Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4+ T cells

Journal of Virology

Volumn 76, Issue 10, 2002, Pages 4709-4722

  Popik, Waldemar ^a   Alce, Timothy M ^a   Au, Wei Chun ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD48 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHOLESTEROL; GANGLIOSIDE GM1; GLYCOPROTEIN GP 120; GLYCOSYLPHOSPHATIDYLINOSITOL; LIPID; LUCIFERASE; METHYL BETA CYCLODEXTRIN; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR;

ARTICLE; CELL FRACTIONATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; SUCROSE GRADIENT; T LYMPHOCYTE; VESICULAR STOMATITIS VIRUS; VIRUS CELL INTERACTION;

ANTIGENS, CD4; BETA-CYCLODEXTRINS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CHOLESTEROL; CYCLODEXTRINS; G(M1) GANGLIOSIDE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; JURKAT CELLS; MEMBRANE LIPIDS; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; VIRUS REPLICATION;

EID: 0036239931     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.10.4709-4722.2002     Document Type: Article

References (57)

1. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
2. Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes
3. Antigenically distinct conformations of CXCR4
4. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
5. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton
6. 2 rafts
7. SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis
8. Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection
9. Beyond receptor expression: The influence of receptor conformation, density, and affinity in HIV-1 infection
10. The plasma membrane as a combat zone in the HIV battlefield
11. Endocytic entry of HIV-1
12. Role of glycosphingolipid microdomains in CD4-dependent HIV-1 fusion
13. Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells
14. Essential role for cholesterol in entry of Mycobacteria into macrophages
15. Human oxytocin receptors in cholesterol-rich vs. cholesterol-poor microdomains of the plasma membrane
16. Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: Evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3)
17. Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies
18. Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging
19. Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5
20. Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling
21. Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells
22. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
23. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes
24. Cellular cholesterol efflux mediated by cyclodextrins
25. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
26. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis
27. HIV requires multiple gp120 molecules for CD4-mediated infection
28. Lipid rafts and HIV pathogenesis: Host membrane cholesterol is required for infection by HIV type 1
29. Ecotropic murine leukemia virus receptor is physically associated with caveolin and membrane rafts
30. Semliki Forest virus budding: Assay, mechanisms, and cholesterol requirement
31. The cholesterol requirement for Sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence
32. Membrane raft microdomains mediate front-rear polarity in migrating cells
33. Measles virus structural components are enriched into lipid raft microdomains: A potential cellular location for virus assembly
34. Cytosolic Gag p24 as an index of productive entry of human immunodeficiency virus type 1
35. CD4 segregates into specific detergent-resistant T-cell membrane microdomains
36. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
37. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton
38. Plasma membrane rafts play a critical role in HIV-1 assembly and release
39. Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40
40. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
41. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
42. Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogenactivated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor
43. - T lymphocytes
44. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
45. Retention of prominin in microvilli reveals distinct cholesterol-based lipid microdomains in the apical plasma membrane
46. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
47. The role of cholesterol and glycosylphosphatidylinositol-anchored proteins of erythrocyte rafts in regulating raft protein content and malarial infection
48. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
49. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain
50. Influenza viruses select ordered lipid domains during budding from the plasma membrane
51. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: Replication is restricted at a postentry level
52. Lipid rafts and signal transduction
53. Functional rafts in cell membranes
54. CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells
55. Membrane compartmentation is required for efficient T cell activation
56. Constitutive cell surface association between CD4 and CCR5
57. Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts