Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

Journal of Virology

Volumn 77, Issue 19, 2003, Pages 10557-10565

  Labrijn, Aran F ^a,i   Poignard, Pascal ^a   Raja, Aarti ^c   Zwick, Michael B ^a   Delgado, Karla ^a   Franti, Michael ^a   Binley, James ^a   Vivona, Veronique ^a   Grundner, Christoph ^c   Huang, Chih Chin ^f   Venturi, Miro ^f   Petropoulos, Christos J ^b   Wrin, Terri ^b   Dimitrov, Dimiter S ^g   Robinson, James ^h   Kwong, Peter D ^f   Wyatt, Richard T ^c,f   Sodroski, Joseph ^c,d,e   Burton, Dennis R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MONOGRAM BIOSCIENCES   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^g NATIONAL CANCER INSTITUTE   (United States)

^h TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ GENMAB   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 INDUCED ANTIBODY; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BINDING SITE; CELL MEMBRANE; CONTROLLED STUDY; DRUG DESIGN; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR BINDING; STEREOCHEMISTRY; TARGET CELL; VACCINATION; VIRUS ENVELOPE; VIRUS ISOLATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; BINDING SITES; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; NEUTRALIZATION TESTS; RECEPTORS, CCR5; RECEPTORS, CXCR4;

EID: 0141521564     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.19.10557-10565.2003     Document Type: Article

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