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Volumn 9, Issue 3, 2003, Pages 186-193

New antiretroviral drugs

Author keywords

Antiretroviral drugs; Entry inhibitors; HIV therapy; Integrase inhibitors; Protease inhibitors; Reverse transcriptase inhibitors

Indexed keywords

1 [5 (4 FLUOROBENZYL) 2 FURYL] 3 (1,2,4 TRIAZOL 3 YL) 1,3 PROPANEDIONE; 4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; 6 CHLORO 4 (2 CYCLOPROPYLVINYL) 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; ABACAVIR; AMDOXOVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; CHEMOKINE RECEPTOR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; INTEGRASE INHIBITOR; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; T 1249; TENOFOVIR; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 0037367636     PISSN: 1198743X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-0691.2003.00570.x     Document Type: Review
Times cited : (102)

References (62)
  • 1
    • 0003667696 scopus 로고    scopus 로고
    • Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents
    • Panel on Clinical Practices for Treatment of HIV Infection. February 4
    • Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents February 4, 2002: http://www.hivatis.org.
    • (2002)
  • 2
    • 0034685037 scopus 로고    scopus 로고
    • Antiretroviral treatment for adult HIV infection in 2002 - Updated recommendations of the International AIDS Society - USA Panel
    • Yeni PG, Hammer SM, Carpenter CCJ et al. Antiretroviral treatment for adult HIV infection in 2002 - updated recommendations of the International AIDS Society - USA Panel. JAMA 2000; 283: 381-90.
    • (2000) JAMA , vol.283 , pp. 381-390
    • Yeni, P.G.1    Hammer, S.M.2    Carpenter, C.C.J.3
  • 3
    • 0035202568 scopus 로고    scopus 로고
    • British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy
    • BHIVA Writing Committee on behalf of the BHIVA Executive Committee
    • BHIVA Writing Committee on behalf of the BHIVA Executive Committee. British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy. HIV Med 2001; 2: 276-313.
    • (2001) HIV Med. , vol.2 , pp. 276-313
  • 4
    • 0034232620 scopus 로고    scopus 로고
    • New French guidelines for antiretroviral treatment
    • Delfraissy J-F. New French guidelines for antiretroviral treatment. HIV Med 2000; 1: 133-6.
    • (2000) HIV Med. , vol.1 , pp. 133-136
    • Delfraissy, J.-F.1
  • 5
    • 9844261693 scopus 로고    scopus 로고
    • Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centers
    • Mouton Y, Alfandari S, Valette M et al. Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centers. AIDS 1997; 11: F101-F105.
    • (1997) AIDS , vol.11
    • Mouton, Y.1    Alfandari, S.2    Valette, M.3
  • 6
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infections
    • Palella FJ Jr, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infections. N Engl J Med 1998; 338: 853-60.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella F.J., Jr.1    Delaney, K.M.2    Moorman, A.C.3
  • 7
    • 0035512875 scopus 로고    scopus 로고
    • From amprenavir to GW433908
    • (review)
    • Gatell JM. From amprenavir to GW433908 (review). J HIV Ther 2001; 6: 95-9.
    • (2001) J. HIV Ther. , vol.6 , pp. 95-99
    • Gatell, J.M.1
  • 8
    • 85031178871 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of GS 7340, an isopropylalaninyl phenyl ester prodrug of tenofovir; selective intracellular activation of GS 7340 leads to preferential distribution in lymphatic tissues
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 384-T
    • Lee W, He G, Mulato A et al. In vivo and in vitro characterization of GS 7340, an isopropylalaninyl phenyl ester prodrug of tenofovir; selective intracellular activation of GS 7340 leads to preferential distribution in lymphatic tissues. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 384-T.
    • (2002)
    • Lee, W.1    He, G.2    Mulato, A.3
  • 9
    • 0036093269 scopus 로고    scopus 로고
    • Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection
    • Gish RG, Leung NWY, Wright TL et al. Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob Agents Chemother 2002; 46: 1734-40.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1734-1740
    • Gish, R.G.1    Leung, N.W.Y.2    Wright, T.L.3
  • 10
    • 0026480950 scopus 로고
    • Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl) -1,3-oxathiolan-5-yl]-cytosine
    • Schinazi RF, McMillian A, Cannon D et al. Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl) -1,3-oxathiolan-5-yl]-cytosine. Antimicrob Agents Chemother 1992; 36: 2423-31.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2423-2431
    • Schinazi, R.F.1    McMillian, A.2    Cannon, D.3
  • 11
    • 0032829089 scopus 로고    scopus 로고
    • Mechanistic studies show that (-) -FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP
    • Feng JY, Shi J, Schinazi RF, Anderson KS. Mechanistic studies show that (-) -FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. FASEB J 1999; 13: 1511-7.
