Induction of bystander T cell proliferation by viruses and type I interferon in vivo

Science

Volumn 272, Issue 5270, 1996, Pages 1947-1950

  Tough, David F ^a   Borrow, Persephone ^a   Sprent, Jonathan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERFERON; INTERLEUKIN 2 RECEPTOR; LEUKOCYTE ANTIGEN; POLYINOSINIC POLYCYTIDYLIC ACID; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS MENINGITIS;

ANIMALIA; CHORIOMENINGITIS VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS;

EID: 0030036342     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5270.1947     Document Type: Article

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38. 6 PFU), and then immediately given BrdU (Sigma) drinking water (0.8 mg/ml) (4). BrdU water was made fresh and changed daily. LN cells were stained for flow cytometry with mAbs to CD8-PE (Gibco-BRL, Gaithersburg, MD), to CD4-PE (Collaborative Biomedical Products, Bedford, MA), to CD44-biotin (IM7.8.1), or to Ly-6C-biotin (Pharmingen, San Diego, CA); with streptavidin-RED613 (Gibco-BRL); and, after fixation, with mAb to BrdU-FITC (Becton Dickinson, Mountainview, CA) (4). Stained cells were analyzed on a FACScan flow cytometer (Becton Dickinson).
39. hi cells in ATx 2C mice, cells were stained with mAb to CD8-CyChrome (Pharmingen), 1B2-biotin (32), Texas Red-streptavidin (Gibco-BRL), and mAb to CD44-PE (Pharmingen) before being stained with mAb to BrdU-FITC. Four-color analysis was done with a FACStar Plus flow cytometer (Becton Dickinson).
40. 5 U of purified murine IFN-β (Lee Biomolecular Laboratory, San Diego, CA) or an equivalent volume (0.45 ml) of mock IFN α/β (Lee Biomolecular Laboratory) and were immediately started on BrdU drinking water. Staining of LN and spleen cells for flow cytometry was carried out as described in Fig. 1.
41. + cells was calculated from total cell counts of pooled LNs and spleens. Experiments 1 and 2 represent independent experiments.
42. We thank M. B. A. Oldstone for advice on viral experiments, D. Y. Loh for 2C mice, I. Gresser for providing antiserum to IFN, T. Knapp for assistance with four-color analysis, and B. Marchand for typing the manuscript. Supported by grants CA38355, CA25803, AI21487, and AI32068 from the USPHS and by a Centennial Fellowship from the Medical Research Council of Canada (to D.F.T.). This is publication 9662-IMM from the Scripps Research Institute.