Peptide-lead CXCR4 antagonists with high anti-HIV activity

Current Opinion in Investigational Drugs

Volumn 2, Issue 9, 2001, Pages 1198-1202

  Fujii, N ^a   Tamamura, H ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

CCR5; CXCR4 antagonist; HIV; Polyphemusin; T 140; T 14012; T 22

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ALPHA N ACETYLNONA DEXTRO ARGININE AMIDE; ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; NONADEXTRO ARGININE; POLYPHEMUSIN II[5,12 TYROSINE 7 LYSINE]; RNA DIRECTED DNA POLYMERASE INHIBITOR; T 140; T 22; TC 14012; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; CONTROLLED DRUG RELEASE; CRAB; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; MOLECULAR SIZE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE; TARGET CELL;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CHEMOKINES, CXC; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034835884     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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