    • (1999) FASEB J. , vol.13 , pp. 1511-1517
    • Feng, J.Y.1    Shi, J.2    Schinazi, R.F.3    Anderson, K.S.4
  • 12
    • 0027285372 scopus 로고
    • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • Tisdale M, Kemp SD, Parry NR, Larder BA. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci USA 1993; 90: 5653-6.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.D.2    Parry, N.R.3    Larder, B.A.4
  • 13
    • 85031190674 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of a once-daily combination with emtricitabine, didanosine and efavirenz in treatment naive HIV-infected adults (ANRS 091 Trial)
    • Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection. Athens, abstract P222
    • Lascoux-Combes C, Peytavin G, Perusat S et al. Pharmacokinetics (PK) of a once-daily combination with emtricitabine, didanosine and efavirenz in treatment naive HIV-infected adults (ANRS 091 Trial). In: Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection. Athens, 2001: abstract P222.
    • (2001)
    • Lascoux-Combes, C.1    Peytavin, G.2    Perusat, S.3
  • 14
    • 0033847883 scopus 로고    scopus 로고
    • Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients
    • Molina J-M, Ferchal F, Rancinan C et al. Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients. J Infect Dis 2000; 182: 599-602.
    • (2000) J. Infect. Dis. , vol.182 , pp. 599-602
    • Molina, J.-M.1    Ferchal, F.2    Rancinan, C.3
  • 15
    • 0003258422 scopus 로고    scopus 로고
    • Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment naive HIV-infected adults 96 week follow-up of the ANRS 091 trial
    • Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection. Athens: abstract P221
    • Molina JM, Ferchal F, Journot V et al. Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment naive HIV-infected adults 96 week follow-up of the ANRS 091 trial. In: Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection. Athens: 2001; abstract P221.
    • (2001)
    • Molina, J.M.1    Ferchal, F.2    Journot, V.3
  • 16
    • 0344627468 scopus 로고    scopus 로고
    • Long-term efficacy and safety of emtricitabine (FTC) in HIV+ adults switching from a lamivudine (3TC) containing HAART regimen
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract I-1932
    • Van der Horst C, Benson C, Rodriguez A, Hulett L, Wakeford C, Quinn J. Long-term efficacy and safety of emtricitabine (FTC) in HIV+ adults switching from a lamivudine (3TC) containing HAART regimen. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001; abstract I-1932.
    • (2001)
    • Van der Horst, C.1    Benson, C.2    Rodriguez, A.3    Hulett, L.4    Wakeford, C.5    Quinn, J.6
  • 17
    • 0042398269 scopus 로고    scopus 로고
    • Efficacy and safety of emtricitabine (FTC) triple combination therapy in HIV-1 infected treatment-naive male and female patients
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Abstract I-1933
    • Zeier M, Sanne I, Van der Berg M, Quinn J, Shaw A. Efficacy and safety of emtricitabine (FTC) triple combination therapy in HIV-1 infected treatment-naive male and female patients. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001: Abstract I-1933.
    • (2001)
    • Zeier, M.1    Sanne, I.2    Van der Berg, M.3    Quinn, J.4    Shaw, A.5
  • 18
    • 0035162759 scopus 로고    scopus 로고
    • Mechanism of action of 1-α-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1- α-D-dioxolane guanosine
    • Fuman PA, Jeffrey J, Kiefer LL et al. Mechanism of action of 1-α-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1- α-D-dioxolane guanosine. Antimicrob Agents Chemother 2001; 45: 158-65.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 158-165
    • Fuman, P.A.1    Jeffrey, J.2    Kiefer, L.L.3
  • 19
    • 0036156325 scopus 로고    scopus 로고
    • Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails
    • Mewshaw JP, Myrick FT, Wakefield DACS et al. Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. JAIDS 2002; 29: 11-20.
