Role of toll-like receptors in costimulating cytotoxic T cell responses

European Journal of Immunology

Volumn 33, Issue 6, 2003, Pages 1465-1470

  Schwarz, Katrin ^a   Storni, Tazio ^a   Manolova, Vania ^a   Didierlaurent, Arnaud ^b   Sirard, Jean Claude ^b   Röthlisberger, Peter ^c   Bachmann, Martin F ^a  

^a CYTOS BIOTECHNOLOGY AG   (Switzerland)

^b Inst Suisse Rech de Exp Cancer   (Switzerland)

^c NONE

Author keywords

Adjuvant; CpG; LCMV; Virus like particle

Indexed keywords

APC PROTEIN; LIGAND; LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; VACCINATION; VIRUS PARTICLE;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, VIRAL; CPG ISLANDS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; DNA-BINDING PROTEINS; FEMALE; FLAGELLIN; GLYCOPROTEINS; HEPATITIS B CORE ANTIGENS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE FRAGMENTS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 6; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; VACCINATION; VIRAL PROTEINS;

EID: 0038759097     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323919     Document Type: Article

References (32)

1. Janeway, C. A. Jr., Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989. 54 Pt 1: 1-13.
2. Singh, M. and O'Hagan, D., Advances in vaccine adjuvants. Nat. Biotechnol. 1999. 17: 1075-1081.
3. Bachmann, M. F., Zinkernagel, R. M. and Oxenius, A., Immune responses in the absence of costimulation: viruses know the trick. J. Immunol. 1998. 161: 5791-5794.
4. Medzhitov, R. and Janeway, C. Jr., The Toll receptor family and microbial recognition. Trends Microbiol. 2000. 8: 452-456.
5. Beutler, B., Toll-like receptors: how they work and what they do. Curr. Opin. Hematol. 2002. 9: 2-10.
6. Kaisho, T. and Akira, S., Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta 2002. 1589: 1-13.
7. Aliprantis, A. O., Yang, R. B., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. and Zychlinsky, A., Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 1999. 285: 736-739.
8. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S., Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999. 11: 443-451.
9. Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A., Wilson, C. B., Bassetti, M. and Aderem, A., The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999. 401: 811-815.
10. Michelsen, K. S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C. J. and Schumann, R. R., The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J. Biol. Chem. 2001. 276: 25680-25686.
11. Alexopoulou, L., Holt, A. C., Medzhitov, R. and Flavell, R. A., Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3. Nature 2001. 413: 732-738.
12. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998. 282: 2085-2088.
13. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 1999. 162: 3749-3752.
14. Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M. and Aderem, A., The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001. 410: 1099-1103.
15. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K. and Akira, S., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 2002. 3: 196-200.
16. Jurk, M., Heil, F., Vollmer, J., Schetter, C., Krieg, A. M., Wagner, H., Lipford, G. and Bauer, S., Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 2002. 3: 499.
17. Schnare, M., Holt, A. C., Takeda, K., Akira, S. and Medzhitov, R., Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 2000. 10: 1139-1142.
18. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S., A Toll-like receptor recognizes bacterial DNA. Nature 2000. 408: 740-745.
19. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S., Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999. 11: 115-122.
20. Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J. M., Wesche, H., Ohashi, P. S., Mak, T. W. and Yeh, W. C., Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 2002. 416: 750-756.
21. Storni, T., Lechner, F., Erdmann, I., Bachi, T., Jegerlehner, A., Dumrese, T., Kundig, T. M., Ruedl, C. and Bachmann, M. F., Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles. J. Immunol. 2002. 168: 2880-2886.
22. Ruedl, C., Storni, T., Lechner, F., Bachi, T. and Bachmann, M. F., Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP. Eur. J. Immunol. 2002. 32: 818-825.
23. Binder, D. and Kundig, T. M., Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL. J. Immunol. 1991. 146: 4301-4307.
24. Horng, T., Barton, G. M. and Medzhitov, R., TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2001. 2: 835-841.
25. Sparwasser, T., Vabulas, R. M., Villmow, B., Lipford, G. B. and Wagner, H., Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J. Immunol. 2000. 30: 3591-3597.
26. Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter-Dambuyant, C., Vicari, A., O'Garra, A., Biron, C., Briere, F. and Trinchieri, G., Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2001. 2: 1144-1150.
27. Boonstra, A., Asselin-Paturel, C., Gilliet, M., Crain, C., Trinchieri, G., Liu, Y. J. and O'Garra, A., Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J. Exp. Med. 2003. 197: 101-109.
28. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R. W., Kastelein, R. A., Bazan, F. and Liu, Y. J., Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001. 194: 863-869.
29. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. and Hartmann, G., Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002. 168: 4531-4537.
30. Roethlisberger, R, Iida-Tanaka, N., Hollemeyer, K., Heinzle, E., Ishizuka, I. and Fischer, W., Unique poly(glycerophosphate) lipoteichoic acid and the glycolipids of a Streptococcus sp. closely related to Streptococcus pneumoniae. Eur. J. Biochem. 2000. 267: 5520-5530.
31. Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J. P. and Sirard, J. C., Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc. Natl. Acad. Sci. U S A 2001. 98: 13722-13727.
32. Bachmann, M. F., Kundig, T. M., Freer, G., Li, Y., Kang, C. Y., Bishop, D. H., Hengartner, H. and Zinkernagel, R. M., Induction of protective cytotoxic T cells with viral proteins. Eur. J. Immunol. 1994. 24: 2228-2236.