. J. Biol. Chem. 272:11176.
36. + T cells. Eur. J. Immunol. 19:771.
37. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
38. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. J. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655.
39. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T.-P. Yao, S. Y. Yang, et al. 2001. Role of T-bet in commitment of Th1 cells before IL-12-dependent selection. Science 292:1907.
40. Palmer, E. M., L. Farrokh-Siar, J. M. van Seventer, and G. A. van Seventer. 2001. IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1:1. IL-12 alters caspase processing and inhibits enzyme function. J. Immunol. 167:749.
41. Stobie, L., S. Gurunathan, C. Prussin, S. L. Sacks, N. Glaichenhaus, C.-Y. Wu, and R. A. Seder. 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl. Acad. Sci. USA 97:8427.
42. Yap, G., M. Pesin, and A. Sher. 2000. Cutting edge: IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen. Toxoplasma gondii. J. Immunol. 165:628.
43. Park, A. Y., B. D. Hondowicz, and P. Scott. 2000. IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 165:896.
44. Dubois, B., C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux. 1998. Critical role of IL-12 in dendritic cell-induced differentiation of naïve B lymphocytes. J. Immunol. 161:2223.
45. + T cells. J. Exp. Med. 194:1711.
46. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-122 subunit expression in developing T helper (Th1) and Th2 cells. J. Exp. Med. 185:817.
47. Murphy, K. M., T. L. Murphy, S. J. Szabo, N. G. Jacobson, M. L. Guler, J. D. Gorham, and U. Gubler. 1997. Regulation of IL-12 receptor expression in early T-helper responses implies two phases of Th1 differentiation: Capacitance and development. Chem. Immunol. 68:54.
48. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, et al. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98:15137.
49. Decken, K., G. Kohler, K. Palmer-Lehmann, A. Wunderlin, F. Mattner, J. Magram, M. K. Gately, and G. Alber. 1998. Interleukin-12 is essential for a protective Th1 response in with Cryptococcus neoformans. Infect. Immun. 66:4994.
50. Huang, L., S. N. Constantinescu, and H. F. Lodish. 2001. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell 8:1327.