    • (2002) JAIDS , vol.29 , pp. 11-20
    • Mewshaw, J.P.1    Myrick, F.T.2    Wakefield, D.A.C.S.3
  • 20
    • 0003361114 scopus 로고    scopus 로고
    • Clinical HIV suppression after short term monotherapy with DAPD
    • Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, abstract 690
    • Eron JJ, Kessler H, Thompson M et al. Clinical HIV suppression after short term monotherapy with DAPD. In: Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, 2000: abstract 690.
    • (2000)
    • Eron, J.J.1    Kessler, H.2    Thompson, M.3
  • 21
    • 4244082941 scopus 로고    scopus 로고
    • Anti-HIV activity of DAPD in treatment-naive and treatment-experienced subjects
    • (abstract P5)
    • Raffi F, Kessler H, Thompson M et al. Anti-HIV activity of DAPD in treatment-naive and treatment-experienced subjects. AIDS 2000; 14: S18(abstract P5).
    • (2000) AIDS , vol.14
    • Raffi, F.1    Kessler, H.2    Thompson, M.3
  • 22
    • 0032786364 scopus 로고    scopus 로고
    • Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1
    • Corbett JW, Ko SS, Rodgers JD et al. Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1999; 43: 2893-7.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2893-2897
    • Corbett, J.W.1    Ko, S.S.2    Rodgers, J.D.3
  • 23
    • 0034128898 scopus 로고    scopus 로고
    • Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors
    • Corbett JW, Ko SS, Rodgers JD et al. Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors. J Med Chem 2000; 43: 2019-30.
    • (2000) J. Med. Chem. , vol.43 , pp. 2019-2030
    • Corbett, J.W.1    Ko, S.S.2    Rodgers, J.D.3
  • 24
    • 0013250344 scopus 로고    scopus 로고
    • Study DPC 083-203, a phase II comparison of 100 and 200 mg once-daily DPC 083 and 2 NRTIs in patients failing a NNRTI-containing regimen
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 6
    • Ruiz N, Nusrat R, Lauenroth-Mai E et al. Study DPC 083-203, a phase II comparison of 100 and 200 mg once-daily DPC 083 and 2 NRTIs in patients failing a NNRTI-containing regimen. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 6.
    • (2002)
    • Ruiz, N.1    Nusrat, R.2    Lauenroth-Mai, E.3
  • 25
    • 0013201757 scopus 로고    scopus 로고
    • Study DPC 083-201: A phase II double-blind (DB) comparison of 3 once daily doses of the NNRTI DPC 083 vs. efavirenz (EFV) in combination with 2 NRTIs in HIV antiretroviral (ARV) treatment-naive patients
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 7
    • Ruiz N, Nusrat R, Lazzarin A et al. Study DPC 083-201: A phase II double-blind (DB) comparison of 3 once daily doses of the NNRTI DPC 083 vs. efavirenz (EFV) in combination with 2 NRTIs in HIV antiretroviral (ARV) treatment-naive patients. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 7.
    • (2002)
    • Ruiz, N.1    Nusrat, R.2    Lazzarin, A.3
  • 26
    • 4243810666 scopus 로고    scopus 로고
    • R165335-TMC125, a third generation nonnucleoside reverse transcriptase inhibitor (NNRTI), inhibits 97% of more than 1000 recombinant NNRTI resistant HIV clinical isolates with an IC50 below 100 nM
    • (abstract P2)
    • De Bethune M, Hertogs K, Azihn H et al. R165335-TMC125, a third generation nonnucleoside reverse transcriptase inhibitor (NNRTI), inhibits 97% of more than 1000 recombinant NNRTI resistant HIV clinical isolates with an IC50 below 100 nM. AIDS 2000; 14: S17(abstract P2).
    • (2000) AIDS , vol.14
    • De Bethune, M.1    Hertogs, K.2    Azihn, H.3
  • 27
    • 0003356660 scopus 로고    scopus 로고
    • TMC125 is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) in antiretroviral therapy (ART) -naive, HIV-1 infected subjects
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, abstract I-668
    • Gruzdev B, Rakhmanova A, De Dier K et al. TMC125 is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) in antiretroviral therapy (ART) -naive, HIV-1 infected subjects. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, 2001: abstract I-668.
    • (2001)
    • Gruzdev, B.1    Rakhmanova, A.2    De Dier, K.3
  • 28
    • 0038327026 scopus 로고    scopus 로고
    • TMC 125, a next-generation NNRTI, demonstrates high potency after 7 days therapy in treatment-experienced HIV-1- infected individuals with phenotypic NNRTI resistance
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 4
    • Gazzard B, Pozniak A, Arasteh K et al. TMC 125, a next-generation NNRTI, demonstrates high potency after 7 days therapy in treatment-experienced HIV-1- infected individuals with phenotypic NNRTI resistance. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 4.
    • (2002)
    • Gazzard, B.1    Pozniak, A.2    Arasteh, K.3
  • 29
    • 0033931167 scopus 로고    scopus 로고
    • BMS-232,632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents
    • Robinson BS, Riccardi KA, Gong Y-F et al. BMS-232,632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents. Antimicrob Agents Chemother 2000; 44: 2093-9.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2093-2099
    • Robinson, B.S.1    Riccardi, K.A.2    Gong, Y.-F.3
  • 30
    • 0033844808 scopus 로고    scopus 로고
    • In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232,632
    • Gong Y-F, Robinson BS, Rose RE et al. In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232,632. Antimicrob Agents Chemother 2000; 44: 2319-26.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2319-2326
    • Gong, Y.-F.1    Robinson, B.S.2    Rose, R.E.3
  • 31
    • 85031183246 scopus 로고    scopus 로고
    • Genotypic and phenotypic resistance to BMS 232632 (atazanavir - ATV), among heavily experienced pediatric patients who were ATV-naïve
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 811-W
    • Aldrovandi G, Samson P, Fenton T, Schnittman S, Rutstein R. Genotypic and phenotypic resistance to BMS 232632 (atazanavir - ATV), among heavily experienced pediatric patients who were ATV-naïve. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 811-W.
    • (2002)
    • Aldrovandi, G.1    Samson, P.2    Fenton, T.3    Schnittman, S.4    Rutstein, R.5
  • 32
    • 0037732201 scopus 로고    scopus 로고
    • BMS-232,632: Single and multiple oral dose safety and pharmacokinetic study in healthy volunteers
    • Abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. San Francisco, abstract 604
    • O'Mara EM, Smith J, Olsen SJ, Tanner T, Schuster AE, Kaul S. BMS-232,632: single and multiple oral dose safety and pharmacokinetic study in healthy volunteers. In: Abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. San Francisco, 1999: abstract 604.
    • (1999)
    • O'Mara, E.M.1    Smith, J.2    Olsen, S.J.3    Tanner, T.4    Schuster, A.E.5    Kaul, S.6
  • 33
    • 0037651432 scopus 로고    scopus 로고
    • Comparative results (phase II 48-week): BMS-232632, stavudine, lamivudine as HAART for treatment-naïve HIV (+) patients (AI424-008)
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract I-667
    • Sanne I, Cahn P, Percival L et al. Comparative results (phase II 48-week): BMS-232632, stavudine, lamivudine as HAART for treatment-naïve HIV (+) patients (AI424-008). In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001: abstract I-667.
    • (2001)
    • Sanne, I.1    Cahn, P.2    Percival, L.3
  • 34
    • 0003316997 scopus 로고    scopus 로고
    • Atazanavir plus saquinavir once daily favorably affects total cholesterol (TC), fasting triglyceride (TG), and fasting LDL cholesterol (LDL) profiles in patients failing prior therapy (trial AI424-009, week 48)
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 42
    • Haas D, Zala C, Schrader S, Thiry A, McGovern R, Schnittman S. Atazanavir plus saquinavir once daily favorably affects total cholesterol (TC), fasting triglyceride (TG), and fasting LDL cholesterol (LDL) profiles in patients failing prior therapy (trial AI424-009, week 48). In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 42.
    • (2002)
    • Haas, D.1    Zala, C.2    Schrader, S.3    Thiry, A.4    McGovern, R.5    Schnittman, S.6
  • 35
    • 0013266121 scopus 로고    scopus 로고
    • Atazanavir: A once-daily protease inhibitor with a superior lipid profile - Results of clinical trials beyond week 48
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 706-T
    • Piliero PJ, Cahn P, Pantaleo G et al. Atazanavir: a once-daily protease inhibitor with a superior lipid profile - results of clinical trials beyond week 48. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002; abstract 706-T.
    • (2002)
    • Piliero, P.J.1    Cahn, P.2    Pantaleo, G.3
  • 36
    • 12944322516 scopus 로고    scopus 로고
    • Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class
    • Turner SR, Strohbach JW, Tommasi RA et al. Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J Med Chem 1998; 41: 3467-76.
    • (1998) J. Med. Chem. , vol.41 , pp. 3467-3476
    • Turner, S.R.1    Strohbach, J.W.2    Tommasi, R.A.3
  • 37
    • 0013200817 scopus 로고    scopus 로고
    • An open-label steady state investigation of the pharmacokinetics (PK) of tipranavir (TPV) and ritonavir (RTV) and their effects on cytochrome P-450 (3A4) activity in normal healthy volunteers. (BI 1182.5)
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 434-W
    • McCallister S, Sabo J, Galitz L, Mayers D. An open-label steady state investigation of the pharmacokinetics (PK) of tipranavir (TPV) and ritonavir (RTV) and their effects on cytochrome P-450 (3A4) activity in normal healthy volunteers. (BI 1182.5). In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 434-W.
    • (2002)
    • McCallister, S.1    Sabo, J.2    Galitz, L.3    Mayers, D.4
  • 38
    • 0034623020 scopus 로고    scopus 로고
    • Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples
    • Larder BA, Hertogs K, Bloor S et al. Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples. AIDS 2000; 14: 1943-8.
    • (2000) AIDS , vol.14 , pp. 1943-1948
    • Larder, B.A.1    Hertogs, K.2    Bloor, S.3
  • 39
    • 0013250209 scopus 로고    scopus 로고
    • Safety and efficacy of tipranavir (TPV), a novel non-peptidic protease inhibitor, plus ritonavir (RTV), in PI-failure patients
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract LB-5
    • Slater L, Farthing C, Jayaweera J et al. Safety and efficacy of tipranavir (TPV), a novel non-peptidic protease inhibitor, plus ritonavir (RTV), in PI-failure patients. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001: abstract LB-5.
    • (2001)
    • Slater, L.1    Farthing, C.2    Jayaweera, J.3
  • 40
    • 0037651419 scopus 로고    scopus 로고
    • Resistance to tipranavir is uncommon in a randomized trial of tipranavir/ritonavir (TPV/RTV) in multiple PI-failure patients (BI 1182.2)
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 562-T
    • Schwartz R, Kazanjian P, Slater L et al. Resistance to tipranavir is uncommon in a randomized trial of tipranavir/ritonavir (TPV/RTV) in multiple PI-failure patients (BI 1182.2). In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002; abstract 562-T.
    • (2002)
    • Schwartz, R.1    Kazanjian, P.2    Slater, L.3
  • 41
    • 0036145503 scopus 로고    scopus 로고
    • A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site
    • Yoshimura K, Kato R, Kavlick MF et al. A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site. J Virol 2002; 76: 1349-58.
    • (2002) J. Virol. , vol.76 , pp. 1349-1358
    • Yoshimura, K.1    Kato, R.2    Kavlick, M.F.3
  • 42
    • 0037989201 scopus 로고    scopus 로고
    • TMC 114, a highly potent protease inhibitor (PI) with an excellent profile against HIV variants highly resistant to current PIs
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract F-, 1677
    • De Bethune M, Wigerinck P, Jonckheere H et al. TMC 114, a highly potent protease inhibitor (PI) with an excellent profile against HIV variants highly resistant to current PIs. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001: abstract F-, 1677.
    • (2001)
    • De Bethune, M.1    Wigerinck, P.2    Jonckheere, H.3
  • 43
    • 0037806272 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of escalating single oral doses of TMC 114, a novel protease inhibitor (PI) highly active against HIV-1 variants resistant to other PIs
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract I-1934
    • Van Der Geest R, Van Der Sandt I, Gille D, Groen K, Tritsmans L, Stoffels P. Safety, tolerability and pharmacokinetics of escalating single oral doses of TMC 114, a novel protease inhibitor (PI) highly active against HIV-1 variants resistant to other PIs. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2001; abstract I-1934.
    • (2001)
    • Van Der Geest, R.1    Van Der Sandt, I.2    Gille, D.3    Groen, K.4    Tritsmans, L.5    Stoffels, P.6
  • 44
    • 0029062687 scopus 로고
    • Expression and characterization of CD4-IgG2, a novel hetrotetramer which neutralizes primary HIV type 1 isolates
    • Allaway GP, Davis-Bruno KL, Beaudry GA et al. Expression and characterization of CD4-IgG2, a novel hetrotetramer which neutralizes primary HIV type 1 isolates. AIDS Res Hum Retroviruses 1995; 11: 533-9.
    • (1995) AIDS Res. Hum. Retroviruses , vol.11 , pp. 533-539
    • Allaway, G.P.1    Davis-Bruno, K.L.2    Beaudry, G.A.3
  • 45
    • 85031187655 scopus 로고    scopus 로고
    • PRO 542 (CD4-IgG2) has a profound impact on HIV-1 replication in the Hu-PBL-SCID mouse model
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 401-T
    • Franti M, O'Neill T, Maddon P, Burton D, Poignard P, Olson W. PRO 542 (CD4-IgG2) has a profound impact on HIV-1 replication in the Hu-PBL-SCID mouse model. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 401-T.
    • (2002)
    • Franti, M.1    O'Neill, T.2    Maddon, P.3    Burton, D.4    Poignard, P.5    Olson, W.6
  • 46
    • 0033914939 scopus 로고    scopus 로고
    • Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults
    • Jacobson JM, Lowy I, Fletcher CV et al. Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults. J Infect Dis 2000; 182: 326-9.
    • (2000) J. Infect. Dis. , vol.182 , pp. 326-329
    • Jacobson, J.M.1    Lowy, I.2    Fletcher, C.V.3
  • 47
    • 0033712475 scopus 로고    scopus 로고
    • Recombinant CD4-IgG2 in human immunodeficiency virus type 1-infected children: Phase 1/2 study
    • Shearer WT, Israel RJ, Starr S et al. Recombinant CD4-IgG2 in human immunodeficiency virus type 1-infected children: phase 1/2 study. J Infect Dis 2000; 182: 1774-9.
    • (2000) J. Infect. Dis. , vol.182 , pp. 1774-1779
    • Shearer, W.T.1    Israel, R.J.2    Starr, S.3
  • 48
    • 0035940445 scopus 로고    scopus 로고
    • SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-infection in vitro and in vivo
    • Strizki JM, Xu S, Wagner NE et al. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-infection in vitro and in vivo. Proc Natl Acad Sci 2001; 98: 12718-23.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 12718-12723
    • Strizki, J.M.1    Xu, S.2    Wagner, N.E.3
  • 49
    • 85031185425 scopus 로고    scopus 로고
    • HIV-1 escape from small molecule CCR5 inhibitors in PBMC does not involve co-receptor switching to CXCR4 use
    • Abstracts of the 1st International AIDS Society Conference on HIV Pathogenesis and Treatment. Buenos Aires, abstract LB-, 05
    • Moore J. HIV-1 escape from small molecule CCR5 inhibitors in PBMC does not involve co-receptor switching to CXCR4 use. In: Abstracts of the 1st International AIDS Society Conference on HIV Pathogenesis and Treatment. Buenos Aires, 2002: abstract LB-, 05.
    • (2002)
    • Moore, J.1
  • 50
    • 0003297005 scopus 로고    scopus 로고
    • Development of CCR5 antagonists as a new class of anti-HIV therapeutic
    • Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Chicago, February 4-8; abstract L-11
    • Reyes G. Development of CCR5 antagonists as a new class of anti-HIV therapeutic. IN. Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Chicago, February 4-8; 2001: abstract L-11.
    • (2001)
    • Reyes, G.1
  • 51
    • 0003339453 scopus 로고    scopus 로고
    • SCH C. safety and antiviral effects of a CCR5 receptor antagonist in HIV-1 infected subjects
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 1
    • Reynes J, Rouzier R, Kanouni T et al. SCH C. safety and antiviral effects of a CCR5 receptor antagonist in HIV-1 infected subjects. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 1.
    • (2002)
    • Reynes, J.1    Rouzier, R.2    Kanouni, T.3
  • 52
    • 0027692502 scopus 로고
    • A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion
    • (letter)
    • Wild C, Greenwell T, Matthews T. A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion (letter). AIDS Res Human Retrovirus 1993; 9: 1051-3.
    • (1993) AIDS Res. Human Retrovirus , vol.9 , pp. 1051-1053
    • Wild, C.1    Greenwell, T.2    Matthews, T.3
  • 53
    • 0031729823 scopus 로고    scopus 로고
    • Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
    • Kilby JM, Hopkins S, Venetta TM et al. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat Med 1998; 4: 1302-7.
    • (1998) Nat. Med. , vol.4 , pp. 1302-1307
    • Kilby, J.M.1    Hopkins, S.2    Venetta, T.M.3
  • 54
    • 0036090585 scopus 로고    scopus 로고
    • Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
    • Wie X, Decker JM, Liu H et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 2002; 46: 1896-905.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1896-1905
    • Wie, X.1    Decker, J.M.2    Liu, H.3
  • 55
    • 85031183849 scopus 로고    scopus 로고
    • Forty-eight week analysis of patients receiving T-20 as a component of multi-drug salvage therapy
    • Abstracts of the XIII International AIDS Conference. Durban, abstract LbPp116
    • Lalezari J, Cohen C, Eron J, Kilby M, Nelson E, Sista P. Forty-eight week analysis of patients receiving T-20 as a component of multi-drug salvage therapy. In: Abstracts of the XIII International AIDS Conference. Durban, 2000: abstract LbPp116.
    • (2000)
    • Lalezari, J.1    Cohen, C.2    Eron, J.3    Kilby, M.4    Nelson, E.5    Sista, P.6
  • 56
    • 0013425084 scopus 로고    scopus 로고
    • A week 48 assessment of a randomized, controlled, open-label phase II trial (T20-206) evaluating 3 doses of T-20 in PI-experienced, NNRTI-naïve patients infected with HIV-1
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 418-W
    • Lalezari J, DeJesus E, Northfelt D et al. A week 48 assessment of a randomized, controlled, open-label phase II trial (T20-206) evaluating 3 doses of T-20 in PI-experienced, NNRTI-naïve patients infected with HIV-1. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002; abstract 418-W.
    • (2002)
    • Lalezari, J.1    DeJesus, E.2    Northfelt, D.3
  • 57
    • 0003245253 scopus 로고    scopus 로고
    • Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in Europe and Australia
    • Abstracts of the XIV International AIDS Conference. Barcelona, abstract LbOr19A
    • Clotet B, Lazzarin A, Cooper D et al. Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in Europe and Australia. In: Abstracts of the XIV International AIDS Conference. Barcelona, 2002: abstract LbOr19A.
    • (2002)
    • Clotet, B.1    Lazzarin, A.2    Cooper, D.3
  • 58
    • 0003209749 scopus 로고    scopus 로고
    • Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in North America and Brazil
    • Abstracts of the XIV International AIDS Conference. Barcelona, abstract LbOr19B
    • Henry K, Lalezari J, O'Hearn M et al. Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in North America and Brazil. In: Abstracts of the XIV International AIDS Conference. Barcelona, 2002: abstract LbOr19B.
    • (2002)
    • Henry, K.1    Lalezari, J.2    O'Hearn, M.3
  • 59
    • 0003340821 scopus 로고    scopus 로고
    • A 14-day assessment of the safety, pharmacokinetics, and antiviral activity of T-1249, a peptide inhibitor of membrane fusion
    • Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Chicago, abstract 14
    • Eron J, Merigan T, Kilby M et al. A 14-day assessment of the safety, pharmacokinetics, and antiviral activity of T-1249, a peptide inhibitor of membrane fusion. In: Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. Chicago, 2001: abstract 14.
    • (2001)
    • Eron, J.1    Merigan, T.2    Kilby, M.3
  • 60
    • 85031181801 scopus 로고    scopus 로고
    • Genotypic resistance to protease and reverse transcriptase inhibitors and antiretroviral history do not affect virologic response to T-1249
    • Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, abstract I-, 669
    • Miralles G, Demasi R, Sista P, Melby T, Duff F, Matthews T. Genotypic resistance to protease and reverse transcriptase inhibitors and antiretroviral history do not affect virologic response to T-1249. In: Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, 2002; abstract I-, 669.
    • (2002)
    • Miralles, G.1    Demasi, R.2    Sista, P.3    Melby, T.4    Duff, F.5    Matthews, T.6
  • 61
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda DJ, Felock P, Witmer M et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000; 287: 646-50.
    • (2000) Science , vol.287 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3
  • 62
    • 0003203586 scopus 로고    scopus 로고
    • S-1360: In vitro activity of a new HIV-1 integrase inhibitor in clinical development
    • Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, abstract 8
    • Yoshinaga T, Sato A, Fujishita T, Fujiwara T. S-1360: in vitro activity of a new HIV-1 integrase inhibitor in clinical development. In: Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002: abstract 8.
    • (2002)
    • Yoshinaga, T.1    Sato, A.2    Fujishita, T.3    Fujiwara, T.4


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